{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:37:12Z","timestamp":1788561432504,"version":"build-2803163510"},"reference-count":56,"publisher":"Royal Society of Chemistry (RSC)","issue":"16","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"am","delay-in-days":443,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["CRG\/2019\/004018"],"award-info":[{"award-number":["CRG\/2019\/004018"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Nanoscale"],"abstract":"<jats:p>A schematic representation of collagen-induced rheumatoiad arthritis (RA) before and after treatment.<\/jats:p>","DOI":"10.1039\/d3nr06476j","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T03:20:47Z","timestamp":1710818447000},"page":"7965-7975","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Biomaterial-based combinatorial approach of aescin-comprised zein-coated gelatin nanoparticles alleviates synovial inflammation in experimental inflammatory arthritis"],"prefix":"10.1039","volume":"16","author":[{"given":"Chandrashekhar","family":"Jori","sequence":"first","affiliation":[{"name":"Chemical Biology Unit, Institute of Nano Science and Technology, Sector 81, Knowledge City, Sahibzada Ajit Singh Nagar, Mohali, Punjab 140306, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5562-2892","authenticated-orcid":false,"given":"Md. Meraj","family":"Ansari","sequence":"additional","affiliation":[{"name":"Chemical Biology Unit, Institute of Nano Science and Technology, Sector 81, Knowledge City, Sahibzada Ajit Singh Nagar, Mohali, Punjab 140306, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1105-7526","authenticated-orcid":false,"given":"Anas","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Julia McFarlane Diabetes Research Centre (JMDRC) and Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nemat","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Pharmacology & Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Shadab","family":"Raza","sequence":"additional","affiliation":[{"name":"Laboratory for Stem Cell and Restorative Neurology, Department of Biotechnology, Era's Lucknow Medical College Hospital, Sarfarazganj, Lucknow 226003, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2406-1129","authenticated-orcid":false,"given":"Rehan","family":"Khan","sequence":"additional","affiliation":[{"name":"Chemical Biology Unit, Institute of Nano Science and Technology, Sector 81, Knowledge City, Sahibzada Ajit Singh Nagar, Mohali, Punjab 140306, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2024]]},"reference":[{"key":"D3NR06476J\/cit1\/1","first-page":"S295","volume":"18","author":"Gibofsky","year":"2012","journal-title":"Am. J. Manag. Care"},{"key":"D3NR06476J\/cit2\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-019-2182-0","volume":"11","author":"Liu","year":"2020","journal-title":"Cell Death Dis."},{"key":"D3NR06476J\/cit3\/1","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1172\/JCI60975","volume":"122","author":"Harre","year":"2012","journal-title":"J. Clin. Invest."},{"key":"D3NR06476J\/cit4\/1","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1136\/annrheumdis-2015-208093","volume":"75","author":"Krishnamurthy","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"D3NR06476J\/cit5\/1","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/cge.13498","volume":"95","author":"Zamanpoor","year":"2019","journal-title":"Clin. Genet."},{"key":"D3NR06476J\/cit6\/1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/B978-0-12-812102-3.00026-9","volume-title":"The Autoimmune Diseases","author":"Taneja","year":"2020","unstructured":"V.Taneja , in  The Autoimmune Diseases , ed.  N. R. Rose  and  I. R. Mackay ,  Academic Press , 6th edn,  2020 , pp.  467\u2013489"},{"key":"D3NR06476J\/cit7\/1","doi-asserted-by":"crossref","first-page":"5036","DOI":"10.1021\/acsnano.9b01710","volume":"13","author":"Liu","year":"2019","journal-title":"ACS Nano"},{"key":"D3NR06476J\/cit8\/1","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1007\/s12274-016-1208-5","volume":"9","author":"Rehman","year":"2016","journal-title":"Nano Res."},{"key":"D3NR06476J\/cit9\/1","doi-asserted-by":"crossref","first-page":"4489","DOI":"10.1007\/s12274-018-2071-3","volume":"11","author":"Oliveira","year":"2018","journal-title":"Nano Res."},{"key":"D3NR06476J\/cit10\/1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s12274-018-2233-3","volume":"12","author":"Wang","year":"2019","journal-title":"Nano Res."