{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:22:00Z","timestamp":1788189720971,"version":"build-2803163510"},"reference-count":64,"publisher":"Royal Society of Chemistry (RSC)","issue":"2","license":[{"start":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T00:00:00Z","timestamp":1704240000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["ID-RBMH\/FW\/2021\/26"],"award-info":[{"award-number":["ID-RBMH\/FW\/2021\/26"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007342","name":"Hamdard National Foundation","doi-asserted-by":"publisher","award":["15\/07\/2021-08\/06\/2022"],"award-info":[{"award-number":["15\/07\/2021-08\/06\/2022"]}],"id":[{"id":"10.13039\/501100007342","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["SR\/PURSE Phase 2\/39[C]"],"award-info":[{"award-number":["SR\/PURSE Phase 2\/39[C]"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["SR\/FST\/LS-1\/2017\/85[C]"],"award-info":[{"award-number":["SR\/FST\/LS-1\/2017\/85[C]"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Nanoscale Adv."],"abstract":"<jats:p>Mechanistic process development and effect on the polycystic ovarian syndrome (PCOS).<\/jats:p>","DOI":"10.1039\/d3na00943b","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T18:50:28Z","timestamp":1704307828000},"page":"648-668","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["<i>In silico<\/i>\n                    and\n                    <i>in vitro<\/i>\n                    assessment of an optimized QbD-guided myoinositol and metformin-loaded mucus-penetrating particle-based gel for the amelioration of PCOS"],"prefix":"10.1039","volume":"6","author":[{"given":"Uzma","family":"Farooq","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmaceutical Education and Research (SPER), Jamia Hamdard, New Delhi 110062, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Aamir","family":"Mirza","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmaceutical Education and Research (SPER), Jamia Hamdard, New Delhi 110062, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Alshetaili","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2124-8537","authenticated-orcid":false,"given":"Sradhanjali","family":"Mohapatra","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmaceutical Education and Research (SPER), Jamia Hamdard, New Delhi 110062, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmaceutical Education and Research (SPER), Jamia Hamdard, New Delhi 110062, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazia","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmaceutical Education and Research (SPER), Jamia Hamdard, New Delhi 110062, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4842-6436","authenticated-orcid":false,"given":"Zeenat","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmaceutical Education and Research (SPER), Jamia Hamdard, New Delhi 110062, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asgar","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmaceutical Education and Research (SPER), Jamia Hamdard, New Delhi 110062, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2024]]},"reference":[{"issue":"77","key":"D3NA00943B\/cit1\/1","first-page":"1","volume":"19","author":"Ohara","year":"2021","journal-title":"Reprod. Biol. Endocrinol."},{"key":"D3NA00943B\/cit2\/1","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.2174\/1871530320666200730225830","volume":"20","author":"Mohapatra","year":"2020","journal-title":"Endocr. Metab. Immune Disord. - Drug Targets"},{"issue":"19","key":"D3NA00943B\/cit3\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms231911246","volume":"23","author":"Antonowski","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"D3NA00943B\/cit4\/1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nrendo.2012.69","volume":"8","author":"Diamanti-Kandarakis","year":"2012","journal-title":"Nat. Rev. Endocrinol."},{"key":"D3NA00943B\/cit5\/1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s40618-020-01351-0","volume":"44","author":"Moghetti","year":"2021","journal-title":"J. Endocrinol. Invest."},{"key":"D3NA00943B\/cit6\/1","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1080\/09513590.2020.1810657","volume":"37","author":"Prabhakar","year":"2021","journal-title":"Gynecol. Endocrinol."},{"key":"D3NA00943B\/cit7\/1","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.jconrel.2014.04.033","volume":"190","author":"Ensign","year":"2014","journal-title":"J. Controlled Release"},{"issue":"138","key":"D3NA00943B\/cit8\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/scitranslmed.3003453","volume":"4","author":"Ensign","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"D3NA00943B\/cit9\/1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.biomaterials.2017.08.029","volume":"144","author":"Mohideen","year":"2017","journal-title":"Biomaterials"},{"issue":"4","key":"D3NA00943B\/cit10\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/pharmaceutics11040184","volume":"11","author":"Yang","year":"2019","journal-title":"Pharmaceutics"},{"key":"D3NA00943B\/cit11\/1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.colsurfb.2016.04.016","volume":"144","author":"Saini","year":"2016","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"D3NA00943B\/cit12\/1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.ejpb.2022.10.015","volume":"180","author":"Waheed","year":"2022","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"15","key":"D3NA00943B\/cit13\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/polym14153220","volume":"14","author":"Gausuzzaman","year":"2022","journal-title":"Polymers"},{"issue":"7","key":"D3NA00943B\/cit14\/1","doi-asserted-by":"crossref","first-page":"6918","DOI":"10.1021\/acsomega.2c07718","volume":"8","author":"Hassan","year":"2023","journal-title":"ACS