{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T12:16:21Z","timestamp":1781784981304,"version":"3.54.5"},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"},{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"am","delay-in-days":366,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/100020716","name":"Wenzhou-Kean University","doi-asserted-by":"publisher","award":["WKUSPS202238"],"award-info":[{"award-number":["WKUSPS202238"]}],"id":[{"id":"10.13039\/100020716","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020716","name":"Wenzhou-Kean University","doi-asserted-by":"publisher","award":["WKUSPS202238"],"award-info":[{"award-number":["WKUSPS202238"]}],"id":[{"id":"10.13039\/100020716","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,11,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Type 1 diabetes (T1D) has been reported to cause systematic metabolic disorders, but metabolic changes in different intestinal segments of T1D remain unclear. In this study, we analyzed metabolic profiles in the jejunum, ileum, cecum and colon of streptozocin-induced T1D and age-matched control (CON) mice by an LC-MS-based metabolomics method. The results show that segment-specific metabolic disorders occurred in the gut of T1D mice. In the jejunum, we found that T1D mainly led to disordered amino acid metabolism and most amino acids were significantly lower relative to CON mice. Moreover, fatty acid metabolism was disrupted mainly in the ileum, cecum and colon of T1D mice, such as arachidonic acid, alpha-linolenic acid and linoleic acid metabolism. Thus, our study reveals spatial metabolic heterogeneity in the gut of T1D mice and provides a metabolic view on diabetes-associated intestinal diseases.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/d3mo00163f","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T07:54:42Z","timestamp":1699343682000},"page":"128-137","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Untargeted metabolomics analysis reveals spatial metabolic heterogeneity in different intestinal segments of type 1 diabetic mice"],"prefix":"10.1093","volume":"20","author":[{"given":"Kaiyan","family":"Gong","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences, Wenzhou Medical University a , Wenzhou 325035, China \u00a0 123zhenghong321@163.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junli","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Wenzhou Medical University a , Wenzhou 325035, China \u00a0 123zhenghong321@163.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Yin","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Wenzhou Medical University a , Wenzhou 325035, China \u00a0 123zhenghong321@163.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjun","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Wenzhou Medical University a , Wenzhou 325035, China \u00a0 123zhenghong321@163.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3401-721X","authenticated-orcid":false,"given":"Hong","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Wenzhou Medical University a , Wenzhou 325035, China \u00a0 123zhenghong321@163.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Jiang","sequence":"additional","affiliation":[{"name":"Wenzhou Municipal Key Laboratory for Applied Biomedical and Biopharmaceutical Informatics, Wenzhou-Kean University c , Wenzhou 325060, China"},{"name":"College of Science and Technology, Wenzhou-Kean University b , Wenzhou 325060, China \u00a0 jianglingling@wku.edu.cn"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,11,7]]},"reference":[{"issue":"10138","key":"2026010813061080200_cit1","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1016\/S0140-6736(18)31320-5","article-title":"Type 1 diabetes","volume":"391","author":"DiMeglio","year":"2018","journal-title":"Lancet"},{"issue":"2","key":"2026010813061080200_cit2","doi-asserted-by":"crossref","first-page":"932","DOI":"10.3390\/ijms22020932","article-title":"Apolipoprotein CIII is an important piece in the type-1 diabetes jigsaw puzzle","volume":"22","author":"Valladolid-Acebes","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"2026010813061080200_cit3","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.ecl.2013.07.006","article-title":"Gastrointestinal complications of diabetes","volume":"42","author":"Boland","year":"2013","journal-title":"Endocrin. Metab. Clin."