{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:24:32Z","timestamp":1791415472794,"version":"4.3.3"},"reference-count":361,"publisher":"Royal Society of Chemistry (RSC)","issue":"1","license":[{"start":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T00:00:00Z","timestamp":1728777600000},"content-version":"am","delay-in-days":286,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Med. Chem."],"abstract":"<jats:p>A review on the discovery of relevant SARS-CoV-2 main protease inhibitors along with insights into their origins as well as on which adopted strategies actually delivered and which did not.<\/jats:p>","DOI":"10.1039\/d3md00493g","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T12:21:15Z","timestamp":1697199675000},"page":"81-118","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["On the origins of SARS-CoV-2 main protease inhibitors"],"prefix":"10.1039","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3019-9842","authenticated-orcid":false,"given":"Yves L.","family":"Janin","sequence":"first","affiliation":[{"name":"Structure et Instabilit\u00e9 des G\u00e9nomes (StrInG), Mus\u00e9um National d'Histoire Naturelle, INSERM, CNRS, Alliance Sorbonne Universit\u00e9, 75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2024]]},"reference":[{"key":"D3MD00493G\/cit1\/1","first-page":"e21573","volume":"35","author":"Yan","year":"2021","journal-title":"FASEB J."},{"key":"D3MD00493G\/cit2\/1","doi-asserted-by":"crossref","first-page":"127377","DOI":"10.1016\/j.bmcl.2020.127377","volume":"30","author":"Ullrich","year":"2020","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D3MD00493G\/cit3\/1","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.001558","volume":"102","author":"Roe","year":"2021","journal-title":"J. Gen. Virol."},{"key":"D3MD00493G\/cit4\/1","doi-asserted-by":"crossref","first-page":"5089","DOI":"10.1111\/febs.15696","volume":"288","author":"Chen","year":"2021","journal-title":"FEBS J."},{"key":"D3MD00493G\/cit5\/1","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1099\/0022-1317-83-3-595","volume":"83","author":"Hegyi","year":"2002","journal-title":"J. Gen. Virol."},{"key":"D3MD00493G\/cit6\/1","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1002\/med.21783","volume":"41","author":"Xiong","year":"2021","journal-title":"Med. Res. Rev."},{"key":"D3MD00493G\/cit7\/1","doi-asserted-by":"crossref","first-page":"5196","DOI":"10.1038\/s41467-022-32854-4","volume":"13","author":"Lee","year":"2022","journal-title":"Nat. Commun."},{"key":"D3MD00493G\/cit8\/1","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1038\/s41593-021-00926-1","volume":"24","author":"Wenzel","year":"2021","journal-title":"Nat. Neurosci."},{"issue":"7","key":"D3MD00493G\/cit9\/1","doi-asserted-by":"crossref","first-page":"102990","DOI":"10.1016\/j.jbc.2023.102990","volume":"7","author":"Song","year":"2023","journal-title":"J. Biol. Chem."},{"key":"D3MD00493G\/cit10\/1","doi-asserted-by":"crossref","first-page":"mjad024","DOI":"10.1093\/jmcb\/mjad024","volume":"15","author":"Lu","year":"2023","journal-title":"J. Mol. Cell Biol."},{"key":"D3MD00493G\/cit11\/1","doi-asserted-by":"crossref","first-page":"104831","DOI":"10.1016\/j.jbc.2023.104831","volume":"299","author":"Zhao","year":"2023","journal-title":"J. Biol. Chem."},{"key":"D3MD00493G\/cit12\/1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.4161\/viru.27902","volume":"5","author":"Devasthanam","year":"2014","journal-title":"Virulence"},{"key":"D3MD00493G\/cit13\/1","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41392-023-01630-1","volume":"8","author":"Li","year":"2023","journal-title":"Signal Transduction Targeted Ther."},{"key":"D3MD00493G\/cit14\/1","doi-asserted-by":"crossref","first-page":"1251705","DOI":"10.3389\/fmicb.2023.1251705","volume":"14","author":"Melano","year":"2023","journal-title":"Front. Microbiol."},{"key":"D3MD00493G\/cit15\/1","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/s41467-020-20718-8","volume":"12","author":"Fu","year":"2021","journal-title":"Nat. Commun."},{"key":"D3MD00493G\/cit16\/1","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1021\/acscentsci.1c00519","volume":"7","author":"Ma","year":"2021","journal-title":"ACS Cent. Sci."},{"key":"D3MD00493G\/cit17\/1","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1002\/cmdc.202000223","volume":"15","author":"Ghosh","year":"2020","journal-title":"ChemMedChem"},{"key":"D3MD00493G\/cit18\/1","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1002\/jmv.26814","volume":"93","author":"Anirudhan","year":"2021","journal-title":"J. Med. Virol."},{"key":"D3MD00493G\/cit19\/1","doi-asserted-by":"crossref","first-page":"7561","DOI":"10.1021\/acs.jmedchem.2c00303","volume":"65","author":"Tan","year":"2022","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit20\/1","doi-asserted-by":"crossref","first-page":"e202300216","DOI":"10.1002\/cmdc.202300216","author":"Chia","year":"2023","journal-title":"ChemMedChem"},{"key":"D3MD00493G\/cit21\/1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/1348-0421.12945","volume":"66","author":"Takeda","year":"2022","journal-title":"Microbiol. Immunol."},{"key":"D3MD00493G\/cit22\/1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41580-021-00418-x","volume":"1","author":"Jackson","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"D3MD00493G\/cit23\/1","doi-asserted-by":"crossref","first-page":"e2024420118","DOI":"10.1073\/pnas.2024420118","volume":"118","author":"Ma","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D3MD00493G\/cit24\/1","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1021\/acsinfecdis.0c00815","volume":"7","author":"Steuten","year":"2021","journal-title":"ACS Infect. Dis."},{"key":"D3MD00493G\/cit25\/1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.bbrc.2021.03.096","volume":"555","author":"Vandyck","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"D3MD00493G\/cit26\/1","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1021\/acsptsci.0c00130","volume":"3","author":"Ma","year":"2020","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"D3MD00493G\/cit27\/1","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1016\/j.apsb.2021.10.026","volume":"12","author":"Ma","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"D3MD00493G\/cit28\/1","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1007\/s00044-022-02903-0","volume":"31","author":"Tan","year":"2022","journal-title":"Med. Chem. Res."},{"key":"D3MD00493G\/cit29\/1","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1021\/acschembio.0c00875","volume":"16","author":"Mellott","year":"2021","journal-title":"ACS Chem. Biol."},{"key":"D3MD00493G\/cit30\/1","doi-asserted-by":"crossref","first-page":"5502","DOI":"10.1128\/JVI.00128-13","volume":"87","author":"Gierer","year":"2013","journal-title":"J. Virol."},{"key":"D3MD00493G\/cit31\/1","doi-asserted-by":"crossref","first-page":"12552","DOI":"10.1128\/JVI.01890-13","volume":"87","author":"Shirato","year":"2013","journal-title":"J. Virol."},{"key":"D3MD00493G\/cit32\/1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","volume":"181","author":"Hoffmann","year":"2020","journal-title":"Cell"},{"key":"D3MD00493G\/cit33\/1","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1186\/s12916-022-02518-7","volume":"20","author":"Kinoshita","year":"2022","journal-title":"BMC Med."},{"key":"D3MD00493G\/cit34\/1","doi-asserted-by":"crossref","first-page":"6532","DOI":"10.1128\/AAC.01043-16","volume":"60","author":"Yamamoto","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"D3MD00493G\/cit35\/1","doi-asserted-by":"crossref","first-page":"103856","DOI":"10.1016\/j.ebiom.2022.103856","volume":"76","author":"Quinn","year":"2022","journal-title":"EBioMedicine"},{"key":"D3MD00493G\/cit36\/1","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.febslet.2008.12.059","volume":"583","author":"Kuo","year":"2009","journal-title":"FEBS Lett."},{"key":"D3MD00493G\/cit37\/1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S1367-5931(02)00345-9","volume":"6","author":"Hernandez","year":"2002","journal-title":"Curr. Opin. Chem. Biol."},{"key":"D3MD00493G\/cit38\/1","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/med.10067","volume":"24","author":"Shih","year":"2004","journal-title":"Med. Res. Rev."},{"key":"D3MD00493G\/cit39\/1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2174\/138920307779941523","volume":"8","author":"Wanga","year":"2007","journal-title":"Curr. Protein Pept. Sci."},{"key":"D3MD00493G\/cit40\/1","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1002\/med.20125","volume":"28","author":"De Palma","year":"2008","journal-title":"Med. Res. Rev."},{"key":"D3MD00493G\/cit41\/1","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1021\/acs.jmedchem.0c02258","volume":"65","author":"Dai","year":"2022","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit42\/1","doi-asserted-by":"crossref","first-page":"4085","DOI":"10.1111\/febs.12936","author":"Hilgenfeld","year":"2014","journal-title":"FEBS J."