{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T08:30:13Z","timestamp":1793953813368,"version":"4.8.0"},"reference-count":58,"publisher":"Royal Society of Chemistry (RSC)","issue":"39","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"am","delay-in-days":614,"URL":"http:\/\/rsc.li\/journals-terms-of-use#chorus"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL160540"],"award-info":[{"award-number":["R01 HL160540"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 EB030824"],"award-info":[{"award-number":["R21 EB030824"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","award":["Career Award at the Scientific Interface"],"award-info":[{"award-number":["Career Award at the Scientific Interface"]}],"id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["BOBOLT23H0"],"award-info":[{"award-number":["BOBOLT23H0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["2129624"],"award-info":[{"award-number":["2129624"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DGE1840349"],"award-info":[{"award-number":["DGE1840349"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["J. Mater. Chem. B"],"abstract":"<jats:p>The release and accumulation of neutrophil extracellular traps (NETs) in the airway mucus barrier is prominent in cystic fibrosis. New biomaterial-based models are developed that mimic important aspects of NET-mediated pathobiology in cystic fibrosis.<\/jats:p>","DOI":"10.1039\/d3tb01489d","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T10:01:45Z","timestamp":1693994505000},"page":"9419-9430","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Engineering\n                    <i>in vitro<\/i>\n                    models of cystic fibrosis lung disease using neutrophil extracellular trap inspired biomaterials"],"prefix":"10.1039","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4203-5928","authenticated-orcid":false,"given":"Allison","family":"Boboltz","sequence":"first","affiliation":[{"name":"Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sydney","family":"Yang","sequence":"additional","affiliation":[{"name":"Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6811-1327","authenticated-orcid":false,"given":"Gregg A.","family":"Duncan","sequence":"additional","affiliation":[{"name":"Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2023]]},"reference":[{"key":"D3TB01489D\/cit1\/1","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1056\/NEJMra0910061","volume":"363","author":"Fahy","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"D3TB01489D\/cit2\/1","doi-asserted-by":"crossref","first-page":"12773","DOI":"10.1021\/acs.langmuir.0c02410","volume":"36","author":"Song","year":"2020","journal-title":"Langmuir"},{"key":"D3TB01489D\/cit3\/1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1164\/rccm.201404-0670OC","volume":"190","author":"Birket","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"D3TB01489D\/cit4\/1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1056\/NEJMra1300109","volume":"372","author":"Stoltz","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"D3TB01489D\/cit5\/1","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1056\/NEJMra043184","volume":"352","author":"Rowe","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"D3TB01489D\/cit6\/1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jcf.2011.09.008","volume":"11","author":"Manzenreiter","year":"2012","journal-title":"J. Cystic Fibrosis"},{"key":"D3TB01489D\/cit7\/1","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1083\/jcb.201203170","volume":"198","author":"Brinkmann","year":"2012","journal-title":"J. Cell Biol."},{"key":"D3TB01489D\/cit8\/1","doi-asserted-by":"crossref","first-page":"14193","DOI":"10.1039\/C6NR03416K","volume":"8","author":"Pires","year":"2016","journal-title":"Nanoscale"},{"key":"D3TB01489D\/cit9\/1","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"key":"D3TB01489D\/cit10\/1","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3389\/fcimb.2017.00104","volume":"7","author":"Mart\u00ednez-Alem\u00e1n","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"D3TB01489D\/cit11\/1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3390\/antibiotics4010062","volume":"4","author":"Gray","year":"2015","journal-title":"Antibiotics"},{"key":"D3TB01489D\/cit12\/1","doi-asserted-by":"crossref","first-page":"210241","DOI":"10.1183\/16000617.0241-2021","volume":"31","author":"Keir","year":"2022","journal-title":"Eur. Respir. Rev."