{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:48:19Z","timestamp":1787064499684,"version":"build-2736575974"},"reference-count":36,"publisher":"Royal Society of Chemistry (RSC)","issue":"12","license":[{"start":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T00:00:00Z","timestamp":1734739200000},"content-version":"am","delay-in-days":355,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["CRG\/2022\/004355"],"award-info":[{"award-number":["CRG\/2022\/004355"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Commun."],"abstract":"<jats:p>\n                    A new Ru(\n                    <jats:sc>ii<\/jats:sc>\n                    ) arene chlorido organometallic complex [(\u03b7\n                    <jats:sup>6<\/jats:sup>\n                    -\n                    <jats:italic>p<\/jats:italic>\n                    -cymene)(L)RuCl]PF\n                    <jats:sub>\n                      <jats:sub>6<\/jats:sub>\n                    <\/jats:sub>\n                    that exhibits potent anticancer activity (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 0.71 \u03bcM) and is \u223c45 times more effective than the standard drug cisplatin in a castration-resistant human prostatic adenocarcinoma cell line (PC-3) is reported.\n                  <\/jats:p>","DOI":"10.1039\/d3cc05083a","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T04:22:21Z","timestamp":1703132541000},"page":"1579-1582","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["A bis-quinoline ruthenium(\n                    <scp>ii<\/scp>\n                    ) arene complex with submicromolar cytotoxicity in castration-resistant prostate cancer cells"],"prefix":"10.1039","volume":"60","author":[{"given":"Tanveer A.","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Chemistry, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandarsindri, District Ajmer, Rajasthan, 305817, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kishalay","family":"Bhar","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandarsindri, District Ajmer, Rajasthan, 305817, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0752-1365","authenticated-orcid":false,"given":"Rohit","family":"Samanta","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandarsindri, District Ajmer, Rajasthan, 305817, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surabhi","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandarsindri, District Ajmer, Rajasthan, 305817, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamta","family":"Singh","sequence":"additional","affiliation":[{"name":"Amity Institute of Molecular Medicine and Stem Cell Research, Amity University, Noida, Uttar Pradesh 201313, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reshma","family":"Rani","sequence":"additional","affiliation":[{"name":"Jubilant Biosys, Greater Noida, UP 201310, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4351-6253","authenticated-orcid":false,"given":"Vinit","family":"Kumar","sequence":"additional","affiliation":[{"name":"Amity Institute of Molecular Medicine and Stem Cell Research, Amity University, Noida, Uttar Pradesh 201313, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5090-3713","authenticated-orcid":false,"given":"Anuj K.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Bandarsindri, District Ajmer, Rajasthan, 305817, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2024]]},"reference":[{"key":"D3CC05083A\/cit1\/1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3322\/caac.21208","volume":"64","author":"Siegel","year":"2014","journal-title":"Ca-Cancer J. Clin."},{"key":"D3CC05083A\/cit2\/1","first-page":"365","volume":"4","author":"Chandrasekar","year":"2015","journal-title":"Transl. Androl. Urol."},{"key":"D3CC05083A\/cit3\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11912-017-0593-6","volume":"19","author":"Vlachostergios","year":"2017","journal-title":"Curr. Oncol. Rep."},{"key":"D3CC05083A\/cit4\/1","doi-asserted-by":"crossref","first-page":"4470","DOI":"10.1021\/cr4004314","volume":"114","author":"Wilson","year":"2014","journal-title":"Chem. Rev."},{"key":"D3CC05083A\/cit5\/1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.2478\/raon-2019-0018","volume":"53","author":"Makovec","year":"2019","journal-title":"Radiol. Oncol."},{"key":"D3CC05083A\/cit6\/1","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1038\/onc.2011.384","volume":"31","author":"Galluzzi","year":"2012","journal-title":"Oncogene"},{"key":"D3CC05083A\/cit7\/1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.critrevonc.2007.02.001","volume":"63","author":"Stewart","year":"2007","journal-title":"Crit. Rev. Oncol.\/Hematol."},{"key":"D3CC05083A\/cit8\/1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S1367-5931(03)00081-4","volume":"7","author":"Zhang","year":"2003","journal-title":"Curr. Opin. Chem. Biol."},{"key":"D3CC05083A\/cit9\/1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.jorganchem.2017.03.038","volume":"839","author":"Zhang","year":"2017","journal-title":"J. Organomet. Chem."},{"key":"D3CC05083A\/cit10\/1","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1002\/ejic.201600908","author":"Zhang","year":"2017","journal-title":"Eur. J. Inorg. Chem."