{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:04:40Z","timestamp":1787004280844,"version":"build-2736575974"},"reference-count":46,"publisher":"Royal Society of Chemistry (RSC)","issue":"2","license":[{"start":{"date-parts":[[2024,11,10]],"date-time":"2024-11-10T00:00:00Z","timestamp":1731196800000},"content-version":"am","delay-in-days":314,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104094"],"award-info":[{"award-number":["82104094"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32000929"],"award-info":[{"award-number":["32000929"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2020QH351"],"award-info":[{"award-number":["ZR2020QH351"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2020QH196"],"award-info":[{"award-number":["ZR2020QH196"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016109","name":"Taishan Industry Leading Talents","doi-asserted-by":"publisher","award":["2019TSCYCX-31"],"award-info":[{"award-number":["2019TSCYCX-31"]}],"id":[{"id":"10.13039\/501100016109","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2019ZX09301-112"],"award-info":[{"award-number":["2019ZX09301-112"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Biomater. Sci."],"abstract":"<jats:p>The eyes have a complicated microenvironment with many clearance mechanisms, making it challenging for effective drug delivery to the targeted areas of the eyes.<\/jats:p>","DOI":"10.1039\/d3bm01349a","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T21:42:17Z","timestamp":1699566137000},"page":"361-374","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["An active transport dual adaptive nanocarrier designed to overcome the corneal microenvironment for neovascularization therapy"],"prefix":"10.1039","volume":"12","author":[{"given":"Rui","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Qilu Hospital of Shandong University, 107 Wenhua Xilu, Jinan 250012, P.R. China"},{"name":"Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, P.R. China"},{"name":"Department of Pharmacy, Qilu Hospital of Shandong University (Qingdao), No. 758 Hefei Road, Qingdao, 266035, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijing","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbo","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoye","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6216-3265","authenticated-orcid":false,"given":"Lei","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Qilu Hospital of Shandong University, 107 Wenhua Xilu, Jinan 250012, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anchang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Qilu Hospital of Shandong University, 107 Wenhua Xilu, Jinan 250012, P.R. China"},{"name":"Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, P.R. China"},{"name":"Department of Pharmacy, Qilu Hospital of Shandong University (Qingdao), No. 758 Hefei Road, Qingdao, 266035, P.R. China"},{"name":"Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Shandong University, 44 Wenhua Xilu, Jinan 250012, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3860-948X","authenticated-orcid":false,"given":"Guangxi","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Qilu Hospital of Shandong University, 107 Wenhua Xilu, Jinan 250012, P.R. China"},{"name":"Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), NMPA Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2024]]},"reference":[{"key":"D3BM01349A\/cit1\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2003.09.016","volume":"269","author":"Kaur","year":"2004","journal-title":"Int. J. Pharm."},{"key":"D3BM01349A\/cit2\/1","doi-asserted-by":"crossref","first-page":"129081","DOI":"10.1016\/j.cej.2021.129081","volume":"416","author":"Chen","year":"2021","journal-title":"Chem. Eng. J."},{"key":"D3BM01349A\/cit3\/1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00417-019-04519-4","volume":"258","author":"Gupta","year":"2020","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"D3BM01349A\/cit4\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2020.01.057","volume":"321","author":"Jumelle","year":"2020","journal-title":"J. Controlled Release"},{"key":"D3BM01349A\/cit5\/1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1080\/1061186X.2021.1878366","volume":"29","author":"Wang","year":"2021","journal-title":"J. Drug Targeting"},{"key":"D3BM01349A\/cit6\/1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1080\/17425247.2018.1496080","volume":"15","author":"Wang","year":"2018","journal-title":"Expert Opin. Drug Delivery"},{"key":"D3BM01349A\/cit7\/1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.4155\/tde-2017-0097","volume":"8","author":"Waite","year":"2017","journal-title":"Ther. Delivery"},{"key":"D3BM01349A\/cit8\/1","doi-asserted-by":"crossref","first-page":"6410","DOI":"10.1021\/acs.nanolett.9b02596","volume":"19","author":"Jiang","year":"2019","journal-title":"Nano Lett."},{"key":"D3BM01349A\/cit9\/1","doi-asserted-by":"crossref","first-page":"3556","DOI":"10.1021\/mp500332m","volume":"11","author":"Mun","year":"2014","journal-title":"Mol. Pharm."},{"key":"D3BM01349A\/cit10\/1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2017.12.009","volume":"126","author":"Vellonen","year":"2018","journal-title":"Adv. Drug Delivery Rev."},{"key":"D3BM01349A\/cit11\/1","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.3109\/10717544.2014.996833","volume":"23","author":"Yang","year":"2016","journal-title":"Drug Delivery"},{"key":"D3BM01349A\/cit12\/1","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/jphp.12357","volume":"67","author":"Verstraelen","year":"2015","journal-title":"J. Pharm. Pharmacol."},{"key":"D3BM01349A\/cit13\/1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jconrel.2017.08.018","volume":"264","author":"Pascual-Pasto","year":"2017","journal-title":"J. Controlled Release"},{"key":"D3BM01349A\/cit14\/1","doi-asserted-by":"crossref","first-page":"117008","DOI":"10.1016\/j.carbpol.2020.117008","volume":"251","author":"Jia","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"D3BM01349A\/cit15\/1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jconrel.2019.07.037","volume":"309","author":"Pai","year":"2019","journal-title":"J. Controlled Release"},{"key":"D3BM01349A\/cit16\/1","doi-asserted-by":"crossref","first-page":"119095","DOI":"10.1016\/j.ijpharm.2020.119095","volume":"577","author":"Pai","year":"2020","journal-title":"Int. J. Pharm."