{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T05:22:27Z","timestamp":1790572947313,"version":"4.1.0"},"reference-count":48,"publisher":"Royal Society of Chemistry (RSC)","issue":"1","license":[{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"am","delay-in-days":339,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103842"],"award-info":[{"award-number":["82103842"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022M72261"],"award-info":[{"award-number":["2022M72261"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>Autism Spectrum Disorder (ASD), a complex neurodevelopmental disorder marked by social communication deficits and repetitive behaviors, may see symptom amelioration through gut microbiota modulation.<\/jats:p>","DOI":"10.1039\/d3fo02663a","type":"journal-article","created":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T08:21:24Z","timestamp":1701764484000},"page":"387-400","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["A synbiotic formulation of\n                    <i>Lactobacillus reuteri<\/i>\n                    and inulin alleviates ASD-like behaviors in a mouse model: the mediating role of the gut\u2013brain axis"],"prefix":"10.1039","volume":"15","author":[{"given":"Chuanchuan","family":"Wang","sequence":"first","affiliation":[{"name":"Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi 712100, China"},{"name":"Northwest A&F University Shenzhen Research Institute, Shenzhen, Guangdong, 518000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4264-7924","authenticated-orcid":false,"given":"Weixuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yishan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Xiao","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianhui","family":"Zou","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarui","family":"Liang","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianxu","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Yuan","sequence":"additional","affiliation":[{"name":"Northwest A&F University Shenzhen Research Institute, Shenzhen, Guangdong, 518000, China"},{"name":"Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Guo","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi 712100, China"},{"name":"Northwest A&F University Shenzhen Research Institute, Shenzhen, Guangdong, 518000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6370-2868","authenticated-orcid":false,"given":"Xuebo","family":"Liu","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi 712100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6863-6561","authenticated-orcid":false,"given":"Zhigang","family":"Liu","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi 712100, China"},{"name":"Northwest A&F University Shenzhen Research Institute, Shenzhen, Guangdong, 518000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2024]]},"reference":[{"key":"D3FO02663A\/cit1\/1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.neubiorev.2019.04.012","volume":"110","author":"Takumi","year":"2020","journal-title":"Neurosci. Biobehav. Rev."},{"key":"D3FO02663A\/cit2\/1","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.cell.2019.07.024","volume":"178","author":"Orefice","year":"2019","journal-title":"Cell"},{"key":"D3FO02663A\/cit3\/1","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/S0140-6736(18)31129-2","volume":"392","author":"Lord","year":"2018","journal-title":"Lancet"},{"key":"D3FO02663A\/cit4\/1","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/s41591-019-0439-x","volume":"25","author":"Suez","year":"2019","journal-title":"Nat. Med."},{"key":"D3FO02663A\/cit5\/1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jcmgh.2018.04.003","volume":"6","author":"Martin","year":"2018","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"D3FO02663A\/cit6\/1","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1002\/aur.2358","volume":"13","author":"Zou","year":"2020","journal-title":"Autism Res."},{"key":"D3FO02663A\/cit7\/1","doi-asserted-by":"crossref","first-page":"3492","DOI":"10.3390\/nu13103492","volume":"13","author":"Lombardi","year":"2021","journal-title":"Nutrients"},{"key":"D3FO02663A\/cit8\/1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/fendo.2020.00025","volume":"11","author":"Silva","year":"2020","journal-title":"Front. Endocrinol."},{"key":"D3FO02663A\/cit9\/1","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1016\/j.cell.2016.06.001","volume":"165","author":"Buffington","year":"2016","journal-title":"Cell"},{"key":"D3FO02663A\/cit10\/1","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.neuron.2018.11.018","volume":"101","author":"Sgritta","year":"2019","journal-title":"Neuron"},{"key":"D3FO02663A\/cit11\/1","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.cmet.2021.02.002","volume":"33","author":"Liu","year":"2021","journal-title":"Cell Metab."},{"key":"D3FO02663A\/cit12\/1","doi-asserted-by":"crossref","first-page":"107477","DOI":"10.1016\/j.neuropharm.2018.12.024","volume":"159","author":"Tartaglione","year":"2019","journal-title":"Neuropharmacology"},{"key":"D3FO02663A\/cit13\/1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.expneurol.2017.04.017","volume":"299","author":"Nicolini","year":"2018","journal-title":"Exp. Neurol."},{"key":"D3FO02663A\/cit14\/1","doi-asserted-by":"crossref","first-page":"111322","DOI":"10.1016\/j.biopha.2021.111322","volume":"137","author":"Taleb","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"D3FO02663A\/cit15\/1","doi-asserted-by":"crossref","first-page":"eabf3002","DOI":"10.1126\/science.abf3002","volume":"373","author":"Lim","year":"2021","journal-title":"Science"},{"key":"D3FO02663A\/cit16\/1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.neuron.2020.01.038","volume":"106","author":"Tai","year":"2020","journal-title":"Neuron"},{"key":"D3FO02663A\/cit17\/1","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/s41467-020-14676-4","volume":"11","author":"Liu","year":"2020","journal-title":"Nat. Commun."