{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T10:41:43Z","timestamp":1779014503277,"version":"3.51.4"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T00:00:00Z","timestamp":1683676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:00Z","timestamp":1715299200000},"content-version":"am","delay-in-days":366,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100019065","name":"Tianjin Science and Technology Program","doi-asserted-by":"publisher","award":["20ZYJDJC00120"],"award-info":[{"award-number":["20ZYJDJC00120"]}],"id":[{"id":"10.13039\/501100019065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019062","name":"Tianjin Research Innovation Project for Postgraduate Students","doi-asserted-by":"publisher","award":["2021YJSB298"],"award-info":[{"award-number":["2021YJSB298"]}],"id":[{"id":"10.13039\/501100019062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019065","name":"Tianjin Science and Technology Program","doi-asserted-by":"publisher","award":["20ZYJDJC00120"],"award-info":[{"award-number":["20ZYJDJC00120"]}],"id":[{"id":"10.13039\/501100019065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019062","name":"Tianjin Research Innovation Project for Postgraduate Students","doi-asserted-by":"publisher","award":["2021YJSB298"],"award-info":[{"award-number":["2021YJSB298"]}],"id":[{"id":"10.13039\/501100019062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,5,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: The DNA damage repair enzyme, poly(ADP-ribose) polymerase 1 (PARP1), is crucial for lipid and glucose metabolism. However, no evidence has been presented on the relationship between liver lipid accumulation and the PARP1 inhibitor, 3-aminobenzamide (3-AB), in atherosclerosis. Methods: ApoE\u2212\/\u2212 mice were used to explore the effect of 3-AB on atherosclerotic liver lipid accumulation, and the experiment of Sprague Dawley (SD) rats was designed to determine if the lowering of liver lipid levels by 3-AB was linked to gut bacteria. The levels of bile acid metabolism-related targets were assessed by ELISA, western blotting, and RT-qPCR. The relative abundances of gut microbes and biomarkers were determined using 16S rRNA sequencing analysis. Bile acid levels in the liver and ileum were examined by ultra-performance liquid chromatography-tandem mass spectrometry. The relationship between gut microbes and bile acids was assessed by Spearman's correlation analysis. Results: 3-AB significantly reduced the formation of aortic plaques in apoE\u2212\/\u2212 mice, according to gross oil red staining. H &amp; E and Oil Red O staining revealed that 3-AB significantly reduced the hepatic lipid droplet area in ApoE\u2212\/\u2212 mice and SD rats. Compared with the atherosclerosis (ATH) group, 3-AB dramatically decreased the levels of total cholesterol (TC), triglyceride (TG), and low-density lipoprotein-cholesterol (LDL-C) in the serum of SD rats and apoE\u2212\/\u2212 mice, and the levels of TC, TG, and LDL-C in the serum and liver of apoE\u2212\/\u2212 mice. Furthermore, in apoE\u2212\/\u2212 mice and SD rats, 3-AB increased the mRNA and protein levels of farnesoid X receptor (FXR) and bile salt export pump (BSEP) in the liver, while inhibiting the mRNA and protein levels of FXR and fibroblast growth factor 15 (FGF15) in the ileum, respectively. 3-AB clearly inhibited the mRNA and protein levels of PARP1 in the liver and ileum of apoE\u2212\/\u2212 mice and rats. Following treatment with 3-AB, the levels of conjugated bile acids decreased in the liver of apoE\u2212\/\u2212 mice and increased in the ileum of SD rats, according to targeted metabolomic analysis. Microbiome sequencing analysis revealed that 3-AB reduced the relative abundance of Lactobacillus, Bifidobacterium, Listeria, Clostridium, Bacillus, and Staphylococcus in the feces of apoE\u2212\/\u2212 mice, and the relative abundance of Blautia, Clostridium, and Listeria in the feces of SD rats, eventually decreasing the total abundance of 10 bile salt hydrolase-associated gut microbes. According to the correlation analysis, 3-AB regulates bile acid metabolism, which is primarily related to Bifidobacterium. Conclusion: 3-AB alleviated atherosclerosis by modulating the bile acid metabolism and bile salt hydrolase-related gut microbes.