{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:35:54Z","timestamp":1787160954571,"version":"build-2736575974"},"reference-count":41,"publisher":"Royal Society of Chemistry (RSC)","issue":"9","license":[{"start":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T00:00:00Z","timestamp":1672704000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 grant GM099040"],"award-info":[{"award-number":["R01 grant GM099040"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["OPUS UMO-2018\/29\/B\/NZ1\/02249"],"award-info":[{"award-number":["OPUS UMO-2018\/29\/B\/NZ1\/02249"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["PRELUDIUM UMO-2017\/25\/N\/ST5\/02831"],"award-info":[{"award-number":["PRELUDIUM UMO-2017\/25\/N\/ST5\/02831"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Sci."],"abstract":"<jats:p>\n                    Activated effector caspases 3, 6 and 7 are responsible for cleaving a number of target substrates, leading to the ultimate destruction of cells\n                    <jats:italic>via<\/jats:italic>\n                    apoptosis.\n                  <\/jats:p>","DOI":"10.1039\/d2sc05827h","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T04:46:06Z","timestamp":1672721166000},"page":"2289-2302","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Selective chemical reagents to investigate the role of caspase 6 in apoptosis in acute leukemia T cells"],"prefix":"10.1039","volume":"14","author":[{"given":"Katarzyna M.","family":"Groborz","sequence":"first","affiliation":[{"name":"Department of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, Wyb. Wyspia\u0144skiego 27, 50-370 Wroclaw, Poland"},{"name":"Genetech Inc., 1 DNA Way, South San Francisco, CA 94080, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Kalinka","sequence":"additional","affiliation":[{"name":"Department of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, Wyb. Wyspia\u0144skiego 27, 50-370 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Grzymska","sequence":"additional","affiliation":[{"name":"Department of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, Wyb. Wyspia\u0144skiego 27, 50-370 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Ko\u0142t","sequence":"additional","affiliation":[{"name":"Department of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, Wyb. Wyspia\u0144skiego 27, 50-370 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott J.","family":"Snipas","sequence":"additional","affiliation":[{"name":"NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0214-6252","authenticated-orcid":false,"given":"Marcin","family":"Por\u0119ba","sequence":"additional","affiliation":[{"name":"Department of Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, Wyb. Wyspia\u0144skiego 27, 50-370 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2023]]},"reference":[{"key":"D2SC05827H\/cit1\/1","doi-asserted-by":"crossref","first-page":"a008656","DOI":"10.1101\/cshperspect.a008656","volume":"5","author":"McIlwain","year":"2013","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"D2SC05827H\/cit2\/1","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/cdd.2014.216","volume":"22","author":"Shalini","year":"2015","journal-title":"Cell Death Differ."},{"key":"D2SC05827H\/cit3\/1","doi-asserted-by":"crossref","first-page":"17907","DOI":"10.1074\/jbc.272.29.17907","volume":"272","author":"Thornberry","year":"1997","journal-title":"J. Biol. Chem."},{"key":"D2SC05827H\/cit4\/1","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/nature15541","volume":"526","author":"Kayagaki","year":"2015","journal-title":"Nature"},{"key":"D2SC05827H\/cit5\/1","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"D2SC05827H\/cit6\/1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1006\/scbi.1995.0003","volume":"6","author":"Canman","year":"1995","journal-title":"Semin. Cancer Biol."},{"key":"D2SC05827H\/cit7\/1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.expneurol.2004.07.009","volume":"190","author":"Tacconi","year":"2004","journal-title":"Exp. Neurol."},{"key":"D2SC05827H\/cit8\/1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/0092-8674(95)90541-3","volume":"81","author":"Tewari","year":"1995","journal-title":"Cell"},{"key":"D2SC05827H\/cit9\/1","doi-asserted-by":"crossref","first-page":"27099","DOI":"10.1074\/jbc.271.43.27099","volume":"271","author":"Srinivasula","year":"1996","journal-title":"J. Biol. Chem."},{"key":"D2SC05827H\/cit10\/1","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1038\/sj.cdd.4400733","volume":"7","author":"Allsopp","year":"2000","journal-title":"Cell Death Differ."},{"key":"D2SC05827H\/cit11\/1","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1038\/sj.cdd.4400442","volume":"5","author":"Miyashita","year":"1998","journal-title":"Cell Death Differ."},{"key":"D2SC05827H\/cit12\/1","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/sj.onc.1204221","volume":"20","author":"Stepczynska","year":"2001","journal-title":"Oncogene"},{"key":"D2SC05827H\/cit13\/1","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.cell.2020.03.040","volume":"181","author":"Zheng","year":"2020","journal-title":"Cell"},{"key":"D2SC05827H\/cit14\/1","first-page":"785","volume":"609","author":"Chu","year":"2022","journal-title":"Nature"},{"key":"D2SC05827H\/cit15\/1","doi-asserted-by":"crossref","first-page":"8395","DOI":"10.1073\/pnas.93.16.8395","volume":"93","author":"Takahashi","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D2SC05827H\/cit16\/1","doi-asserted-by":"crossref","first-page":"16443","DOI":"10.1074\/jbc.271.28.16443","volume":"271","author":"Orth","year":"1996","journal-title":"J. Biol. Chem."