},{"key":"D3FO02663A\/cit18\/1","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.bbi.2021.04.005","volume":"95","author":"Liu","year":"2021","journal-title":"Brain, Behav., Immun."},{"key":"D3FO02663A\/cit19\/1","doi-asserted-by":"crossref","first-page":"e1900521","DOI":"10.1002\/mnfr.201900521","volume":"63","author":"Yan","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"D3FO02663A\/cit20\/1","doi-asserted-by":"crossref","first-page":"101535","DOI":"10.1016\/j.redox.2020.101535","volume":"32","author":"Zhang","year":"2020","journal-title":"Redox Biol."},{"key":"D3FO02663A\/cit21\/1","doi-asserted-by":"crossref","first-page":"e00084","DOI":"10.1128\/mSphere.00084-21","volume":"6","author":"Ba","year":"2021","journal-title":"Msphere"},{"key":"D3FO02663A\/cit22\/1","doi-asserted-by":"crossref","first-page":"D490","DOI":"10.1093\/nar\/gkt1178","volume":"42","author":"Lombard","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"D3FO02663A\/cit23\/1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nrn3379","volume":"14","author":"Park","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"D3FO02663A\/cit24\/1","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s00401-017-1736-4","volume":"134","author":"Varghese","year":"2017","journal-title":"Acta Neuropathol."},{"key":"D3FO02663A\/cit25\/1","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1523\/ENEURO.0332-19.2020","volume":"7","author":"Jaramillo","year":"2020","journal-title":"eNeuro"},{"key":"D3FO02663A\/cit26\/1","first-page":"4526417","volume":"2017","author":"Yang","year":"2017","journal-title":"Neural Plast."},{"key":"D3FO02663A\/cit27\/1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.phrs.2017.08.006","volume":"128","author":"Mahmood","year":"2018","journal-title":"Pharmacol. Res."},{"key":"D3FO02663A\/cit28\/1","doi-asserted-by":"crossref","first-page":"238","DOI":"10.5483\/BMBRep.2022.55.5.038","volume":"55","author":"Choi","year":"2022","journal-title":"BMB Rep."},{"key":"D3FO02663A\/cit29\/1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/s41586-019-1843-6","volume":"577","author":"Reed","year":"2020","journal-title":"Nature"},{"key":"D3FO02663A\/cit30\/1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.bbi.2019.04.037","volume":"79","author":"Matta","year":"2019","journal-title":"Brain, Behav., Immun."},{"key":"D3FO02663A\/cit31\/1","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1542\/peds.2013-3995","volume":"133","author":"McElhanon","year":"2014","journal-title":"Pediatrics"},{"key":"D3FO02663A\/cit32\/1","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.3390\/microorganisms9091833","volume":"9","author":"Nettleton","year":"2021","journal-title":"Microorganisms"},{"key":"D3FO02663A\/cit33\/1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1080\/19490976.2015.1035855","volume":"6","author":"De Angelis","year":"2015","journal-title":"Gut Microbes"},{"key":"D3FO02663A\/cit34\/1","doi-asserted-by":"crossref","first-page":"911259","DOI":"10.3389\/fcimb.2022.911259","volume":"12","author":"Liu","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"D3FO02663A\/cit35\/1","doi-asserted-by":"crossref","first-page":"104784","DOI":"10.1016\/j.phrs.2020.104784","volume":"157","author":"Wang","year":"2020","journal-title":"Pharmacol. Res."},{"key":"D3FO02663A\/cit36\/1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jpsychires.2020.06.032","volume":"129","author":"Ding","year":"2020","journal-title":"J. Psychiatr. Res."},{"key":"D3FO02663A\/cit37\/1","doi-asserted-by":"crossref","first-page":"13981","DOI":"10.1038\/s41598-018-32219-2","volume":"8","author":"Zhang","year":"2018","journal-title":"Sci. Rep."},{"key":"D3FO02663A\/cit38\/1","doi-asserted-by":"crossref","first-page":"871086","DOI":"10.3389\/fmicb.2022.871086","volume":"13","author":"Vernocchi","year":"2022","journal-title":"Front. Microbiol."},{"key":"D3FO02663A\/cit39\/1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s41575-019-0157-3","volume":"16","author":"Dalile","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"D3FO02663A\/cit40\/1","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1039\/D0FO02375B","volume":"12","author":"Kong","year":"2021","journal-title":"Food Funct."},{"key":"D3FO02663A\/cit41\/1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/s41598-018-36430-z","volume":"9","author":"Liu","year":"2019","journal-title":"Sci. Rep."},{"key":"D3FO02663A\/cit42\/1","doi-asserted-by":"crossref","first-page":"4159","DOI":"10.3390\/ijms21114159","volume":"21","author":"Abdellatif","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"D3FO02663A\/cit43\/1","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1158\/1541-7786.MCR-05-0267","volume":"4","author":"Camarero","year":"2006","journal-title":"Mol. Cancer Res."},{"key":"D3FO02663A\/cit44\/1","doi-asserted-by":"crossref","first-page":"8767","DOI":"10.3390\/ijms21228767","volume":"21","author":"Jensen","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"D3FO02663A\/cit45\/1","doi-asserted-by":"crossref","first-page":"10080","DOI":"10.1038\/s41598-022-14268-w","volume":"12","author":"Nishitani","year":"2022","journal-title":"Sci. Rep."},{"key":"D3FO02663A\/cit46\/1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nrn.2017.156","volume":"19","author":"Mattson","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"D3FO02663A\/cit47\/1","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.cmet.2016.12.022","volume":"25","author":"Puchalska","year":"2017","journal-title":"Cell Metab."},{"key":"D3FO02663A\/cit48\/1","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3390\/biom11030402","volume":"11","author":"Mierziak","year":"2021","journal-title":"Biomolecules"}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/FO\/D3FO02663A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:16:30Z","timestamp":1782929790000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/15\/1\/387-400\/809495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1,2]]}},"URL":"https:\/\/doi.org\/10.1039\/d3fo02663a","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}