{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T12:37:53Z","timestamp":1793450273729,"version":"4.5.0"},"reference-count":29,"publisher":"Royal Society of Chemistry (RSC)","issue":"27","license":[{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"vor","delay-in-days":165,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>IVH may be administered orally twice per day for treating heart failure, sinus rhythm, heart-related chest pain and angina pectoris; its overdose may cause problems as blurred vision, uncontrolled blood pressure, prolonged bradycardia, and others.<\/jats:p>","DOI":"10.1039\/d2ra02064e","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T05:57:23Z","timestamp":1655272643000},"page":"17645-17654","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Molecularly-imprinted polymer-base bulk optode for the determination of ivabradine hydrochloride in Procoralan\u00ae"],"prefix":"10.1039","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0260-3011","authenticated-orcid":false,"given":"Fatehy M.","family":"Abdel-Haleem","sequence":"first","affiliation":[{"name":"Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt"},{"name":"Center for Hazards Mitigation, Environmental Studies and Research (CHMESR), Cairo University, Giza, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud S.","family":"Rizk","sequence":"additional","affiliation":[{"name":"Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menna M.","family":"El-Beshlawy","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Women, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2022]]},"reference":[{"issue":"4","key":"D2RA02064E\/cit1\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.9734\/bjpr\/2016\/22566","volume":"9","author":"Tubati","year":"2016","journal-title":"Br. J. Pharm. Res."},{"key":"D2RA02064E\/cit2\/1","doi-asserted-by":"publisher","first-page":"667","DOI":"10.4103\/0250-474X.78545","volume":"72","author":"Seerapu","year":"2010","journal-title":"Indian J. Pharm. Sci."},{"key":"D2RA02064E\/cit3\/1","doi-asserted-by":"publisher","first-page":"95592","DOI":"10.1039\/c5ra21033j","volume":"5","author":"Abo-Talib","year":"2015","journal-title":"RSC Adv."},{"key":"D2RA02064E\/cit4\/1","year":"2019","unstructured":"RAPID AND SELECTIVE UV SPECTROPHOTOMETRIC AND RP-HPLC METHODS FOR DISSOLUTION STUDIES OF IVABRADINE CONTROLLED-RELEASE FORMULATIONS | PharmaTutor, (n.d.).  https:\/\/www.pharmatutor.org\/articles\/rapid-selective-uv-spectrophotometric-rp-hplc-methods-dissolution-studies-ivabradine-controlled-release-formulations  (accessed October 20,  2019 )"},{"issue":"1","key":"D2RA02064E\/cit5\/1","doi-asserted-by":"publisher","first-page":"151","DOI":"10.15171\/apb.2017.019","volume":"7","author":"Attia","year":"2017","journal-title":"Adv. Pharm. Bull."},{"issue":"11","key":"D2RA02064E\/cit6\/1","doi-asserted-by":"publisher","first-page":"13592","DOI":"10.3390\/molecules171113592","volume":"17","author":"Riccioni","year":"2012","journal-title":"Molecules"},{"key":"D2RA02064E\/cit7\/1","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/s11094-019-01992-3","volume":"53","author":"Smirnova","year":"2019","journal-title":"Pharm. Chem. J."},{"key":"D2RA02064E\/cit8\/1","doi-asserted-by":"publisher","first-page":"8459","DOI":"10.1039\/c5ay01657f","volume":"7","author":"Sun","year":"2015","journal-title":"Anal. Methods"},{"key":"D2RA02064E\/cit9\/1","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1080\/22297928.2017.11952555","volume":"7","author":"Mostafa","year":"2017","journal-title":"Anal. Chem. Lett."},{"key":"D2RA02064E\/cit10\/1","year":"2020","unstructured":"Application and Validation of Simple Isocratic HPLC-UV-DAD Method with Dual Wavelength Detection for Ivabradine Determination and Its Application in the Study of Stress Degradation, (n.d.),  https:\/\/www.hindawi.com\/journals\/jchem\/2017\/2069571\/ (accessed April 1,  2020 )"},{"key":"D2RA02064E\/cit11\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fbioe.2021.648704","volume":"9","author":"Abdel-Haleem","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"D2RA02064E\/cit12\/1","doi-asserted-by":"publisher","first-page":"111110","DOI":"10.1016\/j.msec.2020.111110","volume":"116","author":"Abdel-Haleem","year":"2020","journal-title":"Mater. Sci. Eng. C"},{"issue":"5","key":"D2RA02064E\/cit13\/1","first-page":"8","volume":"6","author":"Patel","year":"2014","journal-title":"Der Pharm. Lett."