{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:23:42Z","timestamp":1782973422290,"version":"3.54.5"},"reference-count":47,"publisher":"Royal Society of Chemistry (RSC)","issue":"38","license":[{"start":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T00:00:00Z","timestamp":1726358400000},"content-version":"am","delay-in-days":623,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["ERC-2011-AdG290836"],"award-info":[{"award-number":["ERC-2011-AdG290836"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["ERC-2020-SyG-951231"],"award-info":[{"award-number":["ERC-2020-SyG-951231"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Org. Biomol. Chem."],"abstract":"<jats:p>Acid \u03b2-galactosidase (GLB1) and galactocerebrosidase (GALC) are retaining exo-\u03b2-galactosidases involved in lysosomal glycoconjugate metabolism.<\/jats:p>","DOI":"10.1039\/d3ob01261a","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T10:21:18Z","timestamp":1694773278000},"page":"7813-7820","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The development of a broad-spectrum retaining \u03b2-exo-galactosidase activity-based probe"],"prefix":"10.1039","volume":"21","author":[{"given":"Chi-Lin","family":"Kuo","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry, Leiden Institute of Chemistry, Leiden University, P. O. Box 9502, 2300 RA Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Leiden Institute of Chemistry, Leiden University, P. O. Box 9502, 2300 RA Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrianus M. C. H.","family":"van den Nieuwendijk","sequence":"additional","affiliation":[{"name":"Bioorganic Synthesis group, Leiden Institute of Chemistry, Leiden University, P. O. Box 9502, 2300 RA Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9033-3065","authenticated-orcid":false,"given":"Thomas J. M.","family":"Beenakker","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Leiden Institute of Chemistry, Leiden University, P. O. Box 9502, 2300 RA Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy A.","family":"Offen","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of York, Heslington, York, YO10 5DD York, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5411-1329","authenticated-orcid":false,"given":"Lianne I.","family":"Willems","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Leiden Institute of Chemistry, Leiden University, P. O. Box 9502, 2300 RA Leiden, The Netherlands"},{"name":"Department of Chemistry, University of York, Heslington, York, YO10 5DD York, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf. G.","family":"Boot","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Leiden Institute of Chemistry, Leiden University, P. O. Box 9502, 2300 RA Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexi J.","family":"Sarris","sequence":"additional","affiliation":[{"name":"Bioorganic Synthesis group, Leiden Institute of Chemistry, Leiden University, P. O. Box 9502, 2300 RA Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 R. A.","family":"Marques","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Leiden Institute of Chemistry, Leiden University, P. O. Box 9502, 2300 RA Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3531-2138","authenticated-orcid":false,"given":"Jeroen D. C.","family":"Cod\u00e9e","sequence":"additional","affiliation":[{"name":"Bioorganic Synthesis group, Leiden Institute of Chemistry, Leiden University, P. O. Box 9502, 2300 RA Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gijsbert A.","family":"van der Marel","sequence":"additional","affiliation":[{"name":"Bioorganic Synthesis group, Leiden Institute of Chemistry, Leiden University, P. O. Box 9502, 2300 RA Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7114-2266","authenticated-orcid":false,"given":"Bogdan I.","family":"Florea","sequence":"additional","affiliation":[{"name":"Bioorganic Synthesis group, Leiden Institute of Chemistry, Leiden University, P. O. Box 9502, 2300 RA Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7343-776X","authenticated-orcid":false,"given":"Gideon J.","family":"Davies","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of York, Heslington, York, YO10 5DD York, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6976-7005","authenticated-orcid":false,"given":"Herman S.","family":"Overkleeft","sequence":"additional","affiliation":[{"name":"Bioorganic Synthesis group, Leiden Institute of Chemistry, Leiden University, P. O. Box 9502, 2300 RA Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes M. F. G.","family":"Aerts","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Leiden Institute of Chemistry, Leiden University, P. O. Box 9502, 2300 RA Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2023]]},"reference":[{"key":"D3OB01261A\/cit1\/1","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1007\/s00018-002-8489-4","volume":"59","author":"Hennet","year":"2000","journal-title":"Cell. Mol. Life Sci."