{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:01:00Z","timestamp":1783112460055,"version":"3.54.6"},"reference-count":49,"publisher":"Royal Society of Chemistry (RSC)","issue":"48","license":[{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"am","delay-in-days":690,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100021194","name":"Shenyang Key Laboratory of Functional Drug Carrier Materials","doi-asserted-by":"publisher","award":["19-110-4-08"],"award-info":[{"award-number":["19-110-4-08"]}],"id":[{"id":"10.13039\/501100021194","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["J. Mater. Chem. B"],"abstract":"<jats:p>The multi-functional nanoparticle HN@Cu-MOF integrates PDT\/CDT\/GT, leading to a significant enhancement in GSH consumption and an elevation in ROS production, initiating the sensitization to PDT and cell apoptosis in the treatment of tumors.<\/jats:p>","DOI":"10.1039\/d3tb02433d","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T02:03:55Z","timestamp":1700532235000},"page":"11519-11531","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["All-in-one HN@Cu-MOF nanoparticles with enhanced reactive oxygen species generation and GSH depletion for effective tumor treatment"],"prefix":"10.1039","volume":"11","author":[{"given":"Shuhui","family":"Chen","sequence":"first","affiliation":[{"name":"School of Pharmacy, Shenyang Key Laboratory of Functional Drug Carrier Materials, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shenyang Key Laboratory of Functional Drug Carrier Materials, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shenyang Key Laboratory of Functional Drug Carrier Materials, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaili","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shenyang Key Laboratory of Functional Drug Carrier Materials, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawen","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shenyang Key Laboratory of Functional Drug Carrier Materials, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlong","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shenyang Key Laboratory of Functional Drug Carrier Materials, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xurui","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shenyang Key Laboratory of Functional Drug Carrier Materials, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2297-4346","authenticated-orcid":false,"given":"Jian","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, The Fourth Affiliated Hospital of China Medical University, No. 4 Chongshan East Road, Shenyang, Liaoning, 110032, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2755-3751","authenticated-orcid":false,"given":"Yue","family":"Yuan","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shenyang Key Laboratory of Functional Drug Carrier Materials, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2023]]},"reference":[{"key":"D3TB02433D\/cit1\/1","doi-asserted-by":"crossref","first-page":"10869","DOI":"10.1021\/cr400532z","volume":"114","author":"Cheng","year":"2014","journal-title":"Chem. Rev."},{"key":"D3TB02433D\/cit2\/1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.biomaterials.2018.05.052","volume":"177","author":"Guo","year":"2018","journal-title":"Biomaterials"},{"key":"D3TB02433D\/cit3\/1","doi-asserted-by":"crossref","first-page":"5860","DOI":"10.1002\/smll.201501923","volume":"11","author":"Hu","year":"2015","journal-title":"Small"},{"key":"D3TB02433D\/cit4\/1","doi-asserted-by":"crossref","first-page":"772","DOI":"10.7150\/thno.10853","volume":"5","author":"Wang","year":"2015","journal-title":"Theranostics"},{"key":"D3TB02433D\/cit5\/1","doi-asserted-by":"crossref","first-page":"6597","DOI":"10.1039\/C6CS00271D","volume":"45","author":"Zhou","year":"2016","journal-title":"Chem. Soc. Rev."},{"key":"D3TB02433D\/cit6\/1","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1038\/s41467-020-15591-4","volume":"11","author":"Liu","year":"2020","journal-title":"Nat. Commun."},{"key":"D3TB02433D\/cit7\/1","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1039\/D0CC08162K","volume":"57","author":"Zhang","year":"2021","journal-title":"Chem. Commun."