{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:40:38Z","timestamp":1783017638857,"version":"3.54.6"},"reference-count":67,"publisher":"Royal Society of Chemistry (RSC)","issue":"14","license":[{"start":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T00:00:00Z","timestamp":1717804800000},"content-version":"am","delay-in-days":524,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>Gastrointestinal dysmotility is a common cause of functional dyspepsia. Both fucoidan and laminarin relieve the gastrointestinal symptoms induced by loperamide. The machanisms include restoring the rhythm of the migrating motor complex and regulating gut microecology.<\/jats:p>","DOI":"10.1039\/d3fo00936j","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T04:01:57Z","timestamp":1686196917000},"page":"6513-6525","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The regulatory effects of fucoidan and laminarin on functional dyspepsia mice induced by loperamide"],"prefix":"10.1039","volume":"14","author":[{"given":"Tianxu","family":"Liu","sequence":"first","affiliation":[{"name":"College of Food Science and Technology, Huazhong Agricultural University, Wuhan, 430070, Hubei, China"},{"name":"Key Laboratory of Environment Correlative Dietology (Huazhong Agricultural University), Ministry of Education, Wuhan, 430070, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengting","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Huazhong Agricultural University, Wuhan, 430070, Hubei, China"},{"name":"Key Laboratory of Environment Correlative Dietology (Huazhong Agricultural University), Ministry of Education, Wuhan, 430070, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail Muhammad","family":"Asif","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Huazhong Agricultural University, Wuhan, 430070, Hubei, China"},{"name":"Key Laboratory of Environment Correlative Dietology (Huazhong Agricultural University), Ministry of Education, Wuhan, 430070, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonglin","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Huazhong Agricultural University, Wuhan, 430070, Hubei, China"},{"name":"Key Laboratory of Environment Correlative Dietology (Huazhong Agricultural University), Ministry of Education, Wuhan, 430070, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7763-4245","authenticated-orcid":false,"given":"Bin","family":"Li","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Huazhong Agricultural University, Wuhan, 430070, Hubei, China"},{"name":"Key Laboratory of Environment Correlative Dietology (Huazhong Agricultural University), Ministry of Education, Wuhan, 430070, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1076-0500","authenticated-orcid":false,"given":"Ling","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Huazhong Agricultural University, Wuhan, 430070, Hubei, China"},{"name":"Key Laboratory of Environment Correlative Dietology (Huazhong Agricultural University), Ministry of Education, Wuhan, 430070, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2023]]},"reference":[{"key":"D3FO00936J\/cit1\/1","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1136\/gutjnl-2014-307843","volume":"64","author":"Ford","year":"2015","journal-title":"Gut"},{"key":"D3FO00936J\/cit2\/1","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1136\/gutjnl-2019-318536","volume":"69","author":"Wauters","year":"2020","journal-title":"Gut"},{"key":"D3FO00936J\/cit3\/1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/00042737-200601000-00011","volume":"18","author":"Bouin","year":"2006","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"D3FO00936J\/cit4\/1","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1111\/j.1572-0241.2004.04086.x","volume":"99","author":"Timmons","year":"2004","journal-title":"Am. J. Gastroenterol."},{"key":"D3FO00936J\/cit5\/1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/2050640613499567","volume":"1","author":"Lahner","year":"2013","journal-title":"United Eur. Gastroenterol. J."