{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:53:00Z","timestamp":1790016780518,"version":"4.0.1"},"reference-count":59,"publisher":"Royal Society of Chemistry (RSC)","issue":"1","license":[{"start":{"date-parts":[[2024,11,3]],"date-time":"2024-11-03T00:00:00Z","timestamp":1730592000000},"content-version":"am","delay-in-days":307,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515010199"],"award-info":[{"award-number":["2022A1515010199"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971742"],"award-info":[{"award-number":["81971742"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018935","name":"Lin He's New Medicine and Clinical Translation Academician Workstation Research Fund","doi-asserted-by":"publisher","award":["2021HLKY07"],"award-info":[{"award-number":["2021HLKY07"]}],"id":[{"id":"10.13039\/100018935","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Biomater. Sci."],"abstract":"<jats:p>Application of ATF decorated cisplatin liposomes and anti PD-1 antibodies to mice with pancreatic cancer showed improved efficacy by enhancing drug penetration and remodeling the immunosuppressive microenvironment.<\/jats:p>","DOI":"10.1039\/d3bm01118f","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T11:16:24Z","timestamp":1699010184000},"page":"116-133","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Stromal and tumor immune microenvironment reprogramming through multifunctional cisplatin-based liposomes boosts the efficacy of anti-PD-1 immunotherapy in pancreatic cancer"],"prefix":"10.1039","volume":"12","author":[{"given":"Hang","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Biomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangzhou, 510150, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Biomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangzhou, 510150, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiyan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Biomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangzhou, 510150, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menglei","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Biomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangzhou, 510150, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Biomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangzhou, 510150, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongwen","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Biomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangzhou, 510150, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senglin","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Biomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangzhou, 510150, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8356-2986","authenticated-orcid":false,"given":"Pengke","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Biomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangzhou, 510150, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2024]]},"reference":[{"key":"D3BM01118F\/cit1\/1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"Sung","year":"2021","journal-title":"CA-Cancer J. Clin."},{"key":"D3BM01118F\/cit2\/1","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/j.cell.2023.02.014","volume":"186","author":"Halbrook","year":"2023","journal-title":"Cell"},{"key":"D3BM01118F\/cit3\/1","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1053\/j.gastro.2022.03.056","volume":"163","author":"Wood","year":"2022","journal-title":"Gastroenterology"},{"key":"D3BM01118F\/cit4\/1","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1056\/NEJMoa1011923","volume":"364","author":"Conroy","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"D3BM01118F\/cit5\/1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41575-018-0005-x","volume":"15","author":"Neoptolemos","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"D3BM01118F\/cit6\/1","doi-asserted-by":"crossref","first-page":"o3605","DOI":"10.1126\/scitranslmed.abo3605","volume":"14","author":"Kirchhammer","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"D3BM01118F\/cit7\/1","doi-asserted-by":"crossref","first-page":"2129884","DOI":"10.1080\/08941939.2022.2129884","volume":"36","author":"Kolbeinsson","year":"2023","journal-title":"J. Invest. Surg."},{"key":"D3BM01118F\/cit8\/1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.semcancer.2022.08.009","volume":"86","author":"Li","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"D3BM01118F\/cit9\/1","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.3390\/curroncol30040293","volume":"30","author":"Balsano","year":"2023","journal-title":"Curr. Oncol."},{"key":"D3BM01118F\/cit10\/1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.molmed.2023.03.002","volume":"29","author":"Rebelo","year":"2023","journal-title":"Trends Mol. Med."