{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:15:07Z","timestamp":1791555307290,"version":"4.3.4"},"reference-count":41,"publisher":"Royal Society of Chemistry (RSC)","issue":"21","license":[{"start":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T00:00:00Z","timestamp":1683676800000},"content-version":"vor","delay-in-days":129,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000928","name":"Welch Foundation","doi-asserted-by":"publisher","award":["AT-1989-20190330"],"award-info":[{"award-number":["AT-1989-20190330"]}],"id":[{"id":"10.13039\/100000928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DMR-2003534"],"award-info":[{"award-number":["DMR-2003534"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Sci."],"abstract":"<jats:p>Studying the toxicity of zeolitic imidazolate framework-8 (ZIF-8) in context of intranasal administration will help researchers in building depot platforms for this non-invasive route of delivery.<\/jats:p>","DOI":"10.1039\/d3sc00500c","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T22:59:57Z","timestamp":1683759597000},"page":"5774-5782","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["<i>In vivo<\/i>\n                    biocompatibility of ZIF-8 for slow release\n                    <i>via<\/i>\n                    intranasal administration"],"prefix":"10.1039","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5245-7016","authenticated-orcid":false,"given":"Sneha","family":"Kumari","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 West Campbell Rd., Richardson, TX 75080, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas S.","family":"Howlett","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 West Campbell Rd., Richardson, TX 75080, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryanne N.","family":"Ehrman","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 West Campbell Rd., Richardson, TX 75080, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailendra","family":"Koirala","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 West Campbell Rd., Richardson, TX 75080, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orikeda","family":"Trashi","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 West Campbell Rd., Richardson, TX 75080, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikeda","family":"Trashi","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 West Campbell Rd., Richardson, TX 75080, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalini H.","family":"Wijesundara","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 West Campbell Rd., Richardson, TX 75080, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6400-8106","authenticated-orcid":false,"given":"Jeremiah J.","family":"Gassensmith","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, The University of Texas at Dallas, 800 West Campbell Rd., Richardson, TX 75080, USA"},{"name":"Department of Biomedical Engineering, The University of Texas at Dallas, 800 West Campbell Rd., Richardson, TX 75080, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2023]]},"reference":[{"key":"D3SC00500C\/cit1\/1","first-page":"e1735","volume":"13","author":"Luzuriaga","year":"2021","journal-title":"Wiley Interdiscip. Rev.: Nanomed. Nanobiotechnol."},{"key":"D3SC00500C\/cit2\/1","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1021\/acs.bioconjchem.8b00483","volume":"29","author":"Welch","year":"2018","journal-title":"Bioconjugate Chem."},{"key":"D3SC00500C\/cit3\/1","doi-asserted-by":"crossref","first-page":"e00555","DOI":"10.1128\/mBio.00555-20","volume":"11","author":"Forsyth","year":"2020","journal-title":"mBio"},{"key":"D3SC00500C\/cit4\/1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/s44222-022-00012-6","volume":"1","author":"Cahn","year":"2023","journal-title":"Nat. Rev. Bioeng."},{"key":"D3SC00500C\/cit5\/1","doi-asserted-by":"crossref","first-page":"e5856","DOI":"10.1371\/journal.pone.0005856","volume":"4","author":"Xing","year":"2009","journal-title":"PLoS One"},{"key":"D3SC00500C\/cit6\/1","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s13346-012-0085-z","volume":"3","author":"Zaman","year":"2013","journal-title":"Drug Delivery Transl. Res."},{"key":"D3SC00500C\/cit7\/1","doi-asserted-by":"crossref","first-page":"2203952","DOI":"10.1002\/smll.202203952","volume":"18","author":"Lu","year":"2022","journal-title":"Small"},{"key":"D3SC00500C\/cit8\/1","doi-asserted-by":"crossref","first-page":"e202209110","DOI":"10.1002\/anie.202209110","volume":"61","author":"Tai","year":"2022","journal-title":"Angew. Chem., Int. Ed."},{"key":"D3SC00500C\/cit9\/1","doi-asserted-by":"crossref","first-page":"9174","DOI":"10.1021\/acsnano.6b04996","volume":"10","author":"Li","year":"2016","journal-title":"ACS Nano"},{"key":"D3SC00500C\/cit10\/1","doi-asserted-by":"crossref","first-page":"5678","DOI":"10.1021\/jacs.8b02089","volume":"140","author":"Chen","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"D3SC00500C\/cit11\/1","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1021\/jacsau.1c00226","volume":"1","author":"Yang","year":"2021","journal-title":"JACS Au"},{"key":"D3SC00500C\/cit12\/1","doi-asserted-by":"crossref","first-page":"10691","DOI":"10.1002\/anie.201604879","volume":"55","author":"Li","year":"2016","journal-title":"Angew. Chem., Int. Ed."},{"key":"D3SC00500C\/cit13\/1","doi-asserted-by":"crossref","first-page":"7240","DOI":"10.1038\/ncomms8240","volume":"6","author":"Liang","year":"2015","journal-title":"Nat. Commun."},{"key":"D3SC00500C\/cit14\/1","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1080\/10610278.2019.1616089","volume":"31","author":"Luzuriaga","year":"2019","journal-title":"Supramol. Chem."