{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T03:04:20Z","timestamp":1784603060060,"version":"3.55.0"},"reference-count":34,"publisher":"Royal Society of Chemistry (RSC)","issue":"6","license":[{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"am","delay-in-days":409,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22104093"],"award-info":[{"award-number":["22104093"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22234006"],"award-info":[{"award-number":["22234006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009019","name":"Shenzhen University","doi-asserted-by":"publisher","award":["86901-00000221"],"award-info":[{"award-number":["86901-00000221"]}],"id":[{"id":"10.13039\/501100009019","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Lab Chip"],"abstract":"<jats:p>An ultratrace microRNA detection platform that combines a minipillar array with an aqueous two-phase system to achieve a significant increase in target concentration in microliter droplets.<\/jats:p>","DOI":"10.1039\/d3lc00953j","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T20:41:10Z","timestamp":1707770470000},"page":"1775-1781","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Integrated phase separation in microliter droplets for ultratrace-enriching biomarker analysis"],"prefix":"10.1039","volume":"24","author":[{"given":"Qihao","family":"Zha","sequence":"first","affiliation":[{"name":"College of Chemistry and Environmental Engineering, The Institute for Advanced Study (IAS), Shenzhen University, Shenzhen, Guangdong, 518055, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9867-094X","authenticated-orcid":false,"given":"Yong","family":"Luo","sequence":"additional","affiliation":[{"name":"College of Chemistry and Environmental Engineering, The Institute for Advanced Study (IAS), Shenzhen University, Shenzhen, Guangdong, 518055, P. R. China"},{"name":"Beijing Key Laboratory for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, 100083, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4873-8277","authenticated-orcid":false,"given":"Conghui","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Environmental Engineering, The Institute for Advanced Study (IAS), Shenzhen University, Shenzhen, Guangdong, 518055, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4037-2856","authenticated-orcid":false,"given":"Tailin","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Chemistry and Environmental Engineering, The Institute for Advanced Study (IAS), Shenzhen University, Shenzhen, Guangdong, 518055, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2024]]},"reference":[{"key":"D3LC00953J\/cit1\/1","doi-asserted-by":"crossref","first-page":"16065","DOI":"10.1021\/acsami.9b02947","volume":"11","author":"Kumar","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D3LC00953J\/cit2\/1","doi-asserted-by":"crossref","first-page":"114297","DOI":"10.1016\/j.bios.2022.114297","volume":"210","author":"Luo","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"D3LC00953J\/cit3\/1","first-page":"220904","volume":"35","author":"Hou","year":"2023","journal-title":"Adv. Mater."},{"key":"D3LC00953J\/cit4\/1","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1007\/s00216-008-2570-2","volume":"394","author":"Li","year":"2009","journal-title":"Anal. Bioanal. Chem."},{"key":"D3LC00953J\/cit5\/1","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.ymeth.2010.01.026","volume":"50","author":"Benes","year":"2010","journal-title":"Methods"},{"key":"D3LC00953J\/cit6\/1","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1261\/rna.2533811","volume":"17","author":"Torres","year":"2011","journal-title":"RNA"},{"key":"D3LC00953J\/cit7\/1","doi-asserted-by":"crossref","first-page":"7816","DOI":"10.1021\/acs.analchem.0c01011","volume":"92","author":"Xu","year":"2020","journal-title":"Anal. Chem."},{"key":"D3LC00953J\/cit8\/1","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1002\/anie.201913069","volume":"59","author":"Gnanamani","year":"2020","journal-title":"Angew. Chem., Int. Ed."},{"key":"D3LC00953J\/cit9\/1","doi-asserted-by":"crossref","first-page":"nwad106","DOI":"10.1093\/nsr\/nwad106","author":"Song","year":"2023","journal-title":"Natl. Sci. Rev."},{"key":"D3LC00953J\/cit10\/1","doi-asserted-by":"crossref","first-page":"111845","DOI":"10.1016\/j.bios.2019.111845","volume":"149","author":"Song","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"D3LC00953J\/cit11\/1","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1021\/acs.analchem.2c00008","volume":"94","author":"Zhou","year":"2022","journal-title":"Anal. Chem."