{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:49:18Z","timestamp":1791600558051,"version":"4.3.4"},"reference-count":94,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T00:00:00Z","timestamp":1705276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"am","delay-in-days":366,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["EMR\/2017\/000002"],"award-info":[{"award-number":["EMR\/2017\/000002"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["5\/4\/6\/01\/OPH\/2016-NCD-II"],"award-info":[{"award-number":["5\/4\/6\/01\/OPH\/2016-NCD-II"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","award":["UGC-Faculty Recharge Program"],"award-info":[{"award-number":["UGC-Faculty Recharge Program"]}],"id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["EMR\/2017\/000002"],"award-info":[{"award-number":["EMR\/2017\/000002"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["5\/4\/6\/01\/OPH\/2016-NCD-II"],"award-info":[{"award-number":["5\/4\/6\/01\/OPH\/2016-NCD-II"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","award":["UGC-Faculty Recharge Program"],"award-info":[{"award-number":["UGC-Faculty Recharge Program"]}],"id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Long considered active only in the germline, the PIWI\/piRNA pathway is now known to play a significant role in somatic cells, especially neurons. In this study, piRNAs were profiled in the human retina and retinal pigment epithelium (RPE). Furthermore, RNA immunoprecipitation with HIWI2 (PIWIL4) in ARPE19 cells yielded 261 piRNAs, and the expression of selective piRNAs in donor eyes was assessed by qRT-PCR. Intriguingly, computational analysis revealed complete and partial seed sequence similarity between piR-hsa-26131 and the sensory organ specific miR-183\/96\/182 cluster. Furthermore, the expression of retina-enriched piR-hsa-26131 was positively correlated with miR-182 in HIWI2-silenced Y79 cells. In addition, the lnc-ZNF169 sequence matched with two miRNAs of the let-7 family, and piRNAs, piR-hsa-11361 and piR-hsa-11360, which could modulate the regulatory network of retinal differentiation. Interestingly, we annotated four enriched motifs among the piRNAs and found that the piRNAs containing CACAATG and CTCATCAKYG motifs were snoRNA-derived piRNAs, which are significantly associated with developmental functions. However, piRNAs consisting of ACCACTANACCAC and AKCACGYTCSC motifs were mainly tRNA-derived fragments linked to stress response and sensory perception. Additionally, co-expression network analysis revealed cell cycle control, intracellular transport and stress response as the important biological functions regulated by piRNAs in the retina. Moreover, loss of piRNAs in HIWI2 knockdown ARPE19 confirmed altered expression of targets implicated in intracellular transport, circadian clock, and retinal degeneration. Moreover, piRNAs were dysregulated under oxidative stress conditions, indicating their potential role in retinal pathology. Therefore, we postulate that piRNAs, miRNAs, and lncRNAs might have a functional interplay during retinal development and functions to regulate retinal homeostasis.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/d3mo00122a","type":"journal-article","created":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T10:21:00Z","timestamp":1705314060000},"page":"248-264","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["piRNAs in the human retina and retinal pigment epithelium reveal a potential role in intracellular trafficking and oxidative stress"],"prefix":"10.1093","volume":"20","author":[{"given":"Muthuramalingam","family":"Karpagavalli","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Pondicherry University a , Puducherry-605014, India \u00a0 csubbulakshmi@gmail.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suganya","family":"Sivagurunathan","sequence":"additional","affiliation":[{"name":"RS Mehta Jain Department of Biochemistry and Cell Biology, Vision Research Foundation b , Chennai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T Sayamsmruti","family":"Panda","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Pondicherry University c , Puducherry-605014, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagesh","family":"Srikakulam","sequence":"additional","affiliation":[{"name":"Laboratory of RNA Biology and Epigenomics, Department of Plant Biotechnology, School of Biotechnology, Madurai Kamaraj University d , Madurai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reety","family":"Arora","sequence":"additional","affiliation":[{"name":"National Centre for Biological Sciences, TIFR e , Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamiya","family":"Dohadwala","sequence":"additional","affiliation":[{"name":"National Centre for Biological Sciences, TIFR e , Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basant K","family":"Tiwary","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Pondicherry University c , Puducherry-605014, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudha Rani","family":"Sadras","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Pondicherry University a , Puducherry-605014, India \u00a0 csubbulakshmi@gmail.