{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T02:02:06Z","timestamp":1785549726130,"version":"3.56.0"},"reference-count":59,"publisher":"Royal Society of Chemistry (RSC)","issue":"46","license":[{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"vor","delay-in-days":316,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["SEV-2017-0706"],"award-info":[{"award-number":["SEV-2017-0706"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["CEX2021-001214-S"],"award-info":[{"award-number":["CEX2021-001214-S"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["881603"],"award-info":[{"award-number":["881603"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Nanoscale"],"abstract":"<jats:p>Synaptic potentiation with increased dendritic spine density is a signature of fear memory consolidation in the lateral amygdala. Small graphene oxide reduces synaptic release and potentiation, preventing dendritic spine increase and fear behaviour.<\/jats:p>","DOI":"10.1039\/d3nr04490d","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T10:42:56Z","timestamp":1699872176000},"page":"18581-18591","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Delivery of graphene oxide nanosheets modulates glutamate release and normalizes amygdala synaptic plasticity to improve anxiety-related behavior"],"prefix":"10.1039","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0495-3565","authenticated-orcid":false,"given":"Elisa","family":"Pati","sequence":"first","affiliation":[{"name":"Neuroscience Area, International School for Advanced Studies (SISSA\/ISAS), 34136 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2982-7282","authenticated-orcid":false,"given":"Audrey","family":"Franceschi Biagioni","sequence":"additional","affiliation":[{"name":"Neuroscience Area, International School for Advanced Studies (SISSA\/ISAS), 34136 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Casani","sequence":"additional","affiliation":[{"name":"Neuroscience Area, International School for Advanced Studies (SISSA\/ISAS), 34136 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9026-1743","authenticated-orcid":false,"given":"Neus","family":"Lozano","sequence":"additional","affiliation":[{"name":"Nanomedicine Lab Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, Bellaterra, 08193 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2224-6672","authenticated-orcid":false,"given":"Kostas","family":"Kostarelos","sequence":"additional","affiliation":[{"name":"Nanomedicine Lab Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, Bellaterra, 08193 Barcelona, Spain"},{"name":"Nanomedicine Lab, and Faculty of Biology, Medicine & Health, The National Graphene Institute, University of Manchester, Manchester, M13 9PL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9198-8402","authenticated-orcid":false,"given":"Giada","family":"Cellot","sequence":"additional","affiliation":[{"name":"Neuroscience Area, International School for Advanced Studies (SISSA\/ISAS), 34136 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8420-0787","authenticated-orcid":false,"given":"Laura","family":"Ballerini","sequence":"additional","affiliation":[{"name":"Neuroscience Area, International School for Advanced Studies (SISSA\/ISAS), 34136 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2023]]},"reference":[{"key":"D3NR04490D\/cit1\/1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nmat1849","volume":"6","author":"Geim","year":"2007","journal-title":"Nat. Mater."},{"key":"D3NR04490D\/cit2\/1","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1038\/s41592-021-01270-9","volume":"18","author":"Garcia-Etxarri","year":"2021","journal-title":"Nat. Methods"},{"key":"D3NR04490D\/cit3\/1","volume-title":"Unbounding the Future: The Nanotechnology Revolution","author":"Drexler","year":"1991","unstructured":"E. K.Drexler ,  C.Peterson  and  G.Pergamit ,  Unbounding the Future: The Nanotechnology Revolution ,  William Morrow and Company, Inc. ,  New York, NY, USA , 1st edn,  1991"},{"key":"D3NR04490D\/cit4\/1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3390\/molecules25010112","volume":"25","author":"Bayda","year":"2020","journal-title":"Molecules"},{"key":"D3NR04490D\/cit5\/1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/adma.201203229","volume":"25","author":"Feng","year":"2013","journal-title":"Adv. Mater."},{"key":"D3NR04490D\/cit6\/1","doi-asserted-by":"crossref","first-page":"1700909","DOI":"10.1002\/adma.201700909","volume":"29","author":"Kostarelos","year":"2017","journal-title":"Adv. Mater."},{"key":"D3NR04490D\/cit7\/1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3389\/fnsys.2018.00012","volume":"12","author":"Bramini","year":"2018","journal-title":"Front. Syst. Neurosci."},{"key":"D3NR04490D\/cit8\/1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41390-021-01681-6","volume":"92","author":"Cellot","year":"2022","journal-title":"Pediatr. Res."