},{"key":"D3MD00493G\/cit43\/1","doi-asserted-by":"crossref","first-page":"6595","DOI":"10.1021\/acs.jmedchem.5b01461","volume":"59","author":"Pillaiyar","year":"2016","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit44\/1","doi-asserted-by":"crossref","first-page":"6595","DOI":"10.1021\/acs.jmedchem.5b01461","volume":"59","author":"Thanigaimalai","year":"2016","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit45\/1","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3390\/v10120721","volume":"10","author":"Liang","year":"2018","journal-title":"Viruses"},{"key":"D3MD00493G\/cit46\/1","doi-asserted-by":"crossref","first-page":"112711","DOI":"10.1016\/j.ejmech.2020.112711","volume":"206","author":"Liu","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"D3MD00493G\/cit47\/1","doi-asserted-by":"crossref","first-page":"3920","DOI":"10.3390\/molecules25173920","volume":"25","author":"Akaji","year":"2020","journal-title":"Molecules"},{"key":"D3MD00493G\/cit48\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/rmv.2206","volume":"31","author":"Ng","year":"2021","journal-title":"Rev. Med. Virol."},{"key":"D3MD00493G\/cit49\/1","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.drudis.2020.12.005","volume":"26","author":"Banerjee","year":"2021","journal-title":"Drug Discovery Today"},{"key":"D3MD00493G\/cit50\/1","doi-asserted-by":"crossref","first-page":"16922","DOI":"10.1021\/acs.jmedchem.1c00409","volume":"64","author":"Gao","year":"2021","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit51\/1","doi-asserted-by":"crossref","first-page":"607","DOI":"10.3390\/biom11040607","volume":"11","author":"Citarella","year":"2021","journal-title":"Biomolecules"},{"key":"D3MD00493G\/cit52\/1","doi-asserted-by":"crossref","first-page":"113294","DOI":"10.1016\/j.ejmech.2021.113294","volume":"215","author":"Amin","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"D3MD00493G\/cit53\/1","doi-asserted-by":"crossref","first-page":"131761","DOI":"10.1016\/j.tet.2020.131761","volume":"77","author":"Konwar","year":"2021","journal-title":"Tetrahedron"},{"key":"D3MD00493G\/cit54\/1","doi-asserted-by":"crossref","first-page":"622898","DOI":"10.3389\/fchem.2021.622898","volume":"9","author":"Mengist","year":"2021","journal-title":"Front. Chem."},{"key":"D3MD00493G\/cit55\/1","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1039\/D1MD00066G","volume":"12","author":"Yang","year":"2021","journal-title":"RSC Med. Chem."},{"key":"D3MD00493G\/cit56\/1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.3390\/ijms23010259","volume":"23","author":"Macip","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"D3MD00493G\/cit57\/1","doi-asserted-by":"crossref","first-page":"961","DOI":"10.3390\/v14050961","volume":"14","author":"Ng","year":"2022","journal-title":"Viruses"},{"key":"D3MD00493G\/cit58\/1","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1021\/acs.jmedchem.0c01140","volume":"65","author":"Cannalire","year":"2022","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit59\/1","doi-asserted-by":"crossref","first-page":"e151","DOI":"10.1002\/mco2.151","volume":"3","author":"Hu","year":"2022","journal-title":"MedComm"},{"key":"D3MD00493G\/cit60\/1","doi-asserted-by":"crossref","first-page":"e202100576","DOI":"10.1002\/cmdc.202100576","volume":"17","author":"Chia","year":"2022","journal-title":"ChemMedChem"},{"key":"D3MD00493G\/cit61\/1","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.3390\/molecules27082523","volume":"27","author":"Agost-Beltr\u00e1n","year":"2022","journal-title":"Molecules"},{"key":"D3MD00493G\/cit62\/1","doi-asserted-by":"crossref","first-page":"12500","DOI":"10.1021\/acs.jmedchem.2c01005","volume":"65","author":"La Monica","year":"2022","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit63\/1","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1007\/s00044-022-02951-6","volume":"31","author":"Joyce","year":"2022","journal-title":"Med. Chem. Res."},{"key":"D3MD00493G\/cit64\/1","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.2147\/DDDT.S359009","volume":"16","author":"Zhu","year":"2022","journal-title":"Drug Des., Dev. Ther."},{"key":"D3MD00493G\/cit65\/1","doi-asserted-by":"crossref","first-page":"101159","DOI":"10.1016\/j.mam.2022.101159","volume":"88","author":"Majerov\u00e1","year":"2022","journal-title":"Mol. Aspects Med."},{"key":"D3MD00493G\/cit66\/1","doi-asserted-by":"crossref","first-page":"115491","DOI":"10.1016\/j.ejmech.2023.115491","volume":"257","author":"Pang","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"D3MD00493G\/cit67\/1","doi-asserted-by":"crossref","first-page":"103579","DOI":"10.1016\/j.drudis.2023.103579","volume":"28","author":"Kronenberger","year":"2023","journal-title":"Drug Discovery Today"},{"key":"D3MD00493G\/cit68\/1","doi-asserted-by":"crossref","first-page":"115503","DOI":"10.1016\/j.ejmech.2023.115503","volume":"257","author":"Yang","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"D3MD00493G\/cit69\/1","doi-asserted-by":"crossref","first-page":"102667","DOI":"10.1016\/j.sbi.2023.102667","volume":"82","author":"Duan","year":"2023","journal-title":"Curr. Opin. Struct. Biol."},{"key":"D3MD00493G\/cit70\/1","doi-asserted-by":"crossref","first-page":"115772","DOI":"10.1016\/j.ejmech.2023.115772","volume":"260","author":"Li","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"D3MD00493G\/cit71\/1","doi-asserted-by":"crossref","first-page":"9121","DOI":"10.1039\/D0CS01065K","volume":"50","author":"Muratov","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"D3MD00493G\/cit72\/1","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/med.21862","volume":"42","author":"Macip","year":"2021","journal-title":"Med. Res. Rev."},{"key":"D3MD00493G\/cit73\/1","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1021\/jm010533y","volume":"45","author":"McGovern","year":"2002","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit74\/1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/513481a","volume":"513","author":"Baell","year":"2014","journal-title":"Nature"},{"key":"D3MD00493G\/cit75\/1","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1021\/cb500086e","volume":"9","author":"Ingolfsson","year":"2014","journal-title":"ACS Chem. Biol."},{"key":"D3MD00493G\/cit76\/1","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1021\/acs.jmedchem.5b01009","volume":"59","author":"Bisson","year":"2016","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit77\/1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1021\/acschembio.7b00903","volume":"13","author":"Baell","year":"2018","journal-title":"ACS Chem. Biol."},{"key":"D3MD00493G\/cit78\/1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1021\/acsmedchemlett.5b00032","volume":"6","author":"Baell","year":"2015","journal-title":"ACS Med. Chem. Lett."},{"key":"D3MD00493G\/cit79\/1","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1021\/acs.jnatprod.3c00165","volume":"86","author":"McAlpine","year":"2023","journal-title":"J. Nat. Prod."},{"key":"D3MD00493G\/cit80\/1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1146\/annurev-pharmtox-010818-021625","volume":"59","author":"Parrish","year":"2019","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"D3MD00493G\/cit81\/1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1039\/D0MD00282H","volume":"12","author":"Franco","year":"2020","journal-title":"RSC Med. Chem."},{"key":"D3MD00493G\/cit82\/1","doi-asserted-by":"crossref","first-page":"127990","DOI":"10.1016\/j.bmcl.2021.127990","volume":"41","author":"Zhang","year":"2021","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D3MD00493G\/cit83\/1","doi-asserted-by":"crossref","first-page":"15960","DOI":"10.1039\/D1SC05579H","volume":"12","author":"Gentile","year":"2021","journal-title":"Chem. Sci."},{"key":"D3MD00493G\/cit84\/1","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1126\/science.abf7945","volume":"372","author":"G\u00fcnther","year":"2021","journal-title":"Science"},{"key":"D3MD00493G\/cit85\/1","doi-asserted-by":"crossref","first-page":"12526","DOI":"10.1080\/07391102.2021.1972041","volume":"40","author":"Zheng","year":"2022","journal-title":"J. Biomol. Struct. Dyn."},{"key":"D3MD00493G\/cit86\/1","doi-asserted-by":"crossref","first-page":"114803","DOI":"10.1016\/j.ejmech.2022.114803","volume":"244","author":"Wang","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"D3MD00493G\/cit87\/1","doi-asserted-by":"crossref","first-page":"128867","DOI":"10.1016\/j.bmcl.2022.128867","volume":"72","author":"Deodato","year":"2022","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D3MD00493G\/cit88\/1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1021\/acsptsci.2c00026","volume":"5","author":"Glaser","year":"2022","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"D3MD00493G\/cit89\/1","doi-asserted-by":"crossref","first-page":"4590","DOI":"10.1021\/acs.jmedchem.1c01372","volume":"65","author":"Xu","year":"2022","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit90\/1","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1039\/D1SC05892D","volume":"13","author":"El Khoury","year":"2022","journal-title":"Chem. Sci."},{"key":"D3MD00493G\/cit91\/1","doi-asserted-by":"crossref","first-page":"e4712","DOI":"10.1002\/pro.4712","volume":"32","author":"Fink","year":"2023","journal-title":"Protein Sci."},{"key":"D3MD00493G\/cit92\/1","doi-asserted-by":"crossref","first-page":"11390","DOI":"10.3390\/ijms241411390","volume":"24","author":"Liu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"D3MD00493G\/cit93\/1","doi-asserted-by":"crossref","first-page":"5047","DOI":"10.1038\/s41467-020-18709-w","volume":"11","author":"Douangamath","year":"2020","journal-title":"Nat. Commun."