},{"key":"2026010813061080200_cit4","doi-asserted-by":"crossref","first-page":"3827301","DOI":"10.1155\/2018\/3827301","article-title":"Diabetic enteropathy: from molecule to mechanism-based treatment","volume":"2018","author":"Meldgaard","year":"2018","journal-title":"J. Diabetes Res."},{"issue":"18","key":"2026010813061080200_cit5","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1056\/NEJMra2020927","article-title":"Gastric emptying abnormalities in diabetes mellitus","volume":"384","author":"Goyal","year":"2021","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"2026010813061080200_cit6","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.ejim.2012.03.001","article-title":"Diabetic gastrointestinal autonomic neuropathy: current status and new achievements for everyday clinical practice","volume":"23","author":"Gatopoulou","year":"2012","journal-title":"Eur. J. Intern. Med."},{"issue":"1","key":"2026010813061080200_cit7","doi-asserted-by":"crossref","first-page":"19","DOI":"10.5056\/jnm20149","article-title":"microbial dysbiosis in the pathogenesis of gastrointestinal dysmotility and metabolic disorders","volume":"27","author":"Singh","year":"2021","journal-title":"J. Neurogastroenterol."},{"issue":"2","key":"2026010813061080200_cit8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1365-2982.2010.01659.x","article-title":"Oxidative stress: key player in gastrointestinal complications of diabetes","volume":"23","author":"Kashyap","year":"2011","journal-title":"Neurogastroenterol. Motil."},{"issue":"2","key":"2026010813061080200_cit9","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41575-022-00685-9","article-title":"Antibiotics in the pathogenesis of diabetes and inflammatory diseases of the gastrointestinal tract","volume":"20","author":"Fenneman","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"2","key":"2026010813061080200_cit10","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/jdi.12723","article-title":"Metabolomics window into diabetic complications","volume":"9","author":"Wu","year":"2018","journal-title":"J. Diabetes Invest."},{"issue":"11","key":"2026010813061080200_cit11","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.3390\/cells10112832","article-title":"Metabolomics in diabetes and diabetic complications: Insights from epidemiological studies","volume":"10","author":"Jin","year":"2021","journal-title":"Cells"},{"issue":"23","key":"2026010813061080200_cit12","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.2174\/1568026614666141215124956","article-title":"Metabolomics as a tool for drug discovery and personalised medicine. A review","volume":"14","author":"Mastrangelo","year":"2014","journal-title":"Curr. Top. Med. Chem."},{"issue":"3","key":"2026010813061080200_cit13","doi-asserted-by":"crossref","first-page":"718","DOI":"10.2337\/db14-0509","article-title":"Metabolomics and diabetes: analytical and computational approaches","volume":"64","author":"Sas","year":"2015","journal-title":"Diabetes"},{"issue":"5","key":"2026010813061080200_cit14","doi-asserted-by":"crossref","first-page":"833","DOI":"10.2337\/dc15-2251","article-title":"Metabolomics in prediabetes and diabetes: a systematic review and meta-analysis","volume":"39","author":"Guasch-Ferr\u00e9","year":"2016","journal-title":"Diabetes Care"},{"issue":"1","key":"2026010813061080200_cit15","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.bbadis.2016.11.003","article-title":"Cognitive decline in type 2 diabetic db\/db mice may be associated with brain region-specific metabolic disorders","volume":"1863","author":"Zheng","year":"2017","journal-title":"BBA-Mol. Basis Dis."},{"issue":"2","key":"2026010813061080200_cit16","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s11011-016-9949-0","article-title":"NMR-based metabolomics reveals brain region-specific metabolic alterations in streptozotocin-induced diabetic rats with cognitive dysfunction","volume":"32","author":"Zheng","year":"2017","journal-title":"Metab. Brain Dis."},{"key":"2026010813061080200_cit17","doi-asserted-by":"crossref","first-page":"104941","DOI":"10.1016\/j.neuint.2020.104941","article-title":"Region-specific metabolic characterization of the type 1 diabetic brain in mice with and without cognitive impairment","volume":"143","author":"Xu","year":"2021","journal-title":"Neurochem. Int."