},{"key":"D3TB02433D\/cit8\/1","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1039\/D1TB02299G","volume":"10","author":"Borz\u0119cka","year":"2022","journal-title":"J. Mater. Chem. B"},{"key":"D3TB02433D\/cit9\/1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/1011-1344(96)07342-3","volume":"34","author":"Schuitmaker","year":"1996","journal-title":"J. Photochem. Photobiol., B"},{"key":"D3TB02433D\/cit10\/1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1272\/jnms.JNMS.2023_90-108","volume":"90","author":"Lee","year":"2023","journal-title":"J. Nippon Med. Sch."},{"key":"D3TB02433D\/cit11\/1","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1007\/s00464-019-06846-3","volume":"34","author":"Minamide","year":"2020","journal-title":"Surg. Endosc."},{"key":"D3TB02433D\/cit12\/1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1039\/cs9952400019","volume":"24","author":"Bonnett","year":"1995","journal-title":"Chem. Soc. Rev."},{"key":"D3TB02433D\/cit13\/1","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/j.apsb.2021.12.001","volume":"12","author":"Zhou","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"D3TB02433D\/cit14\/1","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1016\/j.cclet.2021.12.096","volume":"33","author":"Jiang","year":"2022","journal-title":"Chin. Chem. Lett."},{"key":"D3TB02433D\/cit15\/1","doi-asserted-by":"crossref","first-page":"4902","DOI":"10.1002\/anie.201712027","volume":"57","author":"Lin","year":"2018","journal-title":"Angew. Chem., Int. Ed."},{"key":"D3TB02433D\/cit16\/1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s10555-007-9055-1","volume":"26","author":"Vaupel","year":"2007","journal-title":"Cancer Metastasis Rev."},{"key":"D3TB02433D\/cit17\/1","doi-asserted-by":"crossref","first-page":"213743","DOI":"10.1016\/j.ccr.2020.213743","volume":"432","author":"Liu","year":"2021","journal-title":"Coord. Chem. Rev."},{"key":"D3TB02433D\/cit18\/1","doi-asserted-by":"crossref","first-page":"1606314","DOI":"10.1002\/adfm.201606314","volume":"27","author":"Lismont","year":"2017","journal-title":"Adv. Funct. Mater."},{"key":"D3TB02433D\/cit19\/1","doi-asserted-by":"crossref","first-page":"112514","DOI":"10.1016\/j.msec.2021.112514","volume":"131","author":"Alves","year":"2021","journal-title":"Mater. Sci. Eng., C"},{"key":"D3TB02433D\/cit20\/1","doi-asserted-by":"crossref","first-page":"12502","DOI":"10.1021\/jacs.6b06663","volume":"138","author":"Lu","year":"2016","journal-title":"J. Am. Chem. Soc."},{"key":"D3TB02433D\/cit21\/1","doi-asserted-by":"crossref","first-page":"6172","DOI":"10.1039\/D3TB00632H","volume":"11","author":"Jiang","year":"2023","journal-title":"J. Mater. Chem. B"},{"key":"D3TB02433D\/cit22\/1","doi-asserted-by":"crossref","first-page":"6281","DOI":"10.1039\/D0CC01164A","volume":"56","author":"Ou","year":"2020","journal-title":"Chem. Commun."},{"key":"D3TB02433D\/cit23\/1","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1002\/anie.201805664","volume":"58","author":"Tang","year":"2019","journal-title":"Angew. Chem., Int. Ed."},{"key":"D3TB02433D\/cit24\/1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.mam.2005.07.015","volume":"26","author":"Uriu-Adams","year":"2005","journal-title":"Mol. Aspects Med."},{"key":"D3TB02433D\/cit25\/1","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1039\/B312445B","volume":"28","author":"Brillas","year":"2004","journal-title":"New J. Chem."},{"key":"D3TB02433D\/cit26\/1","doi-asserted-by":"crossref","first-page":"19402","DOI":"10.1021\/acsomega.3c00269","volume":"8","author":"Liang","year":"2023","journal-title":"ACS Omega"},{"key":"D3TB02433D\/cit27\/1","doi-asserted-by":"crossref","first-page":"9937","DOI":"10.1021\/jacs.9b03457","volume":"141","author":"Lin","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"D3TB02433D\/cit28\/1","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.jcis.2023.05.001","volume":"645","author":"Sun","year":"2023","journal-title":"J. Colloid Interface Sci."},{"key":"D3TB02433D\/cit29\/1","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1021\/acs.nanolett.8b04763","volume":"19","author":"Zhang","year":"2019","journal-title":"Nano Lett."