{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:16:06Z","timestamp":1790745366052,"version":"4.1.0"},"reference-count":49,"publisher":"Royal Society of Chemistry (RSC)","issue":"18","license":[{"start":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T00:00:00Z","timestamp":1680566400000},"content-version":"am","delay-in-days":458,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Soft Matter"],"abstract":"<jats:p>The water content played a significant role in cone cracking fracture characteristics of polyacrylamide gel during hypodermic needle insertion. The results show that the normalised cone crack speed and the cone angle monotonically decreased with water content.<\/jats:p>","DOI":"10.1039\/d2sm00257d","type":"journal-article","created":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T04:41:01Z","timestamp":1649047261000},"page":"3521-3530","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cone cracks in tissue-mimicking hydrogels during hypodermic needle insertion: the role of water content"],"prefix":"10.1039","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5267-9332","authenticated-orcid":false,"given":"Muthukumar","family":"M.","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering, Indian Institute of Science, Bangalore, 560012, India"},{"name":"Marche Healthcare Pvt Ltd, Pondicherry, 605006, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8703-928X","authenticated-orcid":false,"given":"M. S.","family":"Bobji","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Indian Institute of Science, Bangalore, 560012, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. R. Y.","family":"Simha","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Indian Institute of Science, Bangalore, 560012, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2022]]},"reference":[{"key":"D2SM00257D\/cit1\/1","volume-title":"Biomechanics: mechanical properties of living tissues","author":"Fung","year":"2013","unstructured":"Y. C.Fung ,  Biomechanics: mechanical properties of living tissues ,  Springer Science & Business Media ,  2013"},{"key":"D2SM00257D\/cit2\/1","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1088\/0031-9155\/32\/8\/001","volume":"32","author":"Pethig","year":"1987","journal-title":"Phys. Med. Biol."},{"key":"D2SM00257D\/cit3\/1","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1007\/s11831-019-09352-w","volume":"27","author":"Budday","year":"2020","journal-title":"Archives of Computational Methods in Engineering"},{"key":"D2SM00257D\/cit4\/1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1179\/1743280413Y.0000000022","volume":"59","author":"Oyen","year":"2014","journal-title":"Int. Mater. Rev."},{"key":"D2SM00257D\/cit5\/1","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1080\/13645706.2017.1418753","volume":"27","author":"Sahlabadi","year":"2018","journal-title":"Minimally Invasive Therapy & Allied Technologies"},{"key":"D2SM00257D\/cit6\/1","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1109\/TBME.2009.2036856","volume":"57","author":"Mahvash","year":"2009","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"D2SM00257D\/cit7\/1","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1109\/TBME.2004.831542","volume":"51","author":"Okamura","year":"2004","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"D2SM00257D\/cit8\/1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jneumeth.2014.08.012","volume":"237","author":"Casanova","year":"2014","journal-title":"J. Neurosci. Methods"},{"key":"D2SM00257D\/cit9\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.medengphy.2017.04.004","volume":"45","author":"Takabi","year":"2017","journal-title":"Med. Eng. Phys."},{"key":"D2SM00257D\/cit10\/1","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1039\/D0SM02145H","volume":"17","author":"Muthukumar","year":"2021","journal-title":"Soft Matter"},{"key":"D2SM00257D\/cit11\/1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.medengphy.2006.07.003","volume":"29","author":"Abolhassani","year":"2007","journal-title":"Med. Eng. Phys."