{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:37:47Z","timestamp":1783017467741,"version":"3.54.6"},"reference-count":46,"publisher":"Royal Society of Chemistry (RSC)","issue":"10","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"am","delay-in-days":449,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U23A2096"],"award-info":[{"award-number":["U23A2096"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52173125"],"award-info":[{"award-number":["52173125"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Biomater. Sci."],"abstract":"<jats:p>A reduction-sensitive polymeric carrier was synthesized for the targeted delivery of a quinazoline derivative to deplete intracellular glutathione and promote the reactive oxygen species level against cancer.<\/jats:p>","DOI":"10.1039\/d3bm02136j","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T12:06:55Z","timestamp":1711368415000},"page":"2626-2638","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Reduction-sensitive polymeric carrier for the targeted delivery of a quinazoline derivative for enhanced generation of reactive oxygen species against cancer"],"prefix":"10.1039","volume":"12","author":[{"given":"Jianrong","family":"Cao","sequence":"first","affiliation":[{"name":"College of Chemistry and Materials Science, Jinan University, Guangzhou, 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keze","family":"Hong","sequence":"additional","affiliation":[{"name":"College of Chemistry and Materials Science, Jinan University, Guangzhou, 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengqi","family":"Lv","sequence":"additional","affiliation":[{"name":"College of Chemistry and Materials Science, Jinan University, Guangzhou, 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiting","family":"Jiang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Materials Science, Jinan University, Guangzhou, 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, the First Affiliated Hospital of Jinan University, Guangzhou, 510630, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongze","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Materials Science, Jinan University, Guangzhou, 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8349-7555","authenticated-orcid":false,"given":"Yong","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Chemistry and Materials Science, Jinan University, Guangzhou, 510632, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2024]]},"reference":[{"key":"D3BM02136J\/cit1\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.acr.2020.10.001","volume":"149","author":"Chidambaranathan-Reghupaty","year":"2021","journal-title":"Adv. Cancer Res."},{"key":"D3BM02136J\/cit2\/1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3322\/caac.21763","volume":"73","author":"Siegel","year":"2023","journal-title":"CA-Cancer J. Clin."},{"key":"D3BM02136J\/cit3\/1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.5582\/bst.2022.01044","volume":"16","author":"Hou","year":"2022","journal-title":"BioSci. Trends"},{"key":"D3BM02136J\/cit4\/1","doi-asserted-by":"crossref","first-page":"907","DOI":"10.4254\/wjh.v9.i21.907","volume":"9","author":"Grazie","year":"2017","journal-title":"World J. Hepatol."},{"key":"D3BM02136J\/cit5\/1","doi-asserted-by":"crossref","first-page":"787","DOI":"10.4254\/wjh.v7.i5.787","volume":"7","author":"Deng","year":"2015","journal-title":"World J. Hepatol."},{"key":"D3BM02136J\/cit6\/1","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1200\/JCO.2021.39.3_suppl.278","volume":"39","author":"Koroki","year":"2021","journal-title":"J. Clin. Oncol."},{"key":"D3BM02136J\/cit7\/1","first-page":"102644","volume":"15","author":"Xia","year":"2020","journal-title":"Ebiomedicine"},{"key":"D3BM02136J\/cit8\/1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13046-020-1523-2","volume":"39","author":"Wang","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"D3BM02136J\/cit9\/1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s40880-016-0162-7","volume":"35","author":"Kuczynski","year":"2016","journal-title":"Chin. J. Cancer"},{"key":"D3BM02136J\/cit10\/1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.ejmech.2019.06.015","volume":"178","author":"Zhang","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"D3BM02136J\/cit11\/1","doi-asserted-by":"crossref","first-page":"5011","DOI":"10.1021\/acs.jmedchem.6b00372","volume":"59","author":"Bouley","year":"2016","journal-title":"J. Med. Chem."},{"key":"D3BM02136J\/cit12\/1","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.ejmech.2017.12.065","volume":"144","author":"Moussa","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"D3BM02136J\/cit13\/1","first-page":"871","volume":"8","author":"Shagufta","year":"2017","journal-title":"RSC Med. Chem."},{"key":"D3BM02136J\/cit14\/1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.apsb.2021.07.018","volume":"12","author":"He","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"D3BM02136J\/cit15\/1","doi-asserted-by":"crossref","first-page":"109371","DOI":"10.1016\/j.cbi.2021.109371","volume":"338","author":"Wang","year":"2021","journal-title":"Chem.-Biol. Interact."},{"key":"D3BM02136J\/cit16\/1","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1182\/blood-2007-07-099820","volume":"110","author":"Zipori","year":"2007","journal-title":"Blood"},{"key":"D3BM02136J\/cit17\/1","first-page":"e0257","volume":"7","author":"Tang","year":"2023","journal-title":"Hepatol. Commun."},{"key":"D3BM02136J\/cit18\/1","doi-asserted-by":"crossref","first-page":"102446","DOI":"10.1016\/j.redox.2022.102446","volume":"56","author":"Chen","year":"2022","journal-title":"Redox Biol."