{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:19:18Z","timestamp":1782883158900,"version":"3.54.5"},"reference-count":42,"publisher":"Royal Society of Chemistry (RSC)","issue":"16","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"am","delay-in-days":551,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100008014","name":"Agence R\u00e9gionale de Sant\u00e9 de Champagne-Ardenne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008014","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004097","name":"Fondation ARC pour la Recherche sur le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004097","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Analyst"],"abstract":"<jats:p>Prediction of the efficacy of a treatment against metastatic colon cancer, based on deep learning analysis of histological cuts of the primary tumor, either H&amp;E stained or imaged with FTIR spectroscopy.<\/jats:p>","DOI":"10.1039\/d3an00627a","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T10:21:47Z","timestamp":1688552507000},"page":"3909-3917","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Deep learning for the prediction of the chemotherapy response of metastatic colorectal cancer: comparing and combining H&amp;E staining histopathology and infrared spectral histopathology"],"prefix":"10.1039","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2858-5074","authenticated-orcid":false,"given":"Benjamin","family":"Brunel","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Reims Champagne-Ardenne, EA7506-BioSpectroscopie Translationnelle (BioSpecT), Reims, France"},{"name":"Universit\u00e9 de Franche-Comt\u00e9, CNRS, institut FEMTO-ST, F-25000 Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Prada","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Reims Champagne-Ardenne, EA7506-BioSpectroscopie Translationnelle (BioSpecT), Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5139-7034","authenticated-orcid":false,"given":"Florian","family":"Slimano","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Reims Champagne-Ardenne, EA7506-BioSpectroscopie Translationnelle (BioSpecT), Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5610-1722","authenticated-orcid":false,"given":"Camille","family":"Boulagnon-Rombi","sequence":"additional","affiliation":[{"name":"Laboratoire d'anatomie et cytologie pathologique, CHU Reims, 51100 Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Bouch\u00e9","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Reims Champagne-Ardenne, EA7506-BioSpectroscopie Translationnelle (BioSpecT), Reims, France"},{"name":"Service d'Oncologie Digestive, CHU Reims, 51100 Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7869-5242","authenticated-orcid":false,"given":"Olivier","family":"Piot","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Reims Champagne-Ardenne, EA7506-BioSpectroscopie Translationnelle (BioSpecT), Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2023]]},"reference":[{"key":"D3AN00627A\/cit1\/1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"Sung","year":"2021","journal-title":"Ca-Cancer J. Clin."},{"key":"D3AN00627A\/cit2\/1","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1056\/NEJMoa032691","volume":"350","author":"Hurwitz","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"D3AN00627A\/cit3\/1","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1056\/NEJMoa0805019","volume":"360","author":"Van Cutsem","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"D3AN00627A\/cit4\/1","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1016\/j.dld.2019.05.035","volume":"51","author":"Phelip","year":"2019","journal-title":"Dig. Liver Dis."},{"key":"D3AN00627A\/cit5\/1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ejca.2018.10.009","volume":"106","author":"Baraniskin","year":"2019","journal-title":"Eur. J. Cancer"},{"key":"D3AN00627A\/cit6\/1","doi-asserted-by":"crossref","first-page":"584","DOI":"10.3389\/fcell.2020.00584","volume":"8","author":"Montemagno","year":"2020","journal-title":"Front. Cell Dev. Biol"},{"key":"D3AN00627A\/cit7\/1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/annonc\/mdu378","volume":"26","author":"Sorich","year":"2015","journal-title":"Ann. Oncol."},{"key":"D3AN00627A\/cit8\/1","doi-asserted-by":"crossref","first-page":"641469","DOI":"10.3389\/fcell.2021.641469","volume":"9","author":"Wu","year":"2021","journal-title":"Front. Cell Dev. Biol"},{"key":"D3AN00627A\/cit9\/1","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.1039\/C3AN01022H","volume":"139","author":"Nallala","year":"2014","journal-title":"Analyst"},{"key":"D3AN00627A\/cit10\/1","doi-asserted-by":"crossref","first-page":"4246","DOI":"10.1039\/C8SC04320E","volume":"10","author":"Gaydou","year":"2019","journal-title":"Chem. Sci."},{"key":"D3AN00627A\/cit11\/1","doi-asserted-by":"crossref","first-page":"8461","DOI":"10.1021\/ac801191x","volume":"80","author":"Wolthuis","year":"2008","journal-title":"Anal. Chem."},{"key":"D3AN00627A\/cit12\/1","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1111\/j.1365-2559.2010.03563.x","volume":"56","author":"Travo","year":"2010","journal-title":"Histopathology"},{"key":"D3AN00627A\/cit13\/1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/jbio.201500285","volume":"9","author":"Nguyen","year":"2016","journal-title":"J. Biophotonics"},{"key":"D3AN00627A\/cit14\/1","doi-asserted-by":"crossref","first-page":"3296","DOI":"10.1039\/C5AN02227D","volume":"141","author":"Farah","year":"2016","journal-title":"Analyst"},{"key":"D3AN00627A\/cit15\/1","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.3390\/ma12182884","volume":"12","author":"Balan","year":"2019","journal-title":"Materials"},{"key":"D3AN00627A\/cit16\/1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1177\/0003702818791939","volume":"72","author":"Pahlow","year":"2018","journal-title":"Appl. Spectrosc."