{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T15:52:14Z","timestamp":1783698734132,"version":"3.55.0"},"reference-count":43,"publisher":"Royal Society of Chemistry (RSC)","issue":"36","license":[{"start":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T00:00:00Z","timestamp":1690416000000},"content-version":"am","delay-in-days":572,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["MCM202103"],"award-info":[{"award-number":["MCM202103"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974499"],"award-info":[{"award-number":["81974499"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173761"],"award-info":[{"award-number":["82173761"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Nanoscale"],"abstract":"<jats:p>GD@PP\/Wtmn mediates polarization of TAMs and tumor cell killing, activating antitumor immunity for enhancing antitumor effects.<\/jats:p>","DOI":"10.1039\/d2nr03053e","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T05:01:16Z","timestamp":1658898076000},"page":"13098-13112","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Spatially targeting and regulating tumor-associated macrophages using a raspberry-like micellar system sensitizes pancreatic cancer chemoimmunotherapy"],"prefix":"10.1039","volume":"14","author":[{"given":"Ting","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Med-X Center for Materials, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Med-X Center for Materials, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houqin","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Med-X Center for Materials, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Tao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Med-X Center for Materials, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"He","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Med-X Center for Materials, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuya","family":"Zang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Med-X Center for Materials, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Med-X Center for Materials, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Polymer Science and Engineering, Sichuan university, Chengdu 610065, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Med-X Center for Materials, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Liu","sequence":"additional","affiliation":[{"name":"West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7602-7715","authenticated-orcid":false,"given":"Qin","family":"He","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Med-X Center for Materials, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2022]]},"reference":[{"key":"D2NR03053E\/cit1\/1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21654","volume":"71","author":"Siegel","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"D2NR03053E\/cit2\/1","first-page":"11","volume":"22","author":"Heinemann","year":"1995","journal-title":"Semin. Oncol."},{"key":"D2NR03053E\/cit3\/1","doi-asserted-by":"crossref","first-page":"e406","DOI":"10.1038\/emm.2017.255","volume":"49","author":"Liang","year":"2017","journal-title":"Exp. Mol. Med."},{"key":"D2NR03053E\/cit4\/1","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1136\/gut.2010.226092","volume":"60","author":"Neesse","year":"2010","journal-title":"Gut"},{"key":"D2NR03053E\/cit5\/1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s12935-017-0437-3","volume":"17","author":"Liu","year":"2017","journal-title":"Cancer Cell Int."},{"key":"D2NR03053E\/cit6\/1","doi-asserted-by":"crossref","first-page":"2003572","DOI":"10.1002\/advs.202003572","volume":"8","author":"Huang","year":"2021","journal-title":"Adv. Sci."},{"key":"D2NR03053E\/cit7\/1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.canlet.2015.11.049","volume":"381","author":"Habtezion","year":"2016","journal-title":"Cancer Lett."},{"key":"D2NR03053E\/cit8\/1","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/cas.12663","volume":"106","author":"Takuya","year":"2015","journal-title":"Cancer Sci."},{"key":"D2NR03053E\/cit9\/1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.intimp.2016.01.023","volume":"34","author":"Han","year":"2016","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"D2NR03053E\/cit10\/1","volume":"6","author":"Liu","year":"2011","journal-title":"PLoS One"},{"key":"D2NR03053E\/cit11\/1","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/nm1093","volume":"10","author":"Curiel","year":"2004","journal-title":"Nat. Med."},{"key":"D2NR03053E\/cit12\/1","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0002-9440(10)65601-5","volume":"153","author":"Xiong","year":"1998","journal-title":"Am. J. Pathol."},{"key":"D2NR03053E\/cit13\/1","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1002\/ijc.30289","volume":"139","author":"Li","year":"2016","journal-title":"Int. J. Cancer"},{"key":"D2NR03053E\/cit14\/1","first-page":"849","volume":"20","author":"Shipley","year":"1992","journal-title":"Drug Metab. Dispos."},{"issue":"29","key":"D2NR03053E\/cit15\/1","doi-asserted-by":"crossref","first-page":"3812","DOI":"10.1038\/onc.2013.357","volume":"33","author":"Weizman","year":"2014","journal-title":"Oncogene"},{"key":"D2NR03053E\/cit16\/1","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/ni.1937","volume":"11","author":"Biswas","year":"2010","journal-title":"Nat. Immunol."},{"key":"D2NR03053E\/cit17\/1","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S1471-4906(02)02302-5","volume":"23","author":"Mantovani","year":"2002","journal-title":"Trends Immunol."