},{"key":"D3FO00936J\/cit6\/1","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.3390\/foods11101491","volume":"11","author":"Li","year":"2022","journal-title":"Foods"},{"key":"D3FO00936J\/cit7\/1","doi-asserted-by":"crossref","first-page":"153875","DOI":"10.1016\/j.phymed.2021.153875","volume":"95","author":"Tu","year":"2022","journal-title":"Phytomedicine"},{"key":"D3FO00936J\/cit8\/1","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1365-2982.2011.01827.x","volume":"24","author":"Borrelli","year":"2012","journal-title":"Neurogastroenterol. Motil."},{"key":"D3FO00936J\/cit9\/1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.bbrc.2016.02.078","volume":"472","author":"Asano","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"D3FO00936J\/cit10\/1","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1111\/j.1365-2982.2011.01766.x","volume":"23","author":"F\u00fchrer","year":"2011","journal-title":"Neurogastroenterol. Motil."},{"key":"D3FO00936J\/cit11\/1","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.ijbiomac.2013.06.030","volume":"60","author":"Senthilkumar","year":"2013","journal-title":"Int. J. Biol. Macromol."},{"key":"D3FO00936J\/cit12\/1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3390\/md17010032","volume":"17","author":"van Weelden","year":"2019","journal-title":"Mar. Drugs"},{"key":"D3FO00936J\/cit13\/1","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3390\/md17100571","volume":"17","author":"Fitton","year":"2019","journal-title":"Mar. Drugs"},{"key":"D3FO00936J\/cit14\/1","doi-asserted-by":"crossref","first-page":"4456","DOI":"10.1002\/jsfa.11202","volume":"101","author":"Sun","year":"2021","journal-title":"J. Sci. Food Agric."},{"key":"D3FO00936J\/cit15\/1","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1017\/S0007114513000834","volume":"110","author":"Walsh","year":"2013","journal-title":"Br. J. Nutr."},{"key":"D3FO00936J\/cit16\/1","doi-asserted-by":"crossref","first-page":"735","DOI":"10.31989\/ffhd.v7i9.350","volume":"7","author":"Matayoshi","year":"2017","journal-title":"Funct. Foods Health Dis."},{"key":"D3FO00936J\/cit17\/1","doi-asserted-by":"crossref","first-page":"115774","DOI":"10.1016\/j.carbpol.2019.115774","volume":"232","author":"Zargarzadeh","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"D3FO00936J\/cit18\/1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1017\/S0007114519002678","volume":"123","author":"Rattigan","year":"2020","journal-title":"Br. J. Nutr."},{"key":"D3FO00936J\/cit19\/1","doi-asserted-by":"crossref","first-page":"e14163","DOI":"10.1111\/nmo.14163","volume":"33","author":"Zhang","year":"2021","journal-title":"Neurogastroenterol. Motil."},{"key":"D3FO00936J\/cit20\/1","doi-asserted-by":"crossref","first-page":"111834","DOI":"10.1016\/j.jep.2019.111834","volume":"238","author":"Jeon","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"D3FO00936J\/cit21\/1","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1111\/1755-0998.12616","volume":"17","author":"Arseneau","year":"2017","journal-title":"Mol. Ecol. Resour."},{"key":"D3FO00936J\/cit22\/1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.jpainsymman.2011.06.001","volume":"42","author":"Regnard","year":"2011","journal-title":"J. Pain Symptom Manage."},{"key":"D3FO00936J\/cit23\/1","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.biopha.2017.11.119","volume":"96","author":"Ren","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"D3FO00936J\/cit24\/1","doi-asserted-by":"crossref","first-page":"981","DOI":"10.2165\/00003495-200868070-00007","volume":"68","author":"Curran","year":"2008","journal-title":"Drugs"},{"key":"D3FO00936J\/cit25\/1","doi-asserted-by":"crossref","first-page":"172","DOI":"10.3389\/fpsyt.2020.00172","volume":"11","author":"Van den Houte","year":"2020","journal-title":"Front. Psychiatry"},{"key":"D3FO00936J\/cit26\/1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.pharmthera.2009.04.004","volume":"123","author":"De Smet","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"D3FO00936J\/cit27\/1","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/0016-5085(80)90250-4","volume":"79","author":"Peeters","year":"1980","journal-title":"Gastroenterology"},{"key":"D3FO00936J\/cit28\/1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/nrgastro.2012.57","volume":"9","author":"Deloose","year":"2012","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"D3FO00936J\/cit29\/1","doi-asserted-by":"crossref","first-page":"548457","DOI":"10.1155\/2010\/548457","volume":"2010","author":"Akamizu","year":"2010","journal-title":"Int. J. Pept."