{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:25:28Z","timestamp":1790717128661,"version":"4.1.0"},"reference-count":22,"publisher":"Royal Society of Chemistry (RSC)","issue":"29","license":[{"start":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T00:00:00Z","timestamp":1687996800000},"content-version":"vor","delay-in-days":179,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100014808","name":"Groupement des Entreprises Fran\u00e7aises dans la lutte contre le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014808","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006331","name":"Cancerop\u00f4le PACA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007586","name":"Aix-Marseille Universit\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Chem. Sci."],"abstract":"<jats:p>Our study at the chemistry\u2013biology interface characterized a new alkoxyamine active against glioblastoma and medulloblastoma cancer cells.<\/jats:p>","DOI":"10.1039\/d3sc01315d","type":"journal-article","created":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T05:00:56Z","timestamp":1688014856000},"page":"7988-7998","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Conditional generation of free radicals by selective activation of alkoxyamines: towards more effective and less toxic targeting of brain tumors"],"prefix":"10.1039","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5033-3810","authenticated-orcid":false,"given":"Patricia","family":"Piris","sequence":"first","affiliation":[{"name":"Centre de Recherche en Canc\u00e9rologie de Marseille (CRCM), Inserm UMR1068, CNRS UMR7258, Aix-Marseille Universit\u00e9 UM105, Institut Paoli Calmettes \u2013 Facult\u00e9 de Pharmacie, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duje","family":"Buric","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Canc\u00e9rologie de Marseille (CRCM), Inserm UMR1068, CNRS UMR7258, Aix-Marseille Universit\u00e9 UM105, Institut Paoli Calmettes \u2013 Facult\u00e9 de Pharmacie, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8567-8213","authenticated-orcid":false,"given":"Toshihide","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Institut de Chimie Radicalaire, CNRS UMR7273, Aix-Marseille Universit\u00e9 \u2013 Facult\u00e9 des Sciences, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Huched\u00e9","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Canc\u00e9rologie de Lyon (CRCL), Universit\u00e9 Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre L\u00e9on B\u00e9rard, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u00eflys","family":"Rossi","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Canc\u00e9rologie de Marseille (CRCM), Inserm UMR1068, CNRS UMR7258, Aix-Marseille Universit\u00e9 UM105, Institut Paoli Calmettes \u2013 Facult\u00e9 de Pharmacie, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Matteudi","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Canc\u00e9rologie de Marseille (CRCM), Inserm UMR1068, CNRS UMR7258, Aix-Marseille Universit\u00e9 UM105, Institut Paoli Calmettes \u2013 Facult\u00e9 de Pharmacie, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4280-0674","authenticated-orcid":false,"given":"Marie-Pierre","family":"Montero","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Canc\u00e9rologie de Marseille (CRCM), Inserm UMR1068, CNRS UMR7258, Aix-Marseille Universit\u00e9 UM105, Institut Paoli Calmettes \u2013 Facult\u00e9 de Pharmacie, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Rodallec","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Canc\u00e9rologie de Marseille (CRCM), Inserm UMR1068, CNRS UMR7258, Aix-Marseille Universit\u00e9 UM105, Institut Paoli Calmettes \u2013 Facult\u00e9 de Pharmacie, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Appay","sequence":"additional","affiliation":[{"name":"Service D'anatomie Pathologique et de Neuropathologie, H\u00f4pital de La Timone, Assistance Publique-H\u00f4pitaux de Marseille (APHM), Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Roux","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Canc\u00e9rologie de Marseille (CRCM), Inserm UMR1068, CNRS UMR7258, Aix-Marseille Universit\u00e9 UM105, Institut Paoli Calmettes \u2013 Facult\u00e9 de Pharmacie, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Combes","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Canc\u00e9rologie de Marseille (CRCM), Inserm UMR1068, CNRS UMR7258, Aix-Marseille Universit\u00e9 UM105, Institut Paoli Calmettes \u2013 Facult\u00e9 de Pharmacie, Marseille, France"},{"name":"DOSynth Platform, Centre de Recherche en Canc\u00e9rologie de Marseille (CRCM), Facult\u00e9 de Pharmacie, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eddy","family":"Pasquier","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Canc\u00e9rologie de Marseille (CRCM), Inserm UMR1068, CNRS UMR7258, Aix-Marseille Universit\u00e9 UM105, Institut Paoli Calmettes \u2013 Facult\u00e9 de Pharmacie, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Castets","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Canc\u00e9rologie de Lyon (CRCL), Universit\u00e9 Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre L\u00e9on B\u00e9rard, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Andr\u00e9","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Canc\u00e9rologie de Marseille (CRCM), Inserm UMR1068, CNRS UMR7258, Aix-Marseille Universit\u00e9 UM105, Institut Paoli Calmettes \u2013 Facult\u00e9 de Pharmacie, Marseille, France"},{"name":"Service D'H\u00e9matologie & Oncologie P\u00e9diatrique, H\u00f4pital de La Timone, Assistance Publique-H\u00f4pitaux de Marseille (APHM), Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5263-3473","authenticated-orcid":false,"given":"Paul","family":"Br\u00e9mond","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Canc\u00e9rologie