{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T23:05:33Z","timestamp":1787871933703,"version":"build-2784847793"},"reference-count":68,"publisher":"Royal Society of Chemistry (RSC)","issue":"32","license":[{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"vor","delay-in-days":195,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100002657","name":"Istanbul \u00dcniversitesi","doi-asserted-by":"publisher","award":["FBA-2021-37260"],"award-info":[{"award-number":["FBA-2021-37260"]}],"id":[{"id":"10.13039\/501100002657","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>In an attempt to develop effective and potentially active antibacterial and\/or antifungal agents, we designed, synthesized, and characterized thiolated CoQ analogs (CoQ1\u20138) with an extensive antimicrobial study.<\/jats:p>","DOI":"10.1039\/d2ra02136f","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T05:03:47Z","timestamp":1657861427000},"page":"20507-20518","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Natural-product-inspired design and synthesis of thiolated coenzyme Q analogs as promising agents against Gram-positive bacterial strains: insights into structure\u2013activity relationship, activity profile, mode of action, and molecular docking"],"prefix":"10.1039","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3988-6120","authenticated-orcid":false,"given":"Hatice","family":"Y\u0131ld\u0131r\u0131m","sequence":"first","affiliation":[{"name":"Department of Chemistry, Engineering Faculty, Istanbul University-Cerrahpasa, Avcilar, 34320, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6317-5738","authenticated-orcid":false,"given":"Mahmut","family":"Y\u0131ld\u0131z","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Gebze Technical University, Gebze, 41400, Kocaeli, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0777-4012","authenticated-orcid":false,"given":"Nil\u00fcfer","family":"Bayrak","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Engineering Faculty, Istanbul University-Cerrahpasa, Avcilar, 34320, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4428-5066","authenticated-orcid":false,"given":"Emel","family":"Matarac\u0131-Kara","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Microbiology, Pharmacy Faculty, Istanbul University, Beyazit, 34116, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8909-8398","authenticated-orcid":false,"given":"Berna","family":"\u00d6zbek-\u00c7elik","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Microbiology, Pharmacy Faculty, Istanbul University, Beyazit, 34116, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2968-3939","authenticated-orcid":false,"given":"Masami","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5\u20131 Oe-honmachi, Chuo-ku, Kumamoto 862\u20130973, Japan"},{"name":"Department of Drug Discovery, Science Farm Ltd, 1\u20137\u201330 Kuhonji, Chuo-ku, Kumamoto 862\u20130976, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6705-4052","authenticated-orcid":false,"given":"Mikako","family":"Fujita","sequence":"additional","affiliation":[{"name":"Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5\u20131 Oe-honmachi, Chuo-ku, Kumamoto 862\u20130973, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9220-2659","authenticated-orcid":false,"given":"Mohamed O.","family":"Radwan","sequence":"additional","affiliation":[{"name":"Medicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, 5\u20131 Oe-honmachi, Chuo-ku, Kumamoto 862\u20130973, Japan"},{"name":"Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo 12622, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5698-1109","authenticated-orcid":false,"given":"Ama\u00e7 Fatih","family":"TuYuN","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Istanbul University, Fatih, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2022]]},"reference":[{"key":"D2RA02136F\/cit1\/1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1590\/S0103-50532011000300002","volume":"22","author":"Abraham","year":"2011","journal-title":"J. Braz. Chem. Soc."},{"key":"D2RA02136F\/cit2\/1","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1021\/np070436t","volume":"70","author":"Sansom","year":"2007","journal-title":"J. Nat. Prod."