{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T04:19:46Z","timestamp":1783052386450,"version":"3.54.6"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T00:00:00Z","timestamp":1700092800000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100018780","name":"Servicio Andaluz de Salud","doi-asserted-by":"publisher","award":["PI-0032-2017"],"award-info":[{"award-number":["PI-0032-2017"]}],"id":[{"id":"10.13039\/501100018780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018780","name":"Servicio Andaluz de Salud","doi-asserted-by":"publisher","award":["RH-0145-020"],"award-info":[{"award-number":["RH-0145-020"]}],"id":[{"id":"10.13039\/501100018780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018780","name":"Servicio Andaluz de Salud","doi-asserted-by":"publisher","award":["PI-0032-2017"],"award-info":[{"award-number":["PI-0032-2017"]}],"id":[{"id":"10.13039\/501100018780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018780","name":"Servicio Andaluz de Salud","doi-asserted-by":"publisher","award":["RH-0145-020"],"award-info":[{"award-number":["RH-0145-020"]}],"id":[{"id":"10.13039\/501100018780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,11,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Digital pathology and genomics are increasingly used to improve our understanding of lymphoid neoplasms. Algorithms for quantifying cell populations in the lymph node and genetics can be integrated to identify new biomarkers with prognostic impact in classic Hodgkin lymphoma (cHL). In 16 cHL patients, we have performed whole slide imaging (WSI) analysis and quantification of CD30+, CD20+, CD3+ and MUM1+ cells in whole tissue slides, and Next Generation Sequencing (NGS) in formalin fixed paraffin-embedded (FFPE) tissue, using a widely used NSG panel (Oncomine\u00ae Focus Assay) to define genetic variants underlying tumor development. The different cell populations could be successfully identified in scanned slides of cHL, supporting the inclusion of WSI in the histopathological evaluation of cHL as an adequate method for the quantification of different cell populations. We also performed genetic profiling in FFPE samples of cHL leading to the identification of copy number variations in the Neurofibromin 1 gene (17q11.2) and the Androgen Receptor gene (Xq12) accompanied by chromosomal gains and losses in CDK4, KRAS and FGFR2 genes. Progression-free survival (PFS) was statistically significantly higher in cHL patients with amplification in the NF1 gene combined with CD3+ cells above 28.6% (p = 0.006) and MUM1+ cells above 21.8% (p &amp;lt; 0.001). Moreover, patients with MUM1+ cells above 21.8% showed a statistically significantly higher PFS when combined with amplification of the AR gene (p &amp;lt; 0.001) and wild-type KRAS (p &amp;lt; 0.001). The integration of WSI analysis and DNA sequencing could be useful to improve our understanding of the biology of cHL and define risk subgroups.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/d2mo00195k","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T05:12:42Z","timestamp":1668575562000},"page":"1015-1028","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Identification of prognostic factors in classic Hodgkin lymphoma by integrating whole slide imaging and next generation sequencing"],"prefix":"10.1093","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0827-4263","authenticated-orcid":false,"given":"Antonio","family":"Santisteban-Espejo","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Cadiz c , Cadiz, Spain"},{"name":"Institute of Research and Innovation in Biomedical Sciences of the Province of Cadiz (INiBICA) b , Cadiz, Spain"},{"name":"Pathology Department, Puerta del Mar University Hospital a , Av. Ana de Viya, 21. 11009, Cadiz Spain \u00a0 antoniosantistebanespejo@gmail.com \u00a0 +34 603470838"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Bernal-Florindo","sequence":"additional","affiliation":[{"name":"Pathology Department, Jerez de la Frontera University Hospital d , Cadiz, Spain"},{"name":"Institute of Research and Innovation in Biomedical Sciences of the Province of Cadiz (INiBICA) b , Cadiz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Perez-Requena","sequence":"additional","affiliation":[{"name":"Pathology Department, Puerta del Mar University Hospital a , Av. Ana de Viya, 21. 11009, Cadiz Spain \u00a0 antoniosantistebanespejo@gmail.com \u00a0 +34 603470838"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Atienza-Cuevas","sequence":"additional","affiliation":[{"name":"Pathology Department, Puerta del Mar University Hospital a , Av. Ana de Viya, 21. 11009, Cadiz Spain \u00a0 antoniosantistebanespejo@gmail.com \u00a0 +34 603470838"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Catalina-Fernandez","sequence":"additional","affiliation":[{"name":"Pathology Department, Puerta del Mar University Hospital a , Av. Ana de Viya, 21. 11009, Cadiz Spain \u00a0 antoniosantistebanespejo@gmail.com \u00a0 +34 603470838"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria del Carmen","family":"Fernandez-Valle","sequence":"additional","affiliation":[{"name":"Hemathology Department, Puerta del Mar University Hospital e , Cadiz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Romero-Garcia","sequence":"additional","affiliation":[{"name":"Institute of Research and Innovation in Biomedical Sciences of the Province of Cadiz (INiBICA) b , Cadiz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcial","family":"Garcia-Rojo","sequence":"additional","affiliation":[{"name":"Pathology Department, Jerez de la Frontera University Hospital d , Cadiz, Spain"},{"name":"Institute of Research and Innovation in Biomedical Sciences of the Province of Cadiz (INiBICA) b , Cadiz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,16]]},"reference":[{"key":"2026010813072535500_cit1","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1182\/asheducation-2009.1.491","article-title":"Molecular biology of Hodgkin lymphoma","author":"K\u00fcppers","year":"2009","journal-title":"Hematology"},{"key":"2026010813072535500_cit2","article-title":"International Agency for Research on Cancer, [homepage on the","author":"World Health Organization (WHO)"},{"issue":"9361","key":"2026010813072535500_cit3","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S0140-6736(03)12777-8","article-title":"Hodgkin's lymphoma","volume":"361","author":"Yung","year":"2003","journal-title":"Lancet"},{"issue":"4","key":"2026010813072535500_cit4","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1182\/blood.V96.4.1280","article-title":"Prognostic factors and treatment outcome in primary progressive Hodgkin lymphoma: A report from the German Hodgkin lymphoma study group","volume":"96","author":"Josting","year":"2000","journal-title":"Blood"},{"issue":"10","key":"2026010813072535500_cit5","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.bbmt.2007.06.003","article-title":"Late effects in survivors of Hodgkin and non-Hodgkin lymphoma treated with autologous hematopoietic cell transplantation: A report from the bone marrow transplant survivor study","volume":"13","author":"Majhail","year":"2007","journal-title":"Biol. Blood Marrow Transplant."