},{"key":"D3MD00493G\/cit95\/1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1021\/acs.jmedchem.9b01180","volume":"63","author":"Lanman","year":"2020","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit96\/1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/s41586-019-1694-1","volume":"575","author":"Canon","year":"2019","journal-title":"Nature"},{"key":"D3MD00493G\/cit97\/1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/s41586-023-06123-3","volume":"619","author":"Kim","year":"2023","journal-title":"Nature"},{"key":"D3MD00493G\/cit98\/1","doi-asserted-by":"crossref","first-page":"4639","DOI":"10.1021\/cr010182v","volume":"102","author":"Powers","year":"2002","journal-title":"Chem. Rev."},{"key":"D3MD00493G\/cit99\/1","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/nrd2092","volume":"5","author":"Turk","year":"2006","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D3MD00493G\/cit100\/1","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/bip.22780","volume":"106","author":"Hamada","year":"2016","journal-title":"Biopolymers"},{"key":"D3MD00493G\/cit101\/1","doi-asserted-by":"crossref","first-page":"10497","DOI":"10.1021\/acs.jmedchem.9b00683","volume":"62","author":"Cianni","year":"2019","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit102\/1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1124\/jpet.106.111344","volume":"321","author":"Wannamaker","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"D3MD00493G\/cit103\/1","doi-asserted-by":"crossref","first-page":"12546","DOI":"10.1021\/acs.chemrev.5b00434","volume":"115","author":"Poreba","year":"2015","journal-title":"Chem. Rev."},{"key":"D3MD00493G\/cit105\/1","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/cmdc.200900531","volume":"5","author":"Boxer","year":"2010","journal-title":"ChemMedChem"},{"key":"D3MD00493G\/cit110\/1","doi-asserted-by":"crossref","first-page":"4805","DOI":"10.1016\/j.tet.2018.07.029","volume":"74","author":"Chambon","year":"2018","journal-title":"Tetrahedron"},{"key":"D3MD00493G\/cit111\/1","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.1021\/acs.jmedchem.8b00067","volume":"10","author":"Fournier","year":"2018","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit116\/1","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.biochi.2007.08.011","volume":"90","author":"Lecaille","year":"2008","journal-title":"Biochimie"},{"key":"D3MD00493G\/cit117\/1","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.bmcl.2007.12.047","volume":"18","author":"Gauthier","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D3MD00493G\/cit118\/1","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1042\/BCJ20160985","volume":"474","author":"Law","year":"2017","journal-title":"Biochem. J."},{"key":"D3MD00493G\/cit119\/1","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S2213-8587(19)30346-8","volume":"7","author":"McClung","year":"2019","journal-title":"Lancet Diabetes Endocrinol."},{"key":"D3MD00493G\/cit120\/1","doi-asserted-by":"crossref","first-page":"7444","DOI":"10.1016\/j.bmcl.2010.10.015","volume":"20","author":"Beaulieu","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D3MD00493G\/cit121\/1","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1128\/AAC.01855-13","volume":"58","author":"Ndao","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"D3MD00493G\/cit122\/1","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1021\/jm030628v","volume":"47","author":"Weber","year":"2004","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit123\/1","first-page":"149","volume":"40","author":"Gwaltney","year":"2005","journal-title":"Annu. Rep. Med. Chem."},{"key":"D3MD00493G\/cit124\/1","doi-asserted-by":"crossref","first-page":"579","DOI":"10.2174\/156802607780091000","volume":"7","author":"Peters","year":"2007","journal-title":"Curr. Top. Med. Chem."},{"key":"D3MD00493G\/cit125\/1","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1016\/j.bmc.2009.01.061","volume":"17","author":"Havale","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"D3MD00493G\/cit126\/1","doi-asserted-by":"crossref","first-page":"3982","DOI":"10.2174\/092986712802002491","volume":"19","author":"Liu","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"D3MD00493G\/cit127\/1","doi-asserted-by":"crossref","first-page":"116354","DOI":"10.1016\/j.bmc.2021.116354","volume":"46","author":"Kumar","year":"2021","journal-title":"Bioorg. Med. Chem."},{"key":"D3MD00493G\/cit128\/1","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.1021\/jm030091l","volume":"46","author":"Villhauer","year":"2003","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit129\/1","doi-asserted-by":"crossref","first-page":"5025","DOI":"10.1021\/jm050261p","volume":"48","author":"Augeri","year":"2005","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit130\/1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.bbrc.2013.03.010","volume":"434","author":"Nabeno","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"D3MD00493G\/cit131\/1","doi-asserted-by":"crossref","first-page":"11597","DOI":"10.1021\/bi990852f","volume":"38","author":"Hughes","year":"1999","journal-title":"Biochemistry"},{"key":"D3MD00493G\/cit132\/1","doi-asserted-by":"crossref","first-page":"5063","DOI":"10.1073\/pnas.0230620100","volume":"100","author":"Engel","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D3MD00493G\/cit133\/1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1021\/jm0493156","volume":"48","author":"Kim","year":"2005","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit134\/1","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1021\/jm070104l","volume":"50","author":"Feng","year":"2007","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit135\/1","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1021\/jm101016w","volume":"54","author":"Zhang","year":"2011","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit136\/1","doi-asserted-by":"crossref","first-page":"13197","DOI":"10.1021\/acs.jmedchem.0c01877","volume":"63","author":"Meanwell","year":"2020","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit137\/1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.coviro.2017.03.017","volume":"24","author":"D'Ambrosio","year":"2017","journal-title":"Curr. Opin. Virol."},{"key":"D3MD00493G\/cit138\/1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.coph.2016.07.015","volume":"30","author":"McCauley","year":"2016","journal-title":"Curr. Opin. Pharmacol."},{"key":"D3MD00493G\/cit139\/1","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.2174\/0929867323666160510122525","volume":"29","author":"Pillaiyar","year":"2016","journal-title":"Curr. Med. Chem."},{"key":"D3MD00493G\/cit140\/1","doi-asserted-by":"crossref","first-page":"6074","DOI":"10.1021\/jm060325b","volume":"49","author":"Venkatraman","year":"2006","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit141\/1","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1021\/jm060173k","volume":"50","author":"Prongay","year":"2007","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit142\/1","first-page":"22","volume":"1","author":"Howe","year":"2013","journal-title":"J. Clin. Transl. Hepatol."},{"key":"D3MD00493G\/cit143\/1","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/nbt.2020","volume":"29","author":"Kwong","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"D3MD00493G\/cit144\/1","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1021\/jm0342414","volume":"47","author":"Llin\u00e0s-Brunet","year":"2004","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit145\/1","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nature02099","volume":"426","author":"Lamarre","year":"2003","journal-title":"Nature"},{"key":"D3MD00493G\/cit146\/1","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1021\/jm401507s","volume":"57","author":"Rosenquist","year":"2014","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit147\/1","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1021\/ml300017p","volume":"3","author":"Harper","year":"2012","journal-title":"ACS Med. Chem. Lett."},{"key":"D3MD00493G\/cit148\/1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.antiviral.2013.11.008","volume":"102","author":"Coats","year":"2014","journal-title":"Antiviral Res."},{"issue":"369","key":"D3MD00493G\/cit149\/1","doi-asserted-by":"crossref","first-page":"m1847","DOI":"10.1136\/bmj.m1847","author":"Glasziou","year":"2020","journal-title":"BMJ"},{"issue":"25","key":"D3MD00493G\/cit150\/1","volume-title":"C&En","volume":"99","author":"Boerner","year":"2021","unstructured":"L. K.Boerner , The antivirals that weren't: drug repurposing for COVID-19 produced misleading results,  C&En ,  2021 ,  vol. 99 , ( 25 ),  p. 7"},{"key":"D3MD00493G\/cit151\/1","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1080\/17460441.2021.1863943","volume":"16","author":"Bellera","year":"2021","journal-title":"Expert Opin. Drug Discovery"},{"key":"D3MD00493G\/cit152\/1","doi-asserted-by":"crossref","first-page":"eabd5524","DOI":"10.1126\/scitranslmed.abd5524","volume":"61","author":"Begley","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"D3MD00493G\/cit153\/1","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1021\/acsmedchemlett.0c00521","volume":"11","author":"Ghahremanpour","year":"2020","journal-title":"ACS Med. Chem. Lett."