},{"key":"D2RA02136F\/cit3\/1","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1126\/science.1107163","volume":"307","author":"Nojima","year":"2005","journal-title":"Science"},{"key":"D2RA02136F\/cit4\/1","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1002\/cbdv.200690124","volume":"3","author":"Tasdemir","year":"2006","journal-title":"Chem. Biodiversity"},{"key":"D2RA02136F\/cit5\/1","doi-asserted-by":"crossref","first-page":"10784","DOI":"10.1021\/ja061155v","volume":"128","author":"Bauer","year":"2006","journal-title":"J. Am. Chem. Soc."},{"issue":"2","key":"D2RA02136F\/cit6\/1","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3390\/molecules26020423","volume":"26","author":"Lara","year":"2021","journal-title":"Molecules"},{"key":"D2RA02136F\/cit7\/1","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1248\/cpb.c21-00208","volume":"69","author":"Yamashita","year":"2021","journal-title":"Chem. Pharm. Bull."},{"key":"D2RA02136F\/cit8\/1","doi-asserted-by":"crossref","first-page":"109555","DOI":"10.1016\/j.cbi.2021.109555","volume":"345","author":"Bayrak","year":"2021","journal-title":"Chem.-Biol. Interact."},{"key":"D2RA02136F\/cit9\/1","doi-asserted-by":"crossref","first-page":"109673","DOI":"10.1016\/j.cbi.2021.109673","volume":"349","author":"Jannuzzi","year":"2021","journal-title":"Chem.-Biol. Interact."},{"key":"D2RA02136F\/cit10\/1","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.molstruc.2019.05.076","volume":"1195","author":"Yildirim","year":"2019","journal-title":"J. Mol. Struct."},{"key":"D2RA02136F\/cit11\/1","doi-asserted-by":"crossref","first-page":"13638","DOI":"10.1021\/acs.jmedchem.0c00942","volume":"63","author":"Varricchio","year":"2020","journal-title":"J. Med. Chem."},{"key":"D2RA02136F\/cit12\/1","doi-asserted-by":"crossref","first-page":"20309","DOI":"10.1039\/C4RA13547D","volume":"5","author":"Wellington","year":"2015","journal-title":"RSC Adv."},{"key":"D2RA02136F\/cit13\/1","doi-asserted-by":"crossref","first-page":"19631","DOI":"10.1038\/s41598-020-76372-z","volume":"10","author":"Novais","year":"2020","journal-title":"Sci. Rep."},{"key":"D2RA02136F\/cit14\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmech.2018.06.050","volume":"156","author":"Dias","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"D2RA02136F\/cit15\/1","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/ddr.21512","volume":"80","author":"Wellington","year":"2019","journal-title":"Drug Dev. Res."},{"key":"D2RA02136F\/cit16\/1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/open.201900077","volume":"8","author":"Ravichandiran","year":"2019","journal-title":"Chemistryopen"},{"key":"D2RA02136F\/cit17\/1","doi-asserted-by":"crossref","first-page":"5618","DOI":"10.1016\/j.bmc.2016.09.028","volume":"24","author":"Alfadhli","year":"2016","journal-title":"Bioorg. Med. Chem."},{"key":"D2RA02136F\/cit18\/1","doi-asserted-by":"crossref","first-page":"113084","DOI":"10.1016\/j.ejmech.2020.113084","volume":"210","author":"Patel","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"D2RA02136F\/cit19\/1","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.msec.2018.10.021","volume":"94","author":"Kosiha","year":"2019","journal-title":"Mater. Sci. Eng., C"},{"key":"D2RA02136F\/cit20\/1","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1080\/00958972.2018.1461846","volume":"71","author":"Kosiha","year":"2018","journal-title":"J. Coord. Chem."},{"key":"D2RA02136F\/cit21\/1","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.snb.2016.11.117","volume":"242","author":"Jayasudha","year":"2017","journal-title":"Sens. Actuators, B"},{"key":"D2RA02136F\/cit22\/1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.snb.2017.01.153","volume":"245","author":"Parthiban","year":"2017","journal-title":"Sens. Actuators, B"},{"key":"D2RA02136F\/cit23\/1","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.bioorg.2016.08.008","volume":"68","author":"Wang","year":"2016","journal-title":"Bioorg. Chem."},{"key":"D2RA02136F\/cit24\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0009-2797(91)90029-7","volume":"80","author":"O'Brien","year":"1991","journal-title":"Chem.-Biol. Interact."},{"key":"D2RA02136F\/cit25\/1","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/S1473-3099(05)70217-6","volume":"5","author":"Okeke","year":"2005","journal-title":"Lancet Infect. Dis."},{"key":"D2RA02136F\/cit26\/1","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.2174\/1389557516666160623082714","volume":"17","author":"Basset","year":"2017","journal-title":"Mini-Rev. Med. Chem."