},{"key":"D3OB01261A\/cit2\/1","volume-title":"The metabolic and molecular basis of inherited disease","author":"Suzuki","year":"2000","unstructured":"Y.Suzuki  and  E.Nanba , in  The metabolic and molecular basis of inherited disease ,  McGraw-Hill ,  New York, USA ,  2000"},{"key":"D3OB01261A\/cit3\/1","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1073\/pnas.66.2.302","volume":"66","author":"Suzuki","year":"1970","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D3OB01261A\/cit4\/1","doi-asserted-by":"crossref","first-page":"D490","DOI":"10.1093\/nar\/gkt1178","volume":"42","author":"Lombard","year":"2014","journal-title":"Nucleic Acid Res."},{"key":"D3OB01261A\/cit5\/1","doi-asserted-by":"crossref","first-page":"4535","DOI":"10.1073\/pnas.79.15.4535","volume":"79","author":"d'Azzo","year":"1982","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D3OB01261A\/cit6\/1","doi-asserted-by":"crossref","first-page":"10035","DOI":"10.1074\/jbc.275.14.10035","volume":"275","author":"van der Spoel","year":"2000","journal-title":"J. Biol. Chem."},{"key":"D3OB01261A\/cit7\/1","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1111\/j.1582-4934.2007.00204.x","volume":"12","author":"Kreutzer","year":"2008","journal-title":"J. Cell. Mol. Med."},{"key":"D3OB01261A\/cit8\/1","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1074\/jbc.M111.293795","volume":"287","author":"Ohto","year":"2012","journal-title":"J. Biol. Chem."},{"key":"D3OB01261A\/cit9\/1","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0092-8674(88)90999-3","volume":"54","author":"Galjart","year":"1988","journal-title":"Cell"},{"key":"D3OB01261A\/cit10\/1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/(SICI)1098-1004(1997)10:4<268::AID-HUMU2>3.0.CO;2-D","volume":"10","author":"Wenger","year":"1997","journal-title":"Hum. Mutat."},{"key":"D3OB01261A\/cit11\/1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0009-8981(98)00095-3","volume":"276","author":"Nagano","year":"1998","journal-title":"Clin. Chim. Acta"},{"key":"D3OB01261A\/cit12\/1","doi-asserted-by":"crossref","first-page":"15169","DOI":"10.1073\/pnas.1105639108","volume":"108","author":"Deane","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D3OB01261A\/cit13\/1","doi-asserted-by":"crossref","first-page":"20479","DOI":"10.1073\/pnas.1311990110","volume":"110","author":"Hill","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D3OB01261A\/cit14\/1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.ymgme.2008.04.012","volume":"94","author":"Brunetti-Pierri","year":"2008","journal-title":"Mol. Genet. Metab."},{"key":"D3OB01261A\/cit15\/1","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.molcel.2004.08.029","volume":"15","author":"Tessitore","year":"2004","journal-title":"Mol. Cell"},{"key":"D3OB01261A\/cit16\/1","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.bbrc.2007.12.187","volume":"367","author":"Takamura","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"D3OB01261A\/cit17\/1","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.molcel.2009.10.021","volume":"36","author":"Sano","year":"2009","journal-title":"Mol. Cell"},{"key":"D3OB01261A\/cit18\/1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ymgme.2004.10.004","volume":"84","author":"Spiegel","year":"2005","journal-title":"Mol. Genet. Metab."},{"key":"D3OB01261A\/cit19\/1","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1002\/jnr.23873","volume":"94","author":"Won","year":"2016","journal-title":"J. Neurosci. Res."},{"key":"D3OB01261A\/cit20\/1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.brainres.2013.02.024","volume":"1508","author":"Won","year":"2013","journal-title":"Brain Res."},{"key":"D3OB01261A\/cit21\/1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s10495-015-1183-4","volume":"21","author":"Graziano","year":"2016","journal-title":"Apoptosis"},{"key":"D3OB01261A\/cit22\/1","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1007\/s11011-017-0044-y","volume":"32","author":"Deodato","year":"2017","journal-title":"Metab. Brain Dis."},{"key":"D3OB01261A\/cit23\/1","doi-asserted-by":"crossref","first-page":"112808","DOI":"10.1016\/j.biopha.2022.112808","volume":"149","author":"Zaccariotto","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"D3OB01261A\/cit24\/1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ymgme.2015.12.002","volume":"117","author":"Condori","year":"2016","journal-title":"Mol. Genet. Metab."