{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:07:12Z","timestamp":1782929232807,"version":"3.54.5"},"reference-count":36,"publisher":"Royal Society of Chemistry (RSC)","issue":"1","license":[{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/100018866","name":"Paula and Rodger Riney Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018866","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Med. Chem."],"abstract":"<jats:p>\n                    Increasing activity against TAK1\n                    <jats:italic>via<\/jats:italic>\n                    \u201cmagic\u201d methylation or cyclopropylation.\n                  <\/jats:p>","DOI":"10.1039\/d3md00415e","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T11:29:57Z","timestamp":1701170997000},"page":"178-192","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Discovery of imidazo[1,2-\n                    <i>b<\/i>\n                    ]pyridazine-containing TAK1 kinase inhibitors with excellent activities against multiple myeloma"],"prefix":"10.1039","volume":"15","author":[{"given":"Desmond","family":"Akwata","sequence":"first","affiliation":[{"name":"Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6856-5147","authenticated-orcid":false,"given":"Allison L.","family":"Kempen","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jones","family":"Lamptey","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neetu","family":"Dayal","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5349-2321","authenticated-orcid":false,"given":"Nickolas R.","family":"Brauer","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2280-9359","authenticated-orcid":false,"given":"Herman O.","family":"Sintim","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA"},{"name":"Purdue Institute for Drug Discovery, 720 Clinic Drive, West Lafayette, IN 47907, USA"},{"name":"Purdue Institute for Cancer Research, 201 S. University St., West Lafayette, IN 47907, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2024]]},"reference":[{"key":"D3MD00415E\/cit1\/1","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/ajh.25791","volume":"95","author":"Rajkumar","year":"2020","journal-title":"Am. J. Hematol."},{"key":"D3MD00415E\/cit2\/1","doi-asserted-by":"crossref","first-page":"5419","DOI":"10.1158\/1078-0432.CCR-16-0625","volume":"22","author":"Palumbo","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"D3MD00415E\/cit3\/1","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3816\/CLM.2005.n.035","volume":"6","author":"Wu","year":"2005","journal-title":"Clin. Lymphoma Myeloma"},{"key":"D3MD00415E\/cit4\/1","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1182\/asheducation-2005.1.353","volume":"1","author":"Reece","year":"2005","journal-title":"Hematology Am. Soc. Hematol. Educ. Program"},{"key":"D3MD00415E\/cit5\/1","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.3390\/ijms23031649","volume":"23","author":"Raab","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"D3MD00415E\/cit6\/1","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.4065\/80.10.1371","volume":"80","author":"Rajkumar","year":"2005","journal-title":"Mayo Clin. Proc."},{"key":"D3MD00415E\/cit7\/1","doi-asserted-by":"crossref","first-page":"3992","DOI":"10.1182\/blood-2006-05-026112","volume":"108","author":"Giuliani","year":"2006","journal-title":"Blood"},{"key":"D3MD00415E\/cit8\/1","first-page":"3071","volume":"61","author":"Hideshima","year":"2001","journal-title":"Cancer Res."},{"key":"D3MD00415E\/cit9\/1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10495-018-1490-7","volume":"24","author":"Aashaq","year":"2019","journal-title":"Apoptosis"},{"key":"D3MD00415E\/cit10\/1","doi-asserted-by":"crossref","first-page":"5529","DOI":"10.1128\/MCB.00375-09","volume":"29","author":"Nishimura","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"D3MD00415E\/cit11\/1","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1146\/annurev.biochem.78.070907.102750","volume":"78","author":"Skaug","year":"2009","journal-title":"Annu. Rev. Biochem."},{"key":"D3MD00415E\/cit12\/1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.it.2013.03.007","volume":"34","author":"Ajibade","year":"2013","journal-title":"Trends Immunol."},{"key":"D3MD00415E\/cit13\/1","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1038\/sj.onc.1210413","volume":"26","author":"Adhikari","year":"2007","journal-title":"Oncogene"},{"key":"D3MD00415E\/cit14\/1","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.tips.2012.06.007","volume":"33","author":"Sakurai","year":"2012","journal-title":"Trends Pharmacol. Sci."