{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:43:28Z","timestamp":1782974608387,"version":"3.54.5"},"reference-count":41,"publisher":"Royal Society of Chemistry (RSC)","issue":"7","license":[{"start":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T00:00:00Z","timestamp":1737244800000},"content-version":"am","delay-in-days":384,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22071035"],"award-info":[{"award-number":["22071035"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21961005"],"award-info":[{"award-number":["21961005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region","doi-asserted-by":"publisher","award":["2023GXNSFDA026025"],"award-info":[{"award-number":["2023GXNSFDA026025"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Org. Biomol. Chem."],"abstract":"<jats:p>\n                    An intramolecular 6-\n                    <jats:italic>endo-dig<\/jats:italic>\n                    cyclization and trichloromethylation of\n                    <jats:italic>N<\/jats:italic>\n                    3-alkynyl-2-pyridinyl-tethered quinazolinones in chloroform was developed for the synthesis of various 4-trichloromethylated pyrido-fused quinazolinones in moderate to good yields with high regioselectivity.\n                  <\/jats:p>","DOI":"10.1039\/d3ob02084c","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T12:04:36Z","timestamp":1705665876000},"page":"1386-1390","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Synthesis of 4-(trichloromethyl)pyrido[2\u2032,1\u2032:3,4]pyrazino[2,1-\n                    <i>b<\/i>\n                    ]quinazolinones through a cyclized dearomatization and trichloromethylation cascade strategy"],"prefix":"10.1039","volume":"22","author":[{"given":"Xu","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, 15 Yu Cai Road, Guilin, 541004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Yan","family":"Wei","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, 15 Yu Cai Road, Guilin, 541004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1458-5383","authenticated-orcid":false,"given":"Jun-Cheng","family":"Su","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, 15 Yu Cai Road, Guilin, 541004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui","family":"Liang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, 15 Yu Cai Road, Guilin, 541004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3437-2462","authenticated-orcid":false,"given":"Cheng-Xue","family":"Pan","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, 15 Yu Cai Road, Guilin, 541004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3128-2381","authenticated-orcid":false,"given":"Gui-Fa","family":"Su","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, 15 Yu Cai Road, Guilin, 541004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4005-2249","authenticated-orcid":false,"given":"Dong-Liang","family":"Mo","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, 15 Yu Cai Road, Guilin, 541004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2024]]},"reference":[{"key":"D3OB02084C\/cit1a\/1","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1016\/j.bmcl.2018.03.077","volume":"28","author":"Kapojos","year":"2018","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D3OB02084C\/cit1b\/1","doi-asserted-by":"crossref","first-page":"5017","DOI":"10.1021\/jacs.2c10277","volume":"145","author":"Guo","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"D3OB02084C\/cit1c\/1","doi-asserted-by":"crossref","first-page":"9702","DOI":"10.1002\/anie.201005354","volume":"49","author":"Gu","year":"2010","journal-title":"Angew. Chem., Int. Ed."