{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T23:21:34Z","timestamp":1767914494089,"version":"3.49.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T00:00:00Z","timestamp":1677456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100007937","name":"Peking University","doi-asserted-by":"publisher","award":["Unassigned"],"award-info":[{"award-number":["Unassigned"]}],"id":[{"id":"10.13039\/501100007937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.2021-4-18"],"award-info":[{"award-number":["320.6750.2021-4-18"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007937","name":"Peking University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.2021-4-18"],"award-info":[{"award-number":["320.6750.2021-4-18"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,2,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: Individualized pain therapy conforms to the concept of precision medicine and contributes to adequate pain management after surgery. Preoperative biomarkers associated with postoperative pain may instruct anesthesiologists to improve personalized suitable analgesia. Therefore, it is essential to explore the association between preoperative proteins and postoperative acute pain using the proteomics platform. Methods: In this study, the 24 hours postoperative sufentanil consumption of 80 male patients with gastric cancer was ranked. Patients with sufentanil consumption in the lowest 12% were included in the sufentanil low consumption group, while patients with sufentanil consumption in the highest 12% were included in the sufentanil high consumption group. The secretion of serum proteins in both groups was analyzed using label-free proteomics technology. The results were validated by ELISA. Results: Proteomics identified 29 proteins that were significantly differentially expressed between groups. ELISA confirmed that secretion of TNC and IGFBP2 was down-regulated in the SLC group. The differential proteins were mainly extracellular and were involved in several terms, including calcium ion binding, laminin-1 binding, and so on. Pathway analysis showed that they were mainly enriched in focal adhesion and extracellular matrix-receptor interaction. The protein\u2013protein interaction network analysis showed 22 proteins that interacted with other proteins. F13B had the strongest correlation with sufentanil consumption and its AUC value was 0.859. Conclusions: Several differential proteins are associated with postoperative acute pain and are involved in ECM-related processes, inflammation, and blood coagulation cascades. F13B may be a novel marker for postoperative acute pain. Our results may benefit postoperative pain management.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/d2mo00296e","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T02:02:43Z","timestamp":1677463363000},"page":"351-361","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Label-free serum proteomics for the identification of the putative biomarkers of postoperative pain in patients with gastric cancer"],"prefix":"10.1093","volume":"19","author":[{"given":"Jianing","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Anesthesiology, Peking University Cancer Hospital & Institute a , Beijing, 100142, China \u00a0 maggitan@yeah.net"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Anesthesiology, Peking University Cancer Hospital & Institute a , Beijing, 100142, China \u00a0 maggitan@yeah.net"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianzhuo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Anesthesiology, Peking University Cancer Hospital & Institute a , Beijing, 100142, China \u00a0 maggitan@yeah.net"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Anesthesiology, Peking University Cancer Hospital & Institute a , Beijing, 100142, China \u00a0 maggitan@yeah.net"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Wei","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Anesthesiology, Peking University Cancer Hospital & Institute a , Beijing, 100142, China \u00a0 maggitan@yeah.net"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengge","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Anesthesiology, Peking University Cancer Hospital & Institute a , Beijing, 100142, China \u00a0 maggitan@yeah.net"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yining","family":"Xie","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Anesthesiology, Peking University Cancer Hospital & Institute a , Beijing, 100142, China \u00a0 maggitan@yeah.net"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8721-5068","authenticated-orcid":false,"given":"Hongyu","family":"Tan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Department of Anesthesiology, Peking University Cancer Hospital & Institute a , Beijing, 100142, China \u00a0 maggitan@yeah.net"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,2,27]]},"reference":[{"issue":"6","key":"2026010813050351100_cit1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"Ca-Cancer J. Clin."},{"issue":"8\u2013S","key":"2026010813050351100_cit2","first-page":"110","article-title":"Advanced gastric cancer: the value of surgery","volume":"89","author":"Fugazzola","year":"2018","journal-title":"Acta Biomed."},{"issue":"2","key":"2026010813050351100_cit3","doi-asserted-by":"crossref","first-page":"e70","DOI":"10.1002\/bjs.11477","article-title":"Acute postoperative pain management","volume":"107","author":"Small","year":"2020","journal-title":"Br. J. Surg."},{"key":"2026010813050351100_cit4","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.2147\/JPR.S144066","article-title":"Poorly controlled postoperative pain: prevalence, consequences, and prevention","volume":"10","author":"Gan","year":"2017","journal-title":"J. Pain Res."},{"issue":"6","key":"2026010813050351100_cit5","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1093\/bja\/aew381","article-title":"Patient reported outcome of adult perioperative anaesthesia in the United Kingdom: a cross-sectional observational study","volume":"117","author":"Walker","year":"2016","journal-title":"Br. J. 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Anestesiol."},{"issue":"6","key":"2026010813050351100_cit13","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.knee.2016.02.013","article-title":"TNF-alpha concentrations in pre-operative synovial fluid for predicting early post-operative function and pain after fast-track total knee arthroplasty","volume":"23","author":"Zietek","year":"2016","journal-title":"Knee"},{"issue":"1","key":"2026010813050351100_cit14","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1186\/s12891-017-1597-y","article-title":"Correlations between inflammatory cytokines, muscle damage markers and acute postoperative pain following primary total knee arthroplasty","volume":"18","author":"Si","year":"2017","journal-title":"BMC Musculoskeletal Disord."},{"issue":"2","key":"2026010813050351100_cit15","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1093\/chromsci\/bmw167","article-title":"Proteomics: Technologies and Their Applications","volume":"55","author":"Aslam","year":"2017","journal-title":"J. Chromatogr. Sci."},{"key":"2026010813050351100_cit16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jprot.2018.04.004","article-title":"Proteome-based systems biology in chronic pain","volume":"190","author":"Gomez-Varela","year":"2019","journal-title":"J. Proteomics"},{"issue":"7","key":"2026010813050351100_cit17","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1097\/j.pain.0000000000002207","article-title":"A proteome signature for acute incisional pain in dorsal root ganglia of mice","volume":"162","author":"Pogatzki-Zahn","year":"2021","journal-title":"Pain"},{"issue":"6","key":"2026010813050351100_cit18","first-page":"717","article-title":"Measuring the human immune response to surgery: multiomics for the prediction of postoperative outcomes","volume":"27","author":"Verdonk","year":"2021","journal-title":"Curr. Opin. Crit. 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