},{"issue":"1","key":"2026010813061080200_cit18","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1177\/0271678X15626154","article-title":"Analysis of neuron\u2013astrocyte metabolic cooperation in the brain of db\/db mice with cognitive decline using 13C NMR spectroscopy","volume":"37","author":"Zheng","year":"2017","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"12","key":"2026010813061080200_cit19","doi-asserted-by":"crossref","first-page":"165541","DOI":"10.1016\/j.bbadis.2019.165541","article-title":"Type 1 diabetes induces cognitive dysfunction in rats associated with alterations of the gut microbiome and metabolomes in serum and hippocampus","volume":"1865","author":"Gao","year":"2019","journal-title":"BBA-Mol. Basis Dis"},{"key":"2026010813061080200_cit20","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.jare.2022.02.011","article-title":"Optimized integration of metabolomics and lipidomics reveals brain region-specific changes of oxidative stress and neuroinflammation in type 1 diabetic mice with cognitive decline","volume":"43","author":"Xiong","year":"2023","journal-title":"J. Adv. Res."},{"issue":"5","key":"2026010813061080200_cit21","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1021\/acs.jproteome.0c00879","article-title":"Metabolic interactions and differences between coronary heart disease and diabetes mellitus: a pilot study on biomarker determination and pathogenesis","volume":"20","author":"Liu","year":"2021","journal-title":"J. Proteome Res."},{"issue":"4","key":"2026010813061080200_cit22","doi-asserted-by":"crossref","first-page":"BSR20181379","DOI":"10.1042\/BSR20181379","article-title":"Changes in hepatic metabolic profile during the evolution of STZ-induced diabetic rats via an 1H NMR-based metabonomic investigation","volume":"39","author":"Chen","year":"2019","journal-title":"Biosci. Rep."},{"issue":"11","key":"2026010813061080200_cit23","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1681\/ASN.2013020126","article-title":"Metabolomics reveals signature of mitochondrial dysfunction in diabetic kidney disease","volume":"24","author":"Sharma","year":"2013","journal-title":"J. Am. Soc. Nephrol."},{"issue":"10","key":"2026010813061080200_cit24","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1167\/iovs.62.10.4","article-title":"Metabolomics in diabetic retinopathy: a systematic review","volume":"62","author":"Hou","year":"2021","journal-title":"Invest. Ophthalmol. Visual Sci."},{"issue":"D1","key":"2026010813061080200_cit25","doi-asserted-by":"crossref","first-page":"D622","DOI":"10.1093\/nar\/gkab1062","article-title":"HMDB 5.0: the human metabolome database for 2022","volume":"50","author":"Wishart","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"2026010813061080200_cit26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11306-019-1548-8","article-title":"NMR metabolomics identifies over 60 biomarkers associated with Type II Diabetes impairment in db\/db mice","volume":"15","author":"Mora-Ortiz","year":"2019","journal-title":"Metabolomics"},{"issue":"8","key":"2026010813061080200_cit27","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1021\/acs.jproteome.0c00049","article-title":"Sex-specific metabolic changes in peripheral organs of diabetic mice","volume":"19","author":"Zhang","year":"2020","journal-title":"J. Proteome Res."},{"issue":"4","key":"2026010813061080200_cit28","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1210\/clinem\/dgz240","article-title":"Metabolomics signatures in type 2 diabetes: a systematic review and integrative analysis","volume":"105","author":"Sun","year":"2020","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2026010813061080200_cit29","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1016\/j.csbj.2020.07.019","article-title":"Sex-specific metabolic alterations in the type 1 diabetic brain of mice revealed by an integrated method of metabolomics and mixed-model","volume":"18","author":"Jiang","year":"2020","journal-title":"Comput. Struct. Biotechnol. J."},{"issue":"11","key":"2026010813061080200_cit30","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.1016\/j.apsb.2021.05.013","article-title":"Spatial-resolved metabolomics reveals tissue-specific metabolic reprogramming in diabetic nephropathy by using mass spectrometry imaging","volume":"11","author":"Wang","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"issue":"7","key":"2026010813061080200_cit31","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.1021\/acs.jproteome.1c00179","article-title":"Spatially resolved metabolomics based on air-flow-assisted desorption electrospray ionization\u2013mass spectrometry imaging reveals region-specific metabolic alterations in diabetic encephalopathy","volume":"20","author":"Huo","year":"2021","journal-title":"J. Proteome Res."