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayamuruga Pandian","family":"Arunachalam","sequence":"additional","affiliation":[{"name":"Central Inter-Disciplinary Research Facility, Sri Balaji Vidyapeeth (Deemed to be University) f , Pondicherry-607402, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopal","family":"Pandi","sequence":"additional","affiliation":[{"name":"Laboratory of RNA Biology and Epigenomics, Department of Plant Biotechnology, School of Biotechnology, Madurai Kamaraj University d , Madurai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3180-4429","authenticated-orcid":false,"given":"Subbulakshmi","family":"Chidambaram","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Pondicherry University a , Puducherry-605014, India \u00a0 csubbulakshmi@gmail.com"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,1,15]]},"reference":[{"key":"2026010813064628200_cit1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nature04916","volume":"442","author":"Aravin","year":"2006","journal-title":"Nature"},{"key":"2026010813064628200_cit2","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1101\/gad.1425706","volume":"20","author":"Watanabe","year":"2006","journal-title":"Genes Dev."},{"key":"2026010813064628200_cit3","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1101\/gad.1434406","volume":"20","author":"Grivna","year":"2006","journal-title":"Genes Dev."},{"key":"2026010813064628200_cit4","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev.cellbio.24.110707.175327","volume":"25","author":"Thomson","year":"2009","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"2026010813064628200_cit5","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.devcel.2021.11.025","volume":"57","author":"Cornes","year":"2022","journal-title":"Dev. Cell"},{"key":"2026010813064628200_cit6","doi-asserted-by":"crossref","DOI":"10.1242\/dev.161786","volume":"145","author":"Rojas-R\u0131\u00f3s","year":"2018","journal-title":"Development"},{"key":"2026010813064628200_cit7","volume":"18","author":"Liu","year":"2019","journal-title":"Mol. Cancer"},{"key":"2026010813064628200_cit8","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s10456-020-09750-w","volume":"24","author":"Li","year":"2021","journal-title":"Angiogenesis"},{"key":"2026010813064628200_cit9","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.4239\/wjd.v12.i7.1116","volume":"12","author":"Yu","year":"2021","journal-title":"World J. Diabetes"},{"key":"2026010813064628200_cit10","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1007\/s00125-017-4368-2","volume":"60","author":"Henaoui","year":"2017","journal-title":"Diabetologia"},{"key":"2026010813064628200_cit11","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1261\/rna.2565011","volume":"17","author":"Lee","year":"2011","journal-title":"RNA"},{"key":"2026010813064628200_cit12","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1161\/STROKEAHA.110.598391","volume":"42","author":"Dharap","year":"2011","journal-title":"Stroke"},{"key":"2026010813064628200_cit13","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2012.02.057","volume":"149","author":"Rajasethupathy","year":"2012","journal-title":"Cell"},{"key":"2026010813064628200_cit14","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s12035-016-0340-2","volume":"55","author":"Phay","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"2026010813064628200_cit15","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1039\/C6MB00699J","volume":"13","author":"Roy","year":"2017","journal-title":"Mol. BioSyst."},{"key":"2026010813064628200_cit16","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.4239\/wjd.v12.i7.1116","volume":"12","author":"Yu","year":"2021","journal-title":"World J. Diabetes"},{"key":"2026010813064628200_cit17","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.exer.2016.01.010","volume":"145","author":"Khan","year":"2016","journal-title":"Exp. Eye Res."},{"key":"2026010813064628200_cit18","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1093\/hmg\/ddh061","volume":"13","author":"Aherne","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"2026010813064628200_cit19","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1093\/nar\/gkw039","volume":"44","author":"Karali","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2026010813064628200_cit20","volume":"40","author":"Dong","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"2026010813064628200_cit21","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-15-29","volume":"15","author":"Busk","year":"2014","journal-title":"BMC Bioinf."