},{"key":"D3TB01489D\/cit13\/1","doi-asserted-by":"crossref","first-page":"408935","DOI":"10.1155\/2015\/408935","volume":"2015","author":"Marcos","year":"2015","journal-title":"Mediators Inflammation"},{"key":"D3TB01489D\/cit14\/1","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/s12890-016-0333-y","volume":"16","author":"Crull","year":"2016","journal-title":"BMC Pulm. Med."},{"key":"D3TB01489D\/cit15\/1","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.chom.2019.03.014","volume":"25","author":"Papayannopoulos","year":"2019","journal-title":"Cell Host Microbe"},{"key":"D3TB01489D\/cit16\/1","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1111\/j.1462-2920.2010.02208.x","volume":"12","author":"Mulcahy","year":"2010","journal-title":"Environ. Microbiol."},{"key":"D3TB01489D\/cit17\/1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.jconrel.2016.05.031","volume":"240","author":"Kim","year":"2016","journal-title":"J. Controlled Release"},{"key":"D3TB01489D\/cit18\/1","doi-asserted-by":"crossref","first-page":"114866","DOI":"10.1016\/j.addr.2023.114866","volume":"198","author":"Lee","year":"2023","journal-title":"Adv. Drug Delivery Rev."},{"key":"D3TB01489D\/cit19\/1","first-page":"3","volume":"42","author":"Balfour-Lynn","year":"2022","journal-title":"Paediatr. Respir. Rev."},{"key":"D3TB01489D\/cit20\/1","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1002\/ppul.25733","volume":"57","author":"McBennett","year":"2022","journal-title":"Pediatr. Pulmonol."},{"key":"D3TB01489D\/cit21\/1","doi-asserted-by":"crossref","first-page":"R88","DOI":"10.1093\/hmg\/ddz139","volume":"28","author":"Yan","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"D3TB01489D\/cit22\/1","doi-asserted-by":"crossref","first-page":"113862","DOI":"10.1016\/j.addr.2021.113862","volume":"177","author":"Selo","year":"2021","journal-title":"Adv. Drug Delivery Rev."},{"key":"D3TB01489D\/cit23\/1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1164\/rccm.201706-1139OC","volume":"197","author":"Abdullah","year":"2018","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"D3TB01489D\/cit24\/1","doi-asserted-by":"crossref","first-page":"18131","DOI":"10.1073\/pnas.0606428103","volume":"103","author":"Matsui","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D3TB01489D\/cit25\/1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1165\/rcmb.2020-0168OC","volume":"64","author":"Linssen","year":"2021","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"D3TB01489D\/cit26\/1","doi-asserted-by":"crossref","first-page":"e1807436","DOI":"10.1002\/adma.201807436","volume":"31","author":"Song","year":"2019","journal-title":"Adv. Mater."},{"key":"D3TB01489D\/cit27\/1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1183\/09031936.93.03010019","volume":"3","author":"Lethem","year":"1990","journal-title":"Eur. Respir. J."},{"key":"D3TB01489D\/cit28\/1","doi-asserted-by":"crossref","first-page":"e88198","DOI":"10.1172\/jci.insight.88198","volume":"1","author":"Duncan","year":"2016","journal-title":"JCI Insight"},{"key":"D3TB01489D\/cit29\/1","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1038\/mt.2016.182","volume":"24","author":"Duncan","year":"2016","journal-title":"Mol. Ther."},{"key":"D3TB01489D\/cit30\/1","doi-asserted-by":"crossref","first-page":"2100717","DOI":"10.1002\/admi.202100717","volume":"8","author":"Yang","year":"2021","journal-title":"Adv. Mater. Interfaces"},{"key":"D3TB01489D\/cit31\/1","doi-asserted-by":"crossref","first-page":"eadf2445","DOI":"10.1126\/sciadv.adf2445","volume":"9","author":"Yang","year":"2023","journal-title":"Sci. Adv."},{"key":"D3TB01489D\/cit32\/1","doi-asserted-by":"crossref","first-page":"9632","DOI":"10.1039\/C9SM01715A","volume":"15","author":"Joyner","year":"2019","journal-title":"Soft Matter"},{"key":"D3TB01489D\/cit33\/1","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1021\/acsbiomaterials.0c01728","volume":"7","author":"Song","year":"2021","journal-title":"ACS Biomater. Sci. Eng."},{"key":"D3TB01489D\/cit34\/1","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1002\/jbm.a.37559","volume":"111","author":"Yang","year":"2023","journal-title":"J. Biomed. Mater. Res., Part A"},{"key":"D3TB01489D\/cit35\/1","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1016\/j.biomaterials.2013.01.064","volume":"34","author":"Schuster","year":"2013","journal-title":"Biomaterials"},{"key":"D3TB01489D\/cit36\/1","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1089\/bio.2015.0064","volume":"14","author":"Lucena-Aguilar","year":"2016","journal-title":"Biopreserv. Biobanking"},{"key":"D3TB01489D\/cit37\/1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3390\/jor1010002","volume":"1","author":"Chance","year":"2020","journal-title":"J. Respir."