},{"key":"D3BM01118F\/cit11\/1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12943-018-0927-5","volume":"18","author":"Thomas","year":"2019","journal-title":"Mol. Cancer"},{"key":"D3BM01118F\/cit12\/1","doi-asserted-by":"crossref","first-page":"7956","DOI":"10.3748\/wjg.v27.i46.7956","volume":"27","author":"Goulart","year":"2021","journal-title":"World J. Gastroenterol."},{"key":"D3BM01118F\/cit13\/1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3390\/cancers10010006","volume":"10","author":"Martinez-Bosch","year":"2018","journal-title":"Cancers"},{"key":"D3BM01118F\/cit14\/1","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.3390\/cancers13061188","volume":"13","author":"Chyuan","year":"2021","journal-title":"Cancers"},{"key":"D3BM01118F\/cit15\/1","first-page":"451","volume":"12","author":"Lin","year":"2022","journal-title":"Am. J. Cancer Res."},{"key":"D3BM01118F\/cit16\/1","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1158\/2326-6066.CIR-17-0235","volume":"5","author":"Tran","year":"2017","journal-title":"Cancer Immunol. Res."},{"key":"D3BM01118F\/cit17\/1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s40620-017-0392-z","volume":"31","author":"Manohar","year":"2018","journal-title":"J. Nephrol."},{"key":"D3BM01118F\/cit18\/1","doi-asserted-by":"crossref","first-page":"e479","DOI":"10.1002\/hsr2.479","volume":"5","author":"Fernandes","year":"2022","journal-title":"Health Sci. Rep."},{"key":"D3BM01118F\/cit19\/1","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.jconrel.2022.10.004","volume":"351","author":"Diep","year":"2022","journal-title":"J. Controlled Release"},{"key":"D3BM01118F\/cit20\/1","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1016\/j.drudis.2022.02.026","volume":"27","author":"Iyengar","year":"2022","journal-title":"Drug Discovery Today"},{"key":"D3BM01118F\/cit21\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2022.12.013","volume":"157","author":"Raza","year":"2023","journal-title":"Acta Biomater."},{"key":"D3BM01118F\/cit22\/1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ejca.2018.12.007","volume":"108","author":"Wang-Gillam","year":"2019","journal-title":"Eur. J. Cancer"},{"key":"D3BM01118F\/cit23\/1","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1007\/s40265-020-01336-6","volume":"80","author":"Frampton","year":"2020","journal-title":"Drugs"},{"key":"D3BM01118F\/cit24\/1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.jconrel.2022.03.049","volume":"345","author":"Han","year":"2022","journal-title":"J. Controlled Release"},{"key":"D3BM01118F\/cit25\/1","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nrm977","volume":"3","author":"Blasi","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"D3BM01118F\/cit26\/1","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1053\/j.gastro.2009.01.006","volume":"136","author":"Yang","year":"2009","journal-title":"Gastroenterology"},{"key":"D3BM01118F\/cit27\/1","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1021\/nn3043463","volume":"7","author":"Lee","year":"2013","journal-title":"ACS Nano"},{"key":"D3BM01118F\/cit28\/1","doi-asserted-by":"crossref","first-page":"123316","DOI":"10.1016\/j.ijpharm.2023.123316","volume":"644","author":"Zhu","year":"2023","journal-title":"Int. J. Pharm."},{"key":"D3BM01118F\/cit29\/1","doi-asserted-by":"crossref","first-page":"676","DOI":"10.20892\/j.issn.2095-3941.2020.0454","volume":"17","author":"Zhai","year":"2020","journal-title":"Cancer Biol. Med."},{"key":"D3BM01118F\/cit30\/1","doi-asserted-by":"crossref","first-page":"e2202159","DOI":"10.1002\/smll.202202159","volume":"18","author":"Lee","year":"2022","journal-title":"Small"},{"issue":"5","key":"D3BM01118F\/cit31\/1","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.7150\/thno.53102","volume":"11","author":"Li","year":"2021","journal-title":"Theranostics"},{"key":"D3BM01118F\/cit32\/1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.2147\/IJN.S270939","volume":"16","author":"Chen","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"D3BM01118F\/cit33\/1","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/s41467-020-20723-x","volume":"12","author":"Wei","year":"2021","journal-title":"Nat. Commun."},{"issue":"10","key":"D3BM01118F\/cit34\/1","doi-asserted-by":"crossref","first-page":"e2203324","DOI":"10.1002\/advs.202203324","volume":"10","author":"Geng","year":"2023","journal-title":"Adv. Sci."},{"key":"D3BM01118F\/cit35\/1","doi-asserted-by":"crossref","first-page":"4699","DOI":"10.1158\/1078-0432.CCR-19-4110","volume":"26","author":"Rao","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"D3BM01118F\/cit36\/1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s13105-022-00941-1","volume":"79","author":"Liu","year":"2023","journal-title":"J. Physiol. Biochem."