},{"issue":"7","key":"2026010813072535500_cit6","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/s41408-021-00518-z","article-title":"Latest advances in the management of classical Hodgkin lymphoma: The era of novel therapies","volume":"11","author":"Mohty","year":"2021","journal-title":"Blood Cancer J."},{"issue":"1","key":"2026010813072535500_cit7","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.pathol.2019.09.005","article-title":"Hodgkin lymphoma: A review of pathological features and recent advances in pathogenesis","volume":"52","author":"Piris","year":"2020","journal-title":"Pathology"},{"key":"2026010813072535500_cit8","doi-asserted-by":"crossref","first-page":"16","DOI":"10.4103\/jpi.jpi_16_20","article-title":"Is the time right to start using digital pathology and artificial intelligence for the diagnosis of lymphoma?","volume":"11","author":"Salama","year":"2020","journal-title":"J. Pathol. 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Pediatr."},{"issue":"20","key":"2026010813072535500_cit28","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1182\/blood-2016-01-643569","article-title":"The 2016 revision of the World Health Organization classification of lymphoid neoplasms","volume":"127","author":"Swerdlow","year":"2016","journal-title":"Blood"},{"issue":"7","key":"2026010813072535500_cit29","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1056\/NEJMoa1000067","article-title":"Reduced treatment intensity in patients with early-stage Hodgkin's lymphoma","volume":"363","author":"Engert","year":"2010","journal-title":"N. Engl. J. Med."},{"issue":"21","key":"2026010813072535500_cit30","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1056\/NEJM199811193392104","article-title":"A prognostic score for advanced Hodgkin's disease. International prognostic factors project on advanced Hodgkin's disease","volume":"339","author":"Hasenclever","year":"1998","journal-title":"N. Engl. J. 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Assoc."},{"issue":"5","key":"2026010813072535500_cit38","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1200\/JCO.2006.09.2403","article-title":"Revised response criteria for malignant lymphoma","volume":"25","author":"Cheson","year":"2007","journal-title":"J. Clin. Oncol."},{"issue":"2","key":"2026010813072535500_cit39","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1200\/JCO.2011.39.9881","article-title":"Expression of FOXP3, CD68, and CD20 at diagnosis in the microenvironment of classical Hodgkin lymphoma is predictive of outcome","volume":"31","author":"Greaves","year":"2013","journal-title":"J. Clin. Oncol."},{"issue":"6","key":"2026010813072535500_cit40","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.3109\/10428194.2014.951849","article-title":"High CD20+ background cells predict a favorable outcome in classical Hodgkin lymphoma and antagonize CD68+ macrophages","volume":"56","author":"Panico","year":"2015","journal-title":"Leuk. 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Cancer"},{"issue":"5","key":"2026010813072535500_cit48","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.cell.2007.05.018","article-title":"GEFs and GAPs: Critical elements in the control of small G proteins","volume":"129","author":"Bos","year":"2007","journal-title":"Cell"},{"issue":"1","key":"2026010813072535500_cit49","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1152\/physrev.00003.2012","article-title":"Regulation of small GTPases by GEFs, GAPs, and GDIs","volume":"93","author":"Cherfils","year":"2013","journal-title":"Physiol. Rev."},{"issue":"7","key":"2026010813072535500_cit50","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1093\/hmg\/10.7.747","article-title":"The neurofibromatoses: When less is more","volume":"10","author":"Gutmann","year":"2001","journal-title":"Hum. Mol. 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Pathol."},{"issue":"3","key":"2026010813072535500_cit56","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1046\/j.1365-2141.1999.01727.x","article-title":"X-chromosome inactivation analysis of isolated Reed-Sternberg cells in nodular sclerosing Hodgkin's disease","volume":"107","author":"Chang","year":"1999","journal-title":"Br. J. Haematol."},{"issue":"3","key":"2026010813072535500_cit57","first-page":"137","article-title":"Androgen receptor gene mutation, rearrangement, polymorphism","volume":"2","author":"Eisermann","year":"2013","journal-title":"Transl. Androl. Urol."},{"issue":"4","key":"2026010813072535500_cit58","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1002\/path.1725","article-title":"Constitutive activation of phosphatidyl-inositide 3 kinase contributes to the survival of Hodgkin's lymphoma cells through a mechanism involving Akt kinase and mTOR","volume":"205","author":"Dutton","year":"2005","journal-title":"J. Pathol."},{"issue":"5","key":"2026010813072535500_cit59","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/ajh.21664","article-title":"A Phase II trial of the oral mTOR inhibitor everolimus in relapsed Hodgkin lymphoma","volume":"85","author":"Johnston","year":"2010","journal-title":"Am. J. Hematol."},{"key":"2026010813072535500_cit60","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40164-018-0103-z","article-title":"Phase 2 study of everolimus for relapsed or refractory classical Hodgkin lymphoma","volume":"7","author":"Johnston","year":"2018","journal-title":"Exp. Hematol. 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