},{"key":"D3NR04490D\/cit9\/1","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1021\/acs.nanolett.8b04903","volume":"19","author":"Rauti","year":"2019","journal-title":"Nano Lett."},{"key":"D3NR04490D\/cit10\/1","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1039\/C9NH00777F","volume":"5","author":"Cellot","year":"2020","journal-title":"Nanoscale Horiz."},{"key":"D3NR04490D\/cit11\/1","doi-asserted-by":"crossref","first-page":"120749","DOI":"10.1016\/j.biomaterials.2021.120749","volume":"271","author":"Franceschi Biagioni","year":"2021","journal-title":"Biomaterials"},{"key":"D3NR04490D\/cit12\/1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/npp.2009.83","volume":"35","author":"Shin","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"D3NR04490D\/cit13\/1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nrn3677","volume":"15","author":"Bannerman","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"D3NR04490D\/cit14\/1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.neuron.2014.03.030","volume":"82","author":"Parsons","year":"2014","journal-title":"Neuron"},{"key":"D3NR04490D\/cit15\/1","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.biopsych.2004.01.007","volume":"55","author":"Somerville","year":"2004","journal-title":"Biol. Psychiatry"},{"key":"D3NR04490D\/cit16\/1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.janxdis.2012.08.004","volume":"27","author":"Pacella","year":"2013","journal-title":"J. Anxiety Disord."},{"key":"D3NR04490D\/cit17\/1","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.biopsych.2010.02.008","volume":"67","author":"Rosenkranz","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"D3NR04490D\/cit18\/1","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/S0306-4522(01)00150-6","volume":"104","author":"Dielenberg","year":"2001","journal-title":"Neuroscience"},{"key":"D3NR04490D\/cit19\/1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.yhbeh.2009.08.002","volume":"56","author":"Mu\u00f1oz-Abell\u00e1n","year":"2009","journal-title":"Horm. Behav."},{"key":"D3NR04490D\/cit20\/1","doi-asserted-by":"crossref","first-page":"035020","DOI":"10.1088\/2053-1583\/aac05c","volume":"5","author":"Rodrigues","year":"2018","journal-title":"2D Mater."},{"key":"D3NR04490D\/cit21\/1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1590\/1516-4446-2015-1895","volume":"39","author":"Coimbra","year":"2017","journal-title":"Braz. J. Psychiat."},{"key":"D3NR04490D\/cit22\/1","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1016\/j.neuron.2021.07.003","volume":"109","author":"Choi","year":"2021","journal-title":"Neuron"},{"key":"D3NR04490D\/cit23\/1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s00213-018-5053-y","volume":"236","author":"Chakraborty","year":"2019","journal-title":"Psychopharmacology"},{"key":"D3NR04490D\/cit24\/1","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.bbr.2009.08.014","volume":"205","author":"Mitra","year":"2009","journal-title":"Behav. Brain Res."},{"key":"D3NR04490D\/cit25\/1","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/s41565-018-0163-6","volume":"13","author":"Pampaloni","year":"2018","journal-title":"Nat. Nanotechnol."},{"key":"D3NR04490D\/cit26\/1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s13041-019-0520-x","volume":"12","author":"Yoo","year":"2019","journal-title":"Mol. Brain"},{"key":"D3NR04490D\/cit27\/1","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1038\/s41598-018-38412-7","volume":"9","author":"Borczyk","year":"2019","journal-title":"Sci. Rep."},{"key":"D3NR04490D\/cit28\/1","first-page":"56153","volume":"128","author":"McLeod","year":"2017","journal-title":"J. Visualized Exp."},{"key":"D3NR04490D\/cit29\/1","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/S0006-3495(96)79325-6","volume":"71","author":"Uteshev","year":"1996","journal-title":"Biophys. J."},{"key":"D3NR04490D\/cit30\/1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/357134a0","volume":"357","author":"Malgaroli","year":"1992","journal-title":"Nature"},{"key":"D3NR04490D\/cit31\/1","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/0896-6273(93)90206-7","volume":"10","author":"Cormier","year":"1993","journal-title":"Neuron"},{"key":"D3NR04490D\/cit32\/1","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1038\/nprot.2006.476","volume":"1","author":"Gaffield","year":"2006","journal-title":"Nat. Protoc."},{"issue":"5041","key":"D3NR04490D\/cit33\/1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1126\/science.1553547","volume":"255","author":"Betz","year":"1992","journal-title":"Science"},{"key":"D3NR04490D\/cit34\/1","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/0896-6273(93)90081-2","volume":"11","author":"Ryan","year":"1993","journal-title":"Neuron"},{"key":"D3NR04490D\/cit35\/1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/978-1-59745-178-9_26","volume":"440","author":"Verstreken","year":"2008","journal-title":"Methods Mol. Biol."},{"key":"D3NR04490D\/cit36\/1","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/89498","volume":"4","author":"Zakharenko","year":"2001","journal-title":"Nat. Neurosci."