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/d3mo00033h","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T18:21:43Z","timestamp":1683742903000},"page":"560-573","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["PARP-1 inhibitor alleviates liver lipid accumulation of atherosclerosis\n                    <i>via<\/i>\n                    modulating bile acid metabolism and gut microbes"],"prefix":"10.1093","volume":"19","author":[{"given":"Yingkun","family":"Sheng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Component-based Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine a , 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617 China wangyf0622@tjutcm.edu.cn miaomiaojiang@tjutcm.edu.cn miaomiaojiang@126.com"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guibing","family":"Meng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Component-based Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine a , 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617 China wangyf0622@tjutcm.edu.cn miaomiaojiang@tjutcm.edu.cn miaomiaojiang@126.com"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9121-6776","authenticated-orcid":false,"given":"Zhirong","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Component-based Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine a , 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617 China wangyf0622@tjutcm.edu.cn miaomiaojiang@tjutcm.edu.cn miaomiaojiang@126.com"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8406-8154","authenticated-orcid":false,"given":"Ruijiao","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine c , Tianjin 301617, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuefei","family":"Wang","sequence":"additional","affiliation":[{"name":"Haihe Laboratory of Modern Chinese Medicine b , Tianjin 301617, China"},{"name":"State Key Laboratory of Component-based Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine a , 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617 China wangyf0622@tjutcm.edu.cn miaomiaojiang@tjutcm.edu.cn miaomiaojiang@126.com"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4737-7564","authenticated-orcid":false,"given":"Miaomiao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Haihe Laboratory of Modern Chinese Medicine b , Tianjin 301617, China"},{"name":"State Key Laboratory of Component-based Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine a , 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617 China wangyf0622@tjutcm.edu.cn miaomiaojiang@tjutcm.edu.cn miaomiaojiang@126.com"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,5,10]]},"reference":[{"issue":"10","key":"2026010813045141400_cit1","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1161\/CIRCRESAHA.118.313816","article-title":"Atherosclerosis","volume":"123","author":"Kobiyama","year":"2018","journal-title":"Circ. Res."},{"key":"2026010813045141400_cit2","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.2147\/DDDT.S372143","article-title":"Guanmaitong Granule Attenuates Atherosclerosis by Inhibiting Inflammatory Immune Response in ApoE(-\/-) Mice Fed High-Fat Diet","volume":"16","author":"Yang","year":"2022","journal-title":"Drug Des., Dev. Ther."},{"issue":"7","key":"2026010813045141400_cit3","first-page":"573","article-title":"Report on Cardiovascular Health and Diseases in China 2021: An Updated Summary","volume":"35","author":"The Writing Committee of the Report on Cardiovascular Health and Diseases in China","year":"2022","journal-title":"Biomed. Environ. Sci."},{"issue":"12","key":"2026010813045141400_cit4","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1161\/CIR.0000000000000558","article-title":"Heart Disease and Stroke Statistics-2018 Update: A Report From the American Heart Association","volume":"137","author":"Benjamin","year":"2018","journal-title":"Circulation"},{"issue":"4","key":"2026010813045141400_cit5","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1161\/CIRCRESAHA.115.306301","article-title":"Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis","volume":"118","author":"Gimbrone, Jr.","year":"2016","journal-title":"Circ. Res."},{"key":"2026010813045141400_cit6","first-page":"1","article-title":"PARP1 inhibition enhances reactive oxygen species on gut microbiota","author":"Zhuang","year":"2022","journal-title":"J. Cell Physiol."