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Chem."],"abstract":"<jats:p>\n                    Chemoselective, synthesis of pyrazole and isoxazole \u03b1,\u03b1-difluoromethyl ketones\n                    <jats:italic>via<\/jats:italic>\n                    nucleophilic transfer of \u2212CHF\n                    <jats:sub>2<\/jats:sub>\n                    moiety to Weinreb amides is reported.\n                    <jats:italic>In silico<\/jats:italic>\n                    docking on COX-1 or COX-2 and\n                    <jats:italic>in vitro<\/jats:italic>\n                    biological assays open new application for \u03b1,\u03b1-difluorinated ketones.\n                  <\/jats:p>","DOI":"10.1039\/d2ob01382g","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T17:41:22Z","timestamp":1663695682000},"page":"8293-8304","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Synthesis, computational investigation and biological evaluation of \u03b1,\u03b1-difluoromethyl ketones embodying pyrazole and isoxazole nuclei as COX inhibitors"],"prefix":"10.1039","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5881-7142","authenticated-orcid":false,"given":"Andrea","family":"Citarella","sequence":"first","affiliation":[{"name":"University of Messina, Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, Viale Ferdinando Stagno D'Alcontres 31, I-98166 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9976-0170","authenticated-orcid":false,"given":"Laura","family":"Ielo","sequence":"additional","affiliation":[{"name":"University of Torino, Department of Chemistry, Via P. 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