{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T19:10:13Z","timestamp":1783019413219,"version":"3.54.6"},"reference-count":24,"publisher":"Royal Society of Chemistry (RSC)","issue":"26","license":[{"start":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T00:00:00Z","timestamp":1654473600000},"content-version":"vor","delay-in-days":156,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21907053"],"award-info":[{"award-number":["21907053"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82003989"],"award-info":[{"award-number":["82003989"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>Structural modification of rhein with transcyclooctene (TCO) led to the identification of rhein-TCO2 as the most active probe with specific necrosis affinity.<\/jats:p>","DOI":"10.1039\/d2ra02844a","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T04:53:31Z","timestamp":1654491211000},"page":"16491-16495","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Target identification and occupancy measurement of necrosis avid agent rhein using bioorthogonal chemistry-enabling probes"],"prefix":"10.1039","volume":"12","author":[{"given":"Cuihua","family":"Jiang","sequence":"first","affiliation":[{"name":"Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, Jiangsu, China"},{"name":"Laboratories of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8402-9753","authenticated-orcid":false,"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, Jiangsu, China"},{"name":"Laboratories of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihe","family":"Hu","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, Jiangsu, China"},{"name":"Laboratories of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Gao","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, Jiangsu, China"},{"name":"Laboratories of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongjian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, Jiangsu, China"},{"name":"Laboratories of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Yao","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, Jiangsu, China"},{"name":"Laboratories of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8559-9125","authenticated-orcid":false,"given":"Qiaomei","family":"Jin","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, Jiangsu, China"},{"name":"Laboratories of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2022]]},"reference":[{"key":"D2RA02844A\/cit1\/1","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1039\/C6NP00001K","volume":"33","author":"Wright","year":"2016","journal-title":"Nat. Prod. Rep."},{"key":"D2RA02844A\/cit2\/1","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1002\/anie.200905352","volume":"49","author":"B\u00f6ttcher","year":"2010","journal-title":"Angew. Chem., Int. Ed."},{"key":"D2RA02844A\/cit3\/1","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1021\/acschembio.6b00346","volume":"11","author":"Rutkowska","year":"2016","journal-title":"ACS Chem. Biol."},{"key":"D2RA02844A\/cit4\/1","doi-asserted-by":"crossref","first-page":"7271","DOI":"10.1158\/1078-0432.CCR-07-1595","volume":"13","author":"Amaravadi","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"D2RA02844A\/cit5\/1","doi-asserted-by":"crossref","first-page":"2853522","DOI":"10.1155\/2021\/2853522","volume":"2021","author":"Stroet","year":"2021","journal-title":"Contrast Media Mol. Imaging"},{"key":"D2RA02844A\/cit6\/1","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1007\/s002590100578","volume":"28","author":"Kemerink","year":"2001","journal-title":"Eur. J. Nucl. Med."},{"key":"D2RA02844A\/cit7\/1","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.ejca.2011.11.033","volume":"48","author":"Nguyen","year":"2012","journal-title":"Eur. J. Cancer"},{"key":"D2RA02844A\/cit8\/1","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1097\/01.rli.0000171811.48991.5a","volume":"40","author":"Ni","year":"2005","journal-title":"Invest. Radiol."},{"key":"D2RA02844A\/cit9\/1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1021\/acs.molpharmaceut.5b00630","volume":"13","author":"Wang","year":"2016","journal-title":"Mol. Pharmaceutics"},{"key":"D2RA02844A\/cit10\/1","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1021\/acs.analchem.6b03959","volume":"89","author":"Luo","year":"2017","journal-title":"Anal. Chem."},{"key":"D2RA02844A\/cit11\/1","doi-asserted-by":"crossref","first-page":"21341","DOI":"10.1038\/srep21341","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"key":"D2RA02844A\/cit12\/1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s11307-019-01365-y","volume":"22","author":"Zhang","year":"2020","journal-title":"Mol. Imaging Biol."},{"key":"D2RA02844A\/cit13\/1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.dyepig.2016.05.009","volume":"132","author":"Zhang","year":"2016","journal-title":"Dyes Pigm."},{"key":"D2RA02844A\/cit14\/1","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1021\/acs.analchem.6b03959","volume":"89","author":"Luo","year":"2017","journal-title":"Anal. Chem."},{"key":"D2RA02844A\/cit15\/1","doi-asserted-by":"crossref","first-page":"6121","DOI":"10.1039\/C8NJ06006A","volume":"43","author":"Jin","year":"2019","journal-title":"New J. Chem."},{"key":"D2RA02844A\/cit16\/1","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1002\/cbic.201300551","volume":"14","author":"Rudolf","year":"2013","journal-title":"ChemBioChem"},{"key":"D2RA02844A\/cit17\/1","doi-asserted-by":"crossref","first-page":"E107","DOI":"10.1038\/35014078","volume":"2","author":"Carmo-Fonseca","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"D2RA02844A\/cit18\/1","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1007\/s00259-007-0689-6","volume":"35","author":"Perek","year":"2008","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"D2RA02844A\/cit19\/1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ejpb.2017.04.006","volume":"117","author":"Duan","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"D2RA02844A\/cit20\/1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3109\/10520299509108199","volume":"70","author":"Kapuscinski","year":"1995","journal-title":"Biotech. Histochem."},{"key":"D2RA02844A\/cit21\/1","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1002\/med.21495","volume":"38","author":"Rybczynska","year":"2018","journal-title":"Med. Res. Rev."},{"key":"D2RA02844A\/cit22\/1","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.apsb.2019.02.002","volume":"9","author":"Zhang","year":"2019","journal-title":"Acta Pharm. Sin. B"},{"key":"D2RA02844A\/cit23\/1","doi-asserted-by":"crossref","first-page":"13249","DOI":"10.1021\/acs.analchem.8b01868","volume":"90","author":"Bian","year":"2018","journal-title":"Anal. Chem."},{"key":"D2RA02844A\/cit24\/1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1177\/095632029000100601","volume":"1","author":"Jamison","year":"1990","journal-title":"Antiviral Chem. Chemother."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2022\/RA\/D2RA02844A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:57:23Z","timestamp":1783015043000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ra\/article\/12\/26\/16491-16495\/783224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":24,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2022,6,1]]}},"URL":"https:\/\/doi.org\/10.1039\/d2ra02844a","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}