},{"key":"D3LC00953J\/cit12\/1","doi-asserted-by":"crossref","first-page":"1910329","DOI":"10.1002\/adfm.201910329","volume":"30","author":"Song","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"D3LC00953J\/cit13\/1","doi-asserted-by":"crossref","first-page":"100767","DOI":"10.1016\/j.mtchem.2021.100767","volume":"23","author":"Fan","year":"2022","journal-title":"Mater. Today Chem."},{"key":"D3LC00953J\/cit14\/1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s00604-022-05199-4","volume":"189","author":"Liu","year":"2022","journal-title":"Microchim. Acta"},{"key":"D3LC00953J\/cit15\/1","doi-asserted-by":"crossref","first-page":"3879","DOI":"10.1016\/j.cclet.2021.12.059","volume":"33","author":"Song","year":"2022","journal-title":"Chin. Chem. Lett."},{"key":"D3LC00953J\/cit16\/1","doi-asserted-by":"crossref","first-page":"2200817","DOI":"10.1002\/admi.202200817","volume":"9","author":"Zhang","year":"2022","journal-title":"Adv. Mater. Interfaces"},{"key":"D3LC00953J\/cit17\/1","doi-asserted-by":"crossref","first-page":"114903","DOI":"10.1016\/j.bios.2022.114903","volume":"220","author":"Zhou","year":"2023","journal-title":"Biosens. Bioelectron."},{"key":"D3LC00953J\/cit18\/1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1039\/C9CS00466A","volume":"49","author":"Chao","year":"2020","journal-title":"Chem. Soc. Rev."},{"key":"D3LC00953J\/cit19\/1","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1039\/C1LC20569B","volume":"12","author":"Hardt","year":"2012","journal-title":"Lab Chip"},{"key":"D3LC00953J\/cit20\/1","doi-asserted-by":"crossref","first-page":"10383","DOI":"10.1021\/ja504078b","volume":"136","author":"Ao","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"D3LC00953J\/cit21\/1","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.biortech.2018.07.138","volume":"270","author":"Chang","year":"2018","journal-title":"Bioresour. Technol."},{"key":"D3LC00953J\/cit22\/1","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.cej.2017.10.085","volume":"335","author":"Meng","year":"2018","journal-title":"Chem. Eng. J."},{"key":"D3LC00953J\/cit23\/1","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1080\/10408398.2018.1486283","volume":"59","author":"Khan","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"D3LC00953J\/cit24\/1","doi-asserted-by":"crossref","first-page":"55467","DOI":"10.1021\/acsami.0c16968","volume":"12","author":"Seo","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D3LC00953J\/cit25\/1","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1021\/acsnano.2c06007","volume":"17","author":"Minagawa","year":"2022","journal-title":"ACS Nano"},{"key":"D3LC00953J\/cit26\/1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.bios.2018.12.041","volume":"128","author":"Tian","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"D3LC00953J\/cit27\/1","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.bios.2018.11.028","volume":"126","author":"Zhou","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"D3LC00953J\/cit28\/1","doi-asserted-by":"crossref","first-page":"8577","DOI":"10.1021\/acs.analchem.1c01419","volume":"93","author":"Chen","year":"2021","journal-title":"Anal. Chem."},{"key":"D3LC00953J\/cit29\/1","doi-asserted-by":"crossref","first-page":"4141","DOI":"10.1039\/D0CS00609B","volume":"50","author":"Jet","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"D3LC00953J\/cit30\/1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0927-7757(03)00354-6","volume":"226","author":"Zeng","year":"2003","journal-title":"Colloids Surf., A"},{"key":"D3LC00953J\/cit31\/1","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/nchem.1466","volume":"4","author":"Strulson","year":"2012","journal-title":"Nat. Chem."},{"key":"D3LC00953J\/cit32\/1","doi-asserted-by":"crossref","first-page":"116143","DOI":"10.1016\/j.trac.2020.116143","volume":"134","author":"Bidar","year":"2021","journal-title":"TrAC, Trends Anal. Chem."},{"key":"D3LC00953J\/cit33\/1","doi-asserted-by":"crossref","first-page":"111848","DOI":"10.1016\/j.bios.2019.111848","volume":"149","author":"Xu","year":"2020","journal-title":"Biosens. Bioelectron."},{"key":"D3LC00953J\/cit34\/1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13578-016-0071-0","volume":"6","author":"Fu","year":"2016","journal-title":"Cell Biosci."}],"container-title":["Lab on a Chip"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/LC\/D3LC00953J","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:33:45Z","timestamp":1783013625000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/lc\/article\/24\/6\/1775-1781\/811844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,3,12]]}},"URL":"https:\/\/doi.org\/10.1039\/d3lc00953j","relation":{},"ISSN":["1473-0197","1473-0189"],"issn-type":[{"value":"1473-0197","type":"print"},{"value":"1473-0189","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}