{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:05:02Z","timestamp":1787004302691,"version":"build-2736575974"},"reference-count":42,"publisher":"Royal Society of Chemistry (RSC)","issue":"22","license":[{"start":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T00:00:00Z","timestamp":1729296000000},"content-version":"am","delay-in-days":657,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2023-JC-QN-0101"],"award-info":[{"award-number":["2023-JC-QN-0101"]}],"id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22076115"],"award-info":[{"award-number":["22076115"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32022069"],"award-info":[{"award-number":["32022069"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>\u03b2-Carbolines norharman and harman, belonging to the class of heterocyclic aromatic amines (HAAs), are typical hazardous substances produced during the thermal processing of food.<\/jats:p>","DOI":"10.1039\/d3fo03732k","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T21:03:54Z","timestamp":1697663034000},"page":"10031-10040","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["\u03b2-Carbolines norharman and harman change neurobehavior causing neurological damage in\n                    <i>Caenorhabditis elegans<\/i>"],"prefix":"10.1039","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0020-9506","authenticated-orcid":false,"given":"Luyao","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Food Science and Engineering, Shaanxi University of Science and Technology, Xi'an, 710021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialu","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering, Shaanxi University of Science and Technology, Xi'an, 710021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bufan","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering, Shaanxi University of Science and Technology, Xi'an, 710021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute for Global Food Security, School of Biological Sciences, Queen's University Belfast, Belfast, BT9 5DL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6430-1302","authenticated-orcid":false,"given":"Yongning","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering, Shaanxi University of Science and Technology, Xi'an, 710021, China"},{"name":"NHC Key Laboratory of Food Safety Risk Assessment, Food Safety Research Unit (2019RU014) of Chinese Academy of Medical Science, China National Center for Food Safety Risk Assessment, Beijing 100021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7951-9750","authenticated-orcid":false,"given":"Guoliang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Food Science and Engineering, Shaanxi University of Science and Technology, Xi'an, 710021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2023]]},"reference":[{"key":"D3FO03732K\/cit1\/1","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1081\/DMR-120005665","volume":"34","author":"Turesky","year":"2002","journal-title":"Drug Metab. Rev."},{"key":"D3FO03732K\/cit2\/1","doi-asserted-by":"crossref","first-page":"125937","DOI":"10.1016\/j.foodchem.2019.125937","volume":"310","author":"Dong","year":"2020","journal-title":"Food Chem."},{"key":"D3FO03732K\/cit3\/1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/1541-4337.12186","volume":"15","author":"Gibis","year":"2016","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"D3FO03732K\/cit4\/1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/toxsci\/kfx223","volume":"161","author":"Sammi","year":"2018","journal-title":"Toxicol. Sci."},{"key":"D3FO03732K\/cit5\/1","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/1541-4337.12527","volume":"19","author":"Dong","year":"2020","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"D3FO03732K\/cit6\/1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.neuro.2018.01.009","volume":"65","author":"Cruz-Hernandez","year":"2018","journal-title":"Neurotoxicology"},{"key":"D3FO03732K\/cit7\/1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/toxsci\/kfz210","volume":"173","author":"Lawana","year":"2020","journal-title":"Toxicol. Sci."},{"key":"D3FO03732K\/cit8\/1","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.foodchem.2018.12.058","volume":"280","author":"Barzegar","year":"2019","journal-title":"Food Chem."},{"key":"D3FO03732K\/cit9\/1","doi-asserted-by":"crossref","first-page":"113376","DOI":"10.1016\/j.fct.2022.113376","volume":"168","author":"Feng","year":"2022","journal-title":"Food Chem. Toxicol."},{"key":"D3FO03732K\/cit10\/1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1600-0404.1995.tb00479.x","volume":"92","author":"Kuhn","year":"1995","journal-title":"Acta Neurol. Scand."},{"key":"D3FO03732K\/cit11\/1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s13760-018-0926-8","volume":"119","author":"Nasehi","year":"2019","journal-title":"Acta Neurol. Belg."},{"issue":"5","key":"D3FO03732K\/cit12\/1","doi-asserted-by":"crossref","first-page":"200559","DOI":"10.4209\/aaqr.200559","volume":"21","author":"Tsai","year":"2021","journal-title":"Aerosol Air Qual. Res."},{"key":"D3FO03732K\/cit13\/1","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.copbio.2019.12.011","volume":"63","author":"Markaki","year":"2020","journal-title":"Curr. Opin. Biotechnol"},{"key":"D3FO03732K\/cit14\/1","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1101\/gr.10.5.703","volume":"10","author":"Lai","year":"2000","journal-title":"Genome Res."