{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:57:40Z","timestamp":1782943060743,"version":"3.54.5"},"reference-count":46,"publisher":"Royal Society of Chemistry (RSC)","issue":"46","license":[{"start":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:00:00Z","timestamp":1715731200000},"content-version":"am","delay-in-days":500,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK13221401"],"award-info":[{"award-number":["DK13221401"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG048934"],"award-info":[{"award-number":["AG048934"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Commun."],"abstract":"<jats:p>Monosialoganglioside GM1-bound amyloid \u03b2-peptides have been found in patients\u2019 brains exhibiting early pathological changes of Alzheimer's disease.<\/jats:p>","DOI":"10.1039\/d3cc02186f","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T02:04:50Z","timestamp":1684116290000},"page":"7040-7043","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Ganglioside GM1 produces stable, short, and cytotoxic A\u03b2\n                    <sub>40<\/sub>\n                    protofibrils"],"prefix":"10.1039","volume":"59","author":[{"given":"Manjeet","family":"Kumar","sequence":"first","affiliation":[{"name":"Biophysics, Department of Chemistry, Biomedical Engineering, Macromolecular Science and Engineering, Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109-1055, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"I Ivanova","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1964-1900","authenticated-orcid":false,"given":"Ayyalusamy","family":"Ramamoorthy","sequence":"additional","affiliation":[{"name":"Biophysics, Department of Chemistry, Biomedical Engineering, Macromolecular Science and Engineering, Michigan Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109-1055, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2023]]},"reference":[{"key":"D3CC02186F\/cit1\/1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1146\/annurev.biochem.75.101304.123901","volume":"75","author":"Chiti","year":"2006","journal-title":"Annu. Rev. Biochem."},{"key":"D3CC02186F\/cit2\/1","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"D3CC02186F\/cit3\/1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/0-387-23226-5_8","volume":"38","author":"Glabe","year":"2005","journal-title":"Subcell. Biochem."},{"key":"D3CC02186F\/cit4\/1","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1021\/acs.chemrev.0c01122","volume":"121","author":"Nguyen","year":"2021","journal-title":"Chem Rev."},{"key":"D3CC02186F\/cit5\/1","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1038\/nm1095-1062","volume":"1","author":"Yanagisawa","year":"1995","journal-title":"Nat. Med."},{"key":"D3CC02186F\/cit6\/1","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.1016\/S0197-4580(98)00032-3","volume":"19","author":"Yanagisawa","year":"1998","journal-title":"Neurobiol. Aging"},{"key":"D3CC02186F\/cit7\/1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0163-7827(85)90011-6","volume":"24","author":"Sastry","year":"1985","journal-title":"Prog. Lipid Res."},{"key":"D3CC02186F\/cit8\/1","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1001\/archneur.1991.00530220048018","volume":"48","author":"Davidsson","year":"1991","journal-title":"Arch. Neurol."},{"key":"D3CC02186F\/cit9\/1","doi-asserted-by":"crossref","first-page":"183233","DOI":"10.1016\/j.bbamem.2020.183233","volume":"1862","author":"Matsuzaki","year":"2020","journal-title":"Biochim. Biophys. Acta, Biomembr."},{"key":"D3CC02186F\/cit10\/1","doi-asserted-by":"crossref","first-page":"8125","DOI":"10.1021\/bi300839u","volume":"51","author":"Fukunaga","year":"2012","journal-title":"Biochemistry"},{"key":"D3CC02186F\/cit11\/1","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.jmb.2008.07.072","volume":"382","author":"Okada","year":"2008","journal-title":"J. Mol. Biol."},{"key":"D3CC02186F\/cit12\/1","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1111\/j.1471-4159.2010.06997.x","volume":"116","author":"Ogawa","year":"2011","journal-title":"J. Neurochem."},{"key":"D3CC02186F\/cit13\/1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.jmb.2007.05.069","volume":"371","author":"Okada","year":"2007","journal-title":"J. Mol. Biol."},{"key":"D3CC02186F\/cit14\/1","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1021\/acs.biochem.2c00495","volume":"61","author":"Saha","year":"2022","journal-title":"Biochemistry"},{"key":"D3CC02186F\/cit15\/1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/bs.pmbts.2017.10.005","volume":"156","author":"Matsuzaki","year":"2018","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"D3CC02186F\/cit16\/1","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.bbalip.2010.01.008","volume":"1801","author":"Matsuzaki","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"D3CC02186F\/cit17\/1","doi-asserted-by":"crossref","first-page":"7385","DOI":"10.1021\/bi0255874","volume":"41","author":"Kakio","year":"2002","journal-title":"Biochemistry"},{"key":"D3CC02186F\/cit18\/1","doi-asserted-by":"crossref","first-page":"9303","DOI":"10.1021\/acs.jpclett.2c02362","volume":"13","author":"Chakravorty","year":"2022","journal-title":"J. Phys. Chem. Lett."},{"key":"D3CC02186F\/cit19\/1","doi-asserted-by":"crossref","first-page":"4638","DOI":"10.1074\/jbc.M116.764092","volume":"292","author":"Korshavn","year":"2017","journal-title":"J. Biol. Chem."},{"key":"D3CC02186F\/cit20\/1","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.jmb.2010.09.021","volume":"403","author":"Dahse","year":"2010","journal-title":"J. Mol. Biol."