},{"key":"D3OB01261A\/cit25\/1","doi-asserted-by":"crossref","first-page":"9002","DOI":"10.1021\/acsomega.7b01230","volume":"2","author":"Gupta","year":"2017","journal-title":"ACS Omega"},{"key":"D3OB01261A\/cit26\/1","doi-asserted-by":"crossref","first-page":"3431","DOI":"10.1016\/j.bmcl.2017.05.086","volume":"27","author":"Schalli","year":"2017","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D3OB01261A\/cit27\/1","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/jhg.2015.61","volume":"60","author":"Hossain","year":"2015","journal-title":"J. Hum. Genet."},{"key":"D3OB01261A\/cit28\/1","doi-asserted-by":"crossref","first-page":"e13468","DOI":"10.1371\/journal.pone.0013468","volume":"5","author":"Baek","year":"2010","journal-title":"PLoS One"},{"key":"D3OB01261A\/cit29\/1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ymgme.2018.11.002","volume":"126","author":"Przybilla","year":"2019","journal-title":"Mol. Genet. Metab."},{"key":"D3OB01261A\/cit30\/1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.ymgme.2014.12.300","volume":"114","author":"Rafi","year":"2015","journal-title":"Mol. Genet. Metab."},{"key":"D3OB01261A\/cit31\/1","doi-asserted-by":"crossref","first-page":"e1002583","DOI":"10.1371\/journal.pbio.1002583","volume":"14","author":"Folts","year":"2016","journal-title":"PLoS Biol."},{"key":"D3OB01261A\/cit32\/1","doi-asserted-by":"crossref","first-page":"20097","DOI":"10.1073\/pnas.1912108116","volume":"116","author":"Li","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D3OB01261A\/cit33\/1","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/j.1469-185X.1953.tb01386.x","volume":"28","author":"Koshland","year":"1953","journal-title":"Biol. Rev."},{"key":"D3OB01261A\/cit34\/1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.cbpa.2019.05.030","volume":"53","author":"Wu","year":"2019","journal-title":"Curr. Opin. Chem. Biol."},{"key":"D3OB01261A\/cit35\/1","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1002\/cbic.201600561","volume":"18","author":"Marquez","year":"2017","journal-title":"ChemBioChem"},{"key":"D3OB01261A\/cit36\/1","doi-asserted-by":"crossref","first-page":"12528","DOI":"10.1039\/C7CC07730K","volume":"53","author":"Schr\u00f6der","year":"2017","journal-title":"Chem. Commun."},{"key":"D3OB01261A\/cit37\/1","doi-asserted-by":"crossref","first-page":"6044","DOI":"10.1002\/ejoc.201402589","author":"Willems","year":"2014","journal-title":"Eur. J. Org. Chem."},{"key":"D3OB01261A\/cit38\/1","doi-asserted-by":"crossref","first-page":"12079","DOI":"10.1021\/ja202610x","volume":"133","author":"Harrak","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"D3OB01261A\/cit39\/1","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1021\/bc8004446","volume":"12","author":"Devaraj","year":"2008","journal-title":"Bioconjugate Chem."},{"key":"D3OB01261A\/cit40\/1","doi-asserted-by":"crossref","first-page":"16377","DOI":"10.1002\/chem.202102359","volume":"27","author":"Rowland","year":"2021","journal-title":"Chem. \u2013 Eur. J."},{"key":"D3OB01261A\/cit41\/1","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1373\/clinchem.2008.115873","volume":"55","author":"Martino","year":"2009","journal-title":"Clin. Chem."},{"key":"D3OB01261A\/cit42\/1","doi-asserted-by":"crossref","first-page":"12529","DOI":"10.1002\/anie.201207771","volume":"51","author":"Kallemeijn","year":"2012","journal-title":"Angew. Chem., Int. Ed."},{"key":"D3OB01261A\/cit43\/1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0300-9084(92)90179-I","volume":"74","author":"Percheron","year":"1992","journal-title":"Biochemie"},{"key":"D3OB01261A\/cit44\/1","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1039\/D1OB02287C","volume":"20","author":"McGregor","year":"2022","journal-title":"Org. Biomol. Chem."},{"key":"D3OB01261A\/cit45\/1","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.1002\/anie.201200923","volume":"51","author":"Willems","year":"2012","journal-title":"Angew. Chem., Int. Ed."},{"key":"D3OB01261A\/cit46\/1","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1111\/febs.14744","volume":"286","author":"Kuo","year":"2019","journal-title":"FEBS J."},{"key":"D3OB01261A\/cit47\/1","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1038\/nprot.2013.065","volume":"8","author":"Li","year":"2013","journal-title":"Nat. Protoc."}],"container-title":["Organic &amp; Biomolecular Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2023\/OB\/D3OB01261A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:01:48Z","timestamp":1782968508000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ob\/article\/21\/38\/7813-7820\/819869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":47,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2023,10,4]]}},"URL":"https:\/\/doi.org\/10.1039\/d3ob01261a","relation":{},"ISSN":["1477-0520","1477-0539"],"issn-type":[{"value":"1477-0520","type":"print"},{"value":"1477-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}