},{"key":"D3TB01489D\/cit38\/1","doi-asserted-by":"crossref","first-page":"9188","DOI":"10.1073\/pnas.87.23.9188","volume":"87","author":"Shak","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D3TB01489D\/cit39\/1","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1136\/thx.50.8.880","volume":"50","author":"Brandt","year":"1995","journal-title":"Thorax"},{"key":"D3TB01489D\/cit40\/1","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1159\/000363242","volume":"6","author":"Dwyer","year":"2014","journal-title":"J. Innate Immun."},{"key":"D3TB01489D\/cit41\/1","doi-asserted-by":"crossref","first-page":"e28526","DOI":"10.1371\/journal.pone.0028526","volume":"6","author":"Papayannopoulos","year":"2011","journal-title":"PLoS One"},{"key":"D3TB01489D\/cit42\/1","doi-asserted-by":"crossref","first-page":"276ra27","DOI":"10.1126\/scitranslmed.3010525","volume":"7","author":"Yuan","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"D3TB01489D\/cit43\/1","doi-asserted-by":"crossref","first-page":"50393","DOI":"10.1074\/jbc.M309026200","volume":"278","author":"Dawson","year":"2003","journal-title":"J. Biol. Chem."},{"key":"D3TB01489D\/cit44\/1","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.chest.2018.03.005","volume":"154","author":"Ma","year":"2018","journal-title":"Chest"},{"key":"D3TB01489D\/cit45\/1","doi-asserted-by":"crossref","first-page":"15685","DOI":"10.1038\/s41598-020-72672-6","volume":"10","author":"Patarin","year":"2020","journal-title":"Sci. Rep."},{"key":"D3TB01489D\/cit46\/1","doi-asserted-by":"crossref","first-page":"7695","DOI":"10.1038\/s41598-023-34043-9","volume":"13","author":"Esteban Enjuto","year":"2023","journal-title":"Sci. Rep."},{"key":"D3TB01489D\/cit47\/1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.bpc.2004.07.019","volume":"112","author":"Nielsen","year":"2004","journal-title":"Biophys. Chem."},{"key":"D3TB01489D\/cit48\/1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1164\/rccm.200807-1056OC","volume":"180","author":"Innes","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"D3TB01489D\/cit49\/1","first-page":"L498","volume":"317","author":"Markovetz","year":"2019","journal-title":"Am. J. Physiol.: Lung Cell. Mol. Physiol."},{"key":"D3TB01489D\/cit50\/1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3390\/chemosensors6020021","volume":"6","author":"Wilson","year":"2018","journal-title":"Chemosensors"},{"key":"D3TB01489D\/cit51\/1","author":"Barbier","unstructured":"M.Barbier  and  D.Mittar , Novel Fluorescent Reporters for Studying Host-Pathogen Interactions, 2022,  https:\/\/www.atcc.org\/resources\/application-notes\/novel-fluorescent-reporters-for-studying-host-pathogen-interactions"},{"key":"D3TB01489D\/cit52\/1","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1128\/IAI.73.6.3693-3701.2005","volume":"73","author":"Walker","year":"2005","journal-title":"Infect. Immun."},{"key":"D3TB01489D\/cit53\/1","doi-asserted-by":"crossref","first-page":"e0086021","DOI":"10.1128\/mBio.00860-21","volume":"12","author":"Azimi","year":"2021","journal-title":"mBio"},{"key":"D3TB01489D\/cit54\/1","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1099\/jmm.0.001184","volume":"69","author":"Lewenza","year":"2020","journal-title":"J. Med. Microbiol."},{"key":"D3TB01489D\/cit55\/1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/lam.12134","volume":"57","author":"Jakubovics","year":"2013","journal-title":"Lett. Appl. Microbiol."},{"key":"D3TB01489D\/cit56\/1","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1128\/AAC.01650-15","volume":"60","author":"Wilton","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"D3TB01489D\/cit57\/1","doi-asserted-by":"crossref","first-page":"8487","DOI":"10.1073\/pnas.0602138103","volume":"103","author":"Smith","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D3TB01489D\/cit58\/1","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.2217\/fmb.10.125","volume":"5","author":"H\u00f8iby","year":"2010","journal-title":"Future Microbiol."}],"container-title":["Journal of Materials Chemistry B"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2023\/TB\/D3TB01489D","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2023\/TB\/D3TB01489D","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:03:34Z","timestamp":1782878614000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/tb\/article\/11\/39\/9419-9430\/833404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":58,"journal-issue":{"issue":"39","published-print":{"date-parts":[[2023,10,11]]}},"URL":"https:\/\/doi.org\/10.1039\/d3tb01489d","relation":{},"ISSN":["2050-750X","2050-7518"],"issn-type":[{"value":"2050-750X","type":"print"},{"value":"2050-7518","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}