{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T03:12:00Z","timestamp":1792293120626,"version":"4.4.0"},"reference-count":46,"publisher":"Royal Society of Chemistry (RSC)","issue":"21","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"am","delay-in-days":607,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100006469","name":"Fundo para o Desenvolvimento das Ci\u00eancias e da Tecnologia","doi-asserted-by":"publisher","award":["FDCT 003\/2022\/ALC"],"award-info":[{"award-number":["FDCT 003\/2022\/ALC"]}],"id":[{"id":"10.13039\/501100006469","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006469","name":"Fundo para o Desenvolvimento das Ci\u00eancias e da Tecnologia","doi-asserted-by":"publisher","award":["0009\/2020\/AMJ"],"award-info":[{"award-number":["0009\/2020\/AMJ"]}],"id":[{"id":"10.13039\/501100006469","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006469","name":"Fundo para o Desenvolvimento das Ci\u00eancias e da Tecnologia","doi-asserted-by":"publisher","award":["0083\/2019\/A2"],"award-info":[{"award-number":["0083\/2019\/A2"]}],"id":[{"id":"10.13039\/501100006469","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515012218"],"award-info":[{"award-number":["2023A1515012218"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51903253"],"award-info":[{"award-number":["51903253"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32301104"],"award-info":[{"award-number":["32301104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Biomater. Sci."],"abstract":"<jats:p>Construction of HAP-1 peptide-engineered liposomal leonurine (HAP-Lipo@Leo) for efficient treatment of rheumatoid arthritis by downregulating inflammation, halting migration and invasion of activated FLS, and preserving cartilage\/bone integrity.<\/jats:p>","DOI":"10.1039\/d3bm00911d","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T08:43:13Z","timestamp":1693384993000},"page":"7099-7113","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Surface-decorated nanoliposomal leonurine targets activated fibroblast-like synoviocytes for efficient rheumatoid arthritis therapy"],"prefix":"10.1039","volume":"11","author":[{"given":"Shiyu","family":"Meng","sequence":"first","affiliation":[{"name":"School of Pharmacy and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macao 999078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiling","family":"Song","sequence":"additional","affiliation":[{"name":"School of Pharmacy and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macao 999078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuang","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Pharmacy and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macao 999078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Pharmacy and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macao 999078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Xiao","sequence":"additional","affiliation":[{"name":"School of Pharmacy and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macao 999078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4652-2395","authenticated-orcid":false,"given":"Hui","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering and Technology, Sun Yat-sen University, Zhuhai 519082, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaixiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Center for Advanced Materials Research, Advanced Institute of Natural Sciences, Beijing Normal University at Zhuhai, Zhuhai 519087, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meirong","family":"Du","sequence":"additional","affiliation":[{"name":"School of Pharmacy and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macao 999078, China"},{"name":"Lab of Reproductive Immunology, Hospital of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi Zhun","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Pharmacy and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macao 999078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2870-1111","authenticated-orcid":false,"given":"Xiaolin","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macao 999078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2023]]},"reference":[{"key":"D3BM00911D\/cit1\/1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41413-018-0016-9","volume":"6","author":"Guo","year":"2018","journal-title":"Bone Res."},{"key":"D3BM00911D\/cit2\/1","doi-asserted-by":"crossref","first-page":"e58","DOI":"10.1016\/S2665-9913(20)30221-6","volume":"3","author":"Hansildaar","year":"2021","journal-title":"Lancet Rheumatol."