},{"key":"D3CC02186F\/cit21\/1","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1021\/acschemneuro.0c00588","volume":"11","author":"Sciacca","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"D3CC02186F\/cit22\/1","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nprot.2016.010","volume":"11","author":"Meisl","year":"2016","journal-title":"Nat. Protoc."},{"key":"D3CC02186F\/cit23\/1","doi-asserted-by":"crossref","first-page":"4627","DOI":"10.1039\/D0CC01551B","volume":"56","author":"Sahoo","year":"2020","journal-title":"Chem. Commun."},{"key":"D3CC02186F\/cit24\/1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.bbapap.2008.10.016","volume":"1794","author":"Morris","year":"2009","journal-title":"Biochim. Biophys. Acta, Proteins Proteomics"},{"key":"D3CC02186F\/cit25\/1","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1039\/C8CC00167G","volume":"54","author":"Wang","year":"2018","journal-title":"Chem. Commun."},{"key":"D3CC02186F\/cit26\/1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jsb.2005.06.006","volume":"151","author":"Khurana","year":"2005","journal-title":"J. Struct. Biol."},{"key":"D3CC02186F\/cit27\/1","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.bbapap.2010.04.001","volume":"1804","author":"Biancalana","year":"2010","journal-title":"Biochim. Biophys. Acta, Proteins Proteomics"},{"key":"D3CC02186F\/cit28\/1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.jmb.2007.05.069","volume":"371","author":"Okada","year":"2007","journal-title":"J. Mol. Biol."},{"key":"D3CC02186F\/cit29\/1","doi-asserted-by":"crossref","first-page":"14146","DOI":"10.1074\/jbc.RA118.002787","volume":"293","author":"Matsubara","year":"2018","journal-title":"J. Biol. Chem."},{"key":"D3CC02186F\/cit30\/1","doi-asserted-by":"crossref","first-page":"13874","DOI":"10.1021\/acs.langmuir.7b02091","volume":"33","author":"Matsubara","year":"2017","journal-title":"Langmuir"},{"key":"D3CC02186F\/cit31\/1","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1021\/acschemneuro.8b00424","volume":"10","author":"Okada","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"D3CC02186F\/cit32\/1","doi-asserted-by":"crossref","first-page":"8876","DOI":"10.1523\/JNEUROSCI.19-20-08876.1999","volume":"19","author":"Hartley","year":"1999","journal-title":"J. Neurosci."},{"key":"D3CC02186F\/cit33\/1","doi-asserted-by":"crossref","first-page":"22364","DOI":"10.1074\/jbc.272.35.22364","volume":"272","author":"Walsh","year":"1997","journal-title":"J. Biol. Chem."},{"key":"D3CC02186F\/cit34\/1","doi-asserted-by":"crossref","first-page":"8972","DOI":"10.1021\/bi9904149","volume":"38","author":"Harper","year":"1999","journal-title":"Biochemistry"},{"key":"D3CC02186F\/cit35\/1","doi-asserted-by":"crossref","first-page":"e0186636","DOI":"10.1371\/journal.pone.0186636","volume":"12","author":"Krishtal","year":"2017","journal-title":"PLoS One"},{"key":"D3CC02186F\/cit36\/1","doi-asserted-by":"crossref","first-page":"106507","DOI":"10.1016\/j.bpc.2020.106507","volume":"269","author":"Ivanova","year":"2021","journal-title":"Biophys. Chem."},{"key":"D3CC02186F\/cit37\/1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s12551-017-0353-8","volume":"10","author":"Chatani","year":"2018","journal-title":"Biophys. Rev."},{"key":"D3CC02186F\/cit38\/1","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/0092-8674(93)90635-4","volume":"73","author":"Jarrett","year":"1993","journal-title":"Cell"},{"key":"D3CC02186F\/cit39\/1","doi-asserted-by":"crossref","first-page":"2208022","DOI":"10.1002\/adfm.202208022","volume":"32","author":"Tang","year":"2022","journal-title":"Adv. Funct. Mater."},{"key":"D3CC02186F\/cit40\/1","doi-asserted-by":"crossref","first-page":"8667","DOI":"10.1039\/C8CC02204F","volume":"54","author":"T\u00f6rnquist","year":"2018","journal-title":"Chem. Commun."},{"key":"D3CC02186F\/cit41\/1","doi-asserted-by":"crossref","first-page":"a024398","DOI":"10.1101\/cshperspect.a024398","volume":"6","author":"Walker","year":"2016","journal-title":"Cold Spring Harbor Perspect. Med."},{"key":"D3CC02186F\/cit42\/1","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1126\/science.1222951","volume":"336","author":"Prusiner","year":"2012","journal-title":"Science"},{"key":"D3CC02186F\/cit43\/1","doi-asserted-by":"crossref","first-page":"7606","DOI":"10.1039\/C4CP05563B","volume":"17","author":"Arosio","year":"2015","journal-title":"Phys. Chem. Chem. Phys."},{"key":"D3CC02186F\/cit44\/1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/1873-3468.12526","volume":"591","author":"Tran","year":"2017","journal-title":"FEBS Lett."},{"key":"D3CC02186F\/cit45\/1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1749-6632.1996.tb39061.x","volume":"786","author":"Yanagisawa","year":"1996","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"D3CC02186F\/cit46\/1","doi-asserted-by":"crossref","first-page":"4894","DOI":"10.1523\/JNEUROSCI.0861-04.2004","volume":"24","author":"Hayashi","year":"2004","journal-title":"J. Neurosci."}],"container-title":["Chemical Communications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2023\/CC\/D3CC02186F","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:25:43Z","timestamp":1782941143000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/cc\/article\/59\/46\/7040-7043\/797764"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":46,"journal-issue":{"issue":"46","published-print":{"date-parts":[[2023,6,6]]}},"URL":"https:\/\/doi.org\/10.1039\/d3cc02186f","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.12.28.522135","asserted-by":"object"}]},"ISSN":["1359-7345","1364-548X"],"issn-type":[{"value":"1359-7345","type":"print"},{"value":"1364-548X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}