},{"issue":"1","key":"2026010813061080200_cit32","doi-asserted-by":"crossref","first-page":"48","DOI":"10.4239\/wjd.v14.i1.48","article-title":"Gut region-specific TNFR expression: TNFR2 is more affected than TNFR1 in duodenal myenteric ganglia of diabetic rats","volume":"14","author":"Barta","year":"2023","journal-title":"World J. Diabetes"},{"issue":"9","key":"2026010813061080200_cit33","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.3390\/cells10092410","article-title":"Intestinal region-specific and layer-dependent induction of TNF\u03b1 in rats with streptozotocin-induced diabetes and after insulin replacement","volume":"10","author":"B\u00f3di","year":"2021","journal-title":"Cells"},{"key":"2026010813061080200_cit34","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.biocel.2015.03.005","article-title":"Gut region-specific accumulation of reactive oxygen species leads to regionally distinct activation of antioxidant and apoptotic marker molecules in rats with STZ-induced diabetes","volume":"62","author":"Jancs\u00f3","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"2026010813061080200_cit35","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s00726-008-0152-4","article-title":"Amino acids and gut function","volume":"37","author":"Wang","year":"2009","journal-title":"Amino Acids"},{"key":"2026010813061080200_cit36","first-page":"1","article-title":"Amino acids in intestinal physiology and health","author":"Beaumont","year":"2020","journal-title":"Amino Acids Hum. Nutr. Health"},{"issue":"3","key":"2026010813061080200_cit37","doi-asserted-by":"crossref","first-page":"850S","DOI":"10.3945\/ajcn.2009.27462Y","article-title":"Metabolic fate and function of dietary glutamate in the gut","volume":"90","author":"Burrin","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"2026010813061080200_cit38","doi-asserted-by":"crossref","first-page":"106029","DOI":"10.1016\/j.intimp.2019.106029","article-title":"Arginine accelerates intestinal health through cytokines and intestinal microbiota","volume":"81","author":"Wu","year":"2020","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"2026010813061080200_cit39","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/s42003-020-01347-9","article-title":"Exogenous L-arginine increases intestinal stem cell function through CD90+ stromal cells producing mTORC1-induced Wnt2b","volume":"3","author":"Hou","year":"2020","journal-title":"Commun. Biol."},{"issue":"9","key":"2026010813061080200_cit40","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1021\/acs.jafc.9b07611","article-title":"l-Arginine ameliorates lipopolysaccharide-induced intestinal inflammation through inhibiting the TLR4\/NF-\u03baB and MAPK pathways and stimulating \u03b2-defensin expression in vivo and in vitro","volume":"68","author":"Lan","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"2026010813061080200_cit41","first-page":"21","article-title":"Histidine deficiency attenuates cell viability in rat intestinal epithelial cells by apoptosis via mitochondrial dysfunction","volume":"8","author":"Matsui","year":"2017","journal-title":"J. Nutr."},{"issue":"12","key":"2026010813061080200_cit42","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.3390\/antiox11122399","article-title":"Histidine deficiency inhibits intestinal antioxidant capacity and induces intestinal endoplasmic-reticulum stress, inflammatory response, apoptosis, and necroptosis in Largemouth Bass (Micropterus salmoides)","volume":"11","author":"Liang","year":"2022","journal-title":"Antioxidants"},{"key":"2026010813061080200_cit43","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s00726-013-1514-0","article-title":"Effects of dietary l-lysine intake on the intestinal mucosa and expression of CAT genes in weaned piglets","volume":"45","author":"He","year":"2013","journal-title":"Amino Acids"},{"issue":"8","key":"2026010813061080200_cit44","doi-asserted-by":"crossref","first-page":"476","DOI":"10.3390\/ani9080476","article-title":"l-phenylalanine increased gut hormone secretion through calcium-sensing receptor in the porcine duodenum","volume":"9","author":"Feng","year":"2019","journal-title":"Animals"},{"issue":"11","key":"2026010813061080200_cit45","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1038\/ijo.2017.164","article-title":"l-phenylalanine modulates gut hormone release and glucose tolerance, and suppresses food intake through the calcium-sensing receptor in rodents","volume":"41","author":"Alamshah","year":"2017","journal-title":"Int. J. Obes."