},{"key":"D3OB02084C\/cit1d\/1","doi-asserted-by":"crossref","first-page":"7552","DOI":"10.1021\/ja9024929","volume":"131","author":"Dalisay","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"D3OB02084C\/cit2a\/1","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1039\/C8QO00868J","volume":"5","author":"Chen","year":"2018","journal-title":"Org. Chem. Front."},{"key":"D3OB02084C\/cit2b\/1","doi-asserted-by":"crossref","first-page":"15686","DOI":"10.1021\/acscatal.2c05288","volume":"12","author":"Ansari","year":"2022","journal-title":"ACS Catal."},{"key":"D3OB02084C\/cit2c\/1","doi-asserted-by":"crossref","first-page":"15275","DOI":"10.1021\/jacs.2c05798","volume":"144","author":"Zhao","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"D3OB02084C\/cit2d\/1","doi-asserted-by":"crossref","first-page":"109514","DOI":"10.1016\/j.cclet.2024.109514","volume":"35","author":"Hou","year":"2024","journal-title":"Chin. Chem. Lett."},{"key":"D3OB02084C\/cit3a\/1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/adsc.202000924","volume":"363","author":"Huang","year":"2021","journal-title":"Adv. Synth. Catal."},{"key":"D3OB02084C\/cit3b\/1","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/adsc.202000824","volume":"363","author":"Liang","year":"2021","journal-title":"Adv. Synth. Catal."},{"key":"D3OB02084C\/cit3c\/1","doi-asserted-by":"crossref","first-page":"7009","DOI":"10.1039\/D1QO01263K","volume":"8","author":"Huang","year":"2021","journal-title":"Org. Chem. Front."},{"key":"D3OB02084C\/cit3d\/1","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1039\/D1CC00400J","volume":"57","author":"Liang","year":"2021","journal-title":"Chem. Commun."},{"key":"D3OB02084C\/cit3e\/1","doi-asserted-by":"crossref","first-page":"4809","DOI":"10.1039\/D3QO01040F","volume":"10","author":"Zhao","year":"2023","journal-title":"Org. Chem. Front."},{"key":"D3OB02084C\/cit3f\/1","doi-asserted-by":"crossref","first-page":"4670","DOI":"10.1039\/D3QO01100C","volume":"10","author":"Zhang","year":"2023","journal-title":"Org. Chem. Front."},{"key":"D3OB02084C\/cit4a\/1","doi-asserted-by":"crossref","first-page":"4698","DOI":"10.1021\/ol502411c","volume":"16","author":"Lu","year":"2014","journal-title":"Org. Lett."},{"key":"D3OB02084C\/cit4b\/1","doi-asserted-by":"crossref","first-page":"7242","DOI":"10.1021\/acs.orglett.1c02639","volume":"23","author":"Kusakabe","year":"2021","journal-title":"Org. Lett."},{"key":"D3OB02084C\/cit5\/1","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1021\/ol500200n","volume":"16","author":"Gupta","year":"2014","journal-title":"Org. Lett."},{"key":"D3OB02084C\/cit6\/1","doi-asserted-by":"crossref","first-page":"9728","DOI":"10.1021\/acs.joc.5b01820","volume":"80","author":"Attaba","year":"2015","journal-title":"J. Org. Chem."},{"key":"D3OB02084C\/cit7\/1","doi-asserted-by":"crossref","first-page":"9551","DOI":"10.1021\/jacs.5b06010","volume":"137","author":"Huo","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"D3OB02084C\/cit8a\/1","doi-asserted-by":"crossref","first-page":"3925","DOI":"10.1021\/jo070180w","volume":"72","author":"Kister","year":"2007","journal-title":"J. Org. Chem."},{"key":"D3OB02084C\/cit8b\/1","doi-asserted-by":"crossref","first-page":"7718","DOI":"10.1002\/chem.201402394","volume":"20","author":"Wu","year":"2014","journal-title":"Chem. \u2013 Eur. J."},{"key":"D3OB02084C\/cit9a\/1","doi-asserted-by":"crossref","first-page":"6659","DOI":"10.1039\/D2OB01053D","volume":"20","author":"Li","year":"2022","journal-title":"Org. Biomol. Chem."},{"key":"D3OB02084C\/cit9b\/1","doi-asserted-by":"crossref","first-page":"7211","DOI":"10.1021\/jo000584n","volume":"65","author":"Aggarwal","year":"2000","journal-title":"J. Org. Chem."},{"key":"D3OB02084C\/cit9c\/1","doi-asserted-by":"crossref","first-page":"5259","DOI":"10.1039\/D2OB00471B","volume":"20","author":"Shan","year":"2022","journal-title":"Org. Biomol. Chem."