},{"key":"D3BM00911D\/cit3\/1","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1016\/j.immuni.2022.11.009","volume":"55","author":"Alivernini","year":"2022","journal-title":"Immunity"},{"key":"D3BM00911D\/cit4\/1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1136\/annrheumdis-2020-217344","volume":"80","author":"Nagy","year":"2021","journal-title":"Ann. Rheum. Dis."},{"key":"D3BM00911D\/cit5\/1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/s41586-020-2222-z","volume":"582","author":"Wei","year":"2020","journal-title":"Nature"},{"key":"D3BM00911D\/cit6\/1","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1038\/s41467-021-22365-z","volume":"12","author":"Wang","year":"2021","journal-title":"Nat. Commun."},{"key":"D3BM00911D\/cit7\/1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41584-022-00793-5","volume":"18","author":"Komatsu","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"key":"D3BM00911D\/cit8\/1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/s41392-023-01331-9","volume":"8","author":"Ding","year":"2023","journal-title":"Signal Transduction Targeted Ther."},{"key":"D3BM00911D\/cit9\/1","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.autrev.2019.05.007","volume":"18","author":"Conigliaro","year":"2019","journal-title":"Autoimmun. Rev."},{"key":"D3BM00911D\/cit10\/1","doi-asserted-by":"crossref","first-page":"113126","DOI":"10.1016\/j.biopha.2022.113126","volume":"151","author":"Ben Mrid","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"D3BM00911D\/cit11\/1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.pharmthera.2018.01.006","volume":"188","author":"Zhu","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"D3BM00911D\/cit12\/1","doi-asserted-by":"crossref","first-page":"100674","DOI":"10.1016\/j.mtbio.2023.100674","volume":"20","author":"Tang","year":"2023","journal-title":"Mater. Today Bio"},{"key":"D3BM00911D\/cit13\/1","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1093\/rheumatology\/kex142","volume":"56","author":"Li","year":"2017","journal-title":"Rheumatology"},{"key":"D3BM00911D\/cit14\/1","doi-asserted-by":"crossref","first-page":"556526","DOI":"10.3389\/fimmu.2020.556526","volume":"11","author":"Du","year":"2020","journal-title":"Front. Immunol."},{"key":"D3BM00911D\/cit15\/1","doi-asserted-by":"crossref","first-page":"1901541","DOI":"10.1002\/adhm.201901541","volume":"9","author":"Wang","year":"2020","journal-title":"Adv. Healthcare Mater."},{"key":"D3BM00911D\/cit16\/1","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/j.apsb.2021.03.013","volume":"11","author":"Wang","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"D3BM00911D\/cit17\/1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.addr.2020.07.002","volume":"154","author":"Shah","year":"2020","journal-title":"Adv. Drug Delivery Rev."},{"key":"D3BM00911D\/cit18\/1","doi-asserted-by":"crossref","first-page":"114531","DOI":"10.1016\/j.addr.2022.114531","volume":"190","author":"Tomsen-Melero","year":"2022","journal-title":"Adv. Drug Delivery Rev."},{"key":"D3BM00911D\/cit19\/1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jconrel.2023.02.035","volume":"356","author":"Han","year":"2023","journal-title":"J. Controlled Release"},{"key":"D3BM00911D\/cit20\/1","doi-asserted-by":"crossref","first-page":"100597","DOI":"10.1016\/j.mtbio.2023.100597","volume":"19","author":"Wen","year":"2023","journal-title":"Mater. Today Bio"},{"key":"D3BM00911D\/cit21\/1","doi-asserted-by":"crossref","first-page":"2104640","DOI":"10.1002\/adfm.202104640","volume":"31","author":"Han","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"D3BM00911D\/cit22\/1","doi-asserted-by":"crossref","first-page":"4032","DOI":"10.1016\/j.apsb.2021.04.022","volume":"11","author":"Lei","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"D3BM00911D\/cit23\/1","doi-asserted-by":"crossref","first-page":"2004213","DOI":"10.1002\/advs.202004213","volume":"8","author":"Wang","year":"2021","journal-title":"Adv. Sci."},{"key":"D3BM00911D\/cit24\/1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41565-021-00858-8","volume":"16","author":"Rennick","year":"2021","journal-title":"Nat. Nanotechnol."},{"key":"D3BM00911D\/cit25\/1","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1021\/acsnano.6b06477","volume":"11","author":"Kang","year":"2017","journal-title":"ACS Nano"},{"key":"D3BM00911D\/cit26\/1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41392-022-01050-7","volume":"7","author":"Wang","year":"2022","journal-title":"Signal Transduction Targeted Ther."