},{"key":"2026010813064628200_cit22","doi-asserted-by":"crossref","first-page":"D173","DOI":"10.1093\/nar\/gkm696","volume":"36","author":"Sai Lakshmi","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"2026010813064628200_cit23","doi-asserted-by":"crossref","first-page":"D175","DOI":"10.1093\/nar\/gky1043","volume":"47","author":"Wang","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2026010813064628200_cit24","doi-asserted-by":"crossref","first-page":"D223","DOI":"10.1093\/nar\/gkv1265","volume":"44","author":"Rosenkranz","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2026010813064628200_cit25","volume":"10","author":"Li","year":"2020","journal-title":"Sci. Rep."},{"key":"2026010813064628200_cit26","doi-asserted-by":"crossref","DOI":"10.1186\/s12859-022-05048-4","volume":"23","author":"Zytnicki","year":"2022","journal-title":"BMC Bioinf."},{"key":"2026010813064628200_cit27","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-13-5","volume":"13","author":"Rosenkranz","year":"2012","journal-title":"BMC Bioinf."},{"key":"2026010813064628200_cit28","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.1093\/bioinformatics\/btab203","volume":"37","author":"Bailey","year":"2021","journal-title":"Bioinformatics"},{"key":"2026010813064628200_cit29","doi-asserted-by":"crossref","first-page":"W39","DOI":"10.1093\/nar\/gkv416","volume":"43","author":"Bailey","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"2026010813064628200_cit30","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2007-8-2-r24","volume":"8","author":"Gupta","year":"2007","journal-title":"Genome Biol."},{"key":"2026010813064628200_cit31","doi-asserted-by":"crossref","first-page":"W214","DOI":"10.1093\/nar\/gkq537","volume":"38","author":"Warde-Farley","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"2026010813064628200_cit32","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1080\/15476286.2021.2010960","volume":"19","author":"Ghosh","year":"2022","journal-title":"RNA Biol."},{"key":"2026010813064628200_cit33","doi-asserted-by":"crossref","first-page":"D112","DOI":"10.1093\/nar\/gki041","volume":"33","author":"Liu","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"2026010813064628200_cit34","doi-asserted-by":"crossref","first-page":"D135","DOI":"10.1093\/nar\/gky1031","volume":"47","author":"Volders","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"2026010813064628200_cit35","doi-asserted-by":"crossref","first-page":"D184","DOI":"10.1093\/nar\/gkv1309","volume":"44","author":"Chan","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2026010813064628200_cit36","doi-asserted-by":"crossref","DOI":"10.1186\/s12864-017-4031-9","volume":"18","author":"Gebert","year":"2017","journal-title":"BMC Genomics"},{"key":"2026010813064628200_cit37","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2003-5-1-r1","volume":"5","author":"Enright","year":"2003","journal-title":"Genome Biol."},{"key":"2026010813064628200_cit38","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1093\/bioinformatics\/btt285","volume":"29","author":"Luo","year":"2013","journal-title":"Bioinformatics"},{"key":"2026010813064628200_cit39","doi-asserted-by":"crossref","first-page":"W207","DOI":"10.1093\/nar\/gkad347","volume":"51","author":"Kolberg","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"2026010813064628200_cit40","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"2026010813064628200_cit41","doi-asserted-by":"crossref","first-page":"5773","DOI":"10.1093\/nar\/gkw486","volume":"44","author":"Pinelli","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2026010813064628200_cit42","volume":"18","author":"Hou","year":"2022","journal-title":"PLoS Comput. Biol."},{"key":"2026010813064628200_cit43","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22126549","volume":"22","author":"Salloum-Asfar","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"2026010813064628200_cit44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0287131","volume":"18","author":"Stott","year":"2023","journal-title":"PLoS One"},{"key":"2026010813064628200_cit45","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.molcel.2008.09.003","volume":"31","author":"Aravin","year":"2008","journal-title":"Mol. Cell"},{"key":"2026010813064628200_cit46","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201947789","volume":"20","author":"Krishna","year":"2019","journal-title":"EMBO Rep."