},{"key":"D3BM01349A\/cit17\/1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1177\/1535370216685187","volume":"242","author":"McKay","year":"2017","journal-title":"Exp. Biol. Med."},{"key":"D3BM01349A\/cit18\/1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.carbpol.2018.09.020","volume":"203","author":"Mu","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"D3BM01349A\/cit19\/1","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1021\/jm501562a","volume":"58","author":"Roth","year":"2015","journal-title":"J. Med. Chem."},{"key":"D3BM01349A\/cit20\/1","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1007\/s40262-019-00766-0","volume":"58","author":"Wind","year":"2019","journal-title":"Clin. Pharmacokinet."},{"key":"D3BM01349A\/cit21\/1","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1080\/03602532.2017.1322609","volume":"49","author":"Argikar","year":"2017","journal-title":"Drug Metab. Rev."},{"key":"D3BM01349A\/cit22\/1","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1021\/acs.molpharmaceut.0c01154","volume":"18","author":"Hammid","year":"2021","journal-title":"Mol. Pharm."},{"key":"D3BM01349A\/cit23\/1","doi-asserted-by":"crossref","first-page":"115356","DOI":"10.1016\/j.carbpol.2019.115356","volume":"227","author":"Xu","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"D3BM01349A\/cit24\/1","doi-asserted-by":"crossref","first-page":"4200","DOI":"10.1016\/j.bmc.2005.04.028","volume":"13","author":"Shi","year":"2005","journal-title":"Bioorg. Med. Chem."},{"key":"D3BM01349A\/cit25\/1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3109\/10717544.2013.873501","volume":"22","author":"Duan","year":"2015","journal-title":"Drug Delivery"},{"key":"D3BM01349A\/cit26\/1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.colsurfb.2016.04.054","volume":"145","author":"Sanchez-Lopez","year":"2016","journal-title":"Colloids Surf., B"},{"key":"D3BM01349A\/cit27\/1","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.cej.2019.01.074","volume":"362","author":"Hu","year":"2019","journal-title":"Chem. Eng. J."},{"key":"D3BM01349A\/cit28\/1","first-page":"7325483","volume":"2018","author":"Xu","year":"2018","journal-title":"J. Ophthalmol."},{"key":"D3BM01349A\/cit29\/1","doi-asserted-by":"crossref","first-page":"5143","DOI":"10.1039\/D0TB00874E","volume":"8","author":"Han","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"D3BM01349A\/cit30\/1","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.survophthal.2006.06.010","volume":"51","author":"Chiou","year":"2006","journal-title":"Surv. Ophthalmol."},{"key":"D3BM01349A\/cit31\/1","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/86589","volume":"7","author":"Drexler","year":"2001","journal-title":"Nat. Med."},{"key":"D3BM01349A\/cit32\/1","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1167\/iovs.15-16595","volume":"56","author":"Abengozar-Vela","year":"2015","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"D3BM01349A\/cit33\/1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.lfs.2010.07.004","volume":"87","author":"Chen","year":"2010","journal-title":"Life Sci."},{"key":"D3BM01349A\/cit34\/1","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.addr.2006.07.024","volume":"58","author":"Mannermaa","year":"2006","journal-title":"Adv. Drug Delivery Rev."},{"key":"D3BM01349A\/cit35\/1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1089\/jop.2006.22.110","volume":"22","author":"Katragadda","year":"2006","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"D3BM01349A\/cit36\/1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jtos.2012.01.005","volume":"10","author":"Stevenson","year":"2012","journal-title":"Ocul. Surf."},{"key":"D3BM01349A\/cit37\/1","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.jtos.2018.06.004","volume":"16","author":"Roshandel","year":"2018","journal-title":"Ocul. Surf."},{"key":"D3BM01349A\/cit38\/1","doi-asserted-by":"crossref","first-page":"8871904","DOI":"10.1155\/2020\/8871904","volume":"2020","author":"Dembski","year":"2020","journal-title":"J. Ophthalmol."},{"key":"D3BM01349A\/cit39\/1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1001\/archopht.1974.01010010325013","volume":"92","author":"Baum","year":"1974","journal-title":"Arch. Ophthalmol."},{"key":"D3BM01349A\/cit40\/1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.survophthal.2012.01.007","volume":"57","author":"Chang","year":"2012","journal-title":"Surv. Ophthalmol."},{"key":"D3BM01349A\/cit41\/1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3389\/fphar.2020.00111","volume":"11","author":"Chen","year":"2020","journal-title":"Front. Pharmacol."},{"key":"D3BM01349A\/cit42\/1","doi-asserted-by":"crossref","first-page":"108272","DOI":"10.1016\/j.exer.2020.108272","volume":"201","author":"Wilson","year":"2020","journal-title":"Exp. Eye Res."},{"key":"D3BM01349A\/cit43\/1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1042\/CS20040370","volume":"109","author":"Takahashi","year":"2005","journal-title":"Clin. Sci."},{"key":"D3BM01349A\/cit44\/1","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1126\/science.277.5323.242","volume":"277","author":"Lindahl","year":"1997","journal-title":"Science"},{"key":"D3BM01349A\/cit45\/1","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1242\/dev.126.14.3047","volume":"126","author":"Hellstrom","year":"1999","journal-title":"Development"},{"key":"D3BM01349A\/cit46\/1","first-page":"1163","volume":"7","author":"Li","year":"2012","journal-title":"Int. J. Nanomed."}],"container-title":["Biomaterials Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/BM\/D3BM01349A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:35:42Z","timestamp":1783449342000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/bm\/article\/12\/2\/361-374\/796541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,1,16]]}},"URL":"https:\/\/doi.org\/10.1039\/d3bm01349a","relation":{},"ISSN":["2047-4830","2047-4849"],"issn-type":[{"value":"2047-4830","type":"print"},{"value":"2047-4849","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}