{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:48:46Z","timestamp":1791082126465,"version":"4.1.0"},"reference-count":39,"publisher":"Royal Society of Chemistry (RSC)","issue":"51","license":[{"start":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T00:00:00Z","timestamp":1668988800000},"content-version":"vor","delay-in-days":324,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100012669","name":"Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission","doi-asserted-by":"publisher","award":["cstc2018jszx-cyzdX0023"],"award-info":[{"award-number":["cstc2018jszx-cyzdX0023"]}],"id":[{"id":"10.13039\/501100012669","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012669","name":"Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission","doi-asserted-by":"publisher","award":["cstc2021jcyj-bshX0242"],"award-info":[{"award-number":["cstc2021jcyj-bshX0242"]}],"id":[{"id":"10.13039\/501100012669","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002867","name":"Chongqing University of Arts and Sciences","doi-asserted-by":"publisher","award":["R2021FYX05"],"award-info":[{"award-number":["R2021FYX05"]}],"id":[{"id":"10.13039\/501100002867","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>We report an intramolecular hydrogen bond-promoted Ugi cascade reaction for solvent-free synthesis of 2,5-diketopiperazines. Compounds (\u00b1) 5c and (\u00b1) 5e displayed potent antitumor activity against acute myeloid leukaemia and prostate cancer cell lines, respectively.<\/jats:p>","DOI":"10.1039\/d2ra04958a","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T10:59:08Z","timestamp":1669028348000},"page":"33175-33179","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["An intramolecular hydrogen bond-promoted \u201cgreen\u201d Ugi cascade reaction for the synthesis of 2,5-diketopiperazines with anticancer activity"],"prefix":"10.1039","volume":"12","author":[{"given":"Jie","family":"Li","sequence":"first","affiliation":[{"name":"College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, IATTI, Chongqing University of Arts and Sciences, Chongqing 402160, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiu Hong","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, IATTI, Chongqing University of Arts and Sciences, Chongqing 402160, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing Ya","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, IATTI, Chongqing University of Arts and Sciences, Chongqing 402160, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi Gang","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, IATTI, Chongqing University of Arts and Sciences, Chongqing 402160, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong Zhu","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, IATTI, Chongqing University of Arts and Sciences, Chongqing 402160, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5719-0798","authenticated-orcid":false,"given":"Jie","family":"Lei","sequence":"additional","affiliation":[{"name":"College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, IATTI, Chongqing University of Arts and Sciences, Chongqing 402160, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2022]]},"reference":[{"key":"D2RA04958A\/cit1a\/1","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1039\/c2gc35635j","volume":"14","author":"Gu","year":"2012","journal-title":"Green Chem."},{"key":"D2RA04958A\/cit1b\/1","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1039\/C0OB00611D","volume":"9","author":"Ramachary","year":"2011","journal-title":"Org. Biomol. Chem."},{"key":"D2RA04958A\/cit1c\/1","doi-asserted-by":"crossref","first-page":"9614","DOI":"10.1021\/jo400973g","volume":"78","author":"Gutierrez","year":"2013","journal-title":"J. Org. Chem."},{"key":"D2RA04958A\/cit1d\/1","doi-asserted-by":"crossref","first-page":"11660","DOI":"10.1021\/ja904011s","volume":"131","author":"Jiang","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"D2RA04958A\/cit1e\/1","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1039\/c1gc15223h","volume":"13","author":"Kumar","year":"2011","journal-title":"Green Chem."},{"key":"D2RA04958A\/cit1f\/1","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1021\/ol400606c","volume":"15","author":"Wang","year":"2013","journal-title":"Org. Lett."},{"key":"D2RA04958A\/cit1g\/1","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1039\/c3ob27267b","volume":"11","author":"Jereb","year":"2013","journal-title":"Org. Biomol. Chem."},{"key":"D2RA04958A\/cit1h\/1","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1039\/c3gc40319j","volume":"15","author":"Sardon","year":"2013","journal-title":"Green Chem."},{"key":"D2RA04958A\/cit1i\/1","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1039\/c0gc00373e","volume":"12","author":"Yan","year":"2010","journal-title":"Green Chem."},{"key":"D2RA04958A\/cit2a\/1","doi-asserted-by":"crossref","first-page":"8037","DOI":"10.1002\/anie.201202575","volume":"51","author":"Xu","year":"2012","journal-title":"Angew. Chem., Int. Ed."},{"key":"D2RA04958A\/cit2b\/1","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s11030-017-9811-2","volume":"22","author":"Lei","year":"2018","journal-title":"Mol. Diversity"},{"key":"D2RA04958A\/cit3\/1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41429-020-00390-2","volume":"74","author":"Ishiyama","year":"2021","journal-title":"J. Antibiot."