{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:30:52Z","timestamp":1791574252774,"version":"4.3.4"},"reference-count":42,"publisher":"Royal Society of Chemistry (RSC)","issue":"33","license":[{"start":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:00:00Z","timestamp":1721952000000},"content-version":"am","delay-in-days":572,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["Grant-in-Aid for Scientific Research (B) \/ JP19H04"],"award-info":[{"award-number":["Grant-in-Aid for Scientific Research (B) \/ JP19H04"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["Grant-in-Aid for Scientific Research (C) \/ JP21K12"],"award-info":[{"award-number":["Grant-in-Aid for Scientific Research (C) \/ JP21K12"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["Grant-in-Aid for Transformative Research Areas (A)"],"award-info":[{"award-number":["Grant-in-Aid for Transformative Research Areas (A)"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Soft Matter"],"abstract":"<jats:p>The behavior of enzymatic degradation and substance release of the hydrogel is precisely determined by the mesh size of the enzymatically degradable hydrogel and the size of the enzyme and loaded substance.<\/jats:p>","DOI":"10.1039\/d3sm00475a","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T06:21:46Z","timestamp":1690352506000},"page":"6224-6233","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Tunable enzymatically degradable hydrogels for controlled cargo release with dynamic mechanical properties"],"prefix":"10.1039","volume":"19","author":[{"given":"Riho","family":"Tanimoto","sequence":"first","affiliation":[{"name":"Research Center for Macromolecules and Biomaterials, National Institute for Materials Science, 1-1 Namiki, Tsukuba-shi, Ibaraki 305-0044, Japan"},{"name":"Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki 305-8571, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7906-0350","authenticated-orcid":false,"given":"Mitsuhiro","family":"Ebara","sequence":"additional","affiliation":[{"name":"Research Center for Macromolecules and Biomaterials, National Institute for Materials Science, 1-1 Namiki, Tsukuba-shi, Ibaraki 305-0044, Japan"},{"name":"Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki 305-8571, Japan"},{"name":"Graduate School of Advanced Engineering, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7091-0585","authenticated-orcid":false,"given":"Koichiro","family":"Uto","sequence":"additional","affiliation":[{"name":"Research Center for Macromolecules and Biomaterials, National Institute for Materials Science, 1-1 Namiki, Tsukuba-shi, Ibaraki 305-0044, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2023]]},"reference":[{"key":"D3SM00475A\/cit1\/1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0168-3659(01)00398-4","volume":"76","author":"Elbert","year":"2001","journal-title":"J. Controlled Release"},{"key":"D3SM00475A\/cit2\/1","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/bit.20160","volume":"86","author":"Bryant","year":"2004","journal-title":"Biotechnol. Bioeng."},{"key":"D3SM00475A\/cit3\/1","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1021\/cr000108x","volume":"101","author":"Lee","year":"2001","journal-title":"Chem. Rev."},{"key":"D3SM00475A\/cit4\/1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/jbm.1217","volume":"59","author":"Bryant","year":"2002","journal-title":"J. Biomed. Mater. Res."},{"key":"D3SM00475A\/cit5\/1","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/86715","volume":"19","author":"Saito","year":"2001","journal-title":"Nat. Biotechnol."},{"key":"D3SM00475A\/cit6\/1","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1002\/adma.200802106","volume":"21","author":"Slaughter","year":"2009","journal-title":"Adv. Mater."},{"key":"D3SM00475A\/cit7\/1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.biomaterials.2006.09.017","volume":"28","author":"Brandl","year":"2007","journal-title":"Biomaterials"},{"key":"D3SM00475A\/cit8\/1","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1002\/jbm.a.20110","volume":"68","author":"Orban","year":"2004","journal-title":"J. Biomed. Mater. Res. A"},{"key":"D3SM00475A\/cit9\/1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1146\/annurev.bioeng.3.1.225","volume":"3","author":"Nerem","year":"2001","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"D3SM00475A\/cit10\/1","doi-asserted-by":"crossref","first-page":"6381","DOI":"10.1016\/j.actbio.2013.01.026","volume":"9","author":"Kyburz","year":"2013","journal-title":"Acta Biomater."},{"key":"D3SM00475A\/cit11\/1","doi-asserted-by":"crossref","first-page":"6593","DOI":"10.1016\/j.biomaterials.2009.08.031","volume":"30","author":"Benton","year":"2009","journal-title":"Biomaterials"},{"key":"D3SM00475A\/cit12\/1","doi-asserted-by":"crossref","first-page":"7344","DOI":"10.1016\/j.biomaterials.2013.06.023","volume":"34","author":"Leight","year":"2013","journal-title":"Biomaterials"},{"key":"D3SM00475A\/cit13\/1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3390\/gels3010006","volume":"3","author":"Chai","year":"2017","journal-title":"Gels"},{"key":"D3SM00475A\/cit14\/1","doi-asserted-by":"crossref","first-page":"3564","DOI":"10.1016\/j.biomaterials.2011.01.064","volume":"32","author":"Anderson","year":"2011","journal-title":"Biomaterials"},{"key":"D3SM00475A\/cit15\/1","doi-asserted-by":"crossref","first-page":"5413","DOI":"10.1073\/pnas.0737381100","volume":"100","author":"Lutolf","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D3SM00475A\/cit16\/1","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1021\/bm300752j","volume":"13","author":"Shih","year":"2012","journal-title":"Biomacromolecules"},{"key":"D3SM00475A\/cit17\/1","doi-asserted-by":"crossref","first-page":"6048","DOI":"10.1016\/j.biomaterials.2009.07.043","volume":"30","author":"Aimetti","year":"2009","journal-title":"Biomaterials"},{"key":"D3SM00475A\/cit18\/1","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1021\/bm100137q","volume":"11","author":"Zustiak","year":"2010","journal-title":"Biomacromolecules"},{"key":"D3SM00475A\/cit19\/1","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1021\/ma9915024","volume":"33","author":"Lu","year":"2000","journal-title":"Macromolecules"},{"key":"D3SM00475A\/cit20\/1","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/mabi.200900295","volume":"10","author":"Yang","year":"2010","journal-title":"Macromol. Biosci."