},{"key":"D3NR06476J\/cit11\/1","doi-asserted-by":"crossref","first-page":"6086","DOI":"10.1007\/s12274-018-2126-5","volume":"11","author":"He","year":"2018","journal-title":"Nano Res."},{"key":"D3NR06476J\/cit12\/1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s11926-019-0836-7","volume":"21","author":"Adami","year":"2019","journal-title":"Curr. Rheumatol. Rep."},{"key":"D3NR06476J\/cit13\/1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3389\/fimmu.2012.00077","volume":"3","author":"Komatsu","year":"2012","journal-title":"Front. Immunol."},{"key":"D3NR06476J\/cit14\/1","doi-asserted-by":"crossref","first-page":"e756291","DOI":"10.1155\/2012\/756291","volume":"2012","author":"Scardapane","year":"2012","journal-title":"Int. J. Rheumatol."},{"key":"D3NR06476J\/cit15\/1","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1021\/acs.jmedchem.6b01607","volume":"60","author":"Bua","year":"2017","journal-title":"J. Med. Chem."},{"key":"D3NR06476J\/cit16\/1","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nrd.2017.201","volume":"16","author":"Schwartz","year":"2017","journal-title":"Nat. Rev.\nDrug Discovery"},{"key":"D3NR06476J\/cit17\/1","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nrrheum.2017.81","volume":"13","author":"Nikiphorou","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"key":"D3NR06476J\/cit18\/1","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1021\/acscentsci.8b00764","volume":"5","author":"Feng","year":"2019","journal-title":"ACS Cent. Sci."},{"key":"D3NR06476J\/cit19\/1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s41584-019-0256-0","volume":"15","author":"Ferguson","year":"2019","journal-title":"Nat. Rev. Rheumatol."},{"key":"D3NR06476J\/cit20\/1","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.gene.2016.02.004","volume":"583","author":"Goulielmos","year":"2016","journal-title":"Gene"},{"key":"D3NR06476J\/cit21\/1","first-page":"583","volume":"72","author":"Hamaker","year":"1995","journal-title":"Cereal Chem."},{"key":"D3NR06476J\/cit22\/1","doi-asserted-by":"crossref","first-page":"1806809","DOI":"10.1002\/adfm.201806809","volume":"30","author":"Patel","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"D3NR06476J\/cit23\/1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.colsurfb.2011.02.020","volume":"85","author":"Luo","year":"2011","journal-title":"Colloids Surf., B"},{"key":"D3NR06476J\/cit24\/1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0926-6690(00)00064-9","volume":"13","author":"Shukla","year":"2001","journal-title":"Ind. Crops Prod."},{"key":"D3NR06476J\/cit25\/1","doi-asserted-by":"crossref","first-page":"9746","DOI":"10.1021\/am4028839","volume":"5","author":"He","year":"2013","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D3NR06476J\/cit26\/1","doi-asserted-by":"crossref","first-page":"4788","DOI":"10.1021\/jf040492p","volume":"53","author":"Parris","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"D3NR06476J\/cit27\/1","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1016\/j.lwt.2011.01.005","volume":"44","author":"Quispe-Condori","year":"2011","journal-title":"LWT \u2013 Food Sci. Technol."},{"key":"D3NR06476J\/cit28\/1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1177\/0961203311422709","volume":"21","author":"Luo","year":"2012","journal-title":"Lupus"},{"key":"D3NR06476J\/cit29\/1","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1021\/ma4025619","volume":"47","author":"Shao","year":"2014","journal-title":"Macromolecules"},{"key":"D3NR06476J\/cit30\/1","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.1021\/ja909475m","volume":"132","author":"Shen","year":"2010","journal-title":"J. Am. Chem. Soc."},{"issue":"3","key":"D3NR06476J\/cit31\/1","doi-asserted-by":"publisher","first-page":"692","DOI":"10.6227\/jfda.2012200318","volume":"20","author":"Sagdicoglu Celep","journal-title":"Drug Food Anal."},{"key":"D3NR06476J\/cit32\/1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ejps.2010.10.008","volume":"42","author":"Xin","year":"2011","journal-title":"Eur. J. Pharm. Sci."},{"key":"D3NR06476J\/cit33\/1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.neuint.2010.05.001","volume":"57","author":"Zhang","year":"2010","journal-title":"Neurochem. Int."},{"key":"D3NR06476J\/cit34\/1","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.phymed.2010.08.013","volume":"18","author":"Xin","year":"2011","journal-title":"Phytomedicine"},{"key":"D3NR06476J\/cit35\/1","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1007\/s00268-005-7870-5","volume":"29","author":"Fu","year":"2005","journal-title":"World J. Surg."