},{"key":"D2SM00257D\/cit12\/1","doi-asserted-by":"crossref","DOI":"10.1201\/9780429285097","volume-title":"Hydrogels in medicine and pharmacy: fundamentals","author":"Peppas","year":"2019","unstructured":"N. A.Peppas ,  Hydrogels in medicine and pharmacy: fundamentals ,  CRC press ,  2019 , vol. 1"},{"key":"D2SM00257D\/cit13\/1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.addr.2012.09.010","volume":"64","author":"Hoffman","year":"2012","journal-title":"Adv. Drug Delivery Rev."},{"key":"D2SM00257D\/cit14\/1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jmbbm.2015.05.012","volume":"49","author":"Li","year":"2015","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"D2SM00257D\/cit15\/1","doi-asserted-by":"crossref","first-page":"103896","DOI":"10.1016\/j.jmbbm.2020.103896","volume":"111","author":"Jushiddi","year":"2020","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"D2SM00257D\/cit16\/1","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.1016\/j.jbiomech.2014.08.007","volume":"47","author":"Jiang","year":"2014","journal-title":"J. Biomech."},{"key":"D2SM00257D\/cit17\/1","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1007\/s10853-010-5164-2","volume":"46","author":"Das","year":"2011","journal-title":"J. Mater. Sci."},{"key":"D2SM00257D\/cit18\/1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.eml.2018.11.006","volume":"26","author":"Kundan","year":"2019","journal-title":"Extreme Mech. Lett."},{"key":"D2SM00257D\/cit19\/1","doi-asserted-by":"crossref","first-page":"S130","DOI":"10.1542\/peds.2008-1055e","volume":"122","author":"Kennedy","year":"2008","journal-title":"Pediatrics"},{"key":"D2SM00257D\/cit20\/1","doi-asserted-by":"crossref","first-page":"103632","DOI":"10.1016\/j.jmbbm.2020.103632","volume":"104","author":"Li","year":"2020","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"D2SM00257D\/cit21\/1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jmbbm.2015.11.024","volume":"56","author":"Urrea","year":"2016","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"D2SM00257D\/cit23\/1","doi-asserted-by":"crossref","first-page":"21893","DOI":"10.1021\/acsami.5b09344","volume":"8","author":"Denisin","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D2SM00257D\/cit24\/1","doi-asserted-by":"crossref","first-page":"9495","DOI":"10.1021\/ma101413j","volume":"43","author":"Itagaki","year":"2010","journal-title":"Macromolecules"},{"key":"D2SM00257D\/cit25\/1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jmps.2019.06.018","volume":"131","author":"Yang","year":"2019","journal-title":"J. Mech. Phys. Solids"},{"key":"D2SM00257D\/cit26\/1","doi-asserted-by":"crossref","first-page":"9466","DOI":"10.1021\/jacs.8b03547","volume":"140","author":"Yan","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"D2SM00257D\/cit27\/1","doi-asserted-by":"crossref","first-page":"100617","DOI":"10.1016\/j.eml.2019.100617","volume":"35","author":"Li","year":"2020","journal-title":"Extreme Mech. Lett."},{"key":"D2SM00257D\/cit28\/1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0020-7462(69)90034-1","volume":"4","author":"Wang","year":"1969","journal-title":"Int. J. Non Linear Mech."},{"key":"D2SM00257D\/cit29\/1","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1002\/adfm.200900865","volume":"19","author":"Cha","year":"2009","journal-title":"Adv. Funct. Mater."},{"key":"D2SM00257D\/cit30\/1","first-page":"1","volume-title":"General Properties of Hydrogels","author":"Okay","year":"2010","unstructured":"O.Okay , in  General Properties of Hydrogels , ed.  G. Gerlach  and  K.-F. Arndt ,  Springer Berlin Heidelberg ,  Berlin, Heidelberg ,  2010 ,  pp. 1\u201314"},{"key":"D2SM00257D\/cit31\/1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3390\/gels2030020","volume":"2","author":"Gonz\u00e1lez-D\u00edaz","year":"2016","journal-title":"Gels"},{"key":"D2SM00257D\/cit32\/1","volume-title":"Introduction to Biomechanics","author":"Humphrey","year":"2016","unstructured":"J. D.Humphrey  and  S. L.Delange ,  Introduction to Biomechanics .,  Springer ,  2016"},{"key":"D2SM00257D\/cit33\/1","doi-asserted-by":"crossref","first-page":"4195","DOI":"10.1242\/jcs.023820","volume":"123","author":"Frantz","year":"2010","journal-title":"J. Cell Sci."