},{"issue":"2","key":"2026010813061080200_cit46","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.bbadis.2017.11.009","article-title":"Serine prevented high-fat diet-induced oxidative stress by activating AMPK and epigenetically modulating the expression of glutathione synthesis-related genes","volume":"1864","author":"Zhou","year":"2018","journal-title":"BBA-Mol. Basis Dis."},{"key":"2026010813061080200_cit47","doi-asserted-by":"crossref","first-page":"5821428","DOI":"10.1155\/2020\/5821428","article-title":"Serine deficiency exacerbates inflammation and oxidative stress via microbiota-gut-brain axis in d-galactose-induced aging mice","volume":"2020","author":"Wang","year":"2020","journal-title":"Mediators Inflammation"},{"issue":"10","key":"2026010813061080200_cit48","doi-asserted-by":"crossref","first-page":"1700254","DOI":"10.1002\/biot.201700254","article-title":"Elucidating the impact of CHO cell culture media on tryptophan oxidation of a monoclonal antibody through gene expression analyses","volume":"13","author":"He","year":"2018","journal-title":"Biotechnol. J."},{"issue":"5","key":"2026010813061080200_cit49","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3390\/ani9050266","article-title":"L-tryptophan enhances intestinal integrity in diquat-challenged piglets associated with improvement of redox status and mitochondrial function","volume":"9","author":"Liu","year":"2019","journal-title":"Animals"},{"issue":"10","key":"2026010813061080200_cit50","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1080\/10408398.2019.1598334","article-title":"Tryptophan (Trp) modulates gut homeostasis via aryl hydrocarbon receptor (AhR)","volume":"60","author":"Sun","year":"2020","journal-title":"Crit. Rev. Food Sci."},{"issue":"6","key":"2026010813061080200_cit51","first-page":"678","article-title":"Taurine Protects Gut Barrier Function and Prevents Endothelial Cell Injury Induced by Ischaemia-Reperfusion","volume":"8","author":"Chen","year":"2017","journal-title":"Food Nutr. Sci."},{"issue":"11","key":"2026010813061080200_cit52","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1071\/AN16249","article-title":"Protective effects of taurine on growth performance and intestinal epithelial barrier function in weaned piglets challenged without or with lipopolysaccharide","volume":"58","author":"Tang","year":"2017","journal-title":"Anim. Prod. Sci."},{"key":"2026010813061080200_cit53","doi-asserted-by":"crossref","first-page":"121180","DOI":"10.1016\/j.lfs.2022.121180","article-title":"Taurine attenuated methotrexate-induced intestinal injury by regulating NF-\u03baB\/iNOS and Keap1\/Nrf2\/HO-1 signals","volume":"311","author":"Hassanein","year":"2022","journal-title":"Life Sci."},{"issue":"18","key":"2026010813061080200_cit54","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1080\/10408398.2016.1203286","article-title":"Short chain and polyunsaturated fatty acids in host gut health and foodborne bacterial pathogen inhibition","volume":"57","author":"Peng","year":"2017","journal-title":"Crit. Rev. Food Sci."},{"issue":"1","key":"2026010813061080200_cit55","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3390\/foods10010199","article-title":"Omega-3 polyunsaturated fatty acids and the intestinal epithelium-a review","volume":"10","author":"Durkin","year":"2021","journal-title":"Foods"},{"issue":"9","key":"2026010813061080200_cit56","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/iub.1428","article-title":"Polyunsaturated fatty acids and inflammation","volume":"67","author":"Marion-Letellier","year":"2015","journal-title":"IUBMB Life"},{"issue":"5","key":"2026010813061080200_cit57","doi-asserted-by":"crossref","first-page":"4567","DOI":"10.3390\/ijms24054567","article-title":"Dietary Fatty Acids and Inflammation: Focus on the n-6 Series","volume":"24","author":"Poli","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"2026010813061080200_cit58","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.fsi.2015.11.026","article-title":"Dietary alpha-linolenic acid\/linoleic acid ratios modulate intestinal immunity, tight junctions, anti-oxidant status and mRNA levels of NF-\u03baB p65, MLCK and Nrf2 in juvenile grass carp (Ctenopharyngodon idella)","volume":"51","author":"Zeng","year":"2016","journal-title":"Fish Shellfish Immunol."