},{"key":"D3MD00493G\/cit154\/1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1021\/acscentsci.1c00039","volume":"7","author":"Zhang","year":"2021","journal-title":"ACS Cent. Sci."},{"key":"D3MD00493G\/cit155\/1","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.str.2021.06.002","volume":"29","author":"Deshmukh","year":"2021","journal-title":"Structure"},{"key":"D3MD00493G\/cit156\/1","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1021\/acsmedchemlett.1c00326","volume":"12","author":"Zhang","year":"2021","journal-title":"ACS Med. Chem. Lett."},{"key":"D3MD00493G\/cit157\/1","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1021\/acsmedchemlett.3c00335","volume":"14","author":"Jacobs","year":"2023","journal-title":"ACS Med. Chem. Lett."},{"key":"D3MD00493G\/cit158\/1","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1021\/jm301580n","volume":"56","author":"Jacobs","year":"2013","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit159\/1","doi-asserted-by":"crossref","first-page":"4370","DOI":"10.1016\/j.bmcl.2015.08.049","volume":"25","author":"von Nussbaum","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D3MD00493G\/cit160\/1","first-page":"458","volume":"33","author":"Fischer","year":"2021","journal-title":"Synlett"},{"key":"D3MD00493G\/cit162\/1","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1126\/science.abg5827","volume":"373","author":"Drayman","year":"2021","journal-title":"Science"},{"key":"D3MD00493G\/cit163\/1","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1038\/s41467-017-01582-5","volume":"8","author":"Hammam","year":"2017","journal-title":"Nat. Commun."},{"key":"D3MD00493G\/cit164\/1","doi-asserted-by":"crossref","first-page":"4885","DOI":"10.1128\/AAC.03036-14","volume":"58","author":"Dyall","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"D3MD00493G\/cit165\/1","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1038\/s41375-020-01045-9","volume":"34","author":"Zhao","year":"2020","journal-title":"Leukemia"},{"key":"D3MD00493G\/cit166\/1","doi-asserted-by":"crossref","first-page":"104862","DOI":"10.1016\/j.bioorg.2021.104862","volume":"111","author":"Loschwitz","year":"2021","journal-title":"Bioorg. Chem."},{"key":"D3MD00493G\/cit167\/1","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/s41419-020-02842-x","volume":"11","author":"Sauvat","year":"2020","journal-title":"Cell Death Dis."},{"key":"D3MD00493G\/cit168\/1","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1126\/science.abi4708","volume":"373","author":"Tummino","year":"2021","journal-title":"Science"},{"key":"D3MD00493G\/cit169\/1","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1021\/acs.jproteome.3c00182","volume":"22","author":"Fritch","year":"2023","journal-title":"J. Proteome Res."},{"key":"D3MD00493G\/cit170\/1","doi-asserted-by":"crossref","first-page":"3148","DOI":"10.1021\/jm301848w","volume":"56","author":"Munier-Lehmann","year":"2013","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit171\/1","doi-asserted-by":"crossref","first-page":"e4012","DOI":"10.1093\/cid\/ciaa1417","volume":"73","author":"Wang","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"D3MD00493G\/cit172\/1","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1007\/s40121-022-00690-0","volume":"6","author":"Vehreschild","year":"2022","journal-title":"Infect. Dis. Ther."},{"key":"D3MD00493G\/cit173\/1","doi-asserted-by":"crossref","first-page":"e068179","DOI":"10.1136\/bmjopen-2022-068179","volume":"13","author":"Kralj-Hans","year":"2023","journal-title":"BMJ Open"},{"key":"D3MD00493G\/cit174\/1","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1128\/AAC.48.7.2693-2696.2004","volume":"48","author":"Wu","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"D3MD00493G\/cit175\/1","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1021\/acsinfecdis.0c00052","volume":"8","author":"Xu","year":"2020","journal-title":"ACS Infect. Dis."},{"key":"D3MD00493G\/cit176\/1","doi-asserted-by":"crossref","first-page":"e00819","DOI":"10.1128\/AAC.00819-20","volume":"64","author":"Jeon","year":"2020","journal-title":"Antimicrob. Agents Chemother."},{"key":"D3MD00493G\/cit177\/1","doi-asserted-by":"crossref","first-page":"127906","DOI":"10.1016\/j.bmcl.2021.127906","volume":"40","author":"Shamim","year":"2021","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D3MD00493G\/cit178\/1","doi-asserted-by":"crossref","first-page":"100084","DOI":"10.1016\/j.lanepe.2021.100084","author":"Backer","year":"2021","journal-title":"Lancet Reg. Health Eur."},{"issue":"2","key":"D3MD00493G\/cit179\/1","doi-asserted-by":"crossref","first-page":"e2144942","DOI":"10.1001\/jamanetworkopen.2021.44942","volume":"5","author":"Cairns","year":"2022","journal-title":"JAMA Netw. Open"},{"key":"D3MD00493G\/cit180\/1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41586-021-03491-6","volume":"594","author":"Braga","year":"2021","journal-title":"Nature"},{"key":"D3MD00493G\/cit181\/1","doi-asserted-by":"crossref","first-page":"4469","DOI":"10.1021\/jm050184y","volume":"48","author":"Shie","year":"2005","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit182\/1","doi-asserted-by":"crossref","first-page":"105381","DOI":"10.1016\/j.antiviral.2022.105381","author":"Samrat","year":"2022","journal-title":"Antiviral Res."},{"key":"D3MD00493G\/cit184\/1","doi-asserted-by":"crossref","first-page":"115667","DOI":"10.1016\/j.ejmech.2023.115667","volume":"259","author":"Tan","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"D3MD00493G\/cit185\/1","doi-asserted-by":"crossref","first-page":"eabe0751","DOI":"10.1126\/sciadv.abe0751","volume":"6","author":"Sacco","year":"2020","journal-title":"Sci. Adv."},{"key":"D3MD00493G\/cit186\/1","doi-asserted-by":"crossref","first-page":"4417","DOI":"10.1038\/s41467-020-18233-x","volume":"11","author":"Fu","year":"2020","journal-title":"Nat. Commun."},{"key":"D3MD00493G\/cit187\/1","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/s41422-020-0356-z","volume":"30","author":"Ma","year":"2020","journal-title":"Cell Res."},{"key":"D3MD00493G\/cit188\/1","doi-asserted-by":"crossref","first-page":"eabc5332","DOI":"10.1126\/scitranslmed.abc5332","volume":"12","author":"Rathnayake","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"D3MD00493G\/cit189\/1","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1126\/science.abb4489","volume":"368","author":"Dai","year":"2020","journal-title":"Science"},{"key":"D3MD00493G\/cit190\/1","doi-asserted-by":"crossref","first-page":"e00872","DOI":"10.1128\/AAC.00872-20","volume":"64","author":"Hung","year":"2020","journal-title":"Antimicrob. Agents Chemother."},{"key":"D3MD00493G\/cit191\/1","first-page":"2535","volume":"10","author":"Wang","year":"2020","journal-title":"Am. J. Cancer Res."},{"key":"D3MD00493G\/cit192\/1","doi-asserted-by":"crossref","first-page":"4282","DOI":"10.1038\/s41467-020-18096-2","volume":"27","author":"Vuong","year":"2020","journal-title":"Nat. Commun."},{"key":"D3MD00493G\/cit193\/1","doi-asserted-by":"crossref","first-page":"128263","DOI":"10.1016\/j.bmcl.2021.128263","volume":"48","author":"Vankadara","year":"2021","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D3MD00493G\/cit194\/1","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1038\/s41467-021-22362-2","volume":"12","author":"Iketani","year":"2021","journal-title":"Nat. Commun."},{"key":"D3MD00493G\/cit195\/1","doi-asserted-by":"crossref","first-page":"17846","DOI":"10.1021\/acs.jmedchem.1c01037","volume":"64","author":"Dampalla","year":"2021","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit196\/1","doi-asserted-by":"crossref","first-page":"e2111172118","DOI":"10.1073\/pnas.2111172118","volume":"118","author":"Chamakuri","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D3MD00493G\/cit197\/1","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1126\/science.abf1611","volume":"371","author":"Qiao","year":"2021","journal-title":"Science"},{"key":"D3MD00493G\/cit198\/1","doi-asserted-by":"crossref","first-page":"e2101555118","DOI":"10.1073\/pnas.2101555118","volume":"118","author":"Dampalla","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D3MD00493G\/cit199\/1","doi-asserted-by":"crossref","first-page":"10047","DOI":"10.1021\/acs.jmedchem.1c00319","volume":"64","author":"Dampalla","year":"2021","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit200\/1","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1021\/acsptsci.1c00099","volume":"4","author":"Xia","year":"2021","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"D3MD00493G\/cit201\/1","doi-asserted-by":"crossref","first-page":"7818","DOI":"10.1021\/acs.jmedchem.2c00224","volume":"65","author":"Dampalla","year":"2022","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit202\/1","doi-asserted-by":"crossref","first-page":"114458","DOI":"10.1016\/j.ejmech.2022.114458","volume":"238","author":"Wang","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"D3MD00493G\/cit203\/1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0960-894X(99)00587-9","volume":"10","author":"Dragovich","year":"2000","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D3MD00493G\/cit204\/1","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1002\/cbic.202000371","volume":"21","author":"van de Plassche","year":"2020","journal-title":"ChemBioChem"},{"key":"D3MD00493G\/cit205\/1","doi-asserted-by":"crossref","first-page":"12725","DOI":"10.1021\/acs.jmedchem.0c01063","volume":"63","author":"Hoffman","year":"2020","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit206\/1","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/s41467-021-20900-6","volume":"12","author":"Hattori","year":"2021","journal-title":"Nat. Commun."