},{"issue":"5","key":"2026010813045141400_cit7","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/s41401-018-0044-4","article-title":"PARP1 interacts with HMGB1 and promotes its nuclear export in pathological myocardial hypertrophy","volume":"40","author":"Li","year":"2019","journal-title":"Acta Pharmacol. Sin."},{"issue":"5\u20136","key":"2026010813045141400_cit8","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1101\/gad.334284.119","article-title":"The role of ADP-ribose metabolism in metabolic regulation, adipose tissue differentiation, and metabolism","volume":"34","author":"Sz\u00e1nt\u00f3","year":"2020","journal-title":"Genes Dev."},{"issue":"2","key":"2026010813045141400_cit9","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.tem.2011.10.001","article-title":"Transcriptional networks and chromatin remodeling controlling adipogenesis","volume":"23","author":"Siersb\u00e6k","year":"2012","journal-title":"Trends Endocrinol. Metab."},{"issue":"5","key":"2026010813045141400_cit10","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.jhep.2016.11.020","article-title":"PARP1-mediated PPAR\u03b1 poly(ADP-ribosyl)ation suppresses fatty acid oxidation in non-alcoholic fatty liver disease","volume":"66","author":"Huang","year":"2017","journal-title":"J. Hepatol."},{"issue":"4","key":"2026010813045141400_cit11","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.cmet.2011.03.004","article-title":"PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation","volume":"13","author":"Bai","year":"2011","journal-title":"Cell Metab."},{"issue":"21","key":"2026010813045141400_cit12","doi-asserted-by":"crossref","first-page":"11172","DOI":"10.1074\/jbc.M116.726729","article-title":"Poly(ADP-ribose) Polymerase 1 Represses Liver X Receptor-mediated ABCA1 Expression and Cholesterol Efflux in Macrophages","volume":"291","author":"Shrestha","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"5","key":"2026010813045141400_cit13","doi-asserted-by":"crossref","first-page":"e00070","DOI":"10.1128\/mSystems.00070-16","article-title":"Farnesoid X Receptor Signaling Shapes the Gut Microbiota and Controls Hepatic Lipid Metabolism","volume":"1","author":"Zhang","year":"2016","journal-title":"mSystems"},{"issue":"22","key":"2026010813045141400_cit14","doi-asserted-by":"crossref","first-page":"4492","DOI":"10.1128\/MCB.00160-13","article-title":"Poly(ADP-ribose) polymerase 1 promotes oxidative-stress-induced liver cell death via suppressing farnesoid X receptor \u03b1","volume":"33","author":"Wang","year":"2013","journal-title":"Mol. Cell Biol."},{"issue":"2","key":"2026010813045141400_cit15","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.taap.2012.11.012","article-title":"Modulation of farnesoid X receptor results in post-translational modification of poly(ADP-ribose) polymerase 1 in the liver","volume":"266","author":"Zhu","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"6","key":"2026010813045141400_cit16","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1080\/00498254.2021.1900626","article-title":"FXR activation prevents liver injury induced by Tripterygium wilfordii preparations","volume":"51","author":"Peng","year":"2021","journal-title":"Xenobiotica"},{"issue":"1","key":"2026010813045141400_cit17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s40168-019-0628-3","article-title":"Taxonomic profiling and populational patterns of bacterial bile salt hydrolase (BSH) genes based on worldwide human gut microbiome","volume":"7","author":"Song","year":"2019","journal-title":"Microbiome"},{"issue":"1664-302X (Print)","key":"2026010813045141400_cit18","first-page":"33","article-title":"Antibiotic growth promoters enhance animal production by targeting intestinal bile salt hydrolase and its producers","volume":"5","author":"Lin","year":"2014","journal-title":"Front. Microbiol."},{"issue":"4","key":"2026010813045141400_cit19","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.apsb.2019.02.004","article-title":"Ablation of gut microbiota alleviates obesity-induced hepatic steatosis and glucose intolerance by modulating bile acid metabolism in hamsters","volume":"9","author":"Sun","year":"2019","journal-title":"Acta Pharm. Sin. B"},{"issue":"11","key":"2026010813045141400_cit20","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.tem.2018.04.007","article-title":"Atherosclerosis Is an Epigenetic Disease","volume":"29","author":"Xu","year":"2018","journal-title":"Trends Endocrinol. Metab."