},{"key":"D3BM02136J\/cit19\/1","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.mattod.2015.11.025","volume":"19","author":"Mo","year":"2016","journal-title":"Mater. Today"},{"key":"D3BM02136J\/cit20\/1","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1186\/s12951-022-01604-5","volume":"20","author":"Gao","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"D3BM02136J\/cit21\/1","doi-asserted-by":"crossref","first-page":"14715","DOI":"10.1021\/acsnano.0c00764","volume":"14","author":"Guo","year":"2020","journal-title":"ACS Nano"},{"key":"D3BM02136J\/cit22\/1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jcis.2023.03.057","volume":"641","author":"Li","year":"2023","journal-title":"J. Colloid Interface Sci."},{"key":"D3BM02136J\/cit23\/1","doi-asserted-by":"crossref","first-page":"7866","DOI":"10.1021\/acs.nanolett.9b02904","volume":"19","author":"Meng","year":"2019","journal-title":"Nano Lett."},{"key":"D3BM02136J\/cit24\/1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jcis.2022.08.060","volume":"628","author":"Wang","year":"2022","journal-title":"J. Colloid Interface Sci."},{"key":"D3BM02136J\/cit25\/1","doi-asserted-by":"crossref","first-page":"27183","DOI":"10.1021\/acsami.3c03792","volume":"15","author":"Fan","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D3BM02136J\/cit26\/1","doi-asserted-by":"crossref","first-page":"eabc4373","DOI":"10.1126\/sciadv.abc4373","volume":"6","author":"Zhou","year":"2020","journal-title":"Sci. Adv."},{"key":"D3BM02136J\/cit27\/1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.redox.2018.02.002","volume":"16","author":"Ferreira","year":"2018","journal-title":"Redox Biol."},{"key":"D3BM02136J\/cit28\/1","doi-asserted-by":"crossref","first-page":"1801002","DOI":"10.1002\/adhm.201801002","volume":"8","author":"Wang","year":"2019","journal-title":"Adv. Healthcare Mater."},{"key":"D3BM02136J\/cit29\/1","doi-asserted-by":"crossref","first-page":"134354","DOI":"10.1016\/j.cej.2021.134354","volume":"432","author":"Le","year":"2022","journal-title":"Chem. Eng. J."},{"key":"D3BM02136J\/cit30\/1","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.jconrel.2017.01.047","volume":"261","author":"Zhang","year":"2017","journal-title":"J. Controlled Release"},{"key":"D3BM02136J\/cit31\/1","doi-asserted-by":"crossref","first-page":"7466","DOI":"10.1021\/acsami.9b21311","volume":"12","author":"Guo","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D3BM02136J\/cit32\/1","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.colsurfb.2018.02.042","volume":"165","author":"Chen","year":"2018","journal-title":"Colloids Surf., B"},{"key":"D3BM02136J\/cit33\/1","doi-asserted-by":"crossref","first-page":"7263","DOI":"10.1039\/C8TB01566J","volume":"6","author":"Ju","year":"2018","journal-title":"J. Mater. Chem. B"},{"key":"D3BM02136J\/cit34\/1","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1016\/j.apsb.2020.12.001","volume":"11","author":"Lou","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"D3BM02136J\/cit35\/1","doi-asserted-by":"crossref","first-page":"8508","DOI":"10.1021\/acs.jmedchem.6b00930","volume":"59","author":"Zheng","year":"2016","journal-title":"J. Med. Chem."},{"key":"D3BM02136J\/cit36\/1","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1039\/C5CC09181K","volume":"52","author":"Wang","year":"2016","journal-title":"Chem. Commun."},{"key":"D3BM02136J\/cit37\/1","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1039\/C7BM00866J","volume":"5","author":"Sun","year":"2017","journal-title":"Biomater. Sci."},{"key":"D3BM02136J\/cit38\/1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.actbio.2023.08.007","volume":"169","author":"Wang","year":"2023","journal-title":"Acta Biomater."},{"key":"D3BM02136J\/cit39\/1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12951-021-01221-8","volume":"20","author":"Zhang","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"D3BM02136J\/cit40\/1","doi-asserted-by":"crossref","first-page":"9404","DOI":"10.1002\/anie.201103806","volume":"50","author":"Dai","year":"2011","journal-title":"Angew. Chem., Int. Ed."},{"key":"D3BM02136J\/cit41\/1","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1039\/D0BM00295J","volume":"8","author":"Cai","year":"2020","journal-title":"Biomater. Sci."},{"key":"D3BM02136J\/cit42\/1","doi-asserted-by":"crossref","first-page":"1903138","DOI":"10.1002\/advs.201903138","volume":"7","author":"Lin","year":"2020","journal-title":"Adv. Sci."},{"key":"D3BM02136J\/cit43\/1","doi-asserted-by":"crossref","first-page":"122127","DOI":"10.1016\/j.biomaterials.2023.122127","volume":"298","author":"Jung","year":"2023","journal-title":"Biomaterials"},{"key":"D3BM02136J\/cit44\/1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41568-021-00435-0","volume":"22","author":"Cheung","year":"2022","journal-title":"Nat. Rev. Cancer"},{"key":"D3BM02136J\/cit45\/1","doi-asserted-by":"crossref","first-page":"101390","DOI":"10.1016\/j.nantod.2022.101390","volume":"43","author":"Huang","year":"2022","journal-title":"Nano Today"},{"key":"D3BM02136J\/cit46\/1","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1039\/C9BM00009G","volume":"7","author":"Zhang","year":"2019","journal-title":"Biomater. Sci."}],"container-title":["Biomaterials Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/BM\/D3BM02136J","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:37:05Z","timestamp":1783013825000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/bm\/article\/12\/10\/2626-2638\/796685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":46,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,5,14]]}},"URL":"https:\/\/doi.org\/10.1039\/d3bm02136j","relation":{},"ISSN":["2047-4830","2047-4849"],"issn-type":[{"value":"2047-4830","type":"print"},{"value":"2047-4849","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}