},{"key":"D2SM00257D\/cit34\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2016.11.068","volume":"49","author":"Saldin","year":"2017","journal-title":"Acta Biomater."},{"key":"D2SM00257D\/cit35\/1","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1021\/cr000108x","volume":"101","author":"Lee","year":"2001","journal-title":"Chem. Rev."},{"key":"D2SM00257D\/cit36\/1","first-page":"15","volume-title":"Structure and Swelling of Some Synthetic, Semisynthetic, and Biopolymer Hydrogels","author":"Kulicke","year":"1989","unstructured":"W.-M.Kulicke  and  H.Nottelmann ,  Structure and Swelling of Some Synthetic, Semisynthetic, and Biopolymer Hydrogels ,  American Chemical Society ,  1989 , ch. 2,  pp. 15\u201344"},{"key":"D2SM00257D\/cit37\/1","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1002\/adma.200501612","volume":"18","author":"Peppas","year":"2006","journal-title":"Adv. Mater."},{"key":"D2SM00257D\/cit38\/1","doi-asserted-by":"crossref","first-page":"469","DOI":"10.2217\/nnm.10.12","volume":"5","author":"Geckil","year":"2010","journal-title":"Nanomedicine"},{"key":"D2SM00257D\/cit39\/1","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.1016\/S0142-9612(03)00340-5","volume":"24","author":"Drury","year":"2003","journal-title":"Biomaterials"},{"key":"D2SM00257D\/cit40\/1","doi-asserted-by":"crossref","first-page":"11247","DOI":"10.1073\/pnas.1922364117","volume":"117","author":"Cuccia","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D2SM00257D\/cit41\/1","first-page":"9","volume":"1","author":"Fawcett","year":"1966","journal-title":"Sep. Sci."},{"key":"D2SM00257D\/cit42\/1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/B978-1-895198-92-8.50079-3","volume-title":"Handbook of Polymers","author":"Wypych","year":"2016","unstructured":"G.Wypych , in  Handbook of Polymers , ed.  G. Wypych ,  ChemTec Publishing , 2nd edn,  2016 ,  pp. 254\u2013256"},{"key":"D2SM00257D\/cit43\/1","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/s10924-019-01376-4","volume":"27","author":"Elsayed","year":"2019","journal-title":"J. Polym. Environ."},{"key":"D2SM00257D\/cit44\/1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.eml.2016.09.010","volume":"10","author":"Tang","year":"2017","journal-title":"Extreme Mech. Lett."},{"key":"D2SM00257D\/cit45\/1","doi-asserted-by":"crossref","first-page":"3563","DOI":"10.1039\/C8SM00460A","volume":"14","author":"Zhang","year":"2018","journal-title":"Soft Matter"},{"key":"D2SM00257D\/cit46\/1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1098\/rspa.1967.0160","volume":"300","author":"Lake","year":"1967","journal-title":"Proc. R. Soc. London, Ser. A"},{"key":"D2SM00257D\/cit47\/1","doi-asserted-by":"crossref","first-page":"e2112389119","DOI":"10.1073\/pnas.2112389119","volume":"119","author":"Barney","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D2SM00257D\/cit48\/1","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511623127","volume-title":"Fracture of Brittle Solids","author":"Lawn","year":"1993","unstructured":"B.Lawn ,  Fracture of Brittle Solids ,  Cambridge University Press , 2nd edn,  1993"},{"key":"D2SM00257D\/cit49\/1","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/978-3-540-70521-5_18","volume-title":"Biomedical Simulation","author":"Azar","year":"2008","unstructured":"T.Azar  and  V.Hayward ,  Biomedical Simulation ,  Berlin ,  Heidelberg ,  2008 ,  pp. 166\u2013175"},{"key":"D2SM00257D\/cit50\/1","doi-asserted-by":"crossref","first-page":"5574","DOI":"10.1039\/D0SM01775B","volume":"17","author":"Barney","year":"2021","journal-title":"Soft Matter"}],"container-title":["Soft Matter"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2022\/SM\/D2SM00257D","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:22:29Z","timestamp":1782886949000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/sm\/article\/18\/18\/3521-3530\/788207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":49,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2022,5,11]]}},"URL":"https:\/\/doi.org\/10.1039\/d2sm00257d","relation":{},"ISSN":["1744-683X","1744-6848"],"issn-type":[{"value":"1744-683X","type":"print"},{"value":"1744-6848","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}