},{"key":"D3MD00493G\/cit207\/1","doi-asserted-by":"crossref","first-page":"6055","DOI":"10.1038\/s41467-021-26239-2","volume":"12","author":"Boras","year":"2021","journal-title":"Nat. Commun."},{"key":"D3MD00493G\/cit208\/1","doi-asserted-by":"crossref","first-page":"13208","DOI":"10.1038\/s41598-021-92416-4","volume":"11","author":"Redhead","year":"2021","journal-title":"Sci. Rep."},{"key":"D3MD00493G\/cit209\/1","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1021\/acs.jmedchem.1c00616","volume":"65","author":"Bai","year":"2022","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit210\/1","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1021\/acs.jmedchem.1c00665","volume":"65","author":"Konno","year":"2022","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit211\/1","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1038\/s41467-022-29413-2","volume":"13","author":"Liu","year":"2022","journal-title":"Nat. Commun."},{"key":"D3MD00493G\/cit212\/1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1126\/science.abb3405","volume":"368","author":"Zhang","year":"2020","journal-title":"Science"},{"key":"D3MD00493G\/cit213\/1","doi-asserted-by":"crossref","first-page":"4562","DOI":"10.1021\/acs.jmedchem.9b01828","volume":"63","author":"Zhang","year":"2020","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit214\/1","doi-asserted-by":"crossref","first-page":"13328","DOI":"10.1021\/acs.jmedchem.2c01131","volume":"65","author":"Cooper","year":"2022","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit215\/1","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.1021\/jm980068d","volume":"41","author":"Dragovich","year":"1998","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit216\/1","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.1016\/j.bmcl.2016.05.036","volume":"26","author":"Li","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D3MD00493G\/cit217\/1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41586-020-2223-y","volume":"582","author":"Jin","year":"2020","journal-title":"Nature"},{"key":"D3MD00493G\/cit218\/1","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1021\/acs.biochem.1c00414","volume":"60","author":"Lockbaum","year":"2021","journal-title":"Biochemistry"},{"key":"D3MD00493G\/cit219\/1","doi-asserted-by":"crossref","first-page":"10333","DOI":"10.1021\/acs.jmedchem.8b01335","volume":"61","author":"Ma","year":"2018","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit220\/1","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1021\/acsptsci.0c00108","volume":"3","author":"Zhu","year":"2020","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"D3MD00493G\/cit221\/1","doi-asserted-by":"crossref","first-page":"20697","DOI":"10.1021\/jacs.1c08060","volume":"143","author":"Ma","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"D3MD00493G\/cit222\/1","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1042\/BCJ20210197","volume":"478","author":"Milligan","year":"2021","journal-title":"Biochem. J."},{"key":"D3MD00493G\/cit223\/1","doi-asserted-by":"crossref","first-page":"13852","DOI":"10.1021\/acs.jmedchem.2c01081","volume":"65","author":"Hirose","year":"2022","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit225\/1","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1039\/D0CC06870E","volume":"57","author":"Malla","year":"2021","journal-title":"Chem. Commun."},{"key":"D3MD00493G\/cit226\/1","doi-asserted-by":"crossref","first-page":"7682","DOI":"10.1021\/acs.jmedchem.1c02214","volume":"65","author":"Malla","year":"2022","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit227\/1","doi-asserted-by":"crossref","first-page":"16584","DOI":"10.1021\/acsomega.1c01797","volume":"6","author":"Niesor","year":"2021","journal-title":"ACS Omega"},{"key":"D3MD00493G\/cit228\/1","doi-asserted-by":"crossref","first-page":"12266","DOI":"10.1021\/acs.jmedchem.3c00818","volume":"66","author":"Ren","year":"2023","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit230\/1","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1039\/D1MD00247C","volume":"12","author":"Bai","year":"2021","journal-title":"RSC Med. Chem."},{"key":"D3MD00493G\/cit231\/1","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1126\/science.abl4784","volume":"374","author":"Owen","year":"2021","journal-title":"Science"},{"key":"D3MD00493G\/cit232\/1","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1021\/acs.jmedchem.2c01627","volume":"66","author":"Brewitz","year":"2023","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit233\/1","doi-asserted-by":"crossref","first-page":"12237","DOI":"10.1021\/acs.jmedchem.3c00810","volume":"66","author":"Ngo","year":"2023","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit235\/1","doi-asserted-by":"crossref","first-page":"4156","DOI":"10.1021\/cr608202m","volume":"112","author":"Smoum","year":"2012","journal-title":"Chem. Rev."},{"key":"D3MD00493G\/cit236\/1","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1016\/j.apsb.2021.01.010","volume":"11","author":"Song","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"D3MD00493G\/cit237\/1","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1128\/AAC.43.10.2444","volume":"43","author":"Patick","year":"1999","journal-title":"Antimicrob. Agents Chemother."},{"key":"D3MD00493G\/cit238\/1","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1021\/jm9805384","volume":"42","author":"Dragovich","year":"1999","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit239\/1","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1126\/science.1085658","volume":"300","author":"Anand","year":"2003","journal-title":"Science"},{"key":"D3MD00493G\/cit240\/1","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1128\/AAC.46.2.392-397.2002","volume":"46","author":"Hsyu","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"D3MD00493G\/cit241\/1","doi-asserted-by":"crossref","first-page":"3907","DOI":"10.1128\/AAC.47.12.3907-3916.2003","volume":"47","author":"Hayden","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"D3MD00493G\/cit242\/1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.antiviral.2006.03.011","volume":"71","author":"Patick","year":"2006","journal-title":"Antiviral Res."},{"key":"D3MD00493G\/cit243\/1","doi-asserted-by":"crossref","first-page":"5240","DOI":"10.1016\/j.bmc.2005.05.065","volume":"13","author":"Shie","year":"2005","journal-title":"Bioorg. Med. Chem."},{"key":"D3MD00493G\/cit244\/1","doi-asserted-by":"crossref","first-page":"19403","DOI":"10.1074\/jbc.M115.651463","volume":"290","author":"Tomar","year":"2015","journal-title":"J. Biol. Chem."},{"key":"D3MD00493G\/cit245\/1","doi-asserted-by":"crossref","first-page":"e324","DOI":"10.1371\/journal.pbio.0030324","volume":"3","author":"Yang","year":"2005","journal-title":"PLoS Biol."},{"key":"D3MD00493G\/cit246\/1","doi-asserted-by":"crossref","first-page":"7962","DOI":"10.1021\/jm200870n","volume":"54","author":"Akaji","year":"2011","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit247\/1","doi-asserted-by":"crossref","first-page":"114857","DOI":"10.1016\/j.ejmech.2022.114857","volume":"244","author":"Di Micco","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"D3MD00493G\/cit248\/1","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.1021\/jm980071x","volume":"41","author":"Webber","year":"1998","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit249\/1","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1021\/jm0507678","volume":"49","author":"Zhang","year":"2006","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit250\/1","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1002\/cbic.200500533","volume":"7","author":"Al-Gharabli","year":"2006","journal-title":"ChemBioChem"},{"key":"D3MD00493G\/cit251\/1","doi-asserted-by":"crossref","first-page":"5315","DOI":"10.1016\/j.bmcl.2011.07.016","volume":"21","author":"Tiew","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D3MD00493G\/cit252\/1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1039\/D3CB00075C","volume":"4","author":"Stubbing","year":"2023","journal-title":"RSC Chem. Biol."},{"key":"D3MD00493G\/cit253\/1","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1016\/j.bmcl.2009.03.118","volume":"19","author":"Regnier","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D3MD00493G\/cit254\/1","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.bmc.2012.11.017","volume":"21","author":"Konno","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"D3MD00493G\/cit255\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmech.2012.10.053","volume":"59","author":"Chuck","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"D3MD00493G\/cit256\/1","doi-asserted-by":"crossref","first-page":"11754","DOI":"10.1128\/JVI.01348-12","volume":"86","author":"Kim","year":"2012","journal-title":"J. Virol."