},{"issue":"1","key":"2026010813045141400_cit21","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1186\/s12967-022-03542-0","article-title":"Asprosin inhibits macrophage lipid accumulation and reduces atherosclerotic burden by up-regulating ABCA1 and ABCG1 expression via the p38\/Elk-1 pathway","volume":"20","author":"Zou","year":"2022","journal-title":"J. Transl. Med."},{"issue":"9","key":"2026010813045141400_cit22","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.3390\/cells9092040","article-title":"The Role of PARP1 in Monocyte and Macrophage Commitment and Specification: Future Perspectives and Limitations for the Treatment of Monocyte and Macrophage Relevant Diseases with PARP Inhibitors","volume":"9","author":"Sobczak","year":"2020","journal-title":"Cells"},{"issue":"3","key":"2026010813045141400_cit23","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1002\/med.21300","article-title":"Poly(ADP-ribose) polymerase 1 (PARP1) in atherosclerosis: from molecular mechanisms to therapeutic implications","volume":"34","author":"Xu","year":"2014","journal-title":"Med. Res. Rev."},{"issue":"6","key":"2026010813045141400_cit24","doi-asserted-by":"crossref","first-page":"354","DOI":"10.5483\/BMBRep.2015.48.6.012","article-title":"Poly(ADP-ribose) protects vascular smooth muscle cells from oxidative DNA damage","volume":"48","author":"Zhang","year":"2015","journal-title":"BMB Rep."},{"issue":"2","key":"2026010813045141400_cit25","doi-asserted-by":"crossref","first-page":"e22079","DOI":"10.1096\/fj.202101250RR","article-title":"NRP2 promotes atherosclerosis by upregulating PARP1 expression and enhancing low shear stress-induced endothelial cell apoptosis","volume":"36","author":"Luo","year":"2022","journal-title":"FASEB J."},{"issue":"17","key":"2026010813045141400_cit26","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1080\/15384101.2019.1640008","article-title":"PJ34, a PARP1 inhibitor, promotes endothelial repair in a rabbit model of high fat diet-induced atherosclerosis","volume":"18","author":"Zha","year":"2019","journal-title":"Cell Cycle"},{"key":"2026010813045141400_cit27","doi-asserted-by":"crossref","first-page":"101117","DOI":"10.1016\/j.plipres.2021.101117","article-title":"PARPs in lipid metabolism and related diseases","volume":"84","author":"Sz\u00e1nt\u00f3","year":"2021","journal-title":"Prog. Lipid Res."},{"key":"2026010813045141400_cit28","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.semcdb.2016.12.009","article-title":"Metabolic roles of poly(ADP-ribose) polymerases","volume":"63","author":"Vida","year":"2017","journal-title":"Semin. Cell Dev. Biol."},{"key":"2026010813045141400_cit29","doi-asserted-by":"crossref","first-page":"pp. 325\u2013357","DOI":"10.1007\/164_2019_228","article-title":"Pharmacologic Modulation of Bile Acid-FXR-FGF15\/FGF19 Pathway for the Treatment of Nonalcoholic Steatohepatitis","volume-title":"Bile Acids and Their Receptors","author":"Schumacher","year":"2019"},{"issue":"1","key":"2026010813045141400_cit30","doi-asserted-by":"crossref","first-page":"4971","DOI":"10.1038\/s41467-019-12896-x","article-title":"Theabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism","volume":"10","author":"Huang","year":"2019","journal-title":"Nat. Commun."},{"issue":"135\u2013143","key":"2026010813045141400_cit31","article-title":"Metabolic roles of poly(ADP-ribose) polymerases","volume":"63","author":"Vida","year":"2017","journal-title":"Semin. Cell Dev. Biol."},{"issue":"1","key":"2026010813045141400_cit32","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jhep.2016.08.024","article-title":"Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease","volume":"66","author":"Gariani","year":"2017","journal-title":"J. Hepatol."},{"issue":"3","key":"2026010813045141400_cit33","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jhep.2016.10.023","article-title":"PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis","volume":"66","author":"Mukhopadhyay","year":"2017","journal-title":"J. Hepatol."