},{"key":"D3TB02433D\/cit30\/1","doi-asserted-by":"crossref","first-page":"6335","DOI":"10.1039\/D3TB00749A","volume":"11","author":"Zhong","year":"2023","journal-title":"J. Mater. Chem. B"},{"key":"D3TB02433D\/cit31\/1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.biomaterials.2018.09.043","volume":"187","author":"Deng","year":"2018","journal-title":"Biomaterials"},{"key":"D3TB02433D\/cit32\/1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.jconrel.2022.10.025","volume":"352","author":"Li","year":"2022","journal-title":"J. Controlled Release"},{"key":"D3TB02433D\/cit33\/1","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1021\/acs.nanolett.8b04236","volume":"19","author":"Dong","year":"2019","journal-title":"Nano Lett."},{"key":"D3TB02433D\/cit34\/1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.biomaterials.2018.03.046","volume":"168","author":"Hu","year":"2018","journal-title":"Biomaterials"},{"key":"D3TB02433D\/cit35\/1","doi-asserted-by":"crossref","first-page":"8935","DOI":"10.1021\/acsnano.3c02303","volume":"17","author":"Wang","year":"2023","journal-title":"ACS Nano"},{"key":"D3TB02433D\/cit36\/1","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1054\/bjoc.2000.1157","volume":"82","author":"Korbelik","year":"2000","journal-title":"Br. J. Cancer"},{"key":"D3TB02433D\/cit37\/1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.redox.2015.07.015","volume":"6","author":"Rapozzi","year":"2015","journal-title":"Redox Biol."},{"key":"D3TB02433D\/cit38\/1","doi-asserted-by":"crossref","first-page":"136295","DOI":"10.1016\/j.cej.2022.136295","volume":"442","author":"Xia","year":"2022","journal-title":"Chem. Eng. J."},{"key":"D3TB02433D\/cit39\/1","doi-asserted-by":"crossref","first-page":"R53","DOI":"10.1186\/bcr2108","volume":"10","author":"Honeth","year":"2008","journal-title":"Breast Cancer Res."},{"key":"D3TB02433D\/cit40\/1","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1097\/JCMA.0000000000000056","volume":"82","author":"Wang","year":"2019","journal-title":"J. Chin. Med. Assoc."},{"key":"D3TB02433D\/cit41\/1","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1002\/cam4.1968","volume":"8","author":"Asai","year":"2019","journal-title":"Cancer Med."},{"key":"D3TB02433D\/cit42\/1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1084\/jem.180.1.53","volume":"180","author":"Bartolazzi","year":"1994","journal-title":"J. Exp. Med."},{"key":"D3TB02433D\/cit43\/1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s40164-020-00192-0","volume":"9","author":"Xu","year":"2020","journal-title":"Exp. Hematol. Oncol."},{"key":"D3TB02433D\/cit44\/1","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1021\/acs.bioconjchem.8b00311","volume":"29","author":"Bartheldyov\u00e1","year":"2018","journal-title":"Bioconjugate Chem."},{"key":"D3TB02433D\/cit45\/1","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1021\/acs.bioconjchem.0c00194","volume":"31","author":"Han","year":"2020","journal-title":"Bioconjugate Chem."},{"key":"D3TB02433D\/cit46\/1","doi-asserted-by":"crossref","first-page":"1910084","DOI":"10.1002\/adfm.201910084","volume":"30","author":"Hu","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"D3TB02433D\/cit47\/1","doi-asserted-by":"crossref","first-page":"118248","DOI":"10.1016\/j.apcatb.2019.118248","volume":"261","author":"Han","year":"2020","journal-title":"Appl. Catal., B"},{"key":"D3TB02433D\/cit48\/1","doi-asserted-by":"crossref","first-page":"36782","DOI":"10.1021\/acsami.9b13080","volume":"11","author":"Tan","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D3TB02433D\/cit49\/1","doi-asserted-by":"crossref","first-page":"31671","DOI":"10.1021\/acsami.9b10685","volume":"11","author":"Xie","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"}],"container-title":["Journal of Materials Chemistry B"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2023\/TB\/D3TB02433D","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:34:07Z","timestamp":1782880447000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/tb\/article\/11\/48\/11519-11531\/833644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":49,"journal-issue":{"issue":"48","published-print":{"date-parts":[[2023,12,13]]}},"URL":"https:\/\/doi.org\/10.1039\/d3tb02433d","relation":{},"ISSN":["2050-750X","2050-7518"],"issn-type":[{"value":"2050-750X","type":"print"},{"value":"2050-7518","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023]]}}}