Omega"},{"key":"D3NA00943B\/cit15\/1","doi-asserted-by":"crossref","first-page":"9583","DOI":"10.1021\/acsomega.9b00436","volume":"4","author":"Hassan","year":"2019","journal-title":"ACS Omega"},{"key":"D3NA00943B\/cit16\/1","first-page":"1","author":"Panigrahi","year":"2021","journal-title":"SN Appl. Sci."},{"key":"D3NA00943B\/cit17\/1","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.ijpharm.2019.05.072","volume":"566","author":"Shkodra-Pula","year":"2019","journal-title":"Int. J. Pharm."},{"key":"D3NA00943B\/cit18\/1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2020.102107","volume":"61","author":"Amirsaadat","year":"2021","journal-title":"J. Drug Deliv. Sci. Technol."},{"issue":"10","key":"D3NA00943B\/cit19\/1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14102170","volume":"14","author":"Puri","year":"2022","journal-title":"Pharmaceutics"},{"key":"D3NA00943B\/cit20\/1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2021.102480","volume":"63","author":"Saha","year":"2021","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"D3NA00943B\/cit21\/1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymdegradstab.2021.109535","volume":"187","author":"Maeda","year":"2021","journal-title":"Polym. Degrad. Stab."},{"key":"D3NA00943B\/cit22\/1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2021.102480","volume":"63","author":"Saha","year":"2021","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"D3NA00943B\/cit23\/1","doi-asserted-by":"crossref","first-page":"103850","DOI":"10.1016\/j.jddst.2022.103850","volume":"77","author":"Khuroo","year":"2022","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"D3NA00943B\/cit24\/1","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s40005-015-0221-0","volume":"45","author":"Lee","year":"2015","journal-title":"J. Pharm. Investig."},{"key":"D3NA00943B\/cit25\/1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics11110559","author":"Shukla","year":"2019","journal-title":"Pharmaceutics"},{"key":"D3NA00943B\/cit26\/1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3390\/gels9020112","volume":"9","author":"Khan","year":"2023","journal-title":"Gels"},{"key":"D3NA00943B\/cit27\/1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/909354","author":"Xu","year":"2013","journal-title":"Infect. Dis. Obstet. Gynecol."},{"key":"D3NA00943B\/cit28\/1","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.colsurfb.2014.05.041","volume":"121","author":"Jain","year":"2014","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"D3NA00943B\/cit29\/1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.colsurfb.2014.10.060","volume":"125","author":"Coviello","year":"2015","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"D3NA00943B\/cit30\/1","doi-asserted-by":"crossref","first-page":"103447","DOI":"10.1016\/j.jddst.2022.103447","volume":"73","author":"Nikhat","year":"2022","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"D3NA00943B\/cit31\/1","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1002\/dta.1700","volume":"6","author":"G\u00f6rgens","year":"2014","journal-title":"Drug Test. Anal."},{"key":"D3NA00943B\/cit32\/1","doi-asserted-by":"crossref","first-page":"114078","DOI":"10.1016\/j.jpba.2021.114078","volume":"200","author":"Abou-Omar","year":"2021","journal-title":"J. Pharm. Biomed. Anal."},{"key":"D3NA00943B\/cit33\/1","doi-asserted-by":"crossref","first-page":"101469","DOI":"10.1016\/j.jddst.2019.101469","volume":"55","author":"khan","year":"2020","journal-title":"J. Drug Deliv. Sci. Technol."},{"issue":"1","key":"D3NA00943B\/cit34\/1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1080\/03639045.2019.1698598","volume":"46","author":"Jain","year":"2020","journal-title":"Drug Dev. Ind. Pharm."},{"key":"D3NA00943B\/cit35\/1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jconrel.2016.04.035","volume":"233","author":"Kimball","year":"2016","journal-title":"J. Controlled Release"},{"key":"D3NA00943B\/cit36\/1","doi-asserted-by":"crossref","first-page":"8530","DOI":"10.1039\/C9RA09569A","volume":"10","author":"Jain","year":"2020","journal-title":"RSC Adv."},{"key":"D3NA00943B\/cit37\/1","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.actbio.2016.08.018","volume":"44","author":"Machado","year":"2016","journal-title":"Acta Biomater."},{"key":"D3NA00943B\/cit38\/1","doi-asserted-by":"publisher","DOI":"10.1186\/2050-6511-13-9","volume":"13","author":"Lozenski","year":"2012","journal-title":"BMC Pharmacol. Toxicol."},{"key":"D3NA00943B\/cit39\/1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.18519\/jer\/2015\/v19\/86061","volume":"19","author":"Yakubu","year":"2015","journal-title":"J. Endocrinol. Reprod."