{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T19:36:38Z","timestamp":1783539398243,"version":"3.55.0"},"reference-count":45,"publisher":"Royal Society of Chemistry (RSC)","issue":"48","license":[{"start":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T00:00:00Z","timestamp":1732924800000},"content-version":"am","delay-in-days":699,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Anal. Methods"],"abstract":"<jats:p>An HPLC-FLD method was proposed to determine remdesivir, hydroxychloroquine, and levofloxacin in their pure form and in human plasma, with high sensitivity and a wide linear range. Validation was done as per ICH and FDA guidelines, and the method greenness was evaluated.<\/jats:p>","DOI":"10.1039\/d3ay01562a","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T02:58:16Z","timestamp":1701313096000},"page":"6666-6678","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A validated eco-friendly HPLC-FLD for analysis of the first approved antiviral remdesivir with other potential add-on therapies for COVID-19 in human plasma and pharmaceuticals"],"prefix":"10.1039","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0110-3572","authenticated-orcid":false,"given":"Asmaa M.","family":"Taha","sequence":"first","affiliation":[{"name":"Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wafaa S.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3120-5909","authenticated-orcid":false,"given":"Manal S.","family":"Elmasry","sequence":"additional","affiliation":[{"name":"Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8603-5073","authenticated-orcid":false,"given":"Rania A.","family":"Sayed","sequence":"additional","affiliation":[{"name":"Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2023]]},"reference":[{"key":"D3AY01562A\/cit1\/1","unstructured":"https:\/\/covid19.who.int\/ , accessed 1 August 2023"},{"key":"D3AY01562A\/cit2\/1","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/S0140-6736(20)30633-4","volume":"395","author":"Weiss","year":"2020","journal-title":"Lancet"},{"key":"D3AY01562A\/cit3\/1","doi-asserted-by":"crossref","first-page":"e291","DOI":"10.1093\/pubmed\/fdaa282","volume":"43","author":"Vergara","year":"2021","journal-title":"J. Public Health"},{"key":"D3AY01562A\/cit4\/1","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0140-6736(21)00306-8","volume":"397","author":"Wouters","year":"2021","journal-title":"Lancet"},{"key":"D3AY01562A\/cit5\/1","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/s41591-021-01285-x","volume":"27","author":"Wibmer","year":"2021","journal-title":"Nat. Med."},{"key":"D3AY01562A\/cit6\/1","doi-asserted-by":"crossref","first-page":"4536","DOI":"10.2174\/0929867327666200416131117","volume":"27","author":"Costanzo","year":"2020","journal-title":"Curr. Med. Chem."},{"key":"D3AY01562A\/cit7\/1","doi-asserted-by":"crossref","first-page":"7726","DOI":"10.1080\/07391102.2021.1902392","volume":"40","author":"Ishola","year":"2022","journal-title":"J. Biomol. Struct. Dyn."},{"key":"D3AY01562A\/cit8\/1","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1056\/NEJMoa2001282","volume":"382","author":"Cao","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"D3AY01562A\/cit9\/1","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1056\/NEJMoa2007016","volume":"382","author":"Grein","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"D3AY01562A\/cit10\/1","doi-asserted-by":"crossref","first-page":"6785","DOI":"10.1074\/jbc.RA120.013679","volume":"295","author":"Gordon","year":"2020","journal-title":"J. Biol. Chem."},{"key":"D3AY01562A\/cit11\/1","first-page":"1","volume":"8","author":"Elshaboury","year":"2021","journal-title":"Ther. Adv. Infect. Dis."},{"key":"D3AY01562A\/cit12\/1","doi-asserted-by":"crossref","first-page":"830990","DOI":"10.3389\/fimmu.2022.830990","volume":"13","author":"Chatterjee","year":"2022","journal-title":"Front. Immunol."},{"key":"D3AY01562A\/cit13\/1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41422-020-0282-0","volume":"30","author":"Wang","year":"2020","journal-title":"Cell Res."},{"key":"D3AY01562A\/cit14\/1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/10937404.2020.1752340","volume":"23","author":"Pereira","year":"2020","journal-title":"J. Toxicol. Environ. Health, Part B"},{"key":"D3AY01562A\/cit15\/1","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/art.27289","volume":"62","author":"Jung","year":"2010","journal-title":"Arthritis Rheum."},{"key":"D3AY01562A\/cit16\/1","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1136\/postgradmedj-2020-137785","volume":"96","author":"Sinha","year":"2020","journal-title":"Postgrad. Med. J."},{"key":"D3AY01562A\/cit17\/1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s40495-020-00231-8","volume":"6","author":"Satarker","year":"2020","journal-title":"Curr. Pharmacol. Rep."},{"key":"D3AY01562A\/cit18\/1","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.2165\/00003495-200363240-00008","volume":"63","author":"Croom","year":"2003","journal-title":"Drugs"},{"key":"D3AY01562A\/cit19\/1","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1007\/s43440-021-00282-8","volume":"73","author":"Marciniec","year":"2021","journal-title":"Pharmacol. Rep."},{"key":"D3AY01562A\/cit20\/1","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.arcmed.2020.06.004","volume":"51","author":"Karampela","year":"2020","journal-title":"Arch. Med. Res."},{"key":"D3AY01562A\/cit21\/1","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.7326\/M21-0857","volume":"174","author":"Mehta","year":"2021","journal-title":"Ann. Intern. Med."