},{"key":"2026010813064628200_cit47","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1080\/15476286.2020.1757908","volume":"17","author":"Barre\u00f1ada","year":"2020","journal-title":"RNA Biol."},{"key":"2026010813064628200_cit48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0006186","volume":"12","author":"Eng","year":"2018","journal-title":"PLoS Neglected Trop. Dis."},{"key":"2026010813064628200_cit49","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1016\/j.bbamcr.2011.05.015","volume":"1813","author":"Overlack","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"2026010813064628200_cit50","doi-asserted-by":"crossref","DOI":"10.1093\/nsr\/nwu014","volume":"1","author":"Ku","year":"2014","journal-title":"Natl. Sci. Rev."},{"key":"2026010813064628200_cit51","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202153801","volume":"24","author":"Gasperini","year":"2023","journal-title":"EMBO Rep."},{"key":"2026010813064628200_cit52","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1007\/s12035-021-02678-2","volume":"59","author":"Subhramanyam","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"2026010813064628200_cit53","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1080\/15476286.2020.1757896","volume":"17","author":"Subhramanyam","year":"2020","journal-title":"RNA Biol."},{"key":"2026010813064628200_cit54","doi-asserted-by":"crossref","DOI":"10.1186\/s11658-017-0048-y","volume":"22","author":"Sivagurunathan","year":"2017","journal-title":"Cell. Mol. Biol. Lett."},{"key":"2026010813064628200_cit55","doi-asserted-by":"crossref","first-page":"8318","DOI":"10.1128\/MCB.01209-07","volume":"27","author":"Koike","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"2026010813064628200_cit56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biocel.2016.04.012","volume":"76","author":"Vella","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"2026010813064628200_cit57","volume":"13","author":"Singh","year":"2018","journal-title":"PLoS One"},{"key":"2026010813064628200_cit58","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/fd65b655-d35b-47d1-8793-07da2273c144","volume":"8","author":"Yang","year":"2013","journal-title":"PLoS One"},{"key":"2026010813064628200_cit59","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nrneurol.2012.227","volume":"9","author":"London","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"2026010813064628200_cit60","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s11010-016-2906-8","volume":"427","author":"Sivagurunathan","year":"2017","journal-title":"Mol. Cell. Biochem."},{"key":"2026010813064628200_cit61","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1167\/iovs.18-24166","volume":"60","author":"Wu","year":"2019","journal-title":"Invest. Ophthalmol. Visual Sci."},{"key":"2026010813064628200_cit62","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.4161\/rna.24955","volume":"10","author":"Rinck","year":"2013","journal-title":"RNA Biol."},{"key":"2026010813064628200_cit63","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.cell.2018.02.002","volume":"172","author":"Shen","year":"2018","journal-title":"Cell"},{"key":"2026010813064628200_cit64","doi-asserted-by":"crossref","first-page":"13415","DOI":"10.1073\/pnas.0605506103","volume":"103","author":"Grivna","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2026010813064628200_cit65","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.tig.2017.08.002","volume":"33","author":"Jandura","year":"2017","journal-title":"Trends Genet."},{"key":"2026010813064628200_cit66","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-51703-x","volume":"9","author":"Fairchild","year":"2019","journal-title":"Sci. Rep."},{"key":"2026010813064628200_cit67","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ydbio.2015.12.010","volume":"410","author":"Xia","year":"2016","journal-title":"Dev. Biol."},{"key":"2026010813064628200_cit68","first-page":"246","volume":"41","author":"Makarova","year":"2007","journal-title":"Molekuliarnaia Biologiia"},{"key":"2026010813064628200_cit69","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1007\/s00018-020-03720-7","volume":"78","author":"Krishna","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"2026010813064628200_cit70","volume":"11","author":"Cao","year":"2020","journal-title":"Front. Pharmacol."},{"key":"2026010813064628200_cit71","doi-asserted-by":"crossref","first-page":"6048","DOI":"10.1093\/nar\/gkn596","volume":"36","author":"Li","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"2026010813064628200_cit72","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.cell.2014.08.011","volume":"158","author":"Gingold","year":"2014","journal-title":"Cell"},{"key":"2026010813064628200_cit73","doi-asserted-by":"crossref","first-page":"38944","DOI":"10.1074\/jbc.M110.160325","volume":"285","author":"Xu","year":"2010","journal-title":"J. Biol. Chem."