},{"key":"D2RA02064E\/cit14\/1","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.saa.2018.04.057","author":"Abdel-Haleem","year":"2018","journal-title":"Spectrochim. Acta, Part A"},{"issue":"8","key":"D2RA02064E\/cit15\/1","doi-asserted-by":"publisher","first-page":"3083","DOI":"10.1021\/cr940394a","volume":"97","author":"Bakker","year":"1997","journal-title":"Chem. Rev."},{"key":"D2RA02064E\/cit16\/1","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.snb.2016.04.088","volume":"233","author":"Abdel-Haleem","year":"2016","journal-title":"Sens. Actuators, B"},{"issue":"4","key":"D2RA02064E\/cit17\/1","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1021\/cr970113+","volume":"98","author":"B\u00fchlmann","year":"1998","journal-title":"Chem. Rev."},{"key":"D2RA02064E\/cit18\/1","doi-asserted-by":"publisher","first-page":"3899","DOI":"10.1007\/s00216-014-8413-4","volume":"407","author":"Xie","year":"2015","journal-title":"Anal. Bioanal. Chem."},{"key":"D2RA02064E\/cit19\/1","doi-asserted-by":"publisher","first-page":"129368","DOI":"10.1016\/J.SNB.2020.129368","volume":"335","author":"Du","year":"2021","journal-title":"Sens. Actuators, B"},{"issue":"5","key":"D2RA02064E\/cit20\/1","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1002\/elan.202060141","volume":"33","author":"El-Beshlawy","year":"2021","journal-title":"Electroanalysis"},{"issue":"1","key":"D2RA02064E\/cit21\/1","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1021\/acs.chemrev.8b00171","volume":"119","author":"Belbruno","year":"2019","journal-title":"Chem. Rev."},{"issue":"7","key":"D2RA02064E\/cit22\/1","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.1002\/elan.201501130","volume":"28","author":"Abdel Ghani","year":"2016","journal-title":"Electroanalysis"},{"key":"D2RA02064E\/cit23\/1","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.bios.2016.05.081","volume":"85","author":"Abdel-Haleem","year":"2016","journal-title":"Biosens. Bioelectron."},{"issue":"2","key":"D2RA02064E\/cit24\/1","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/0003-2670(93)85281-N","volume":"283","author":"Wang","year":"1993","journal-title":"Anal. Chim. Acta"},{"key":"D2RA02064E\/cit25\/1","doi-asserted-by":"crossref","DOI":"10.1002\/0471728411","volume-title":"Statistical Methods in Analytical Chemistry","author":"Meier","year":"2000","unstructured":"P. C.Meier  and  R.E.Zund ,  Statistical Methods in Analytical Chemistry ,  John Wiley & Sons , 2nd edn,  2000"},{"key":"D2RA02064E\/cit26\/1","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.msec.2018.04.001","volume":"89","author":"Abdel-Haleem","year":"2018","journal-title":"Mater. Sci. Eng. C"},{"key":"D2RA02064E\/cit27\/1","first-page":"1","author":"Pharmacology","year":"2009","journal-title":"Food Drug Adm."},{"key":"D2RA02064E\/cit28\/1","doi-asserted-by":"crossref","first-page":"107276","DOI":"10.1016\/j.microc.2022.107276","volume":"177","author":"Ahmed","year":"2023","journal-title":"Microchem. J."},{"issue":"6","key":"D2RA02064E\/cit29\/1","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.cclet.2016.01.027","volume":"27","author":"Abdel-Haleem","year":"2016","journal-title":"Chin. Chem. Lett."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2022\/RA\/D2RA02064E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:40:30Z","timestamp":1783014030000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ra\/article\/12\/27\/17645-17654\/782918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":29,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2022,6,7]]}},"URL":"https:\/\/doi.org\/10.1039\/d2ra02064e","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}