{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:34:34Z","timestamp":1782970474542,"version":"3.54.5"},"reference-count":27,"publisher":"Royal Society of Chemistry (RSC)","issue":"4","license":[{"start":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T00:00:00Z","timestamp":1704240000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000761","name":"Imperial College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000761","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018336","name":"National Institute for Health Research Health Protection Research Unit","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000276","name":"Department of Health and Social Care","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000276","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Anal. Methods"],"abstract":"<jats:p>Fast and highly sensitive analysis of phenoxymethylpenicillin, benzylpenicillin and probenecid in human serum using a triple quadrupole LC\/MS method for therapeutic drug monitoring.<\/jats:p>","DOI":"10.1039\/d3ay01816d","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T08:26:09Z","timestamp":1704270369000},"page":"558-565","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A low-volume LC\/MS method for highly sensitive monitoring of phenoxymethylpenicillin, benzylpenicillin, and probenecid in human serum"],"prefix":"10.1039","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1829-5770","authenticated-orcid":false,"given":"Alaa","family":"Riezk","sequence":"first","affiliation":[{"name":"National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK"},{"name":"Centre for Antimicrobial Optimisation, Imperial College London, Hammersmith Hospital, Du Cane Road, Acton, London, W12 0NN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard C.","family":"Wilson","sequence":"additional","affiliation":[{"name":"National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK"},{"name":"Centre for Antimicrobial Optimisation, Imperial College London, Hammersmith Hospital, Du Cane Road, Acton, London, W12 0NN, UK"},{"name":"Imperial College Healthcare NHS Trust, Hammersmith Hospital, Du Cane Road, London, W12 0HS, UK"},{"name":"David Price Evans Infectious Diseases & Global Health Group, The University of Liverpool, Liverpool, L7 8TX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8881-4786","authenticated-orcid":false,"given":"Anthony E. G.","family":"Cass","sequence":"additional","affiliation":[{"name":"Centre for Antimicrobial Optimisation, Imperial College London, Hammersmith Hospital, Du Cane Road, Acton, London, W12 0NN, UK"},{"name":"Department of Chemistry, Molecular Sciences Research Hub, Imperial College, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison H.","family":"Holmes","sequence":"additional","affiliation":[{"name":"National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK"},{"name":"Centre for Antimicrobial Optimisation, Imperial College London, Hammersmith Hospital, Du Cane Road, Acton, London, W12 0NN, UK"},{"name":"David Price Evans Infectious Diseases & Global Health Group, The University of Liverpool, Liverpool, L7 8TX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy M.","family":"Rawson","sequence":"additional","affiliation":[{"name":"National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Imperial College London, Hammersmith Campus, Du Cane Road, London, W12 0NN, UK"},{"name":"Centre for Antimicrobial Optimisation, Imperial College London, Hammersmith Hospital, Du Cane Road, Acton, London, W12 0NN, UK"},{"name":"David Price Evans Infectious Diseases & Global Health Group, The University of Liverpool, Liverpool, L7 8TX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2024]]},"reference":[{"key":"D3AY01816D\/cit1\/1","volume-title":"Phenoxymethylpenicillin","year":"2023","unstructured":"Phenoxymethylpenicillin ,  https:\/\/bnf.nice.org.uk\/drugs\/phenoxymethylpenicillin\/ ,  2023"},{"key":"D3AY01816D\/cit2\/1","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1039\/D2AY01276F","volume":"15","author":"Riezk","year":"2023","journal-title":"Anal. Methods"},{"key":"D3AY01816D\/cit3\/1","volume-title":"The WHO AWaRe (Access, Watch, Reserve) Antibiotic Book","year":"2022","unstructured":"The WHO AWaRe (Access, Watch, Reserve) Antibiotic Book ,  World Health Organization ,  Geneva ,  2022 , available from:  https:\/\/www.who.int\/publications\/i\/item\/9789240062382  [cited 2023 Aug]"},{"key":"D3AY01816D\/cit4\/1","doi-asserted-by":"crossref","first-page":"ofab573","DOI":"10.1093\/ofid\/ofab573","volume":"8","author":"Rawson","year":"2021","journal-title":"Open Forum Infect. Dis."},{"key":"D3AY01816D\/cit5\/1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1039\/C7MD00528H","volume":"9","author":"Melander","year":"2018","journal-title":"MedChemComm"},{"key":"D3AY01816D\/cit6\/1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s13073-017-0504-3","volume":"9","author":"Paharik","year":"2017","journal-title":"Genome Med."},{"key":"D3AY01816D\/cit7\/1","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1093\/jac\/dkz122","volume":"74","author":"Seaton","year":"2019","journal-title":"J. Antimicrob. Chemother."},{"key":"D3AY01816D\/cit8\/1","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1093\/jac\/dkac200","volume":"77","author":"Wilson","year":"2022","journal-title":"J. Antimicrob. Chemother."