},{"key":"D3MD00415E\/cit15\/1","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1038\/celldisc.2017.23","volume":"3","author":"Li","year":"2017","journal-title":"Cell Discovery"},{"key":"D3MD00415E\/cit16\/1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.5694\/mja2.50129","volume":"210","author":"Niesvizky","year":"2019","journal-title":"Med. J. Aust."},{"key":"D3MD00415E\/cit17\/1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bbadis.2008.01.006","volume":"1782","author":"Gordon","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"D3MD00415E\/cit18\/1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.5694\/mja2.50129","volume":"210","author":"Joshua","year":"2019","journal-title":"Med. J. Aust."},{"key":"D3MD00415E\/cit19\/1","doi-asserted-by":"crossref","first-page":"19478","DOI":"10.1073\/pnas.0609329103","volume":"103","author":"Podar","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D3MD00415E\/cit20\/1","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.3324\/haematol.2019.234476","volume":"106","author":"Teramachi","year":"2021","journal-title":"Haematologica"},{"key":"D3MD00415E\/cit21\/1","doi-asserted-by":"crossref","first-page":"4441","DOI":"10.3390\/cancers13174441","volume":"13","author":"Harada","year":"2021","journal-title":"Cancers"},{"key":"D3MD00415E\/cit22\/1","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.chembiol.2017.07.011","volume":"24","author":"Totzke","year":"2017","journal-title":"Cell Chem. Biol."},{"key":"D3MD00415E\/cit23\/1","doi-asserted-by":"crossref","first-page":"e1767","DOI":"10.1038\/cddis.2015.130","volume":"6","author":"Fauster","year":"2015","journal-title":"Cell Death Dis."},{"key":"D3MD00415E\/cit24\/1","doi-asserted-by":"crossref","first-page":"113867","DOI":"10.1016\/j.ejmech.2021.113867","volume":"226","author":"Garrido","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"D3MD00415E\/cit25\/1","first-page":"281","volume":"7","author":"Al-Ghorbani","year":"2015","journal-title":"J. Chem. Pharm. Res."},{"key":"D3MD00415E\/cit26\/1","doi-asserted-by":"crossref","first-page":"10257","DOI":"10.1021\/jm501100b","volume":"57","author":"Vitaku","year":"2014","journal-title":"J. Med. Chem."},{"key":"D3MD00415E\/cit27\/1","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1089\/adt.2009.0222","volume":"7","author":"Zegzouti","year":"2009","journal-title":"Assay Drug Dev. Technol."},{"key":"D3MD00415E\/cit28\/1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ddtec.2004.11.007","volume":"1","author":"Lipinski","year":"2004","journal-title":"Drug Discovery Today: Technol."},{"key":"D3MD00415E\/cit29\/1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.2174\/0929867053363540","volume":"12","author":"Lima","year":"2005","journal-title":"Curr. Med. Chem."},{"key":"D3MD00415E\/cit30\/1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s10593-012-0960-z","volume":"48","author":"Gomtsyan","year":"2012","journal-title":"Chem. Heterocycl. Compd."},{"key":"D3MD00415E\/cit31\/1","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.2174\/092986712801323225","volume":"19","author":"Chen","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"D3MD00415E\/cit32\/1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s12551-021-00795-9","volume":"13","author":"Ovung","year":"2021","journal-title":"Biophys. Rev."},{"key":"D3MD00415E\/cit33\/1","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1021\/acschemneuro.0c00729","volume":"12","author":"Lenci","year":"2021","journal-title":"ACS Chem. Neurosci."},{"key":"D3MD00415E\/cit34\/1","doi-asserted-by":"crossref","first-page":"103578","DOI":"10.1016\/j.bioorg.2020.103578","volume":"96","author":"Kumari","year":"2020","journal-title":"Bioorg. Chem."},{"key":"D3MD00415E\/cit35\/1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1002\/med.21634","volume":"40","author":"Kourounakis","year":"2020","journal-title":"Med. Res. Rev."},{"key":"D3MD00415E\/cit36\/1","doi-asserted-by":"crossref","first-page":"24226","DOI":"10.1074\/jbc.M114.559963","volume":"289","author":"Ouyang","year":"2014","journal-title":"J. Biol. Chem."}],"container-title":["RSC Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/MD\/D3MD00415E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:28:24Z","timestamp":1782926904000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/md\/article\/15\/1\/178-192\/813034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1,25]]}},"URL":"https:\/\/doi.org\/10.1039\/d3md00415e","relation":{},"ISSN":["2632-8682"],"issn-type":[{"value":"2632-8682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}