},{"key":"D3NA00943B\/cit40\/1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.addr.2018.04.004","volume":"128","author":"Colombo","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"key":"D3NA00943B\/cit41\/1","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.2217\/nnm-2020-0079","volume":"15","author":"Zakir","year":"2020","journal-title":"Nanomedicine"},{"key":"D3NA00943B\/cit42\/1","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1016\/j.sjbs.2021.03.046","volume":"28","author":"Jain","year":"2021","journal-title":"Saudi J. Biol. Sci."},{"key":"D3NA00943B\/cit43\/1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.120428","volume":"599","author":"Hasan","year":"2021","journal-title":"Int. J. Pharm."},{"key":"D3NA00943B\/cit44\/1","doi-asserted-by":"crossref","first-page":"798","DOI":"10.2174\/1573411018666220304085236","volume":"18","author":"Hasan","year":"2022","journal-title":"Curr. Anal. Chem."},{"key":"D3NA00943B\/cit45\/1","doi-asserted-by":"crossref","first-page":"105060","DOI":"10.1016\/j.chemphyslip.2021.105060","volume":"236","author":"Khanna","year":"2021","journal-title":"Chem. Phys. Lipids"},{"key":"D3NA00943B\/cit46\/1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ejpb.2015.04.019","volume":"94","author":"ud Din","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"D3NA00943B\/cit47\/1","doi-asserted-by":"publisher","DOI":"10.1016\/J.COLSURFA.2021.126928","volume":"625","author":"Beck-Broichsitter","year":"2021","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"D3NA00943B\/cit48\/1","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.jphotobiol.2018.04.022","volume":"183","author":"Padhi","year":"2018","journal-title":"J. Photochem. Photobiol., B"},{"key":"D3NA00943B\/cit49\/1","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jconrel.2011.06.036","volume":"156","author":"Cu","year":"2011","journal-title":"J. Controlled Release"},{"key":"D3NA00943B\/cit50\/1","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.ijbiomac.2020.02.311","volume":"152","author":"Siddiqui","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"D3NA00943B\/cit51\/1","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.2217\/nnm-2020-0079","volume":"15","author":"Zakir","year":"2020","journal-title":"Nanomedicine"},{"key":"D3NA00943B\/cit52\/1","doi-asserted-by":"publisher","DOI":"10.1007\/s11051-015-2875-y","volume":"17","author":"Dur\u00e1n-Lobato","year":"2015","journal-title":"J. Nanopart. Res."},{"key":"D3NA00943B\/cit53\/1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.3390\/pharmaceutics15020465","volume":"15","author":"Zydowsky","year":"2023","journal-title":"Pharmaceutics"},{"key":"D3NA00943B\/cit54\/1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.sjbs.2020.10.005","volume":"28","author":"Firdaus","year":"2021","journal-title":"Saudi J. Biol. Sci."},{"key":"D3NA00943B\/cit55\/1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.03.101","volume":"102","author":"Arya","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"D3NA00943B\/cit56\/1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.biomaterials.2015.08.048","volume":"72","author":"Wang","year":"2015","journal-title":"Biomaterials"},{"key":"D3NA00943B\/cit57\/1","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1208\/s12249-022-02384-9","volume":"23","author":"Zahid","year":"2022","journal-title":"AAPS PharmSciTech"},{"key":"D3NA00943B\/cit58\/1","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1002\/adhm.201300519","volume":"3","author":"Yang","year":"2014","journal-title":"Adv. Healthc. Mater."},{"issue":"1","key":"D3NA00943B\/cit59\/1","doi-asserted-by":"publisher","DOI":"10.1186\/s40738-020-00074-3","volume":"6","author":"Ajayi","year":"2020","journal-title":"Fertil. Res. Pract."},{"key":"D3NA00943B\/cit60\/1","doi-asserted-by":"crossref","first-page":"174062","DOI":"10.1016\/j.ejphar.2021.174062","volume":"900","author":"Mihanfar","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"D3NA00943B\/cit61\/1","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1038\/s41591-019-0509-0","volume":"25","author":"Qi","year":"2019","journal-title":"Nat. Med."},{"key":"D3NA00943B\/cit62\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13048-018-0427-7","volume":"11","author":"Furat Rencber","year":"2018","journal-title":"J. Ovarian Res."},{"issue":"6","key":"D3NA00943B\/cit63\/1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11061099","volume":"11","author":"Rudic","year":"2022","journal-title":"Antioxidants"},{"key":"D3NA00943B\/cit64\/1","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1038\/s41591-019-0509-0","volume":"25","author":"Qi","year":"2019","journal-title":"Nat. Med."}],"container-title":["Nanoscale Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/NA\/D3NA00943B","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:47:16Z","timestamp":1782884836000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/na\/article\/6\/2\/648-668\/814514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":64,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,1,16]]}},"URL":"https:\/\/doi.org\/10.1039\/d3na00943b","relation":{},"ISSN":["2516-0230"],"issn-type":[{"value":"2516-0230","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}