},{"key":"D2RA04958A\/cit4a\/1","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1002\/hlca.201000455","volume":"94","author":"Chen","year":"2011","journal-title":"Helv. Chim. Acta"},{"key":"D2RA04958A\/cit4b\/1","doi-asserted-by":"crossref","first-page":"152895","DOI":"10.1016\/j.tetlet.2021.152895","volume":"67","author":"Takahashi","year":"2021","journal-title":"Terahedron Lett."},{"key":"D2RA04958A\/cit5a\/1","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1039\/c39890000849","volume":"13","author":"King","year":"1989","journal-title":"J. Chem. Soc., Chem. Commun."},{"key":"D2RA04958A\/cit5b\/1","doi-asserted-by":"crossref","first-page":"8125","DOI":"10.1039\/C4OB01148A","volume":"12","author":"Bourgault","year":"2014","journal-title":"Org. Biomol. Chem."},{"key":"D2RA04958A\/cit6\/1","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1002\/anie.201710529","volume":"57","author":"Meng","year":"2018","journal-title":"Angew. Chem., Int. Ed."},{"key":"D2RA04958A\/cit7\/1","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1016\/S0960-894X(97)10104-4","volume":"22","author":"Kanoh","year":"1997","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D2RA04958A\/cit8a\/1","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1007\/s10126-021-10074-z","volume":"23","author":"Labriere","year":"2021","journal-title":"Mar. Biotechnol."},{"key":"D2RA04958A\/cit8b\/1","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1039\/C5OB02416A","volume":"14","author":"Olsen","year":"2016","journal-title":"Org. Biomol. Chem."},{"key":"D2RA04958A\/cit9\/1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.7164\/antibiotics.49.527","volume":"49","author":"Cui","year":"1996","journal-title":"J. Antibiot."},{"key":"D2RA04958A\/cit10a\/1","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1021\/jm2009088","volume":"55","author":"Yamazaki","year":"2012","journal-title":"J. Med. Chem."},{"key":"D2RA04958A\/cit10b\/1","doi-asserted-by":"crossref","first-page":"785","DOI":"10.3389\/fmicb.2015.00785","volume":"6","author":"Giessen","year":"2015","journal-title":"Front. Microbiol."},{"key":"D2RA04958A\/cit11a\/1","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1002\/bkcs.10802","volume":"37","author":"Lee","year":"2016","journal-title":"Bull. Korean Chem. Soc."},{"key":"D2RA04958A\/cit11b\/1","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1016\/j.bmc.2018.11.042","volume":"27","author":"Simon","year":"2019","journal-title":"Bioorg. Med. Chem."},{"key":"D2RA04958A\/cit11c\/1","doi-asserted-by":"crossref","first-page":"3641","DOI":"10.1021\/cr200398y","volume":"7","author":"Borthwick","year":"2012","journal-title":"Chem. Rev."},{"key":"D2RA04958A\/cit12\/1","doi-asserted-by":"crossref","first-page":"3688","DOI":"10.1016\/j.tet.2009.02.058","volume":"65","author":"Yamazaki","year":"2009","journal-title":"Tetrahedron"},{"key":"D2RA04958A\/cit13\/1","doi-asserted-by":"crossref","first-page":"8125","DOI":"10.1039\/C4OB01148A","volume":"12","author":"Bourgault","year":"2014","journal-title":"Org. Biomol. Chem."},{"key":"D2RA04958A\/cit14\/1","doi-asserted-by":"crossref","first-page":"10245","DOI":"10.1021\/acscatal.9b03415","volume":"9","author":"Azambuja","year":"2019","journal-title":"ACS Catal."},{"key":"D2RA04958A\/cit15\/1","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1016\/j.tetlet.2008.01.134","volume":"49","author":"Faggi","year":"2008","journal-title":"Tetrahedron Lett."},{"key":"D2RA04958A\/cit16a\/1","doi-asserted-by":"crossref","first-page":"5770","DOI":"10.1002\/ejoc.201600847","volume":"2016","author":"Li","year":"2016","journal-title":"Eur. J. Org. Chem."},{"key":"D2RA04958A\/cit16b\/1","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1039\/D0QO00028K","volume":"7","author":"Lei","year":"2020","journal-title":"Org. Chem. Front."},{"key":"D2RA04958A\/cit16c\/1","doi-asserted-by":"crossref","first-page":"4084","DOI":"10.1002\/adsc.202000736","volume":"362","author":"Song","year":"2020","journal-title":"Adv. Synth. Catal."},{"key":"D2RA04958A\/cit17\/1","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1039\/C9CC08220D","volume":"56","author":"Lei","year":"2020","journal-title":"Chem. Commun."},{"key":"D2RA04958A\/cit18\/1","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1021\/ol0256015","volume":"4","author":"Kennedy","year":"2002","journal-title":"Org. Lett."},{"key":"D2RA04958A\/cit19a\/1","doi-asserted-by":"crossref","first-page":"4140","DOI":"10.1021\/cr9001098","volume":"109","author":"Martins","year":"2009","journal-title":"Chem. Rev."},{"key":"D2RA04958A\/cit19b\/1","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1039\/b106677n","author":"Cave","year":"2001","journal-title":"Chem. Commun."},{"key":"D2RA04958A\/cit19c\/1","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1039\/c1gc15183e","volume":"13","author":"Cheng","year":"2011","journal-title":"Green Chem."},{"key":"D2RA04958A\/cit19d\/1","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1039\/c3gc42130a","volume":"16","author":"Vidyacharan","year":"2014","journal-title":"Green Chem."}],"updated-by":[{"DOI":"10.1039\/d3ra90013d","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T00:00:00Z","timestamp":1675900800000}}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2022\/RA\/D2RA04958A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:47:03Z","timestamp":1782884823000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ra\/article\/12\/51\/33175-33179\/784082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":39,"journal-issue":{"issue":"51","published-print":{"date-parts":[[2022,11,15]]}},"URL":"https:\/\/doi.org\/10.1039\/d2ra04958a","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}