},{"key":"D3MD00493G\/cit257\/1","doi-asserted-by":"crossref","first-page":"e1005531","DOI":"10.1371\/journal.ppat.1005531","volume":"12","author":"Kim","year":"2016","journal-title":"PLoS Pathog."},{"key":"D3MD00493G\/cit258\/1","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1177\/1098612X17729626","volume":"20","author":"Pedersen","year":"2018","journal-title":"J. Feline Med. Surg."},{"key":"D3MD00493G\/cit259\/1","doi-asserted-by":"crossref","first-page":"9609","DOI":"10.1038\/s41598-021-89013-w","volume":"11","author":"C\u00e1ceres","year":"2021","journal-title":"Sci. Rep."},{"key":"D3MD00493G\/cit260\/1","doi-asserted-by":"crossref","first-page":"4820","DOI":"10.1016\/j.bmcl.2012.05.055","volume":"22","author":"Mandadapu","year":"2012","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D3MD00493G\/cit261\/1","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1002\/cmdc.202000924","volume":"16","author":"Yang","year":"2021","journal-title":"ChemMedChem"},{"key":"D3MD00493G\/cit262\/1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1021\/acsptsci.2c00206","volume":"6","author":"Dampalla","year":"2023","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"D3MD00493G\/cit263\/1","doi-asserted-by":"crossref","first-page":"115376","DOI":"10.1016\/j.ejmech.2023.115376","volume":"254","author":"Dampalla","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"D3MD00493G\/cit264\/1","doi-asserted-by":"crossref","first-page":"113584","DOI":"10.1016\/j.ejmech.2021.113584","volume":"222","author":"Vuong","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"D3MD00493G\/cit265\/1","doi-asserted-by":"crossref","first-page":"3144","DOI":"10.1021\/jm5019934","volume":"58","author":"Galasiti Kankanamalage","year":"2015","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit266\/1","doi-asserted-by":"crossref","first-page":"11945","DOI":"10.1021\/acs.jmedchem.0c01252","volume":"63","author":"Rathnayake","year":"2020","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit267\/1","doi-asserted-by":"crossref","first-page":"4971","DOI":"10.1021\/jm0603926","volume":"49","author":"Yang","year":"2006","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit268\/1","doi-asserted-by":"crossref","first-page":"114570","DOI":"10.1016\/j.ejmech.2022.114570","volume":"240","author":"Ma","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"D3MD00493G\/cit276\/1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.oprd.2c00375","author":"Allais","year":"2023","journal-title":"Org. Process Res. Dev."},{"key":"D3MD00493G\/cit277\/1","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1124\/dmd.123.001416","volume":"51","author":"Cheruvu","year":"2023","journal-title":"Drug Metab. Dispos."},{"key":"D3MD00493G\/cit278\/1","doi-asserted-by":"crossref","first-page":"ofad355","DOI":"10.1093\/ofid\/ofad355","volume":"10","author":"Robinson","year":"2023","journal-title":"Open Forum Infect. Dis."},{"key":"D3MD00493G\/cit279\/1","doi-asserted-by":"crossref","first-page":"105450","DOI":"10.1016\/j.antiviral.2022.105450","volume":"208","author":"Shang","year":"2022","journal-title":"Antiviral Res."},{"key":"D3MD00493G\/cit281\/1","author":"Pardes Biosciences","year":"2023","unstructured":"Pardes Biosciences ,  https:\/\/ir.pardesbio.com\/news , (accessed July, 26,  2023 )"},{"key":"D3MD00493G\/cit282\/1","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.ejmech.2013.07.037","volume":"68","author":"Thanigaimalai","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"D3MD00493G\/cit283\/1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1006\/abbi.1998.1038","volume":"362","author":"Kati","year":"1999","journal-title":"Arch. Biochem. Biophys."},{"key":"D3MD00493G\/cit285\/1","doi-asserted-by":"crossref","first-page":"e0245962","DOI":"10.1371\/journal.pone.0245962","volume":"16","author":"Baker","year":"2021","journal-title":"PLoS One"},{"key":"D3MD00493G\/cit286\/1","doi-asserted-by":"crossref","first-page":"105020","DOI":"10.1016\/j.antiviral.2021.105020","volume":"187","author":"Liu","year":"2021","journal-title":"Antiviral Res."},{"key":"D3MD00493G\/cit287\/1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41392-021-00468-9","volume":"6","author":"Bai","year":"2021","journal-title":"Signal Transduction Targeted Ther."},{"key":"D3MD00493G\/cit288\/1","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/j.str.2020.10.007","volume":"28","author":"Kneller","year":"2020","journal-title":"Structure"},{"key":"D3MD00493G\/cit289\/1","first-page":"16","volume-title":"C&En","volume":"100","author":"Halford","year":"2022","unstructured":"B.Halford , The path to Paxlovid,  C&En ,  2022 ,  vol. 100 ,  p. 16"},{"key":"D3MD00493G\/cit290\/1","volume-title":"C&En","volume":"99","author":"Halford","year":"2021","unstructured":"B.Halford , Pfizer unveils its oral SARS-CoV-2 inhibitor,  C&En ,  2021 ,  vol. 99 ,  p. 7"},{"key":"D3MD00493G\/cit291\/1","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1056\/NEJMoa2118542","volume":"386","author":"Hammond","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"D3MD00493G\/cit292\/1","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1038\/s41467-023-36729-0","volume":"14","author":"Higashi-Kuwata","year":"2023","journal-title":"Nat. Commun."},{"key":"D3MD00493G\/cit293\/1","doi-asserted-by":"crossref","first-page":"13516","DOI":"10.1021\/acs.jmedchem.3c00777","volume":"66","author":"Tsuji","year":"2023","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit295\/1","doi-asserted-by":"crossref","first-page":"4292","DOI":"10.3390\/molecules27134292","volume":"27","author":"G\u00f6hl","year":"2022","journal-title":"Molecules"},{"key":"D3MD00493G\/cit298\/1","doi-asserted-by":"crossref","first-page":"129324","DOI":"10.1016\/j.bmcl.2023.129324","volume":"90","author":"Chen","year":"2023","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D3MD00493G\/cit299\/1","doi-asserted-by":"publisher","DOI":"10.1101\/2023.03.09.53186","volume-title":"BioRxiv","author":"Chen","year":"2023","unstructured":"X.Chen ,  X.Huang ,  Q.Ma ,  P.Kuzmic ,  B.Zhou ,  J.Xu ,  B.Liu ,  H.Jiang ,  W.Zhang ,  C.Yang ,  S.Wu ,  J.Huang ,  H.Li ,  C.Long ,  X.Zhao ,  H.Xu ,  Y. J.Sheng ,  Y.Guo ,  C.Niu ,  L.Xue ,  Y.Xu ,  J.Liu ,  T.Zhang ,  J.Spencer ,  W.Deng ,  S.-H.Chen ,  X.Xiong ,  Z.Yang  and  N.Zhong , Inhibition mechanism and antiviral activity of an \u03b1-ketoamide based SARS-CoV-2 main protease inhibitor,  BioRxiv ,  2023 , preprint,  10.1101\/2023.03.09.53186"},{"key":"D3MD00493G\/cit301\/1","doi-asserted-by":"crossref","first-page":"102189","DOI":"10.1016\/j.eclinm.2023.102189","volume":"63","author":"Wang","year":"2023","journal-title":"EClinicalMedicine"},{"key":"D3MD00493G\/cit302\/1","doi-asserted-by":"crossref","first-page":"115311","DOI":"10.1016\/j.ejmech.2023.115311","volume":"253","author":"Stefanelli","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"D3MD00493G\/cit303\/1","doi-asserted-by":"crossref","first-page":"100835","DOI":"10.1016\/j.lanwpc.2023.100835","volume":"38","author":"Wang","year":"2023","journal-title":"Lancet Reg. Health West. Pac."},{"key":"D3MD00493G\/cit305\/1","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1021\/acsptsci.3c00134","volume":"6","author":"Zhu","year":"2023","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"D3MD00493G\/cit306\/1","doi-asserted-by":"crossref","first-page":"6463","DOI":"10.1038\/s41467-023-42102-y","volume":"14","author":"Jiang","year":"2023","journal-title":"Nat. Commun."},{"key":"D3MD00493G\/cit307\/1","doi-asserted-by":"crossref","first-page":"106598","DOI":"10.1016\/j.ejps.2023.106598","volume":"30","author":"Yang","year":"2023","journal-title":"Eur. J. Pharm. Sci."},{"key":"D3MD00493G\/cit310\/1","doi-asserted-by":"crossref","first-page":"115512","DOI":"10.1016\/j.ejmech.2023.115512","volume":"257","author":"Yang","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"D3MD00493G\/cit311\/1","doi-asserted-by":"crossref","first-page":"114596","DOI":"10.1016\/j.ejmech.2022.114596","volume":"240","author":"Alugubelli","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"D3MD00493G\/cit312\/1","doi-asserted-by":"crossref","first-page":"11040","DOI":"10.1021\/acs.jmedchem.3c00221","volume":"66","author":"Geng","year":"2023","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit314\/1","doi-asserted-by":"publisher","DOI":"10.1101\/2023.10.24.563688","volume-title":"BioRxiv","author":"Elshan","year":"2023","unstructured":"N. G. R. D.Elshan ,  K. C.Wolff ,  L.Riva ,  A. K.Woods ,  G.Grabovyi ,  K.Wilson ,  A.Rahimi ,  J.Pedroarena ,  S.Ghorai ,  A. K.Gupta ,  A.Nazarian ,  F.Weiss ,  Y.Liu ,  W.Mazumdar ,  L.Song ,  N.Okwor ,  J.Malvin ,  M. A.Bakowski ,  N.Beutler ,  M. G.Kirkpatrick ,  A.Gebara-Lamb ,  E.Huang ,  V.Nguyen-Tran ,  V.Chi ,  S.Li ,  T. F.Rogers ,  C. W.McNamara ,  J. J.Chen ,  S. B.Joseph ,  P. G.Schultz  and  A. K.Chatterjee , Discovery of CMX990: A Potent SARS-CoV-2 3CL Protease Inhibitor Bearing a Novel Covalent Warhead,  BioRxiv ,  2023 , preprint,  10.1101\/2023.10.24.563688"},{"key":"D3MD00493G\/cit315\/1","doi-asserted-by":"crossref","first-page":"117316","DOI":"10.1016\/j.bmc.2023.117316","volume":"87","author":"Zhu","year":"2023","journal-title":"Bioorg. Med. Chem."