},{"key":"D3AN00627A\/cit17\/1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1146\/annurev-bioeng-071516-044442","volume":"19","author":"Shen","year":"2017","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"D3AN00627A\/cit18\/1","doi-asserted-by":"crossref","first-page":"880093","DOI":"10.3389\/fgene.2022.880093","volume":"13","author":"Li","year":"2022","journal-title":"Front. Genet."},{"key":"D3AN00627A\/cit19\/1","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/s41591-021-01343-4","volume":"27","author":"Van der Laak","year":"2021","journal-title":"Nat. Med."},{"key":"D3AN00627A\/cit20\/1","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1039\/C8AN01495G","volume":"144","author":"Berisha","year":"2019","journal-title":"Analyst"},{"key":"D3AN00627A\/cit21\/1","doi-asserted-by":"crossref","first-page":"116459","DOI":"10.1016\/j.trac.2021.116459","volume":"145","author":"Debus","year":"2021","journal-title":"TrAC, Trends Anal. Chem."},{"key":"D3AN00627A\/cit22\/1","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/s41416-022-01852-0","volume":"127","author":"Moretto","year":"2022","journal-title":"Br. J. Cancer"},{"key":"D3AN00627A\/cit23\/1","doi-asserted-by":"crossref","first-page":"16878","DOI":"10.1038\/s41598-017-17204-5","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci. Rep."},{"key":"D3AN00627A\/cit24\/1","author":"Macenko","unstructured":"M.Macenko ,  M.Niethammer ,  J. S.Marron ,  D.Borland ,  J. T.Woosley ,  X.Guan ,  C.Schmitt  and  N. E.Thomas"},{"key":"D3AN00627A\/cit25\/1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1080\/01621459.1984.10478083","volume":"79","author":"Picard","year":"1984","journal-title":"J. Am. Stat. Assoc."},{"key":"D3AN00627A\/cit26\/1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.chemolab.2012.03.004","volume":"117","author":"Afseth","year":"2012","journal-title":"Chemom. Intell. Lab. Syst."},{"key":"D3AN00627A\/cit27\/1","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1039\/C4AN01937G","volume":"140","author":"Nguyen","year":"2015","journal-title":"Analyst"},{"key":"D3AN00627A\/cit28\/1","author":"Ioffe","unstructured":"S.Ioffe  and  C.Szegedy"},{"key":"D3AN00627A\/cit29\/1","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature14539","volume":"521","author":"LeCun","year":"2015","journal-title":"Nature"},{"key":"D3AN00627A\/cit30\/1","doi-asserted-by":"crossref","first-page":"e763","DOI":"10.1016\/S2589-7500(21)00180-1","volume":"3","author":"Bilal","year":"2021","journal-title":"Lancet Digital Health"},{"key":"D3AN00627A\/cit31\/1","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1038\/s41591-022-01768-5","volume":"28","author":"Saldanha","year":"2022","journal-title":"Nat. Med."},{"key":"D3AN00627A\/cit32\/1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/path.5800","volume":"256","author":"Schrammen","year":"2022","journal-title":"J. Pathol."},{"key":"D3AN00627A\/cit33\/1","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1016\/j.ajpath.2019.05.007","volume":"189","author":"Wang","year":"2019","journal-title":"Am. J. Pathol."},{"key":"D3AN00627A\/cit34\/1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/path.5921","volume":"257","author":"Bankhead","year":"2022","journal-title":"J. Pathol."},{"key":"D3AN00627A\/cit35\/1","doi-asserted-by":"crossref","first-page":"c2289","DOI":"10.1136\/bmj.c2289","volume":"340","author":"Hutcheon","year":"2010","journal-title":"Br. Med. J."},{"key":"D3AN00627A\/cit36\/1","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.3892\/ol.2017.6639","volume":"14","author":"Jakubowska","year":"2017","journal-title":"Oncol. Lett."},{"key":"D3AN00627A\/cit37\/1","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1093\/annonc\/mdt593","volume":"25","author":"Park","year":"2014","journal-title":"Ann. Oncol."},{"key":"D3AN00627A\/cit38\/1","doi-asserted-by":"crossref","first-page":"e1002730","DOI":"10.1371\/journal.pmed.1002730","volume":"16","author":"Kather","year":"2019","journal-title":"PLoS Med."},{"key":"D3AN00627A\/cit39\/1","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1111\/his.14438","volume":"79","author":"Jones","year":"2021","journal-title":"Histopathology"},{"key":"D3AN00627A\/cit40\/1","doi-asserted-by":"crossref","first-page":"8002","DOI":"10.3390\/ijms22158002","volume":"22","author":"Yamamoto","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"D3AN00627A\/cit41\/1","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1089\/dna.2020.5490","volume":"39","author":"Wang","year":"2020","journal-title":"DNA Cell Biol."},{"key":"D3AN00627A\/cit42\/1","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1080\/01635581.2019.1675725","volume":"72","author":"Bai","year":"2020","journal-title":"Nutr. Cancer"}],"container-title":["The Analyst"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2023\/AN\/D3AN00627A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:10:45Z","timestamp":1782879045000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/an\/article\/148\/16\/3909-3917\/794832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":42,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2023,8,7]]}},"URL":"https:\/\/doi.org\/10.1039\/d3an00627a","relation":{},"ISSN":["0003-2654","1364-5528"],"issn-type":[{"value":"0003-2654","type":"print"},{"value":"1364-5528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}