},{"key":"2026010813064628200_cit74","volume":"8","author":"Lyons","year":"2017","journal-title":"Nat. Commun."},{"key":"2026010813064628200_cit75","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.exer.2018.08.018","volume":"177","author":"Sivagurunathan","year":"2018","journal-title":"Exp. Eye Res."},{"key":"2026010813064628200_cit76","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1242\/jcs.108.1.215","volume":"108","author":"Deretic","year":"1995","journal-title":"J. Cell Sci."},{"key":"2026010813064628200_cit77","doi-asserted-by":"crossref","first-page":"6346","DOI":"10.1073\/pnas.1002401107","volume":"107","author":"Kn\u00f6dler","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2026010813064628200_cit78","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1083\/jcb.200710085","volume":"180","author":"Marshall","year":"2008","journal-title":"J. Cell Biol."},{"key":"2026010813064628200_cit79","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.cell.2007.03.053","volume":"129","author":"Nachury","year":"2007","journal-title":"Cell"},{"key":"2026010813064628200_cit80","doi-asserted-by":"crossref","first-page":"16881","DOI":"10.1038\/s41598-017-12838-x","volume":"7","author":"Raghupathy","year":"2017","journal-title":"Sci. Rep."},{"key":"2026010813064628200_cit81","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.ajhg.2013.06.002","volume":"93","author":"Aldahmesh","year":"2013","journal-title":"Am. J. Hum. Genet."},{"key":"2026010813064628200_cit82","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/1096-8628(20010108)105:1<76::AID-AJMG1066>3.0.CO;2-R","volume":"105","author":"S\u00e1nchez","year":"2001","journal-title":"Am. J. Med. Genet."},{"key":"2026010813064628200_cit83","doi-asserted-by":"crossref","first-page":"e22727","DOI":"10.1371\/journal.pone.0022727","volume":"6","author":"Esposito","year":"2011","journal-title":"PLoS One"},{"key":"2026010813064628200_cit84","doi-asserted-by":"crossref","first-page":"14529","DOI":"10.1038\/ncomms14529","volume":"8","author":"Kuintzle","year":"2017","journal-title":"Nat. Commun."},{"key":"2026010813064628200_cit85","doi-asserted-by":"crossref","first-page":"54913","DOI":"10.18632\/oncotarget.18973","volume":"8","author":"Lu","year":"2017","journal-title":"Oncotarget"},{"key":"2026010813064628200_cit86","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/3164734","volume":"2016","author":"Nita","year":"2016","journal-title":"Oxid. Med. Cell. Longevity"},{"key":"2026010813064628200_cit87","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.4103\/1673-5374.355819","volume":"18","author":"Yu","year":"2023","journal-title":"Neural Regener. Res."},{"key":"2026010813064628200_cit88","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.7150\/ijms.46209","volume":"17","author":"Peng","year":"2020","journal-title":"Int. J. Med. Sci."},{"key":"2026010813064628200_cit89","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Endocrinol"},{"key":"2026010813064628200_cit90","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.neulet.2015.02.026","volume":"591","author":"Ding","year":"2015","journal-title":"Neurosci. Lett."},{"key":"2026010813064628200_cit91","doi-asserted-by":"crossref","first-page":"4017","DOI":"10.1093\/hmg\/ddq316","volume":"19","author":"Saus","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"2026010813064628200_cit92","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.1093\/nar\/gkt1275","volume":"42","author":"Tang","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"2026010813064628200_cit93","doi-asserted-by":"crossref","first-page":"4017","DOI":"10.1093\/hmg\/ddq316","volume":"19","author":"Saus","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"2026010813064628200_cit94","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1093\/hmg\/9.14.2085","volume":"9","author":"Boylan","year":"2000","journal-title":"Hum. Mol. Genet."}],"container-title":["Molecular Omics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/molecular-omics\/article-pdf\/20\/4\/248\/65029301\/d3mo00122a.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/molecular-omics\/article-pdf\/20\/4\/248\/65029301\/d3mo00122a.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T18:09:02Z","timestamp":1767895742000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/molecular-omics\/article\/20\/4\/248\/8277337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,15]]},"references-count":94,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,1,15]]}},"URL":"https:\/\/doi.org\/10.1039\/d3mo00122a","relation":{},"ISSN":["2515-4184"],"issn-type":[{"value":"2515-4184","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,5,1]]},"published":{"date-parts":[[2024,1,15]]}}}