de Marseille (CRCM), Inserm UMR1068, CNRS UMR7258, Aix-Marseille Universit\u00e9 UM105, Institut Paoli Calmettes \u2013 Facult\u00e9 de Pharmacie, Marseille, France"},{"name":"DOSynth Platform, Centre de Recherche en Canc\u00e9rologie de Marseille (CRCM), Facult\u00e9 de Pharmacie, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0427-7317","authenticated-orcid":false,"given":"Manon","family":"Carr\u00e9","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Canc\u00e9rologie de Marseille (CRCM), Inserm UMR1068, CNRS UMR7258, Aix-Marseille Universit\u00e9 UM105, Institut Paoli Calmettes \u2013 Facult\u00e9 de Pharmacie, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2023]]},"reference":[{"issue":"59","key":"D3SC01315D\/cit1\/1","doi-asserted-by":"crossref","first-page":"7921","DOI":"10.1039\/C4CC01364F","volume":"50","author":"Audran","year":"2014","journal-title":"Chem. Commun."},{"issue":"7","key":"D3SC01315D\/cit2\/1","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.3390\/polym12071481","volume":"12","author":"Audran","year":"2020","journal-title":"Polymers"},{"issue":"1","key":"D3SC01315D\/cit3\/1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/tcr.20033","volume":"5","author":"Studer","year":"2005","journal-title":"Chem. Rec."},{"issue":"7","key":"D3SC01315D\/cit4\/1","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1021\/mp5001394","volume":"11","author":"Moncelet","year":"2014","journal-title":"Mol. Pharm."},{"issue":"5","key":"D3SC01315D\/cit5\/1","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1039\/C3OB42076K","volume":"12","author":"Audran","year":"2014","journal-title":"Org. Biomol. Chem."},{"issue":"10","key":"D3SC01315D\/cit6\/1","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1016\/j.bmc.2019.03.029","volume":"27","author":"Yamasaki","year":"2019","journal-title":"Bioorg. Med. Chem."},{"issue":"2","key":"D3SC01315D\/cit7\/1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s40263-016-0405-9","volume":"31","author":"Patel","year":"2017","journal-title":"CNS Drugs"},{"issue":"suppl_4","key":"D3SC01315D\/cit8\/1","doi-asserted-by":"crossref","first-page":"iv1","DOI":"10.1093\/neuonc\/noy131","volume":"20","author":"Ostrom","year":"2018","journal-title":"Neuro Oncol."},{"issue":"10","key":"D3SC01315D\/cit9\/1","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1158\/1055-9965.EPI-14-0275","volume":"23","author":"Thakkar","year":"2014","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"issue":"6","key":"D3SC01315D\/cit10\/1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3892\/ijo.2022.5359","volume":"60","author":"Khabibov","year":"2022","journal-title":"Int. J. Oncol."},{"key":"D3SC01315D\/cit11\/1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jocn.2018.05.002","volume":"54","author":"Tykocki","year":"2018","journal-title":"J. Clin. Neurosci."},{"issue":"3","key":"D3SC01315D\/cit12\/1","first-page":"91","volume":"33","author":"Lukas","year":"2019","journal-title":"Oncology"},{"key":"D3SC01315D\/cit13\/1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.2147\/JMDH.S167808","volume":"12","author":"Thomas","year":"2019","journal-title":"J. Multidiscip. Healthc."},{"issue":"1","key":"D3SC01315D\/cit14\/1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.neuchi.2018.01.006","volume":"67","author":"Bernier","year":"2021","journal-title":"Neurochirurgie"},{"issue":"1","key":"D3SC01315D\/cit15\/1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.cell.2010.03.015","volume":"141","author":"Kessenbrock","year":"2010","journal-title":"Cell"},{"issue":"13","key":"D3SC01315D\/cit16\/1","doi-asserted-by":"crossref","first-page":"9253","DOI":"10.1021\/acs.jmedchem.2c00455","volume":"65","author":"Seren","year":"2022","journal-title":"J. Med. Chem."},{"issue":"39","key":"D3SC01315D\/cit17\/1","doi-asserted-by":"crossref","first-page":"8425","DOI":"10.1039\/C7OB02223A","volume":"15","author":"Audran","year":"2017","journal-title":"Org. Biomol. Chem."},{"issue":"12","key":"D3SC01315D\/cit18\/1","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1002\/jcp.25349","volume":"231","author":"Yang","year":"2016","journal-title":"J. Cell. Physiol."},{"key":"D3SC01315D\/cit19\/1","doi-asserted-by":"crossref","first-page":"101084","DOI":"10.1016\/j.redox.2018.101084","volume":"25","author":"Sai Srinivas","year":"2019","journal-title":"Redox Biol."},{"issue":"1","key":"D3SC01315D\/cit20\/1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1021\/mp0340183","volume":"1","author":"Kline","year":"2004","journal-title":"Mol. Pharmacol."},{"key":"D3SC01315D\/cit21\/1","doi-asserted-by":"crossref","first-page":"101084","DOI":"10.1016\/j.redox.2018.101084","volume":"25","author":"Sai Srinivas","year":"2019","journal-title":"Redox Biol."},{"issue":"4","key":"D3SC01315D\/cit22\/1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1080\/17460441.2017.1297416","volume":"12","author":"Brown","year":"2017","journal-title":"Expet Opin. Drug Discov."}],"updated-by":[{"DOI":"10.1039\/d6sc90135b","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000}}],"container-title":["Chemical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2023\/SC\/D3SC01315D","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:08:44Z","timestamp":1782886124000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/sc\/article\/14\/29\/7988-7998\/826913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":22,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2023,7,26]]}},"URL":"https:\/\/doi.org\/10.1039\/d3sc01315d","relation":{},"ISSN":["2041-6520","2041-6539"],"issn-type":[{"value":"2041-6520","type":"print"},{"value":"2041-6539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}