{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:40:16Z","timestamp":1782974416338,"version":"3.54.5"},"reference-count":41,"publisher":"Royal Society of Chemistry (RSC)","issue":"1","license":[{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"am","delay-in-days":332,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001941"],"award-info":[{"award-number":["82001941"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2021J01344"],"award-info":[{"award-number":["2021J01344"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003410","name":"Department of Education, Fujian Province","doi-asserted-by":"publisher","award":["JAT200711"],"award-info":[{"award-number":["JAT200711"]}],"id":[{"id":"10.13039\/501100003410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["J. Mater. Chem. B"],"abstract":"<jats:p>Intracellular-synthesized chemo-drugs based on the inherent characteristics of the tumor microenvironment (TME) have been extensively applied in oncotherapy.<\/jats:p>","DOI":"10.1039\/d2tb01943d","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T07:41:44Z","timestamp":1669707704000},"page":"119-130","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Biomimetic dual-responsive bioengineered nanotheranostics for intracellular cascade-synthesizing chemo-drugs and efficient oncotherapy"],"prefix":"10.1039","volume":"11","author":[{"given":"Xin","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Materials, Xiamen University, Xiamen, 361005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinglin","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Materials, Xiamen University, Xiamen, 361005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, the Affiliated Dongnan Hospital of Xiamen University, Zhangzhou, 363005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Huang","sequence":"additional","affiliation":[{"name":"Xiamen Key Laboratory of Traditional Chinese Bio-engineering, Xiamen Medical College, Xiamen, 361021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Yi","sequence":"additional","affiliation":[{"name":"Institute of Respiratory Diseases, Xiamen Medical College, Xiamen, 361021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Xiamen Key Laboratory of Traditional Chinese Bio-engineering, Xiamen Medical College, Xiamen, 361021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5537-075X","authenticated-orcid":false,"given":"Zhenqing","family":"Hou","sequence":"additional","affiliation":[{"name":"College of Materials, Xiamen University, Xiamen, 361005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5751-9530","authenticated-orcid":false,"given":"Zhongxiong","family":"Fan","sequence":"additional","affiliation":[{"name":"College of Materials, Xiamen University, Xiamen, 361005, China"},{"name":"Institute of Materia Medica & College of Life Science and Technology, Xinjiang University, Urumqi, 830017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2023]]},"reference":[{"key":"D2TB01943D\/cit1\/1","doi-asserted-by":"crossref","first-page":"121071","DOI":"10.1016\/j.biomaterials.2021.121071","volume":"277","author":"Xiang","year":"2021","journal-title":"Biomaterials"},{"key":"D2TB01943D\/cit2\/1","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.1038\/s41467-022-31601-z","volume":"13","author":"Hingorani","year":"2022","journal-title":"Nat. Commun."},{"key":"D2TB01943D\/cit3\/1","doi-asserted-by":"crossref","first-page":"100919","DOI":"10.1016\/j.pmatsci.2021.100919","volume":"125","author":"Liu","year":"2022","journal-title":"Prog. Mater. Sci."},{"key":"D2TB01943D\/cit4\/1","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1016\/j.matt.2022.04.032","volume":"5","author":"Yi","year":"2022","journal-title":"Matter"},{"key":"D2TB01943D\/cit5\/1","doi-asserted-by":"crossref","first-page":"120574","DOI":"10.1016\/j.biomaterials.2020.120574","volume":"268","author":"Shu","year":"2021","journal-title":"Biomaterials"},{"key":"D2TB01943D\/cit6\/1","doi-asserted-by":"crossref","first-page":"25654","DOI":"10.1021\/acsami.9b01433","volume":"11","author":"Luan","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D2TB01943D\/cit7\/1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.actbio.2022.07.003","volume":"149","author":"He","year":"2022","journal-title":"Acta Biomater."},{"key":"D2TB01943D\/cit8\/1","doi-asserted-by":"crossref","first-page":"8817","DOI":"10.1039\/D0SC02387F","volume":"11","author":"He","year":"2020","journal-title":"Chem. Sci."},{"key":"D2TB01943D\/cit9\/1","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.1021\/acs.nanolett.2c01131","volume":"22","author":"Yang","year":"2022","journal-title":"Nano Lett."},{"key":"D2TB01943D\/cit10\/1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.biomaterials.2017.11.001","volume":"154","author":"Shen","year":"2018","journal-title":"Biomaterials"},{"key":"D2TB01943D\/cit11\/1","doi-asserted-by":"crossref","first-page":"2203236","DOI":"10.1002\/adma.202203236","volume":"34","author":"Cao","year":"2022","journal-title":"Adv. Mater."