},{"key":"D3FO00936J\/cit30\/1","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1111\/j.1365-2982.2010.01609.x","volume":"22","author":"Khoo","year":"2010","journal-title":"Neurogastroenterol. Motil."},{"key":"D3FO00936J\/cit31\/1","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1002\/cphy.c200035","volume":"11","author":"Ayala-Lopez","year":"2021","journal-title":"Compr. Physiol."},{"key":"D3FO00936J\/cit32\/1","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.2174\/1567205018666211215150547","volume":"18","author":"Moss","year":"2021","journal-title":"Curr. Alzheimer Res."},{"key":"D3FO00936J\/cit33\/1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3390\/md15030077","volume":"15","author":"Wei","year":"2017","journal-title":"Mar. Drugs"},{"key":"D3FO00936J\/cit34\/1","doi-asserted-by":"crossref","first-page":"153278","DOI":"10.1016\/j.tox.2022.153278","volume":"477","author":"Lei","year":"2022","journal-title":"Toxicology"},{"key":"D3FO00936J\/cit35\/1","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1007\/BF02285463","volume":"18","author":"Vald\u00e9s Olmos","year":"1991","journal-title":"Eur. J. Nucl. Med."},{"key":"D3FO00936J\/cit36\/1","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1111\/nmo.12370","volume":"26","author":"Appleby","year":"2014","journal-title":"Neurogastroenterol. Motil."},{"key":"D3FO00936J\/cit37\/1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/apt.14214","volume":"46","author":"Vijayvargiya","year":"2017","journal-title":"Aliment. Pharmacol. Ther."},{"key":"D3FO00936J\/cit38\/1","doi-asserted-by":"crossref","first-page":"12724","DOI":"10.1039\/D1FO03490A","volume":"12","author":"Yu","year":"2021","journal-title":"Food Funct."},{"key":"D3FO00936J\/cit39\/1","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1039\/D2FO03181G","volume":"14","author":"Wu","year":"2023","journal-title":"Food Funct."},{"key":"D3FO00936J\/cit40\/1","doi-asserted-by":"crossref","first-page":"4540","DOI":"10.3390\/ijms21124540","volume":"21","author":"Foong","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"D3FO00936J\/cit41\/1","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1053\/j.gastro.2008.10.031","volume":"136","author":"Kwon","year":"2009","journal-title":"Gastroenterology"},{"key":"D3FO00936J\/cit42\/1","first-page":"9952691","volume":"2021","author":"Joung","year":"2021","journal-title":"J. Evidence-Based Complementary Altern. Med."},{"key":"D3FO00936J\/cit43\/1","doi-asserted-by":"crossref","first-page":"753153","DOI":"10.3389\/fphar.2021.753153","volume":"12","author":"Hwang","year":"2021","journal-title":"Front. Pharmacol."},{"key":"D3FO00936J\/cit44\/1","doi-asserted-by":"crossref","first-page":"1089231","DOI":"10.3389\/fphar.2022.1089231","volume":"13","author":"Song","year":"2022","journal-title":"Front. Pharmacol."},{"key":"D3FO00936J\/cit45\/1","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1113\/JP277335","volume":"597","author":"Hwang","year":"2019","journal-title":"J. Physiol."},{"key":"D3FO00936J\/cit46\/1","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.bbrc.2005.01.029","volume":"328","author":"Liu","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"D3FO00936J\/cit47\/1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.5152\/tjg.2016.16281","volume":"27","author":"Kayar","year":"2016","journal-title":"Turk. J. Gastroenterol."},{"key":"D3FO00936J\/cit48\/1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/MCG.0b013e318157187a","volume":"43","author":"Sha","year":"2009","journal-title":"J. Clin. Gastroenterol."