},{"key":"D3OB02084C\/cit9d\/1","doi-asserted-by":"crossref","first-page":"7079","DOI":"10.1039\/D3OB01191G","volume":"21","author":"Wu","year":"2023","journal-title":"Org. Biomol. Chem."},{"key":"D3OB02084C\/cit9e\/1","doi-asserted-by":"crossref","first-page":"e202300441","DOI":"10.1002\/ejoc.202300441","author":"Wu","year":"2023","journal-title":"Eur. J. Org. Chem."},{"key":"D3OB02084C\/cit10\/1","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1039\/C9CC00557A","volume":"55","author":"Huang","year":"2019","journal-title":"Chem. Commun."},{"key":"D3OB02084C\/cit11\/1","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1021\/acs.orglett.0c00582","volume":"22","author":"Luo","year":"2020","journal-title":"Org. Lett."},{"key":"D3OB02084C\/cit12\/1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/adsc.202201307","volume":"365","author":"Wu","year":"2023","journal-title":"Adv. Synth. Catal."},{"key":"D3OB02084C\/cit13a\/1","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1021\/acscentsci.0c01651","volume":"7","author":"Zheng","year":"2021","journal-title":"ACS Cent. Sci."},{"key":"D3OB02084C\/cit13b\/1","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1039\/C9CS00311H","volume":"51","author":"Cheng","year":"2022","journal-title":"Chem. Soc. Rev."},{"key":"D3OB02084C\/cit13c\/1","doi-asserted-by":"crossref","first-page":"107647","DOI":"10.1016\/j.cclet.2022.06.070","volume":"34","author":"Zhang","year":"2023","journal-title":"Chin. Chem. Lett."},{"key":"D3OB02084C\/cit14a\/1","doi-asserted-by":"crossref","first-page":"13793","DOI":"10.1002\/anie.202104115","volume":"60","author":"Heusler","year":"2021","journal-title":"Angew. Chem., Int. Ed."},{"key":"D3OB02084C\/cit14b\/1","doi-asserted-by":"crossref","first-page":"6473","DOI":"10.1021\/acscatal.6b01962","volume":"6","author":"Bertuzzi","year":"2016","journal-title":"ACS Catal."},{"key":"D3OB02084C\/cit14c\/1","doi-asserted-by":"crossref","first-page":"6986","DOI":"10.1002\/anie.201404286","volume":"53","author":"Yang","year":"2014","journal-title":"Angew. Chem., Int. Ed."},{"key":"D3OB02084C\/cit14d\/1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gresc.2022.06.006","author":"Wang","year":"2023","journal-title":"Green Synth. Catal."},{"key":"D3OB02084C\/cit14e\/1","first-page":"e2023076","author":"Tian","year":"2023","journal-title":"Angew. Chem., Int. Ed."},{"key":"D3OB02084C\/cit15a\/1","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/adsc.202101054","volume":"364","author":"Wang","year":"2022","journal-title":"Adv. Synth. Catal."},{"key":"D3OB02084C\/cit15b\/1","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1039\/D0QO00437E","volume":"7","author":"Kong","year":"2020","journal-title":"Org. Chem. Front."},{"key":"D3OB02084C\/cit15c\/1","doi-asserted-by":"crossref","first-page":"6719","DOI":"10.1021\/acs.joc.8b00168","volume":"83","author":"Wei","year":"2018","journal-title":"J. Org. Chem."},{"key":"D3OB02084C\/cit15d\/1","doi-asserted-by":"crossref","first-page":"111851","DOI":"10.1016\/j.ejmech.2019.111851","volume":"186","author":"Wei","year":"2020","journal-title":"Eur. J. Med. Chem."}],"container-title":["Organic &amp; Biomolecular Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/OB\/D3OB02084C","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:16:19Z","timestamp":1782969379000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ob\/article\/22\/7\/1386-1390\/820264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":41,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,2,14]]}},"URL":"https:\/\/doi.org\/10.1039\/d3ob02084c","relation":{},"ISSN":["1477-0520","1477-0539"],"issn-type":[{"value":"1477-0520","type":"print"},{"value":"1477-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}