},{"key":"D2TB01943D\/cit12\/1","doi-asserted-by":"crossref","first-page":"2005918","DOI":"10.1002\/adfm.202005918","volume":"30","author":"Chu","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"D2TB01943D\/cit13\/1","doi-asserted-by":"crossref","first-page":"121693","DOI":"10.1016\/j.biomaterials.2022.121693","volume":"288","author":"Zhou","year":"2022","journal-title":"Biomaterials"},{"key":"D2TB01943D\/cit14\/1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jconrel.2021.05.025","volume":"335","author":"Chen","year":"2021","journal-title":"J. Controlled Release"},{"key":"D2TB01943D\/cit15\/1","doi-asserted-by":"crossref","first-page":"5033","DOI":"10.1021\/acsami.1c22350","volume":"14","author":"Fan","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D2TB01943D\/cit16\/1","doi-asserted-by":"crossref","first-page":"12912","DOI":"10.1021\/acsnano.9b05425","volume":"13","author":"Li","year":"2019","journal-title":"ACS Nano"},{"key":"D2TB01943D\/cit17\/1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jconrel.2020.08.006","volume":"327","author":"Cheng","year":"2020","journal-title":"J. Controlled Release"},{"key":"D2TB01943D\/cit18\/1","doi-asserted-by":"crossref","first-page":"2103498","DOI":"10.1002\/advs.202103498","volume":"9","author":"Lin","year":"2022","journal-title":"Adv. Sci."},{"key":"D2TB01943D\/cit19\/1","doi-asserted-by":"crossref","first-page":"120557","DOI":"10.1016\/j.biomaterials.2020.120557","volume":"268","author":"Huang","year":"2021","journal-title":"Biomaterials"},{"key":"D2TB01943D\/cit20\/1","doi-asserted-by":"crossref","first-page":"4285","DOI":"10.1007\/s12274-022-4085-0","volume":"15","author":"Yang","year":"2022","journal-title":"Nano Res."},{"key":"D2TB01943D\/cit21\/1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.bioactmat.2021.06.035","volume":"8","author":"Mei","year":"2022","journal-title":"Bioact. Mater."},{"key":"D2TB01943D\/cit22\/1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jconrel.2021.11.021","volume":"341","author":"Shao","year":"2022","journal-title":"J. Controlled Release"},{"key":"D2TB01943D\/cit23\/1","doi-asserted-by":"crossref","first-page":"15966","DOI":"10.1021\/jacs.0c06872","volume":"142","author":"Feng","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"D2TB01943D\/cit24\/1","doi-asserted-by":"crossref","first-page":"5033","DOI":"10.1021\/acsami.1c22350","volume":"14","author":"Fan","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D2TB01943D\/cit25\/1","doi-asserted-by":"crossref","first-page":"3841","DOI":"10.1016\/j.polymer.2009.05.047","volume":"50","author":"Zhou","year":"2009","journal-title":"Polymer"},{"key":"D2TB01943D\/cit26\/1","doi-asserted-by":"crossref","first-page":"1701429","DOI":"10.1002\/adma.201701429","volume":"29","author":"Gao","year":"2017","journal-title":"Adv. Mater."},{"key":"D2TB01943D\/cit27\/1","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.apsb.2019.01.011","volume":"9","author":"Xia","year":"2019","journal-title":"Acta Pharm. Sin. B"},{"key":"D2TB01943D\/cit28\/1","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.biomaterials.2018.11.021","volume":"192","author":"Jiang","year":"2019","journal-title":"Biomaterials"},{"key":"D2TB01943D\/cit29\/1","doi-asserted-by":"crossref","first-page":"1707567","DOI":"10.1002\/adma.201707567","volume":"30","author":"Shan","year":"2018","journal-title":"Adv. Mater."},{"key":"D2TB01943D\/cit30\/1","doi-asserted-by":"crossref","first-page":"15262","DOI":"10.1021\/acsami.9b00897","volume":"11","author":"Ye","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D2TB01943D\/cit31\/1","doi-asserted-by":"crossref","first-page":"14980","DOI":"10.1021\/jacs.8b09396","volume":"140","author":"Zhang","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"D2TB01943D\/cit32\/1","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1007\/s00259-021-05654-z","volume":"49","author":"Zhang","year":"2022","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"D2TB01943D\/cit33\/1","doi-asserted-by":"crossref","first-page":"127108","DOI":"10.1016\/j.cej.2020.127108","volume":"407","author":"Fu","year":"2021","journal-title":"Chem. Eng. J."},{"key":"D2TB01943D\/cit34\/1","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.jconrel.2022.06.007","volume":"348","author":"Xiang","year":"2022","journal-title":"J. Controlled Release"},{"key":"D2TB01943D\/cit35\/1","doi-asserted-by":"crossref","first-page":"19756","DOI":"10.1021\/acsnano.1c07180","volume":"15","author":"Xiong","year":"2021","journal-title":"ACS Nano"},{"key":"D2TB01943D\/cit36\/1","doi-asserted-by":"crossref","first-page":"2201049","DOI":"10.1002\/adma.202201049","volume":"34","author":"Shi","year":"2022","journal-title":"Adv. Mater."},{"key":"D2TB01943D\/cit37\/1","doi-asserted-by":"crossref","first-page":"e202203444","DOI":"10.1002\/anie.202203444","volume":"61","author":"Heng","year":"2022","journal-title":"Angew. Chem., Int. Ed."},{"key":"D2TB01943D\/cit38\/1","doi-asserted-by":"crossref","first-page":"121452","DOI":"10.1016\/j.biomaterials.2022.121452","volume":"283","author":"Fan","year":"2022","journal-title":"Biomaterials"},{"key":"D2TB01943D\/cit39\/1","doi-asserted-by":"crossref","first-page":"eabl5862","DOI":"10.1126\/sciadv.abl5862","volume":"7","author":"Lin","year":"2021","journal-title":"Sci. Adv."},{"key":"D2TB01943D\/cit40\/1","doi-asserted-by":"crossref","first-page":"121449","DOI":"10.1016\/j.biomaterials.2022.121449","volume":"283","author":"Pan","year":"2022","journal-title":"Biomaterials"},{"key":"D2TB01943D\/cit41\/1","doi-asserted-by":"crossref","first-page":"8449","DOI":"10.1021\/acs.analchem.2c01241","volume":"94","author":"Chen","year":"2022","journal-title":"Anal. Chem."}],"container-title":["Journal of Materials Chemistry B"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2023\/TB\/D2TB01943D","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:14:39Z","timestamp":1782969279000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/tb\/article\/11\/1\/119-130\/792106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12,22]]}},"URL":"https:\/\/doi.org\/10.1039\/d2tb01943d","relation":{},"ISSN":["2050-750X","2050-7518"],"issn-type":[{"value":"2050-750X","type":"print"},{"value":"2050-7518","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}