},{"key":"D3CC05083A\/cit11\/1","doi-asserted-by":"crossref","first-page":"14413","DOI":"10.1021\/ja508808v","volume":"136","author":"Suntharalingam","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"D3CC05083A\/cit12\/1","doi-asserted-by":"crossref","first-page":"9246","DOI":"10.1021\/acs.jmedchem.8b00958","volume":"61","author":"Coverdale","year":"2018","journal-title":"J. Med. Chem."},{"key":"D3CC05083A\/cit13\/1","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1038\/sj.bjc.6600290","volume":"86","author":"Aird","year":"2002","journal-title":"Br. J. Cancer"},{"key":"D3CC05083A\/cit14\/1","doi-asserted-by":"crossref","first-page":"e2303","DOI":"10.1371\/journal.pone.0002303","volume":"3","author":"Lange","year":"2008","journal-title":"PLoS One"},{"key":"D3CC05083A\/cit15\/1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1039\/C9NJ03663F","volume":"44","author":"Khan","year":"2020","journal-title":"New J. Chem."},{"key":"D3CC05083A\/cit16\/1","doi-asserted-by":"crossref","first-page":"5805","DOI":"10.1021\/acs.jmedchem.7b01689","volume":"61","author":"Thota","year":"2018","journal-title":"J. Med. Chem."},{"key":"D3CC05083A\/cit17\/1","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1002\/ejic.201600986","author":"Alessio","year":"2017","journal-title":"Eur. J. Inorg. Chem."},{"key":"D3CC05083A\/cit18\/1","first-page":"353","volume":"17","author":"Sava","year":"2000","journal-title":"Int. J. Oncol."},{"key":"D3CC05083A\/cit19\/1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/BF02904692","volume":"4","author":"Sava","year":"1998","journal-title":"Pathol. Oncol. Res."},{"key":"D3CC05083A\/cit20\/1","first-page":"1898","volume":"9","author":"Sava","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"D3CC05083A\/cit21\/1","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1002\/cbdv.200890195","volume":"5","author":"Hartinger","year":"2008","journal-title":"Chem. Biodiversity"},{"key":"D3CC05083A\/cit22\/1","doi-asserted-by":"crossref","first-page":"5063","DOI":"10.1002\/anie.202015962","volume":"60","author":"Neuditschko","year":"2021","journal-title":"Angew. Chem., Int. Ed."},{"key":"D3CC05083A\/cit23\/1","doi-asserted-by":"crossref","first-page":"TPS145","DOI":"10.1200\/JCO.2021.39.3_suppl.TPS145","volume":"39","author":"O\u2019Kane","year":"2021","journal-title":"J. Clin. Oncol."},{"key":"D3CC05083A\/cit24\/1","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.3390\/cancers12092647","volume":"12","author":"Bakewell","year":"2020","journal-title":"Cancers"},{"key":"D3CC05083A\/cit25\/1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.jinorgbio.2010.10.009","volume":"105","author":"Moreno","year":"2011","journal-title":"J. Inorg. Biochem."},{"key":"D3CC05083A\/cit26\/1","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1021\/acs.molpharmaceut.8b00003","volume":"15","author":"Chow","year":"2018","journal-title":"Mol. Pharmaceutics"},{"key":"D3CC05083A\/cit27\/1","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1039\/C6SC00268D","volume":"7","author":"Chow","year":"2016","journal-title":"Chem. Sci."},{"key":"D3CC05083A\/cit28\/1","doi-asserted-by":"crossref","first-page":"6043","DOI":"10.1021\/jm500455p","volume":"57","author":"Chow","year":"2014","journal-title":"J. Med. Chem."},{"key":"D3CC05083A\/cit29\/1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.poly.2017.02.011","volume":"127","author":"Skoczynska","year":"2017","journal-title":"Polyhedron"},{"key":"D3CC05083A\/cit30\/1","doi-asserted-by":"crossref","first-page":"14768","DOI":"10.1002\/chem.201303341","volume":"19","author":"Patra","year":"2013","journal-title":"Chem. \u2013 Eur. J."},{"key":"D3CC05083A\/cit31\/1","doi-asserted-by":"crossref","first-page":"6180","DOI":"10.1021\/om200713v","volume":"30","author":"Marchetti","year":"2011","journal-title":"Organometallics"},{"key":"D3CC05083A\/cit32\/1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1186\/1476-4598-9-319","volume":"9","author":"Zhang","year":"2010","journal-title":"Mol. Cancer"},{"key":"D3CC05083A\/cit33\/1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1021\/ar100140e","volume":"44","author":"Liu","year":"2011","journal-title":"Acc. Chem. Res."},{"key":"D3CC05083A\/cit34\/1","doi-asserted-by":"crossref","first-page":"4246","DOI":"10.1021\/bi00067a012","volume":"32","author":"Almes","year":"1993","journal-title":"Biochemistry"},{"key":"D3CC05083A\/cit35\/1","doi-asserted-by":"crossref","first-page":"4477","DOI":"10.1016\/j.ejmech.2009.06.009","volume":"44","author":"Liu","year":"2009","journal-title":"Eur. J. Med. Chem."},{"key":"D3CC05083A\/cit36\/1","doi-asserted-by":"crossref","first-page":"4339","DOI":"10.1021\/bi00664a031","volume":"15","author":"Howe-Grant","year":"1976","journal-title":"Biochemistry"}],"container-title":["Chemical Communications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/CC\/D3CC05083A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:02:33Z","timestamp":1782968553000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/cc\/article\/60\/12\/1579-1582\/798824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":36,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,2,6]]}},"URL":"https:\/\/doi.org\/10.1039\/d3cc05083a","relation":{},"ISSN":["1359-7345","1364-548X"],"issn-type":[{"value":"1359-7345","type":"print"},{"value":"1364-548X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}