{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T04:00:17Z","timestamp":1794024017381,"version":"4.8.0"},"reference-count":51,"publisher":"Royal Society of Chemistry (RSC)","issue":"39","license":[{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"vor","delay-in-days":247,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>\n                    Novel quinoxaline derivatives (2a\u2013d, 3, 4a, 4b, 5\u201315) have been synthesized and screened for their\n                    <jats:italic>in vitro<\/jats:italic>\n                    anticancer and COX-2 inhibitory activities. Compounds 4a, 5, 11 and 13 proved to be the most potent anticancer and COX-2 inhibitors.\n                  <\/jats:p>","DOI":"10.1039\/d2ra04498f","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T10:21:47Z","timestamp":1662373307000},"page":"25204-25216","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Novel quinoxaline derivatives as dual EGFR and COX-2 inhibitors: synthesis, molecular docking and biological evaluation as potential anticancer and anti-inflammatory agents"],"prefix":"10.1039","volume":"12","author":[{"given":"Eman A.","family":"Ahmed","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Sohag University, Sohag 82524, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7046-1799","authenticated-orcid":false,"given":"Mamdouh F. 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