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However, due to the implications of ZIKV infections for pregnancy outcomes, understanding differences in their molecular impact on the host is of high interest. Viral infections change the host proteome, including post-translational modifications. As modifications are diverse and of low abundance, they typically require additional sample processing which is not feasible for large cohort studies. Therefore, we tested the potential of next-generation proteomics data in its ability to prioritize specific modifications for later analysis. We re-mined published mass spectra from 122 serum samples from ZIKV and DENV patients for the presence of phosphorylated, methylated, oxidized, glycosylated\/glycated, sulfated, and carboxylated peptides. We identified 246 modified peptides with significantly differential abundance in ZIKV and DENV patients. Amongst these, methionine-oxidized peptides from apolipoproteins and glycosylated peptides from immunoglobulin proteins were more abundant in ZIKV patient serum and generate hypotheses on the potential roles of the modification in the infection. The results demonstrate how data-independent acquisition techniques can help prioritize future analyses of peptide modifications.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/d2mo00258b","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T08:41:22Z","timestamp":1676450482000},"page":"308-320","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Re-mining serum proteomics data reveals extensive post-translational modifications upon Zika and dengue infection"],"prefix":"10.1093","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4984-6413","authenticated-orcid":false,"given":"Kristina","family":"Allgoewer","sequence":"first","affiliation":[{"name":"Humboldt University, Department of Biology b , Berlin, Germany"},{"name":"New York University, Department of Biology, Center for Genomics and Systems Biology a , New York, NY, USA \u00a0 cvogel@nyu.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohuan","family":"Wu","sequence":"additional","affiliation":[{"name":"New York University, Department of Biology, Center for Genomics and Systems Biology a , New York, NY, USA \u00a0 cvogel@nyu.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6687-3088","authenticated-orcid":false,"given":"Hyungwon","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Yong Loo Lin School of Medicine, National University c , Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2856-3118","authenticated-orcid":false,"given":"Christine","family":"Vogel","sequence":"additional","affiliation":[{"name":"New York University, Department of Biology, Center for Genomics and Systems Biology a , New York, NY, USA \u00a0 cvogel@nyu.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,2,15]]},"reference":[{"key":"2026010813050069800_cit1","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.3201\/eid2410.172079","article-title":"Zika Virus Infection during Pregnancy and Effects on Early Childhood Development, French Polynesia, 2013\u20132016","volume":"24","author":"Subissi","year":"2018","journal-title":"Emerg. 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