},{"key":"D3BM00911D\/cit27\/1","doi-asserted-by":"crossref","first-page":"119730","DOI":"10.1016\/j.biomaterials.2019.119730","volume":"232","author":"Ni","year":"2020","journal-title":"Biomaterials"},{"key":"D3BM00911D\/cit28\/1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1021\/acs.nanolett.8b03439","volume":"19","author":"Li","year":"2018","journal-title":"Nano Lett."},{"key":"D3BM00911D\/cit29\/1","doi-asserted-by":"crossref","first-page":"6716","DOI":"10.1021\/acs.nanolett.9b00496","volume":"19","author":"Yeo","year":"2019","journal-title":"Nano Lett."},{"key":"D3BM00911D\/cit30\/1","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1038\/s41565-018-0254-4","volume":"13","author":"Zhang","year":"2018","journal-title":"Nat. Nanotechnol."},{"key":"D3BM00911D\/cit31\/1","doi-asserted-by":"crossref","first-page":"101791","DOI":"10.1016\/j.nantod.2023.101791","volume":"49","author":"Lin","year":"2023","journal-title":"Nano Today"},{"key":"D3BM00911D\/cit32\/1","doi-asserted-by":"crossref","first-page":"18579","DOI":"10.1021\/acsnano.2c07027","volume":"16","author":"Vyawahare","year":"2022","journal-title":"ACS Nano"},{"key":"D3BM00911D\/cit33\/1","doi-asserted-by":"crossref","first-page":"e141008","DOI":"10.1172\/JCI141008","volume":"131","author":"Levescot","year":"2021","journal-title":"J. Clin. Invest."},{"key":"D3BM00911D\/cit34\/1","doi-asserted-by":"crossref","first-page":"4358","DOI":"10.1021\/acsnano.2c09127","volume":"17","author":"Zhou","year":"2023","journal-title":"ACS Nano"},{"key":"D3BM00911D\/cit35\/1","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1038\/s41423-020-0380-4","volume":"17","author":"Zhang","year":"2020","journal-title":"Cell. Mol. Immunol."},{"key":"D3BM00911D\/cit36\/1","doi-asserted-by":"crossref","first-page":"120772","DOI":"10.1016\/j.ijpharm.2021.120772","volume":"605","author":"Liu","year":"2021","journal-title":"Int. J. Pharm."},{"key":"D3BM00911D\/cit37\/1","doi-asserted-by":"crossref","first-page":"100986","DOI":"10.1016\/j.nantod.2020.100986","volume":"35","author":"Zhao","year":"2020","journal-title":"Nano Today"},{"key":"D3BM00911D\/cit38\/1","doi-asserted-by":"crossref","first-page":"6886","DOI":"10.1021\/acsnano.2c02084","volume":"16","author":"Chen","year":"2022","journal-title":"ACS Nano"},{"key":"D3BM00911D\/cit39\/1","doi-asserted-by":"crossref","first-page":"37411","DOI":"10.1021\/acsami.9b08901","volume":"11","author":"Du","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D3BM00911D\/cit40\/1","doi-asserted-by":"crossref","first-page":"e376","DOI":"10.1002\/ctm2.376","volume":"11","author":"Wang","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"D3BM00911D\/cit41\/1","doi-asserted-by":"crossref","first-page":"15144","DOI":"10.1038\/ncomms15144","volume":"8","author":"Huang","year":"2017","journal-title":"Nat. Commun."},{"key":"D3BM00911D\/cit42\/1","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1039\/C7BM01024A","volume":"6","author":"Wang","year":"2018","journal-title":"Biomater. Sci."},{"key":"D3BM00911D\/cit43\/1","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s40820-020-0410-x","volume":"12","author":"Fan","year":"2020","journal-title":"Nano-Micro Lett."},{"key":"D3BM00911D\/cit44\/1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jare.2021.08.015","volume":"38","author":"Chen","year":"2022","journal-title":"J. Adv. Res."},{"key":"D3BM00911D\/cit45\/1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jconrel.2018.08.007","volume":"286","author":"Meka","year":"2018","journal-title":"J. Controlled Release"},{"key":"D3BM00911D\/cit46\/1","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1111\/bph.14718","volume":"176","author":"Wong","year":"2019","journal-title":"Br. J. Pharmacol."}],"container-title":["Biomaterials Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2023\/BM\/D3BM00911D","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:46:29Z","timestamp":1782881189000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/bm\/article\/11\/21\/7099-7113\/796442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":46,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2023,10,24]]}},"URL":"https:\/\/doi.org\/10.1039\/d3bm00911d","relation":{},"ISSN":["2047-4830","2047-4849"],"issn-type":[{"value":"2047-4830","type":"print"},{"value":"2047-4849","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}