},{"key":"D2SC05827H\/cit17\/1","doi-asserted-by":"crossref","first-page":"5591","DOI":"10.1128\/MCB.21.16.5591-5604.2001","volume":"21","author":"Galande","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"D2SC05827H\/cit18\/1","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1093\/hmg\/ddn139","volume":"17","author":"Warby","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"D2SC05827H\/cit19\/1","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1038\/cdd.2014.64","volume":"21","author":"Poreba","year":"2014","journal-title":"Cell Death Differ."},{"key":"D2SC05827H\/cit20\/1","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1007\/s10495-008-0259-9","volume":"13","author":"Fu","year":"2008","journal-title":"Apoptosis"},{"key":"D2SC05827H\/cit21\/1","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/nm.1938","volume":"15","author":"Edgington","year":"2009","journal-title":"Nat. Med."},{"key":"D2SC05827H\/cit22\/1","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.chembiol.2011.12.021","volume":"19","author":"Edgington","year":"2012","journal-title":"Chem. Biol."},{"key":"D2SC05827H\/cit23\/1","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1038\/s41418-019-0329-2","volume":"26","author":"Poreba","year":"2019","journal-title":"Cell Death Differ."},{"key":"D2SC05827H\/cit24\/1","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1021\/jo016140o","volume":"67","author":"Maly","year":"2002","journal-title":"J. Org. Chem."},{"key":"D2SC05827H\/cit25\/1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1006\/meth.1999.0745","volume":"17","author":"Stennicke","year":"1999","journal-title":"Methods"},{"key":"D2SC05827H\/cit26\/1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/s41418-018-0110-y","volume":"26","author":"Poreba","year":"2019","journal-title":"Cell Death Differ."},{"key":"D2SC05827H\/cit27\/1","doi-asserted-by":"crossref","first-page":"12824","DOI":"10.1074\/jbc.M513331200","volume":"281","author":"Choe","year":"2006","journal-title":"J. Biol. Chem."},{"key":"D2SC05827H\/cit28\/1","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1038\/nprot.2016.085","volume":"11","author":"Grootjans","year":"2016","journal-title":"Nat. Protoc."},{"key":"D2SC05827H\/cit29\/1","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/sj.cr.7310112","volume":"16","author":"Berger","year":"2006","journal-title":"Cell Response"},{"key":"D2SC05827H\/cit30\/1","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1039\/C6SC04322D","volume":"8","author":"Yuan","year":"2017","journal-title":"Chem. Sci."},{"key":"D2SC05827H\/cit31\/1","doi-asserted-by":"crossref","first-page":"11718","DOI":"10.1021\/acs.chemrev.5b00263","volume":"115","author":"Mei","year":"2015","journal-title":"Chem. Rev."},{"key":"D2SC05827H\/cit32\/1","doi-asserted-by":"crossref","first-page":"4228","DOI":"10.1039\/C4CS00325J","volume":"44","author":"Kwok","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"D2SC05827H\/cit33\/1","doi-asserted-by":"crossref","first-page":"101379","DOI":"10.1016\/j.jbc.2021.101379","volume":"297","author":"Zheng","year":"2021","journal-title":"J. Biol. Chem."},{"key":"D2SC05827H\/cit34\/1","doi-asserted-by":"crossref","first-page":"43135","DOI":"10.1038\/srep43135","volume":"7","author":"Poreba","year":"2017","journal-title":"Sci. Rep."},{"key":"D2SC05827H\/cit35\/1","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1038\/cdd.2009.29","volume":"16","author":"Inoue","year":"2009","journal-title":"Cell Death Differ."},{"key":"D2SC05827H\/cit36\/1","doi-asserted-by":"crossref","first-page":"9492","DOI":"10.1073\/pnas.132241599","volume":"99","author":"MacLachlan","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D2SC05827H\/cit37\/1","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1021\/acs.biochem.1c00459","volume":"60","author":"Soni","year":"2021","journal-title":"Biochemistry"},{"key":"D2SC05827H\/cit38\/1","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.cell.2016.04.019","volume":"165","author":"Spitzer","year":"2016","journal-title":"Cell"},{"key":"D2SC05827H\/cit39\/1","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/nbt.2317","volume":"30","author":"Bodenmiller","year":"2012","journal-title":"Nat. Biotechnol."},{"key":"D2SC05827H\/cit40\/1","doi-asserted-by":"crossref","first-page":"7320","DOI":"10.1074\/jbc.M008363200","volume":"276","author":"Slee","year":"2001","journal-title":"J. Biol. Chem."},{"key":"D2SC05827H\/cit41\/1","doi-asserted-by":"crossref","first-page":"9042","DOI":"10.1073\/pnas.92.20.9042","volume":"92","author":"Lazebnik","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Chemical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2023\/SC\/D2SC05827H","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:06:12Z","timestamp":1782965172000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/sc\/article\/14\/9\/2289-2302\/786918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":41,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,3,1]]}},"URL":"https:\/\/doi.org\/10.1039\/d2sc05827h","relation":{},"ISSN":["2041-6520","2041-6539"],"issn-type":[{"value":"2041-6520","type":"print"},{"value":"2041-6539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}