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For the identification of novel therapeutic targets in KSD, we adopted high-throughput sequencing and mass spectrometry (MS) techniques in this study and carried out an integrative analysis of exosome proteomic data and DNA methylation data from blood samples of normal and KSD individuals. Our research delineated the profiling of exosomal proteins and DNA methylation in both healthy individuals and those afflicted with KSD, finding that the overexpressed proteins and the demethylated genes in KSD samples are associated with immune responses. The consistency of the results in proteomics and epigenetics supports the feasibility of the comprehensive strategy. Our insights into the molecular landscape of KSD pave the way for a deeper understanding of its pathogenic mechanism, providing an opportunity for more precise diagnosis and targeted treatment strategies for KSD.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/d3mo00261f","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T04:33:45Z","timestamp":1713242025000},"page":"322-332","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A blood-based multi-omic landscape for the molecular characterization of kidney stone disease"],"prefix":"10.1093","volume":"20","author":[{"given":"Weibing","family":"Pan\u2021","sequence":"first","affiliation":[{"name":"Department of Urology, Shenzhen Pingshan People's Hospital a , Shenzhen, Guangdong 518118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianwei","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Urology, Shenzhen Pingshan People's Hospital a , Shenzhen, Guangdong 518118, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Shenzhen Pingshan People's Hospital b , Shenzhen, Guangdong 518118, China \u00a0 gdszpsrmyy@163.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijun","family":"Ruan","sequence":"additional","affiliation":[{"name":"Pingshan Translational Medicine Center, Shenzhen Bay Laboratory c , Shenzhen, Guangdong 518020, China \u00a0 anyh@szbl.ac.cn \u00a0 wangrui@szbl.ac.cn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuanjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Pingshan Translational Medicine Center, Shenzhen Bay Laboratory c , Shenzhen, Guangdong 518020, China \u00a0 anyh@szbl.ac.cn \u00a0 wangrui@szbl.ac.cn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0224-9709","authenticated-orcid":false,"given":"Yuhao","family":"An","sequence":"additional","affiliation":[{"name":"Pingshan Translational Medicine Center, Shenzhen Bay Laboratory c , Shenzhen, Guangdong 518020, China \u00a0 anyh@szbl.ac.cn \u00a0 wangrui@szbl.ac.cn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3830-4133","authenticated-orcid":false,"given":"Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"Pingshan Translational Medicine Center, Shenzhen Bay Laboratory c , Shenzhen, Guangdong 518020, China \u00a0 anyh@szbl.ac.cn \u00a0 wangrui@szbl.ac.cn"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Shenzhen Pingshan People's Hospital b , Shenzhen, Guangdong 518118, China \u00a0 gdszpsrmyy@163.com"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,4,16]]},"reference":[{"issue":"4","key":"2026010813055670200_cit1","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/s41581-021-00513-4","article-title":"The genetics of kidney stone disease and nephrocalcinosis","volume":"18","author":"Singh","year":"2022","journal-title":"Nat Rev Nephrol"},{"issue":"7","key":"2026010813055670200_cit2","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1046\/j.1464-410X.2003.04472.x","article-title":"Influence of cranberry juice on the urinary risk factors for calcium o xalate kidney stone formation","volume":"92","author":"McHarg","year":"2003","journal-title":"BJU Int."},{"issue":"11 Pt B","key":"2026010813055670200_cit3","first-page":"E438","article-title":"A 970 Hounsfield units (HU) threshold of kidney stone density on non-c ontrast computed tomography (NCCT) improves patients\u2019 selection for ex tracorporeal shockwave lithotripsy (ESWL): evidence from a prospective study","volume":"110","author":"Ouzaid","year":"2012","journal-title":"BJU Int."},{"issue":"12","key":"2026010813055670200_cit4","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1002\/jbmr.158","article-title":"Renal macrophage migration and crystal phagocytosis via inflammatory-related gene expression during kidney stone formation and elimination in mice: Detection by association analysis of stone-related gene expression and microstructural observation","volume":"25","author":"Okada","year":"2010","journal-title":"J. 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