},{"key":"D2RA02136F\/cit27\/1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.molmed.2019.09.002","volume":"26","author":"Weissig","year":"2020","journal-title":"Trends Mol. Med."},{"key":"D2RA02136F\/cit28\/1","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1177\/0883073814538509","volume":"29","author":"Enns","year":"2014","journal-title":"J. Child Neurol."},{"key":"D2RA02136F\/cit29\/1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00415-009-1005-0","volume":"256","author":"Meier","year":"2009","journal-title":"J. Neurol."},{"key":"D2RA02136F\/cit30\/1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s11357-011-9331-4","volume":"35","author":"Yubero-Serrano","year":"2013","journal-title":"Age"},{"key":"D2RA02136F\/cit31\/1","doi-asserted-by":"crossref","first-page":"S154","DOI":"10.1016\/j.mito.2007.02.005","volume":"7","author":"Pepe","year":"2007","journal-title":"Mitochondrion"},{"key":"D2RA02136F\/cit32\/1","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1002\/ddr.21591","volume":"80","author":"Tuyun","year":"2019","journal-title":"Drug Dev. Res."},{"key":"D2RA02136F\/cit33\/1","doi-asserted-by":"crossref","first-page":"647","DOI":"10.2174\/157018081406170606155530","volume":"14","author":"Bayrak","year":"2017","journal-title":"Lett. Drug Des. Discovery"},{"key":"D2RA02136F\/cit34\/1","doi-asserted-by":"crossref","first-page":"25753","DOI":"10.1039\/C7RA00868F","volume":"7","author":"Yildirim","year":"2017","journal-title":"RSC Adv."},{"key":"D2RA02136F\/cit35\/1","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1007\/s00044-021-02772-z","volume":"30","author":"Mataraci-Kara","year":"2021","journal-title":"Med. Chem. Res."},{"key":"D2RA02136F\/cit36\/1","doi-asserted-by":"crossref","first-page":"128560","DOI":"10.1016\/j.molstruc.2020.128560","volume":"1219","author":"Bayrak","year":"2020","journal-title":"J. Mol. Struct."},{"key":"D2RA02136F\/cit37\/1","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s12223-020-00783-8","volume":"65","author":"Kara","year":"2020","journal-title":"Folia Microbiol."},{"key":"D2RA02136F\/cit38\/1","doi-asserted-by":"crossref","first-page":"105160","DOI":"10.1016\/j.bioorg.2021.105160","volume":"114","author":"Ciftci","year":"2021","journal-title":"Bioorg. Chem."},{"issue":"3","key":"D2RA02136F\/cit39\/1","first-page":"628","volume":"83","author":"Mataraci-Kara","year":"2021","journal-title":"Drug Dev. Res."},{"key":"D2RA02136F\/cit40\/1","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1042\/bj3630825","volume":"363","author":"Petit","year":"2002","journal-title":"Biochem. J."},{"key":"D2RA02136F\/cit41\/1","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1021\/cb300316n","volume":"7","author":"Keating","year":"2012","journal-title":"ACS Chem. Biol."},{"key":"D2RA02136F\/cit42\/1","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1039\/b806712k","volume":"6","author":"Keinan","year":"2008","journal-title":"Org. Biomol. Chem."},{"key":"D2RA02136F\/cit43\/1","doi-asserted-by":"crossref","first-page":"103368","DOI":"10.1016\/j.bioorg.2019.103368","volume":"94","author":"Acar","year":"2020","journal-title":"Bioorg. Chem."},{"key":"D2RA02136F\/cit44\/1","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1002\/cmdc.201800790","volume":"14","author":"Cerone","year":"2019","journal-title":"Chemmedchem"},{"key":"D2RA02136F\/cit45\/1","doi-asserted-by":"crossref","first-page":"5861","DOI":"10.1016\/j.ejmech.2011.09.048","volume":"46","author":"Ibis","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"D2RA02136F\/cit46\/1","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing, Clinical and Laboratory Standards Institute","author":"Clinical and Laboratory Standards Institute (CLSI)","year":"2020","unstructured":"Clinical and Laboratory Standards Institute (CLSI) ,  Performance Standards for Antimicrobial Susceptibility Testing, Clinical and Laboratory Standards Institute ,  950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087, USA ,  2020"},{"key":"D2RA02136F\/cit47\/1","volume-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts; Approved Standard-Second Edition","author":"Clinical and Laboratory Standards Institute (CLSI)","year":"1997","unstructured":"Clinical and Laboratory Standards Institute (CLSI) ,  Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts; Approved Standard-Second Edition ,  Wayne, PA, USA ,  1997"},{"key":"D2RA02136F\/cit48\/1","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1021\/ci500276x","volume":"54","author":"Yilancioglu","year":"2014","journal-title":"J. Chem. Inf. Model."