},{"key":"D3SM00475A\/cit21\/1","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.polymdegradstab.2016.09.008","volume":"133","author":"Yu","year":"2016","journal-title":"Polym. Degrad. Stab."},{"key":"D3SM00475A\/cit22\/1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1039\/C2SM27303A","volume":"9","author":"Schultz","year":"2013","journal-title":"Soft Matter"},{"key":"D3SM00475A\/cit23\/1","doi-asserted-by":"crossref","first-page":"4132","DOI":"10.1021\/acs.jpcb.2c00771","volume":"126","author":"Moncure","year":"2022","journal-title":"J. Phys. Chem. B"},{"key":"D3SM00475A\/cit24\/1","volume-title":"Scaling concepts in polymer physics","author":"De Gennes","year":"1979","unstructured":"P.-G.De Gennes  and  P.-G.Gennes ,  Scaling concepts in polymer physics ,  Cornell University Press ,  1979"},{"key":"D3SM00475A\/cit25\/1","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1021\/ma60051a002","volume":"9","author":"Pincus","year":"1976","journal-title":"Macromolecules"},{"key":"D3SM00475A\/cit26\/1","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1021\/ma60050a004","volume":"9","author":"Miller","year":"1976","journal-title":"Macromolecules"},{"key":"D3SM00475A\/cit27\/1","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1002\/bit.10605","volume":"82","author":"Baier Leach","year":"2003","journal-title":"Biotechnol. Bioeng."},{"key":"D3SM00475A\/cit28\/1","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/0142-9612(93)90154-T","volume":"14","author":"Merrill","year":"1993","journal-title":"Biomaterials"},{"key":"D3SM00475A\/cit29\/1","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/S0142-9612(98)00025-8","volume":"19","author":"Cruise","year":"1998","journal-title":"Biomaterials"},{"key":"D3SM00475A\/cit30\/1","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0142-9612(00)00258-1","volume":"22","author":"Mellott","year":"2001","journal-title":"Biomaterials"},{"key":"D3SM00475A\/cit31\/1","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1039\/C2SM27303A","volume":"9","author":"Schultz","year":"2013","journal-title":"Soft Matter"},{"key":"D3SM00475A\/cit32\/1","doi-asserted-by":"crossref","first-page":"11385","DOI":"10.1021\/acs.chemrev.0c01177","volume":"121","author":"Correa","year":"2021","journal-title":"Chem. Rev."},{"key":"D3SM00475A\/cit33\/1","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1016\/S0006-3495(03)74649-9","volume":"85","author":"Braeckmans","year":"2003","journal-title":"Biophys. J."},{"key":"D3SM00475A\/cit34\/1","doi-asserted-by":"crossref","first-page":"5005","DOI":"10.1002\/adma.200901808","volume":"21","author":"Fairbanks","year":"2009","journal-title":"Adv. Mater."},{"key":"D3SM00475A\/cit35\/1","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1021\/bm300671s","volume":"13","author":"McCall","year":"2012","journal-title":"Biomacromolecules"},{"key":"D3SM00475A\/cit36\/1","doi-asserted-by":"crossref","first-page":"611","DOI":"10.3103\/S0027134920060168","volume":"75","author":"Petrova","year":"2020","journal-title":"Moscow Univ. Phys. Bull."},{"key":"D3SM00475A\/cit37\/1","doi-asserted-by":"crossref","first-page":"7836","DOI":"10.1016\/j.biomaterials.2010.06.061","volume":"31","author":"Patterson","year":"2010","journal-title":"Biomaterials"},{"key":"D3SM00475A\/cit38\/1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/(SICI)1097-0282(1996)40:4<399::AID-BIP5>3.0.CO;2-R","volume":"40","author":"Nagase","year":"1996","journal-title":"Peptide Sci."},{"key":"D3SM00475A\/cit39\/1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0168-3659(01)00248-6","volume":"73","author":"Huang","year":"2001","journal-title":"J. Controlled Release"},{"key":"D3SM00475A\/cit40\/1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jconrel.2006.08.006","volume":"115","author":"Liang","year":"2006","journal-title":"J. Controlled Release"},{"key":"D3SM00475A\/cit41\/1","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1021\/bm049607o","volume":"6","author":"Metters","year":"2005","journal-title":"Biomacromolecules"},{"key":"D3SM00475A\/cit42\/1","doi-asserted-by":"crossref","first-page":"4293","DOI":"10.1021\/acsbiomaterials.0c01723","volume":"7","author":"Lust","year":"2021","journal-title":"ACS Biomater. Sci. Eng."}],"container-title":["Soft Matter"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2023\/SM\/D3SM00475A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:41:54Z","timestamp":1782927714000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/sm\/article\/19\/33\/6224-6233\/829476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":42,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2023,8,23]]}},"URL":"https:\/\/doi.org\/10.1039\/d3sm00475a","relation":{},"ISSN":["1744-683X","1744-6848"],"issn-type":[{"value":"1744-683X","type":"print"},{"value":"1744-6848","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}