},{"key":"D3MD00493G\/cit317\/1","author":"Sorrento Therapeutics","year":"2023","unstructured":"Sorrento Therapeutics ,  https:\/\/sorrentotherapeutics.com\/research\/covid , (accessed July, 26,  2023 )"},{"key":"D3MD00493G\/cit319\/1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.2022.36.S1.0R514","volume":"36","author":"Balakrishnan","year":"2022","journal-title":"FASEB J."},{"key":"D3MD00493G\/cit328\/1","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1021\/jm010469k","volume":"45","author":"Dragovich","year":"2002","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit329\/1","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0960-894X(02)00008-2","volume":"12","author":"Dragovich","year":"2002","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D3MD00493G\/cit330\/1","doi-asserted-by":"crossref","first-page":"4572","DOI":"10.1021\/jm030166l","volume":"46","author":"Dragovich","year":"2003","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit331\/1","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1128\/AAC.49.6.2267-2275.2005","volume":"49","author":"Patick","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"D3MD00493G\/cit332\/1","doi-asserted-by":"crossref","first-page":"e0102921","DOI":"10.1128\/AAC.01029-21","volume":"65","author":"Kankam","year":"2021","journal-title":"Antimicrob. Agents Chemother."},{"key":"D3MD00493G\/cit333\/1","doi-asserted-by":"crossref","first-page":"105458","DOI":"10.1016\/j.antiviral.2022.105458","volume":"208","author":"F\u00e0brega-Ferrer","year":"2022","journal-title":"Antiviral Res."},{"key":"D3MD00493G\/cit334\/1","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.antiviral.2011.08.001","volume":"92","author":"Zhu","year":"2011","journal-title":"Antiviral Res."},{"key":"D3MD00493G\/cit338\/1","doi-asserted-by":"crossref","first-page":"3709","DOI":"10.1016\/j.bmcl.2013.05.021","volume":"23","author":"Mandadapu","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D3MD00493G\/cit339\/1","doi-asserted-by":"crossref","first-page":"e202300476","DOI":"10.1002\/chem.202300476","volume":"29","author":"Wang","year":"2023","journal-title":"Chemistry"},{"key":"D3MD00493G\/cit340\/1","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/j.chembiol.2004.08.011","volume":"11","author":"Blanchard","year":"2004","journal-title":"Chem. Biol."},{"key":"D3MD00493G\/cit341\/1","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1021\/jm061425k","volume":"50","author":"Zhang","year":"2007","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit342\/1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.bmc.2007.09.034","volume":"16","author":"Niu","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"D3MD00493G\/cit343\/1","doi-asserted-by":"crossref","first-page":"5684","DOI":"10.1016\/j.bmcl.2008.08.082","volume":"18","author":"Ghosh","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D3MD00493G\/cit344\/1","doi-asserted-by":"crossref","first-page":"10423","DOI":"10.1002\/anie.202016961","volume":"60","author":"Breidenbach","year":"2021","journal-title":"Angew. Chem., Int. Ed."},{"key":"D3MD00493G\/cit345\/1","doi-asserted-by":"crossref","first-page":"e202200635","DOI":"10.1002\/cmdc.202200635","volume":"18","author":"Wamser","year":"2023","journal-title":"ChemMedChem"},{"key":"D3MD00493G\/cit346\/1","doi-asserted-by":"crossref","first-page":"115721","DOI":"10.1016\/j.ejmech.2023.115721","volume":"260","author":"Zhang","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"D3MD00493G\/cit347\/1","doi-asserted-by":"crossref","first-page":"115720","DOI":"10.1016\/j.ejmech.2023.115720","volume":"260","author":"Kang","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"D3MD00493G\/cit348\/1","doi-asserted-by":"crossref","first-page":"9376","DOI":"10.1021\/acs.jmedchem.2c00636","volume":"65","author":"Pillaiyar","year":"2022","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit349\/1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.bioorg.2008.01.001","volume":"26","author":"Zhang","year":"2008","journal-title":"Bioorg. Chem."},{"key":"D3MD00493G\/cit350\/1","doi-asserted-by":"crossref","first-page":"6172","DOI":"10.1016\/j.bmcl.2013.08.112","volume":"23","author":"Turlington","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D3MD00493G\/cit351\/1","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3390\/v13020174","volume":"13","author":"Lockbaum","year":"2021","journal-title":"Viruses"},{"key":"D3MD00493G\/cit352\/1","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1021\/acs.jmedchem.1c00598","volume":"65","author":"Han","year":"2022","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit353\/1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/s41557-020-0496-2","volume":"12","author":"Chodera","year":"2020","journal-title":"Nat. Chem."},{"key":"D3MD00493G\/cit354\/1","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/d41586-021-01571-1","volume":"594","author":"von Delft","year":"2021","journal-title":"Nature"},{"key":"D3MD00493G\/cit355\/1","doi-asserted-by":"publisher","DOI":"10.33774\/chemrxiv","volume-title":"ChemRxiv","author":"The COVID Moonshot Consortium","year":"2021","unstructured":"The COVID Moonshot Consortium ,  J.Chodera ,  A.Lee ,  N.London  and  F.von Delft , Open Science Discovery of Oral Non-Covalent SARS-CoV-2 Main Protease Inhibitors,  ChemRxiv ,  2021 , preprint,  10.33774\/chemrxiv"},{"key":"D3MD00493G\/cit356\/1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.10.29.339317","volume-title":"BioRxiv","author":"Achdout","year":"2022","unstructured":"H.Achdout ,  A.Aimon ,  E.Bar-David ,  H.Barr ,  A.Ben-Shmuel ,  J.Bennett ,  V. A.Bilenko ,  M. L.Boby ,  B.Borden ,  G. R.Bowman ,  J.Brun ,  B. V. N. B. S.Sarma ,  M.Calmiano ,  A.Carbery ,  D.Carney ,  E.Cattermole ,  E.Chang ,  E.Chernyshenko ,  J. D.Chodera ,  A.Clyde ,  J. E.Coffland ,  G.Cohen ,  J.Cole ,  A.Contini ,  L.Cox ,  M.Cvitkovic ,  A.Dias ,  K.Donckers ,  D. L.Dotson ,  A.Douangamath ,  S.Duberstein ,  T.Dudgeon ,  L.Dunnett ,  P. K.Eastman ,  N.Erez ,  C. J.Eyermann ,  M.Fairhead ,  G.Fate ,  D.Fearon ,  O.Fedorov ,  M.Ferla ,  R. S.Fernandes ,  L.Ferrins ,  R.Foster ,  H.Foster ,  R.Gabizon ,  A.Garcia-Sastre ,  V. O.Gawriljuk ,  P.Gehrtz ,  C.Gileadi ,  C.Giroud ,  W. G.Glass ,  R.Glen ,  I.Glinert ,  A. S.Godoy ,  M.Gorichko ,  T.Gorrie-Stone ,  E. J.Griffen ,  S.Hassell Hart ,  J.Heer ,  M.Henry ,  M.Hill ,  S.Horrell ,  V. D.Huliak ,  M. F. D.Hurley ,  T.Israely ,  A.Jajack ,  J.Jansen ,  E.Jnoff ,  D.Jochmans ,  T.John ,  S.De Jonghe ,  A. L.Kantsadi ,  P. W.Kenny ,  J. L.Kiappes ,  S. O.Kinakh ,  L.Koekemoer ,  B.Kovar ,  T.Krojer ,  A.Lee ,  B. A.Lefker ,  H.Levy ,  I. G.Logvinenko ,  N.London ,  P.Lukacik ,  H. B.Macdonald ,  B.MacLean ,  T. R.Malla ,  T.Matviiuk ,  W.McCorkindale ,  B. L.McGovern ,  S.Melamed ,  K. P.Melnykov ,  O.Michurin ,  H.Mikolajek ,  B. F.Milne ,  A.Morris ,  G. M.Morris ,  M. J.Morwitzer ,  D.Moustakas ,  A. M.Nakamura ,  J.Brandao Neto ,  J.Neyts ,  L.Nguyen ,  G. D.Noske ,  V.Oleinikovas ,  G.Oliva ,  G. J.Overheul ,  D.Owen ,  R.Pai ,  J.Pan ,  N.Paran ,  B.Perry ,  M.Pingle ,  J.Pinjari ,  B.Politi ,  A.Powell ,  V.Psenak ,  R.Puni ,  V. L.Rangel ,  R. N.Reddi ,  S. P.Reid ,  E.Resnick ,  E. G.Ripka ,  M. C.Robinson ,  R. P.Robinson ,  J.Rodriguez-Guerra ,  R.Rosales ,  D.Rufa ,  K.Saar ,  K.Singh Saikatendu ,  C.Schofield ,  M.Shafeev ,  A.Shaikh ,  J.Shi ,  K.Shurrush ,  S.Singh ,  A.Sittner ,  R.Skyner ,  A.Smalley ,  B.Smeets ,  M. D.Smilova ,  L. J.Solmesky ,  J.Spencer ,  C.Strain-Damerell ,  V.Swamy ,  H.Tamir ,  R.Tennant ,  W.Thompson ,  A.Thompson ,  S.Tomasio ,  I. S.Tsurupa ,  A.Tumber ,  I.Vakonakis ,  R. P.van Rij ,  L.Vangeel ,  F. S.Varghese ,  M.Vaschetto ,  E. B.Vitner ,  V.Voelz ,  A.Volkamer ,  F.von Delft ,  A.von Delft ,  M.Walsh ,  W.Ward ,  C.Weatherall ,  S.Weiss ,  K. M.White ,  C. F.Wild ,  M.Wittmann ,  N.Wright ,  Y.Yahalom-Ronen ,  D.Zaidmann ,  H.Zidane  and  N.Zitzmann , Open Science Discovery of Oral Non-Covalent SARS-CoV-2 Main Protease Inhibitor Therapeutics,  BioRxiv ,  2022 , preprint,  10.1101\/2020.10.29.339317"},{"key":"D3MD00493G\/cit357\/1","doi-asserted-by":"crossref","first-page":"e2214168120","DOI":"10.1073\/pnas.2214168120","volume":"120","author":"Saar","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D3MD00493G\/cit358\/1","author":"Griffen","year":"2022","unstructured":"E.Griffen ,  https:\/\/dndi.org\/wp-content\/uploads\/2021\/09\/COVID_Moonshot_RSC_Cambridge_MedChem_Sept_2021.pdf , (accessed 6th of January  2022 )"},{"key":"D3MD00493G\/cit359\/1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.10.29.339317","volume-title":"BioRxiv","author":"Boby","year":"2023","unstructured":"M. L.Boby ,  D.Fearon ,  M.Ferla ,  M.Filep ,  L.Koekemoer ,  M. C.Robinson ,  The COVID Moonshot Consortium ,  J. D.Chodera ,  A. A.Lee ,  N.London ,  A.von Delft  and  F.von Delft , Open Science Discovery of Potent Non-Covalent SARS-CoV-2 Main Protease Inhibitors,  BioRxiv ,  2023 , preprint,  10.1101\/2020.10.29.339317"},{"key":"D3MD00493G\/cit360\/1","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1021\/jacs.1c08402","volume":"144","author":"Luttens","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"D3MD00493G\/cit361\/1","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1021\/acs.jmedchem.1c00509","volume":"65","author":"Kitamura","year":"2022","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit362\/1","doi-asserted-by":"crossref","first-page":"1036208","DOI":"10.3389\/fphar.2022.1036208","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"D3MD00493G\/cit363\/1","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/s42004-023-00961-y","volume":"6","author":"Jimmidi","year":"2023","journal-title":"Commun. Chem."