},{"key":"D3AY01816D\/cit9\/1","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1093\/jac\/dku517","volume":"70","author":"Gilchrist","year":"2015","journal-title":"J. Antimicrob. Chemother."},{"key":"D3AY01816D\/cit10\/1","doi-asserted-by":"crossref","first-page":"107647","DOI":"10.1016\/j.pharmthera.2020.107647","volume":"217","author":"Zhang","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"D3AY01816D\/cit11\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12012-011-9145-8","volume":"12","author":"Robbins","year":"2012","journal-title":"Cardiovasc. Toxicol."},{"key":"D3AY01816D\/cit12\/1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ejps.2014.04.004","volume":"59","author":"Maeda","year":"2014","journal-title":"Eur. J. Pharm. Sci."},{"key":"D3AY01816D\/cit13\/1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4236\/ajac.2016.71002","volume":"07","author":"Palem","year":"2016","journal-title":"Am. J. Anal. Chem."},{"key":"D3AY01816D\/cit14\/1","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/bmc.2824","volume":"27","author":"Dong","year":"2013","journal-title":"Biomed. Chromatogr."},{"key":"D3AY01816D\/cit15\/1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jmsacl.2022.11.001","volume":"26","author":"Radovanovic","year":"2022","journal-title":"J. Mass Spectrom. Adv. Clin. Lab"},{"key":"D3AY01816D\/cit16\/1","doi-asserted-by":"crossref","first-page":"e01540","DOI":"10.1128\/AAC.01540-17","volume":"62","author":"Kipper","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"D3AY01816D\/cit17\/1","volume-title":"ICH Harmonised Guideline, Validation of Analytical Procedures Q2(R2)","author":"International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use","unstructured":"International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use ,  ICH Harmonised Guideline, Validation of Analytical Procedures Q2(R2) ,  https:\/\/www.ema.europa.eu\/en\/documents\/scientific-guideline\/ich-guideline-q2r2-validation-analytical-procedures-step-2b_en.pdf"},{"key":"D3AY01816D\/cit18\/1","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1039\/D2AY01459A","volume":"15","author":"Riezk","year":"2023","journal-title":"Anal. Methods"},{"key":"D3AY01816D\/cit19\/1","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.jasms.2008.01.013","volume":"19","author":"Van De Steene","year":"2008","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"D3AY01816D\/cit20\/1","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.4155\/bio-2017-0059","volume":"9 14","author":"De Nicol\u00f2","year":"2017","journal-title":"Bioanalysis"},{"key":"D3AY01816D\/cit21\/1","volume-title":"Phenoxymethylpenicillin-DrugBank","year":"2023","unstructured":"Phenoxymethylpenicillin-DrugBank ,  https:\/\/go.drugbank.com\/drugs\/DB00417 ,  2023"},{"key":"D3AY01816D\/cit22\/1","doi-asserted-by":"crossref","first-page":"e335","DOI":"10.1016\/S2589-7500(19)30131-1","volume":"1","author":"Rawson","year":"2019","journal-title":"Lancet Digital Health"},{"key":"D3AY01816D\/cit23\/1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1292\/jvms.68.361","volume":"68","author":"Kakizaki","year":"2006","journal-title":"J. Vet. Med. Sci."},{"key":"D3AY01816D\/cit24\/1","volume-title":"PubChem Compound Summary for CID 6869, Penicillin V","author":"National Center for Biotechnology Information","year":"2023","unstructured":"National Center for Biotechnology Information ,  PubChem Compound Summary for CID 6869, Penicillin V ,  2023 , retrieved January 27, 2023,  https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Penicillin-v"},{"key":"D3AY01816D\/cit25\/1","volume-title":"PubChem Compound Summary for CID 3084757, Benzylpenicilline-d7 N-Ethylpiperidinium Salt","author":"National Center for Biotechnology Information","year":"2023","unstructured":"National Center for Biotechnology Information ,  PubChem Compound Summary for CID 3084757, Benzylpenicilline-d7 N-Ethylpiperidinium Salt ,  2023 , retrieved January 27, 2023,  https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Benzylpenicilline-d7-N-ethylpiperidinium-salt"},{"key":"D3AY01816D\/cit26\/1","volume-title":"PubChem Compound Summary for CID 4911, Probenecid","author":"National Center for Biotechnology Information","year":"2023","unstructured":"National Center for Biotechnology Information ,  PubChem Compound Summary for CID 4911, Probenecid ,  2023 , retrieved January 27, 2023,  https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Probenecid"},{"key":"D3AY01816D\/cit27\/1","volume-title":"PubChem Compound Summary for CID 46782784, Probenecid-d14","author":"National Center for Biotechnology Information","year":"2023","unstructured":"National Center for Biotechnology Information ,  PubChem Compound Summary for CID 46782784, Probenecid-d14 ,  2023 , retrieved January 27, 2023,  https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Probenecid-d14"}],"container-title":["Analytical Methods"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/AY\/D3AY01816D","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:20:54Z","timestamp":1782966054000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ay\/article\/16\/4\/558-565\/795929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,1,25]]}},"URL":"https:\/\/doi.org\/10.1039\/d3ay01816d","relation":{},"ISSN":["1759-9660","1759-9679"],"issn-type":[{"value":"1759-9660","type":"print"},{"value":"1759-9679","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}