},{"key":"D3AY01562A\/cit22\/1","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1001\/jama.2019.20153","volume":"323","author":"Sanders","year":"2020","journal-title":"JAMA"},{"key":"D3AY01562A\/cit23\/1","first-page":"82","volume":"13","author":"Hasan","year":"2022","journal-title":"J. Pharm. Negat. Results"},{"key":"D3AY01562A\/cit24\/1","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/bjd.19264","volume":"183","author":"Marzano","year":"2020","journal-title":"Br. J. Dermatol."},{"key":"D3AY01562A\/cit25\/1","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1080\/10826070701386629","volume":"30","author":"Hurtado","year":"2007","journal-title":"J. Liq. Chromatogr. Relat. Technol."},{"key":"D3AY01562A\/cit26\/1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1365\/s10337-007-0292-9","volume":"66","author":"Nemutlu","year":"2007","journal-title":"Chromatographia"},{"key":"D3AY01562A\/cit27\/1","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1002\/bmc.1060","volume":"22","author":"Srinivas","year":"2008","journal-title":"Biomed. Chromatogr."},{"key":"D3AY01562A\/cit28\/1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s41664-020-00121-4","volume":"4","author":"G\u00fclfen","year":"2020","journal-title":"J. Anal. Test."},{"key":"D3AY01562A\/cit29\/1","first-page":"2586","volume":"14","author":"Jasmina Surati","year":"2023","journal-title":"Int. J. Pharm. Sci. Res."},{"key":"D3AY01562A\/cit30\/1","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jchromb.2017.06.011","volume":"1060","author":"Armstrong","year":"2017","journal-title":"J. Chromatogr. B"},{"key":"D3AY01562A\/cit31\/1","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1007\/s10337-020-03945-5","volume":"83","author":"Dongala","year":"2020","journal-title":"Chromatographia"},{"key":"D3AY01562A\/cit32\/1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3390\/separations8120243","volume":"8","author":"Ibrahim","year":"2021","journal-title":"Separations"},{"key":"D3AY01562A\/cit33\/1","doi-asserted-by":"crossref","first-page":"e5212","DOI":"10.1002\/bmc.5212","volume":"35","author":"Hamdy","year":"2021","journal-title":"Biomed. Chromatogr."},{"key":"D3AY01562A\/cit34\/1","doi-asserted-by":"crossref","first-page":"113935","DOI":"10.1016\/j.jpba.2021.113935","volume":"196","author":"Habler","year":"2021","journal-title":"J. Pharm. Biomed. Anal."},{"key":"D3AY01562A\/cit35\/1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1515\/revac-2021-0141","volume":"40","author":"Abdel Moneim","year":"2021","journal-title":"Rev. Anal. Chem."},{"key":"D3AY01562A\/cit36\/1","doi-asserted-by":"crossref","first-page":"121625","DOI":"10.1016\/j.saa.2022.121625","volume":"281","author":"Ramzy","year":"2022","journal-title":"Spectrochim. Acta, Part A"},{"key":"D3AY01562A\/cit37\/1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/978-1-4939-0597-3_2","volume-title":"Hydroxychloroquine and Chloroquine Retinopathy","author":"Browning","year":"2014","unstructured":"D. J.Browning ,  Hydroxychloroquine and Chloroquine Retinopathy ,  Springer ,  New York, NY, United States ,  2014 ,  pp. 35\u201363"},{"key":"D3AY01562A\/cit38\/1","volume-title":"ICH Harmonised Tripartite Guideline","author":"ICH","year":"2005","unstructured":"ICH ,  Validation of Analytical Procedures: Text and Methodology, Q2(R1) ,  ICH Harmonised Tripartite Guideline ,  2005"},{"key":"D3AY01562A\/cit39\/1","volume-title":"Guidance for Industry Bioanalytical Method Validation Guidance for Industry Bioanalytical Method Validation","author":"FDA","year":"2013","unstructured":"FDA ,  Guidance for Industry Bioanalytical Method Validation Guidance for Industry Bioanalytical Method Validation ,  2013"},{"key":"D3AY01562A\/cit40\/1","volume-title":"United States Pharmacopeia and National Formulary (USP 37-NF 32)","year":"2014","unstructured":"United States Pharmacopeia and National Formulary (USP 37-NF 32) ,  United States Pharmacopeial Convention ,  Rockville ,  2014"},{"key":"D3AY01562A\/cit41\/1","doi-asserted-by":"crossref","first-page":"107580","DOI":"10.1016\/j.microc.2022.107580","volume":"179","author":"Emam","year":"2022","journal-title":"Microchem. J."},{"key":"D3AY01562A\/cit42\/1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2165\/00003088-199732020-00002","volume":"32","author":"Fish","year":"1997","journal-title":"Clin. Pharmacokinet."},{"key":"D3AY01562A\/cit43\/1","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.talanta.2018.01.013","volume":"181","author":"P\u0142otka-Wasylka","year":"2018","journal-title":"Talanta"},{"key":"D3AY01562A\/cit44\/1","doi-asserted-by":"crossref","first-page":"10076","DOI":"10.1021\/acs.analchem.0c01887","volume":"92","author":"Pena-Pereira","year":"2020","journal-title":"Anal. Chem."},{"key":"D3AY01562A\/cit45\/1","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1134\/S1061934816080049","volume":"71","author":"Czyrski","year":"2016","journal-title":"J. Anal. Chem."}],"container-title":["Analytical Methods"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2023\/AY\/D3AY01562A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T18:03:48Z","timestamp":1783533828000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ay\/article\/15\/48\/6666-6678\/795845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":45,"journal-issue":{"issue":"48","published-print":{"date-parts":[[2023,12,14]]}},"URL":"https:\/\/doi.org\/10.1039\/d3ay01562a","relation":{},"ISSN":["1759-9660","1759-9679"],"issn-type":[{"value":"1759-9660","type":"print"},{"value":"1759-9679","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}