},{"key":"2026010813045141400_cit34","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1016\/j.csbj.2021.04.029","article-title":"Farnesoid X receptor (FXR): Structures and ligands","volume":"19","author":"Jiang","year":"2021","journal-title":"Comput. Struct. Biotechnol. J."},{"issue":"1","key":"2026010813045141400_cit35","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S1050-1738(00)00043-8","article-title":"FXR, a bile acid receptor and biological sensor","volume":"10","author":"Tu","year":"2000","journal-title":"Trends Cardiovasc. Med."},{"key":"2026010813045141400_cit36","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.foodres.2018.06.035","article-title":"New insights into bacterial bile resistance mechanisms: the role of bile salt hydrolase and its impact on human health","volume":"112","author":"Bustos","year":"2018","journal-title":"Food Res. Int."},{"issue":"3","key":"2026010813045141400_cit37","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1002\/jsfa.12222","article-title":"L-Theanine regulates lipid metabolism by modulating gut microbiota and bile acid metabolism","volume":"103","author":"Xu","year":"2023","journal-title":"J. Sci. Food Agric."},{"issue":"10","key":"2026010813045141400_cit38","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1002\/pro.3484","article-title":"Bile salt hydrolases: Structure and function, substrate preference, and inhibitor development","volume":"27","author":"Dong","year":"2018","journal-title":"Protein Sci."},{"issue":"24","key":"2026010813045141400_cit39","doi-asserted-by":"crossref","first-page":"5200","DOI":"10.3390\/nu14245200","article-title":"Impact of Fecal Microbiota Transplantation on Gut Bacterial Bile Acid Metabolism in Humans","volume":"14","author":"Bustamante","year":"2022","journal-title":"Nutrients"},{"issue":"2","key":"2026010813045141400_cit40","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3390\/nu15020255","article-title":"Bifidobacterium pseudocatenulatum-Mediated Bile Acid Metabolism to Prevent Rheumatoid Arthritis via the Gut-Joint Axis","volume":"15","author":"Zhao","year":"2023","journal-title":"Nutrients"},{"key":"2026010813045141400_cit41","doi-asserted-by":"crossref","first-page":"858263","DOI":"10.3389\/fmicb.2022.858263","article-title":"Bile Salt Hydrolase Degrades \u03b2-Lactam Antibiotics and Confers Antibiotic Resistance on Lactobacillus paragasseri","volume":"13","author":"Kusada","year":"2022","journal-title":"Front. Microbiol."},{"issue":"2","key":"2026010813045141400_cit42","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1039\/D1FO03143K","article-title":"Cholesterol-lowering effect of bile salt hydrolase from a Lactobacillus johnsonii strain mediated by FXR pathway regulation","volume":"13","author":"Zhu","year":"2022","journal-title":"Food Funct."},{"issue":"5","key":"2026010813045141400_cit43","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1053\/j.gastro.2016.08.057","article-title":"An Intestinal Microbiota-Farnesoid X Receptor Axis Modulates Metabolic Disease","volume":"151","author":"Gonzalez","year":"2016","journal-title":"Gastroenterology"},{"issue":"11","key":"2026010813045141400_cit44","doi-asserted-by":"crossref","first-page":"9903","DOI":"10.1039\/D0FO02255A","article-title":"Probiotics improved hyperlipidemia in mice induced by a high cholesterol diet via downregulating FXR","volume":"11","author":"Liang","year":"2020","journal-title":"Food Funct."}],"container-title":["Molecular Omics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/molecular-omics\/article-pdf\/19\/7\/560\/65033841\/d3mo00033h.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/molecular-omics\/article-pdf\/19\/7\/560\/65033841\/d3mo00033h.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T18:05:45Z","timestamp":1767895545000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/molecular-omics\/article\/19\/7\/560\/8277109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,10]]},"references-count":44,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,5,10]]}},"URL":"https:\/\/doi.org\/10.1039\/d3mo00033h","relation":{},"ISSN":["2515-4184"],"issn-type":[{"value":"2515-4184","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,8,1]]},"published":{"date-parts":[[2023,5,10]]}}}