},{"key":"D3FO03732K\/cit15\/1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/1541-4337.12511","volume":"19","author":"Chen","year":"2020","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"D3FO03732K\/cit16\/1","doi-asserted-by":"crossref","first-page":"108929","DOI":"10.1016\/j.foodcont.2022.108929","volume":"137","author":"Feng","year":"2022","journal-title":"Food Control"},{"key":"D3FO03732K\/cit17\/1","doi-asserted-by":"crossref","first-page":"814","DOI":"10.3390\/nu11040814","volume":"11","author":"Piechowska","year":"2019","journal-title":"Nutrients"},{"key":"D3FO03732K\/cit18\/1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/toxsci\/kfx223","volume":"161","author":"Sammi","year":"2018","journal-title":"Toxicol. Sci."},{"key":"D3FO03732K\/cit19\/1","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/cr.2008.279","volume":"18","author":"Weidong","year":"2008","journal-title":"Cell Res."},{"key":"D3FO03732K\/cit20\/1","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1002\/etc.5620091007","volume":"9","author":"Williams","year":"1990","journal-title":"Environ. Toxicol. Chem."},{"key":"D3FO03732K\/cit21\/1","first-page":"e59082","author":"Gao","year":"2019","journal-title":"J. Visualized Exp."},{"key":"D3FO03732K\/cit22\/1","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.envpol.2018.09.140","volume":"244","author":"Cao","year":"2019","journal-title":"Environ. Pollut."},{"key":"D3FO03732K\/cit23\/1","doi-asserted-by":"crossref","first-page":"119141","DOI":"10.1016\/j.envpol.2022.119141","volume":"304","author":"Zhang","year":"2022","journal-title":"Environ. Pollut."},{"key":"D3FO03732K\/cit24\/1","doi-asserted-by":"crossref","first-page":"4856761","DOI":"10.1155\/2016\/4856761","volume":"2016","author":"Li","year":"2016","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"D3FO03732K\/cit25\/1","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1242\/jeb.204.10.1757","volume":"204","author":"Saeki","year":"2001","journal-title":"J. Exp. Biol."},{"key":"D3FO03732K\/cit26\/1","doi-asserted-by":"crossref","first-page":"20460","DOI":"10.1039\/C5NR05914C","volume":"7","author":"Wu","year":"2015","journal-title":"Nanoscale"},{"key":"D3FO03732K\/cit27\/1","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/978-1-62703-239-1_32","volume-title":"Cell Senescence: Methods and protocols","author":"Lionaki","year":"2013","unstructured":"E.Lionaki and N.Tavernarakis , High-throughput and longitudinal analysis of aging and senescent decline in Caenorhabditis elegans , in Cell Senescence: Methods and protocols , 2013 , pp. 485\u2013500"},{"key":"D3FO03732K\/cit28\/1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ejphar.2008.03.050","volume":"587","author":"Yang","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"D3FO03732K\/cit29\/1","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.3390\/molecules25143194","volume":"25","author":"Ayuda-Dur\u00e1n","year":"2020","journal-title":"Molecules"},{"key":"D3FO03732K\/cit30\/1","doi-asserted-by":"crossref","first-page":"130051","DOI":"10.1016\/j.jhazmat.2022.130051","volume":"442","author":"Li","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"D3FO03732K\/cit31\/1","doi-asserted-by":"crossref","first-page":"dev199687","DOI":"10.1242\/dev.199687","volume":"148","author":"Tekieli","year":"2021","journal-title":"Development"},{"key":"D3FO03732K\/cit32\/1","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1111\/jnc.15164","volume":"158","author":"Treinin","year":"2021","journal-title":"J. Neurochem."},{"key":"D3FO03732K\/cit33\/1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41586-020-2395-5","volume":"583","author":"O'Donnell","year":"2020","journal-title":"Nature"},{"key":"D3FO03732K\/cit34\/1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00508-012-0221-2","volume":"125","author":"Jie","year":"2013","journal-title":"Wien. Klin. Wochenschr."},{"key":"D3FO03732K\/cit35\/1","doi-asserted-by":"crossref","first-page":"125230","DOI":"10.1016\/j.jhazmat.2021.125230","volume":"412","author":"Li","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"D3FO03732K\/cit36\/1","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/j.scitotenv.2017.07.088","volume":"607\u2013608","author":"Zhao","year":"2017","journal-title":"Sci. Total Environ."},{"key":"D3FO03732K\/cit37\/1","doi-asserted-by":"crossref","first-page":"112494","DOI":"10.1016\/j.ecoenv.2021.112494","volume":"222","author":"Zhang","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"D3FO03732K\/cit38\/1","doi-asserted-by":"crossref","first-page":"117554","DOI":"10.1016\/j.envpol.2021.117554","volume":"287","author":"Li","year":"2021","journal-title":"Environ. Pollut."},{"issue":"3","key":"D3FO03732K\/cit39\/1","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3390\/biom12030342","volume":"12","author":"Larigot","year":"2022","journal-title":"Biomolecules"},{"key":"D3FO03732K\/cit40\/1","first-page":"172","volume":"2","author":"Imanikia","year":"2015","journal-title":"Biochem. Biophys. Rep."},{"key":"D3FO03732K\/cit41\/1","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1007\/s00204-022-03382-3","volume":"96","author":"Lim","year":"2022","journal-title":"Arch. Toxicol."},{"key":"D3FO03732K\/cit42\/1","doi-asserted-by":"crossref","first-page":"552","DOI":"10.3389\/fimmu.2022.840272","volume":"13","author":"Mello","year":"2022","journal-title":"Front. Immunol."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2023\/FO\/D3FO03732K","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:34:09Z","timestamp":1782851649000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/fo\/article\/14\/22\/10031-10040\/809628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":42,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2023,11,13]]}},"URL":"https:\/\/doi.org\/10.1039\/d3fo03732k","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}