},{"issue":"10","key":"2026010813061080200_cit59","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.3945\/jn.109.119768","article-title":"An \u03b1-linolenic acid-rich formula reduces oxidative stress and inflammation by regulating NF-\u03baB in rats with TNBS-induced colitis","volume":"140","author":"Hassan","year":"2010","journal-title":"J. Nutr."},{"issue":"12","key":"2026010813061080200_cit60","doi-asserted-by":"crossref","first-page":"3873","DOI":"10.1002\/fsn3.1225","article-title":"Alpha-linolenic acid given as an anti-inflammatory agent in a mouse model of colonic inflammation","volume":"7","author":"Wen","year":"2019","journal-title":"Food Sci. Nutr."},{"issue":"3","key":"2026010813061080200_cit61","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/00001432-200106000-00003","article-title":"Roles of prostaglandins and leukotrienes in acute inflammation caused by bacterial infection","volume":"14","author":"Yoshikai","year":"2001","journal-title":"Curr. Opin. Infect. Dis."},{"issue":"12","key":"2026010813061080200_cit62","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1111\/apt.17473","article-title":"Type 1 diabetes and microscopic colitis: A nationwide matched case\u2013control study in Sweden","volume":"57","author":"Kang","year":"2023","journal-title":"Aliment. Pharmacol. Ther."},{"key":"2026010813061080200_cit63","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3389\/fendo.2020.00125","article-title":"Evaluating the causal role of gut microbiota in type 1 diabetes and its possible pathogenic mechanisms","volume":"11","author":"Zhou","year":"2020","journal-title":"Front. Endocrinol."},{"issue":"23","key":"2026010813061080200_cit64","doi-asserted-by":"crossref","first-page":"14650","DOI":"10.3390\/ijms232314650","article-title":"Pathophysiology of type 1 diabetes and gut microbiota role","volume":"23","author":"Del Chierico","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"2026010813061080200_cit65","doi-asserted-by":"crossref","first-page":"6356","DOI":"10.1038\/s41467-022-33656-4","article-title":"Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetes","volume":"13","author":"Yuan","year":"2022","journal-title":"Nat. Commun."},{"issue":"10","key":"2026010813061080200_cit66","doi-asserted-by":"crossref","first-page":"834","DOI":"10.15252\/msb.20156487","article-title":"The gut microbiota modulates host amino acid and glutathione metabolism in mice","volume":"11","author":"Mardinoglu","year":"2015","journal-title":"Mol. Syst. Biol."},{"issue":"1","key":"2026010813061080200_cit67","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.1038\/s41467-018-05767-4","article-title":"The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice","volume":"9","author":"Kindt","year":"2018","journal-title":"Nat. Commun."},{"issue":"12","key":"2026010813061080200_cit68","doi-asserted-by":"crossref","first-page":"e110440","DOI":"10.1371\/journal.pone.0110440","article-title":"Regionally distinct alterations in the composition of the gut microbiota in rats with streptozotocin-induced diabetes","volume":"9","author":"Wirth","year":"2014","journal-title":"PLoS One"}],"container-title":["Molecular Omics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/molecular-omics\/article-pdf\/20\/2\/128\/65027953\/d3mo00163f.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/molecular-omics\/article-pdf\/20\/2\/128\/65027953\/d3mo00163f.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T18:07:51Z","timestamp":1767895671000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/molecular-omics\/article\/20\/2\/128\/8277291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,7]]},"references-count":68,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,11,7]]}},"URL":"https:\/\/doi.org\/10.1039\/d3mo00163f","relation":{},"ISSN":["2515-4184"],"issn-type":[{"value":"2515-4184","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,2,1]]},"published":{"date-parts":[[2023,11,7]]}}}