},{"key":"D2NR03053E\/cit18\/1","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nature19834","volume":"539","author":"Kaneda","year":"2016","journal-title":"Nature"},{"key":"D2NR03053E\/cit19\/1","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1158\/2159-8290.CD-15-1346","volume":"6","author":"Kaneda","year":"2016","journal-title":"Cancer Discovery"},{"key":"D2NR03053E\/cit20\/1","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3109\/07853890.2014.912836","volume":"46","author":"Martini","year":"2014","journal-title":"Ann. Med."},{"key":"D2NR03053E\/cit21\/1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1006\/jsre.2000.5833","volume":"90","author":"Perugini","year":"2000","journal-title":"J. Surg. Res."},{"key":"D2NR03053E\/cit22\/1","doi-asserted-by":"crossref","first-page":"19402","DOI":"10.1073\/pnas.1311939110","volume":"110","author":"Carmona-Fontaine","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D2NR03053E\/cit23\/1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1021\/mp800051m","volume":"5","author":"Alexis","year":"2008","journal-title":"Mol. Pharm."},{"key":"D2NR03053E\/cit24\/1","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/nnano.2011.166","volume":"6","author":"Cabral","year":"2011","journal-title":"Nat. Nanotechnol."},{"key":"D2NR03053E\/cit25\/1","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1007\/978-1-4614-7876-8_23","volume-title":"Cancer Targeted Drug Delivery","author":"Yhee","year":"2013","unstructured":"J. Y.Yhee ,  S.Son ,  S.Son ,  M. K.Joo  and  I. C.Kwon , in  Cancer Targeted Drug Delivery ,  2013 , ch. 23, pp.  621\u2013632 ,  10.1007\/978-1-4614-7876-8_23"},{"key":"D2NR03053E\/cit26\/1","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1136\/gutjnl-2011-300850","volume":"61","author":"Gopinathan","year":"2012","journal-title":"Gut"},{"key":"D2NR03053E\/cit27\/1","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/nrc4027","volume":"15","author":"Olson","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"D2NR03053E\/cit28\/1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1101\/gad.1874010","volume":"24","author":"Gocheva","year":"2010","journal-title":"Genes Dev."},{"issue":"4","key":"D2NR03053E\/cit29\/1","volume":"37","author":"Zajc","year":"2003","journal-title":"Oncology"},{"key":"D2NR03053E\/cit30\/1","doi-asserted-by":"crossref","first-page":"9935","DOI":"10.1039\/C8NR00640G","volume":"10","author":"Cun","year":"2018","journal-title":"Nanoscale"},{"key":"D2NR03053E\/cit31\/1","doi-asserted-by":"crossref","first-page":"39545","DOI":"10.1021\/acsami.9b13957","volume":"11","author":"Cun","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D2NR03053E\/cit32\/1","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1039\/C5TB02224J","volume":"4","author":"Tang","year":"2016","journal-title":"J. Mater. Chem. B"},{"key":"D2NR03053E\/cit33\/1","first-page":"39","volume":"30","author":"Du","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"D2NR03053E\/cit34\/1","first-page":"989","volume":"1","author":"Bondar","year":"2002","journal-title":"Mol. Cancer Ther."},{"key":"D2NR03053E\/cit35\/1","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.intimp.2009.03.015","volume":"9","author":"Le","year":"2009","journal-title":"Int. Immunopharmacol."},{"key":"D2NR03053E\/cit36\/1","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/s43018-021-00218-4","volume":"2","author":"Castel","year":"2021","journal-title":"Nat. Cancer"},{"issue":"4","key":"D2NR03053E\/cit37\/1","doi-asserted-by":"crossref","first-page":"5778","DOI":"10.1021\/acsnano.1c10892","volume":"16","author":"Li","year":"2022","journal-title":"ACS Nano"},{"key":"D2NR03053E\/cit38\/1","doi-asserted-by":"crossref","first-page":"4231","DOI":"10.1021\/acs.nanolett.1c00209","volume":"21","author":"Wei","year":"2021","journal-title":"Nano Lett."},{"key":"D2NR03053E\/cit39\/1","doi-asserted-by":"crossref","first-page":"7525","DOI":"10.1038\/nature13862","volume":"515","author":"Bonapace","year":"2014","journal-title":"Nature"},{"key":"D2NR03053E\/cit40\/1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.pharmthera.2015.11.008","volume":"158","author":"Van Acker","year":"2016","journal-title":"Pharmacol. Ther."},{"key":"D2NR03053E\/cit41\/1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nature13444","volume":"510","author":"Ali","year":"2014","journal-title":"Nature"},{"key":"D2NR03053E\/cit42\/1","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/s41375-017-0008-6","volume":"32","author":"Zheng","year":"2018","journal-title":"Leukemia"},{"key":"D2NR03053E\/cit43\/1","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1158\/0008-5472.CAN-16-2534","volume":"77","author":"Davis","year":"2017","journal-title":"Cancer Res."}],"container-title":["Nanoscale"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2022\/NR\/D2NR03053E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:19:18Z","timestamp":1782850758000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/nr\/article\/14\/36\/13098-13112\/776951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":43,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2022,9,22]]}},"URL":"https:\/\/doi.org\/10.1039\/d2nr03053e","relation":{},"ISSN":["2040-3364","2040-3372"],"issn-type":[{"value":"2040-3364","type":"print"},{"value":"2040-3372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}