},{"key":"D3FO00936J\/cit49\/1","doi-asserted-by":"crossref","first-page":"910568","DOI":"10.3389\/fphys.2022.910568","volume":"13","author":"Zhou","year":"2022","journal-title":"Front. Physiol."},{"key":"D3FO00936J\/cit50\/1","doi-asserted-by":"crossref","first-page":"117218","DOI":"10.1016\/j.carbpol.2020.117218","volume":"253","author":"Zhang","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"D3FO00936J\/cit51\/1","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1007\/s00394-019-02020-6","volume":"59","author":"Kan","year":"2020","journal-title":"Eur. J. Nutr."},{"key":"D3FO00936J\/cit52\/1","doi-asserted-by":"crossref","first-page":"14864","DOI":"10.1021\/acs.jafc.2c06417","volume":"70","author":"Liu","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"D3FO00936J\/cit53\/1","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1039\/C7FO01677H","volume":"9","author":"Xue","year":"2018","journal-title":"Food Funct."},{"key":"D3FO00936J\/cit54\/1","doi-asserted-by":"crossref","first-page":"117389","DOI":"10.1016\/j.carbpol.2020.117389","volume":"255","author":"Cui","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"D3FO00936J\/cit55\/1","doi-asserted-by":"crossref","first-page":"154180","DOI":"10.1016\/j.phymed.2022.154180","volume":"102","author":"Zhang","year":"2022","journal-title":"Phytomedicine"},{"key":"D3FO00936J\/cit56\/1","doi-asserted-by":"crossref","first-page":"670335","DOI":"10.3389\/fphar.2021.670335","volume":"12","author":"Wu","year":"2021","journal-title":"Front. Pharmacol."},{"key":"D3FO00936J\/cit57\/1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3390\/md21010031","volume":"21","author":"Ye","year":"2022","journal-title":"Mar. Drugs"},{"key":"D3FO00936J\/cit58\/1","doi-asserted-by":"crossref","first-page":"107683","DOI":"10.1016\/j.intimp.2021.107683","volume":"97","author":"Hua","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"D3FO00936J\/cit59\/1","doi-asserted-by":"crossref","first-page":"953962","DOI":"10.3389\/fcimb.2022.953962","volume":"12","author":"Zhu","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"D3FO00936J\/cit60\/1","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.chom.2023.01.013","volume":"31","author":"Zhang","year":"2023","journal-title":"Cell Host Microbe"},{"key":"D3FO00936J\/cit61\/1","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1053\/j.gastro.2021.09.061","volume":"162","author":"Lima","year":"2022","journal-title":"Gastroenterology"},{"key":"D3FO00936J\/cit62\/1","doi-asserted-by":"crossref","first-page":"5519","DOI":"10.1002\/jmv.28001","volume":"94","author":"Dong","year":"2022","journal-title":"J. Med. Virol."},{"key":"D3FO00936J\/cit63\/1","doi-asserted-by":"crossref","first-page":"21002","DOI":"10.1038\/s41598-020-77919-w","volume":"10","author":"Patrizz","year":"2020","journal-title":"Sci. Rep."},{"key":"D3FO00936J\/cit64\/1","doi-asserted-by":"crossref","first-page":"573","DOI":"10.3390\/microorganisms8040573","volume":"8","author":"Vacca","year":"2020","journal-title":"Microorganisms"},{"key":"D3FO00936J\/cit65\/1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1177\/2050640617724061","volume":"6","author":"Chiarioni","year":"2018","journal-title":"United Eur. Gastroenterol. J."},{"key":"D3FO00936J\/cit66\/1","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.ijbiomac.2022.01.102","volume":"201","author":"Liu","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"D3FO00936J\/cit67\/1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3390\/md17030183","volume":"17","author":"Wang","year":"2019","journal-title":"Mar. Drugs"}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2023\/FO\/D3FO00936J","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:38:33Z","timestamp":1783013913000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/14\/14\/6513-6525\/809271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":67,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2023,7,17]]}},"URL":"https:\/\/doi.org\/10.1039\/d3fo00936j","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}