},{"key":"D3MD00493G\/cit364\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chembiol.2021.05.018","volume":"28","author":"Zaidman","year":"2021","journal-title":"Cell Chem. Biol."},{"key":"D3MD00493G\/cit368\/1","doi-asserted-by":"crossref","first-page":"114046","DOI":"10.1016\/j.ejmech.2021.114046","volume":"229","author":"Stille","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"D3MD00493G\/cit369\/1","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/s41564-022-01119-7","volume":"7","author":"Quan","year":"2022","journal-title":"Nat. Microbiol."},{"key":"D3MD00493G\/cit372\/1","year":"2023","unstructured":"https:\/\/fragalysis.diamond.ac.uk\/viewer\/react\/preview\/target\/Mpro , (accessed 18th of August  2023 )"},{"key":"D3MD00493G\/cit373\/1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1021\/acscentsci.2c01359","volume":"9","author":"Hou","year":"2023","journal-title":"ACS Cent. Sci."},{"key":"D3MD00493G\/cit375\/1","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs","author":"Hooper","year":"2023","journal-title":"Res. Sq."},{"key":"D3MD00493G\/cit378\/1","doi-asserted-by":"crossref","first-page":"2246594","DOI":"10.1080\/22221751.2023.2246594","author":"P\u00e9rez-Vargas","year":"2023","journal-title":"Emerging Microbes Infect."},{"key":"D3MD00493G\/cit383\/1","doi-asserted-by":"crossref","first-page":"128333","DOI":"10.1016\/j.bmcl.2021.128333","volume":"50","author":"Ullrich","year":"2021","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D3MD00493G\/cit384\/1","doi-asserted-by":"crossref","first-page":"816166","DOI":"10.3389\/fmolb.2021.816166","volume":"8","author":"Hern\u00e1ndez Gonz\u00e1lez","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"D3MD00493G\/cit385\/1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1021\/acschembio.2c00735","volume":"18","author":"Eberle","year":"2023","journal-title":"ACS Chem. Biol."},{"key":"D3MD00493G\/cit386\/1","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/s41557-023-01205-1","volume":"15","author":"Miura","year":"2023","journal-title":"Nat. Chem."},{"key":"D3MD00493G\/cit387\/1","doi-asserted-by":"crossref","first-page":"661424","DOI":"10.3389\/fmolb.2021.661424","volume":"8","author":"Zhai","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"D3MD00493G\/cit388\/1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1021\/acs.jcim.1c00851","volume":"62","author":"Clyde","year":"2022","journal-title":"J. Chem. Inf. Model."},{"key":"D3MD00493G\/cit389\/1","doi-asserted-by":"crossref","first-page":"17366","DOI":"10.1021\/acs.jmedchem.1c01475","volume":"64","author":"Kneller","year":"2021","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit390\/1","doi-asserted-by":"crossref","first-page":"13343","DOI":"10.1021\/acs.jmedchem.2c01146","volume":"65","author":"Gao","year":"2022","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit391\/1","doi-asserted-by":"crossref","first-page":"16902","DOI":"10.1021\/acs.jmedchem.2c01716","volume":"65","author":"Gao","year":"2022","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit392\/1","doi-asserted-by":"crossref","first-page":"5909","DOI":"10.1039\/D1CC00050K","volume":"57","author":"Morris","year":"2021","journal-title":"Chem. Commun."},{"key":"D3MD00493G\/cit393\/1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41392-023-01482-9","volume":"8","author":"Jiang","year":"2023","journal-title":"Signal Transduction Targeted Ther."},{"key":"D3MD00493G\/cit395\/1","doi-asserted-by":"crossref","first-page":"115657","DOI":"10.1016\/j.ejmech.2023.115657","volume":"259","author":"Huang","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"D3MD00493G\/cit396\/1","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41392-023-01392-w","volume":"8","author":"Huang","year":"2023","journal-title":"Signal Transduction Targeted Ther."},{"key":"D3MD00493G\/cit397\/1","doi-asserted-by":"crossref","first-page":"4652","DOI":"10.1016\/j.bmc.2008.02.040","volume":"16","author":"Shao","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"D3MD00493G\/cit398\/1","doi-asserted-by":"crossref","first-page":"113267","DOI":"10.1016\/j.ejmech.2021.113267","volume":"215","author":"Wang","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"D3MD00493G\/cit399\/1","first-page":"e202309657","author":"Liu","year":"2023","journal-title":"Angew. Chem., Int. Ed."},{"key":"D3MD00493G\/cit400\/1","doi-asserted-by":"crossref","first-page":"e202300116","DOI":"10.1002\/cbic.202300116","volume":"24","author":"Moon","year":"2023","journal-title":"ChemBioChem"},{"key":"D3MD00493G\/cit401\/1","doi-asserted-by":"crossref","first-page":"129407","DOI":"10.1016\/j.bmcl.2023.129407","volume":"92","author":"Wang","year":"2023","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D3MD00493G\/cit402\/1","doi-asserted-by":"crossref","first-page":"6499","DOI":"10.1021\/acs.jmedchem.2c00117","volume":"65","author":"Unoh","year":"2022","journal-title":"J. Med. Chem."},{"key":"D3MD00493G\/cit404\/1","doi-asserted-by":"crossref","first-page":"103004","DOI":"10.1016\/j.jbc.2023.103004","volume":"299","author":"Noske","year":"2023","journal-title":"J. Biol. Chem."},{"key":"D3MD00493G\/cit406\/1","doi-asserted-by":"crossref","first-page":"e0069722","DOI":"10.1128\/aac.00697-22","volume":"66","author":"Mukae","year":"2022","journal-title":"Antimicrob. Agents Chemother."},{"key":"D3MD00493G\/cit407\/1","doi-asserted-by":"crossref","first-page":"e0063222","DOI":"10.1128\/aac.00632-22","volume":"66","author":"Shimizu","year":"2022","journal-title":"Antimicrob. Agents Chemother."},{"key":"D3MD00493G\/cit408\/1","doi-asserted-by":"crossref","first-page":"e33024","DOI":"10.1097\/MD.0000000000033024","volume":"102","author":"Yotsuyanagi","year":"2023","journal-title":"Medicine"},{"key":"D3MD00493G\/cit411\/1","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/s41573-023-00672-y","volume":"22","author":"Li","year":"2023","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D3MD00493G\/cit412\/1","author":"U.S. Department of Health & Human Services","year":"2023","unstructured":"U.S. Department of Health & Human Services ,  https:\/\/www.nih.gov\/research , (accessed 22\/08\/ 2023 )"},{"key":"D3MD00493G\/cit413\/1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1021\/acscentsci.2c00369","volume":"8","author":"Halford","year":"2022","journal-title":"ACS Cent. Sci."},{"key":"D3MD00493G\/cit414\/1","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1021\/acsmedchemlett.2c00260","volume":"13","author":"Vankadara","year":"2022","journal-title":"ACS Med. Chem. Lett."},{"key":"D3MD00493G\/cit415\/1","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1021\/acsnano.0c07383","volume":"15","author":"Pathak","year":"2021","journal-title":"ACS Nano"},{"key":"D3MD00493G\/cit416\/1","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1021\/ja01088a024","volume":"87","author":"Finch","year":"1965","journal-title":"J. Am. Chem. Soc."},{"key":"D3MD00493G\/cit417\/1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/hlca.19960790116","volume":"79","author":"Pelligrini","year":"1996","journal-title":"Helv. Chim. Acta"},{"key":"D3MD00493G\/cit418\/1","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/s41586-022-05514-2","volume":"613","author":"Iketani","year":"2023","journal-title":"Nature"},{"key":"D3MD00493G\/cit419\/1","doi-asserted-by":"crossref","first-page":"3952","DOI":"10.1038\/s41467-023-39704-x","volume":"14","author":"Kiso","year":"2023","journal-title":"Nat. Commun."},{"key":"D3MD00493G\/cit420\/1","doi-asserted-by":"crossref","first-page":"105671","DOI":"10.1016\/j.antiviral.2023.105671","volume":"216","author":"Takashita","year":"2023","journal-title":"Antiviral Res."},{"key":"D3MD00493G\/cit421\/1","doi-asserted-by":"crossref","first-page":"4231","DOI":"10.1038\/s41467-023-40018-1","volume":"14","author":"Kiso","year":"2023","journal-title":"Nat. Commun."},{"key":"D3MD00493G\/cit422\/1","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1021\/acscentsci.3c00538","volume":"9","author":"Hu","year":"2023","journal-title":"ACS Cent. Sci."},{"key":"D3MD00493G\/cit423\/1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1021\/acs.accounts.2c00735","volume":"56","author":"Tan","year":"2023","journal-title":"Acc. Chem. Res."}],"container-title":["RSC Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/MD\/D3MD00493G","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T03:48:31Z","timestamp":1782877711000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/md\/article\/15\/1\/81-118\/813062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":361,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1,25]]}},"URL":"https:\/\/doi.org\/10.1039\/d3md00493g","relation":{},"ISSN":["2632-8682"],"issn-type":[{"value":"2632-8682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}