},{"key":"D2RA02136F\/cit49\/1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1080\/1120009X.2017.1390633","volume":"30","author":"Mataraci-Kara","year":"2018","journal-title":"J. Chemother."},{"key":"D2RA02136F\/cit50\/1","doi-asserted-by":"crossref","first-page":"566325","DOI":"10.3389\/fmicb.2020.566325","volume":"11","author":"Mishra","year":"2020","journal-title":"Front. Microbiol."},{"key":"D2RA02136F\/cit51\/1","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1080\/21505594.2017.1313372","volume":"9","author":"Roy","year":"2018","journal-title":"Virulence"},{"key":"D2RA02136F\/cit52\/1","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1146\/annurev.mi.49.100195.003431","volume":"49","author":"Costerton","year":"1995","journal-title":"Annu. Rev. Microbiol."},{"key":"D2RA02136F\/cit53\/1","doi-asserted-by":"crossref","first-page":"e69751","DOI":"10.1371\/journal.pone.0069751","volume":"8","author":"Sun","year":"2013","journal-title":"PLoS One"},{"key":"D2RA02136F\/cit54\/1","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.biopha.2018.04.021","volume":"103","author":"Khan","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"D2RA02136F\/cit55\/1","doi-asserted-by":"crossref","first-page":"3743","DOI":"10.1002\/(SICI)1521-3773(19991216)38:24<3743::AID-ANIE3743>3.0.CO;2-U","volume":"38","author":"Teague","year":"1999","journal-title":"Angew. Chem., Int. Ed. Engl."},{"key":"D2RA02136F\/cit56\/1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(00)00129-0","volume":"46","author":"Lipinski","year":"2001","journal-title":"Adv. Drug Delivery Rev."},{"key":"D2RA02136F\/cit57\/1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1021\/cc9800071","volume":"1","author":"Ghose","year":"1999","journal-title":"J. Comb. Chem."},{"key":"D2RA02136F\/cit58\/1","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1021\/jm020017n","volume":"45","author":"Veber","year":"2002","journal-title":"J. Med. Chem."},{"key":"D2RA02136F\/cit59\/1","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1021\/jm000292e","volume":"43","author":"Egan","year":"2000","journal-title":"J. Med. Chem."},{"key":"D2RA02136F\/cit60\/1","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1021\/jm015507e","volume":"44","author":"Muegge","year":"2001","journal-title":"J. Med. Chem."},{"key":"D2RA02136F\/cit61\/1","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1021\/ci034243x","volume":"44","author":"Delaney","year":"2004","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"D2RA02136F\/cit62\/1","doi-asserted-by":"crossref","first-page":"3164","DOI":"10.1021\/jm0492002","volume":"48","author":"Martin","year":"2005","journal-title":"J. Med. Chem."},{"key":"D2RA02136F\/cit67\/1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1107\/S090744490804362X","volume":"65","author":"Spek","year":"2009","journal-title":"Acta Crystallogr., Sect. D: Biol. Crystallogr."},{"key":"D2RA02136F\/cit68\/1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1107\/S002188980600731X","volume":"39","author":"Macrae","year":"2006","journal-title":"J. Appl. Crystallogr."},{"key":"D2RA02136F\/cit69\/1","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1248\/cpb.c21-00701","volume":"69","author":"Tateishi","year":"2021","journal-title":"Chem. Pharm. Bull."},{"key":"D2RA02136F\/cit70\/1","doi-asserted-by":"crossref","first-page":"115409","DOI":"10.1016\/j.bmc.2020.115409","volume":"28","author":"Radwan","year":"2020","journal-title":"Bioorg. Med. Chem."},{"key":"D2RA02136F\/cit71\/1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s00044-020-02640-2","volume":"30","author":"Mingle","year":"2021","journal-title":"Med. Chem. Res."},{"key":"D2RA02136F\/cit72\/1","doi-asserted-by":"crossref","first-page":"42717","DOI":"10.1038\/srep42717","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2022\/RA\/D2RA02136F","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:25:15Z","timestamp":1782941115000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ra\/article\/12\/32\/20507-20518\/782946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":68,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2022,7,14]]}},"URL":"https:\/\/doi.org\/10.1039\/d2ra02136f","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}