},{"key":"D3NR06476J\/cit36\/1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1631\/jzus.2005.B0028","volume":"6","author":"Xiao","year":"2005","journal-title":"J. Zhejiang Univ., Sci., B"},{"key":"D3NR06476J\/cit37\/1","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.phymed.2011.06.011","volume":"18","author":"Jiang","year":"2011","journal-title":"Phytomedicine"},{"key":"D3NR06476J\/cit38\/1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1006\/phrs.2001.0847","volume":"44","author":"Sirtori","year":"2001","journal-title":"Pharmacol. Res."},{"key":"D3NR06476J\/cit39\/1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0047-6374(01)00371-2","volume":"1","author":"Holmdahl","year":"2002","journal-title":"Ageing Res. Rev."},{"key":"D3NR06476J\/cit40\/1","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S1734-1140(09)70122-7","volume":"61","author":"Wang","year":"2009","journal-title":"Pharmacol. Rep."},{"key":"D3NR06476J\/cit41\/1","first-page":"102","volume":"34","author":"Wang","year":"2014","journal-title":"Chin. J. Biochem. Pharm."},{"key":"D3NR06476J\/cit42\/1","first-page":"4515","author":"Li","year":"2015","journal-title":"China Pharm."},{"key":"D3NR06476J\/cit43\/1","first-page":"147","volume":"45","author":"Li","year":"2014","journal-title":"Sichuan Daxue Xuebao, Yixueban"},{"key":"D3NR06476J\/cit44\/1","doi-asserted-by":"crossref","first-page":"117600","DOI":"10.1016\/j.carbpol.2020.117600","volume":"258","author":"Ansari","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"D3NR06476J\/cit45\/1","doi-asserted-by":"crossref","first-page":"450","DOI":"10.3109\/02652048.2015.1046516","volume":"32","author":"Songsurang","year":"2015","journal-title":"J. Microencapsulation"},{"key":"D3NR06476J\/cit46\/1","doi-asserted-by":"crossref","first-page":"100578","DOI":"10.1016\/j.apmt.2020.100578","volume":"19","author":"Liu","year":"2020","journal-title":"Appl. Mater. Today"},{"key":"D3NR06476J\/cit47\/1","first-page":"879","volume":"19","author":"Va\u0161kov\u00e1","year":"2015","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"D3NR06476J\/cit48\/1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/WOX.0b013e3182439613","volume":"5","author":"Birben","year":"2012","journal-title":"World Allergy Organ. J."},{"key":"D3NR06476J\/cit49\/1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0378-8741(01)00221-5","volume":"76","author":"Seo","year":"2001","journal-title":"J. Ethnopharmacol."},{"key":"D3NR06476J\/cit50\/1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/cbf.1550","volume":"27","author":"de Oliveira","year":"2009","journal-title":"Cell Biochem. Funct."},{"key":"D3NR06476J\/cit51\/1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1476-9255-5-9","volume":"5","author":"Shukla","year":"2008","journal-title":"J. Inflammation"},{"key":"D3NR06476J\/cit52\/1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1254\/jphs.CRJ06009X","volume":"101","author":"Bian","year":"2006","journal-title":"J. Pharmacol. Sci."},{"key":"D3NR06476J\/cit53\/1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s12291-015-0514-0","volume":"31","author":"Tangvarasittichai","year":"2016","journal-title":"Indian J. Clin. Biochem."},{"key":"D3NR06476J\/cit54\/1","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1111\/j.1532-5415.2011.03570.x","volume":"59","author":"Giovannini","year":"2011","journal-title":"J. Am. Geriatr. Soc."},{"key":"D3NR06476J\/cit55\/1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s00011-007-6135-1","volume":"56","author":"Sandler","year":"2007","journal-title":"Inflammation Res."},{"key":"D3NR06476J\/cit56\/1","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/sj.bjp.0703557","volume":"131","author":"Molina-Holgado","year":"2000","journal-title":"Br. J. Pharmacol."}],"container-title":["Nanoscale"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/NR\/D3NR06476J","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:53:49Z","timestamp":1782928429000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/nr\/article\/16\/16\/7965-7975\/818972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":56,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2024,4,25]]}},"URL":"https:\/\/doi.org\/10.1039\/d3nr06476j","relation":{},"ISSN":["2040-3364","2040-3372"],"issn-type":[{"value":"2040-3364","type":"print"},{"value":"2040-3372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}