},{"key":"D3SC00500C\/cit15\/1","doi-asserted-by":"crossref","first-page":"4538","DOI":"10.1039\/C9CE00757A","volume":"21","author":"Vel\u00e1squez-Hern\u00e1ndez","year":"2019","journal-title":"CrystEngComm"},{"key":"D3SC00500C\/cit16\/1","doi-asserted-by":"crossref","first-page":"9740","DOI":"10.1021\/acsami.8b20504","volume":"11","author":"Luzuriaga","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D3SC00500C\/cit17\/1","doi-asserted-by":"crossref","first-page":"18161","DOI":"10.1021\/acsami.8b01369","volume":"10","author":"Li","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D3SC00500C\/cit18\/1","doi-asserted-by":"crossref","first-page":"11884","DOI":"10.1021\/acsami.9b15667","volume":"12","author":"Li","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D3SC00500C\/cit19\/1","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1021\/acs.chemmater.7b04713","volume":"30","author":"Wang","year":"2018","journal-title":"Chem. Mater."},{"key":"D3SC00500C\/cit20\/1","doi-asserted-by":"crossref","first-page":"13803","DOI":"10.1039\/D2SC04982A","volume":"13","author":"Wijesundara","year":"2022","journal-title":"Chem. Sci."},{"key":"D3SC00500C\/cit21\/1","doi-asserted-by":"crossref","first-page":"1902268","DOI":"10.1002\/smll.201902268","volume":"15","author":"Poddar","year":"2019","journal-title":"Small"},{"key":"D3SC00500C\/cit22\/1","doi-asserted-by":"crossref","first-page":"13697","DOI":"10.1021\/acsanm.1c03555","volume":"5","author":"Brohlin","year":"2022","journal-title":"ACS Appl. Nano Mater."},{"key":"D3SC00500C\/cit23\/1","doi-asserted-by":"crossref","first-page":"15406","DOI":"10.1039\/D0CC06241C","volume":"56","author":"Poddar","year":"2020","journal-title":"Chem. Commun."},{"key":"D3SC00500C\/cit24\/1","doi-asserted-by":"crossref","first-page":"10004","DOI":"10.1039\/D2CC03072A","volume":"58","author":"Gan","year":"2022","journal-title":"Chem. Commun."},{"key":"D3SC00500C\/cit25\/1","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1038\/s41467-021-22285-y","volume":"12","author":"Herbert","year":"2021","journal-title":"Nat. Commun."},{"key":"D3SC00500C\/cit26\/1","doi-asserted-by":"crossref","first-page":"e2218247120","DOI":"10.1073\/pnas.2218247120","volume":"120","author":"Kumari","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D3SC00500C\/cit27\/1","doi-asserted-by":"crossref","first-page":"51867","DOI":"10.1021\/acsami.1c04785","volume":"13","author":"Maddigan","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D3SC00500C\/cit28\/1","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1021\/jacs.8b10302","volume":"141","author":"Liang","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"D3SC00500C\/cit29\/1","doi-asserted-by":"crossref","first-page":"10835","DOI":"10.1039\/D0SC01204A","volume":"11","author":"Vel\u00e1squez-Hern\u00e1ndez","year":"2020","journal-title":"Chem. Sci."},{"key":"D3SC00500C\/cit30\/1","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1039\/C8MH01611A","volume":"6","author":"Astria","year":"2019","journal-title":"Mater. Horiz."},{"key":"D3SC00500C\/cit31\/1","doi-asserted-by":"crossref","first-page":"17426","DOI":"10.1021\/acsnano.1c03092","volume":"15","author":"Luzuriaga","year":"2021","journal-title":"ACS Nano"},{"key":"D3SC00500C\/cit32\/1","doi-asserted-by":"crossref","first-page":"2204011","DOI":"10.1002\/smll.202204011","volume":"18","author":"Peng","year":"2022","journal-title":"Small"},{"key":"D3SC00500C\/cit33\/1","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1039\/c3sc22116d","volume":"4","author":"Baati","year":"2013","journal-title":"Chem. Sci."},{"key":"D3SC00500C\/cit34\/1","doi-asserted-by":"crossref","first-page":"5568","DOI":"10.3390\/ijms22115568","volume":"22","author":"Abramenko","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"D3SC00500C\/cit35\/1","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.3390\/nano12193398","volume":"12","author":"Lan","year":"2022","journal-title":"Nanomaterials"},{"key":"D3SC00500C\/cit36\/1","doi-asserted-by":"crossref","first-page":"1360S","DOI":"10.1093\/jn\/130.5.1360S","volume":"130","author":"King","year":"2000","journal-title":"J. Nutr."},{"key":"D3SC00500C\/cit37\/1","doi-asserted-by":"crossref","first-page":"31111","DOI":"10.1007\/s11356-019-06022-z","volume":"26","author":"Riaz","year":"2019","journal-title":"Environ. Sci. Pollut. Res."},{"key":"D3SC00500C\/cit38\/1","doi-asserted-by":"crossref","first-page":"5444","DOI":"10.1016\/j.bbagen.2013.06.018","volume":"1830","author":"Bal","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"D3SC00500C\/cit39\/1","first-page":"52216","volume":"95","author":"Limjunyawong","year":"2015","journal-title":"J. Vis. Exp."},{"key":"D3SC00500C\/cit40\/1","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1152\/japplphysiol.01347.2010","volume":"110","author":"Fallica","year":"2011","journal-title":"J. Appl. Physiol."},{"key":"D3SC00500C\/cit41\/1","doi-asserted-by":"crossref","first-page":"4354","DOI":"10.1038\/s41467-021-24521-x","volume":"12","author":"Robinot","year":"2021","journal-title":"Nat. Commun."}],"container-title":["Chemical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2023\/SC\/D3SC00500C","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2023\/SC\/D3SC00500C","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:17:41Z","timestamp":1782929861000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/sc\/article\/14\/21\/5774-5782\/826760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":41,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2023,5,31]]}},"URL":"https:\/\/doi.org\/10.1039\/d3sc00500c","relation":{},"ISSN":["2041-6520","2041-6539"],"issn-type":[{"value":"2041-6520","type":"print"},{"value":"2041-6539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}