},{"key":"D3BM01118F\/cit37\/1","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.pharmthera.2019.05.012","volume":"201","author":"Stone","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"D3BM01118F\/cit38\/1","doi-asserted-by":"crossref","first-page":"e2001261","DOI":"10.1002\/adhm.202001261","volume":"10","author":"Kang","year":"2021","journal-title":"Adv. Healthcare Mater."},{"key":"D3BM01118F\/cit39\/1","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1039\/D0BM01709D","volume":"9","author":"Liu","year":"2021","journal-title":"Biomater. Sci."},{"key":"D3BM01118F\/cit40\/1","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.jconrel.2023.02.029","volume":"356","author":"Xiao","year":"2023","journal-title":"J. Controlled Release"},{"key":"D3BM01118F\/cit41\/1","doi-asserted-by":"crossref","first-page":"119745","DOI":"10.1016\/j.biomaterials.2019.119745","volume":"232","author":"Han","year":"2020","journal-title":"Biomaterials"},{"key":"D3BM01118F\/cit42\/1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/bs.apha.2021.03.003","volume":"91","author":"Manchanda","year":"2021","journal-title":"Adv. Pharmacol."},{"key":"D3BM01118F\/cit43\/1","doi-asserted-by":"crossref","first-page":"e2202155","DOI":"10.1002\/adhm.202202155","volume":"12","author":"Ren","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"D3BM01118F\/cit44\/1","doi-asserted-by":"crossref","first-page":"7072","DOI":"10.7150\/thno.57803","volume":"11","author":"Hsieh","year":"2021","journal-title":"Theranostics"},{"key":"D3BM01118F\/cit45\/1","doi-asserted-by":"crossref","first-page":"4996","DOI":"10.1021\/nn5010815","volume":"8","author":"Guo","year":"2014","journal-title":"ACS Nano"},{"key":"D3BM01118F\/cit46\/1","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1021\/acs.nanolett.9b00374","volume":"19","author":"Chen","year":"2019","journal-title":"Nano Lett."},{"key":"D3BM01118F\/cit47\/1","doi-asserted-by":"crossref","first-page":"8744","DOI":"10.1021\/acs.nanolett.2c03663","volume":"22","author":"Yu","year":"2022","journal-title":"Nano Lett."},{"key":"D3BM01118F\/cit48\/1","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.ccell.2015.10.012","volume":"28","author":"Galluzzi","year":"2015","journal-title":"Cancer Cell"},{"key":"D3BM01118F\/cit49\/1","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1158\/1078-0432.CCR-09-2891","volume":"16","author":"Zitvogel","year":"2010","journal-title":"Clin. Cancer Res."},{"key":"D3BM01118F\/cit50\/1","doi-asserted-by":"crossref","first-page":"925290","DOI":"10.3389\/fimmu.2022.925290","volume":"13","author":"Catanzaro","year":"2022","journal-title":"Front. Immunol."},{"key":"D3BM01118F\/cit51\/1","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1039\/D1BM00112D","volume":"9","author":"Wang","year":"2021","journal-title":"Biomater. Sci."},{"key":"D3BM01118F\/cit52\/1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.canlet.2019.08.005","volume":"464","author":"Fournel","year":"2019","journal-title":"Cancer Lett."},{"key":"D3BM01118F\/cit53\/1","doi-asserted-by":"crossref","first-page":"e2100590","DOI":"10.1002\/adhm.202100590","volume":"10","author":"Cheng","year":"2021","journal-title":"Adv. Healthcare Mater."},{"key":"D3BM01118F\/cit54\/1","doi-asserted-by":"crossref","first-page":"3434","DOI":"10.3390\/cells11213434","volume":"11","author":"Kim","year":"2022","journal-title":"Cells"},{"key":"D3BM01118F\/cit55\/1","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1038\/s41388-023-02711-9","volume":"42","author":"Duan","year":"2023","journal-title":"Oncogene"},{"key":"D3BM01118F\/cit56\/1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12943-021-01489-2","volume":"21","author":"Yi","year":"2022","journal-title":"Mol. Cancer"},{"key":"D3BM01118F\/cit57\/1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13045-022-01242-2","volume":"15","author":"Wu","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"D3BM01118F\/cit58\/1","doi-asserted-by":"crossref","first-page":"e001367","DOI":"10.1136\/jitc-2020-001367","volume":"8","author":"Ho","year":"2020","journal-title":"J. Immunother. Cancer"},{"key":"D3BM01118F\/cit59\/1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jare.2021.12.005","volume":"40","author":"Glorieux","year":"2022","journal-title":"J. Adv. Res."}],"container-title":["Biomaterials Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/BM\/D3BM01118F","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:30:18Z","timestamp":1782883818000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/bm\/article\/12\/1\/116-133\/796486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,12,19]]}},"URL":"https:\/\/doi.org\/10.1039\/d3bm01118f","relation":{},"ISSN":["2047-4830","2047-4849"],"issn-type":[{"value":"2047-4830","type":"print"},{"value":"2047-4849","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}