},{"key":"D3NR04490D\/cit37\/1","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1152\/jn.1993.69.4.1350","volume":"69","author":"Rainnie","year":"1993","journal-title":"J. Neurophysiol."},{"key":"D3NR04490D\/cit38\/1","doi-asserted-by":"crossref","first-page":"9741","DOI":"10.1073\/pnas.170032297","volume":"97","author":"Gasparini","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D3NR04490D\/cit39\/1","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0896-6273(00)80301-3","volume":"18","author":"Murthy","year":"1997","journal-title":"Neuron"},{"key":"D3NR04490D\/cit40\/1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1146\/annurev.ne.12.030189.000305","volume":"12","author":"Zucker","year":"1989","journal-title":"Annu. Rev. Neurosci."},{"key":"D3NR04490D\/cit41\/1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1113\/jphysiol.1996.sp021204","volume":"491","author":"Debanne","year":"1996","journal-title":"J. Physiol."},{"key":"D3NR04490D\/cit42\/1","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1152\/jn.1993.70.4.1451","volume":"70","author":"Manabe","year":"1993","journal-title":"J. Neurophysiol."},{"key":"D3NR04490D\/cit43\/1","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/j.neubiorev.2005.04.008","volume":"29","author":"Takahashi","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"D3NR04490D\/cit44\/1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1101\/lm.30901","volume":"8","author":"Blair","year":"2001","journal-title":"Learn. Mem."},{"key":"D3NR04490D\/cit45\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-4328(01)00324-2","volume":"129","author":"McGregor","year":"2002","journal-title":"Behav. Brain Res."},{"key":"D3NR04490D\/cit46\/1","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.neuron.2014.03.021","volume":"82","author":"Bosch","year":"2014","journal-title":"Neuron"},{"key":"D3NR04490D\/cit47\/1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.taml.2015.11.003","volume":"5","author":"Song","year":"2015","journal-title":"Theor. Appl. Mech. Lett."},{"key":"D3NR04490D\/cit48\/1","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.chempr.2017.12.017","volume":"4","author":"Mukherjee","year":"2018","journal-title":"Chem"},{"key":"D3NR04490D\/cit49\/1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3389\/fnsyn.2015.00009","volume":"7","author":"High","year":"2015","journal-title":"Front. Synaptic Neurosci."},{"key":"D3NR04490D\/cit50\/1","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.neuron.2005.08.009","volume":"47","author":"Maren","year":"2005","journal-title":"Neuron"},{"key":"D3NR04490D\/cit51\/1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1126\/science.1103944","volume":"308","author":"Rumpel","year":"2005","journal-title":"Science"},{"key":"D3NR04490D\/cit52\/1","doi-asserted-by":"crossref","first-page":"11510","DOI":"10.1523\/JNEUROSCI.3077-07.2007","volume":"27","author":"Bayazitov","year":"2007","journal-title":"J. Neurosci."},{"key":"D3NR04490D\/cit53\/1","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/S0896-6273(00)80338-4","volume":"18","author":"Dobrunz","year":"1997","journal-title":"Neuron"},{"key":"D3NR04490D\/cit54\/1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.tins.2011.06.007","volume":"35","author":"Mahan","year":"2012","journal-title":"Trends Neurosci."},{"key":"D3NR04490D\/cit55\/1","doi-asserted-by":"crossref","first-page":"31858","DOI":"10.3402\/ejpt.v7.31858","volume":"7","author":"Kelmendi","year":"2016","journal-title":"Eur. J. Psychotraumatology"},{"key":"D3NR04490D\/cit56\/1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41390-021-01681-6","volume":"92","author":"Cellot","year":"2022","journal-title":"Pediatr. Res."},{"key":"D3NR04490D\/cit57\/1","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.3390\/nano12071149","volume":"12","author":"Oliveira","year":"2022","journal-title":"Nanomaterials"},{"key":"D3NR04490D\/cit58\/1","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1021\/acs.nanolett.3c00377","volume":"23","author":"Castagnola","year":"2023","journal-title":"Nano Lett."},{"key":"D3NR04490D\/cit59\/1","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1016\/j.neuron.2021.05.017","volume":"109","author":"Bienvenu","year":"2021","journal-title":"Neuron"}],"container-title":["Nanoscale"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2023\/NR\/D3NR04490D","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:23:27Z","timestamp":1782887007000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/nr\/article\/15\/46\/18581-18591\/818417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":59,"journal-issue":{"issue":"46","published-print":{"date-parts":[[2023,11,30]]}},"URL":"https:\/\/doi.org\/10.1039\/d3nr04490d","relation":{},"ISSN":["2040-3364","2040-3372"],"issn-type":[{"value":"2040-3364","type":"print"},{"value":"2040-3372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}