{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T18:57:30Z","timestamp":1783537050983,"version":"3.55.0"},"reference-count":63,"publisher":"Royal Society of Chemistry (RSC)","issue":"13","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"am","delay-in-days":505,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2021YFA1301604"],"award-info":[{"award-number":["2021YFA1301604"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Analyst"],"abstract":"<jats:p>We demonstrated that the combination of SP3 with precipitation achieved highly efficient urobilin removal, and enhanced the robustness of urine proteome analysis.<\/jats:p>","DOI":"10.1039\/d4an00312h","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T10:20:48Z","timestamp":1716200448000},"page":"3625-3635","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An effective urobilin clearance strategy based on paramagnetic beads facilitates microscale proteomic analysis of urine"],"prefix":"10.1039","volume":"149","author":[{"given":"Kemiao","family":"Zhen","sequence":"first","affiliation":[{"name":"State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Hou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Urology Surgery, The Second Affiliated Hospital of Guilin Medical University, Guilin, 541199, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingchao","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan","family":"Yue","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zanxin","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyun","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Urology Surgery, The Second Affiliated Hospital of Guilin Medical University, Guilin, 541199, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Urology Surgery, The Second Affiliated Hospital of Guilin Medical University, Guilin, 541199, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8309-2198","authenticated-orcid":false,"given":"Wantao","family":"Ying","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2024]]},"reference":[{"key":"D4AN00312H\/cit1\/1","doi-asserted-by":"crossref","first-page":"11906","DOI":"10.1038\/ncomms11906","volume":"7","author":"Kim","year":"2016","journal-title":"Nat. Commun."},{"key":"D4AN00312H\/cit2\/1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/978-94-017-9523-4_4","volume":"845","author":"Zou","year":"2015","journal-title":"Adv. Exp. Med. Biol."},{"key":"D4AN00312H\/cit3\/1","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1038\/s41467-022-30391-8","volume":"13","author":"Sun","year":"2022","journal-title":"Nat. Commun."},{"key":"D4AN00312H\/cit4\/1","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1021\/acs.chemrestox.0c00126","volume":"33","author":"Gao","year":"2020","journal-title":"Chem. Res. Toxicol."},{"key":"D4AN00312H\/cit5\/1","doi-asserted-by":"crossref","first-page":"7872","DOI":"10.7150\/thno.44634","volume":"10","author":"Chen","year":"2020","journal-title":"Theranostics"},{"key":"D4AN00312H\/cit6\/1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1559-0275-11-7","volume":"11","author":"Sigdel","year":"2014","journal-title":"Clin. Proteomics"},{"key":"D4AN00312H\/cit7\/1","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1038\/s41598-017-03226-6","volume":"7","author":"Zhao","year":"2017","journal-title":"Sci. Rep."},{"key":"D4AN00312H\/cit8\/1","doi-asserted-by":"crossref","first-page":"782798","DOI":"10.1155\/2015\/782798","volume":"2015","author":"Kalantari","year":"2015","journal-title":"Int. J. Proteomics"},{"key":"D4AN00312H\/cit9\/1","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1074\/mcp.M300031-MCP200","volume":"2","author":"Tirumalai","year":"2003","journal-title":"Mol. Cell. Proteomics"},{"key":"D4AN00312H\/cit10\/1","doi-asserted-by":"crossref","first-page":"4752","DOI":"10.1021\/acs.jproteome.5b00826","volume":"14","author":"Muntel","year":"2015","journal-title":"J. Proteome Res."},{"key":"D4AN00312H\/cit11\/1","doi-asserted-by":"crossref","first-page":"5517","DOI":"10.1021\/acs.analchem.8b05234","volume":"91","author":"Clark","year":"2019","journal-title":"Anal. Chem."},{"key":"D4AN00312H\/cit12\/1","doi-asserted-by":"crossref","first-page":"11963","DOI":"10.7150\/thno.50093","volume":"10","author":"Liu","year":"2020","journal-title":"Theranostics"},{"key":"D4AN00312H\/cit13\/1","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1016\/j.kint.2019.01.020","volume":"95","author":"Xie","year":"2019","journal-title":"Kidney Int."},{"key":"D4AN00312H\/cit14\/1","doi-asserted-by":"crossref","first-page":"e13257","DOI":"10.15252\/emmm.202013257","volume":"13","author":"Virreira Winter","year":"2021","journal-title":"EMBO Mol. Med."},{"key":"D4AN00312H\/cit15\/1","doi-asserted-by":"crossref","first-page":"104340","DOI":"10.1016\/j.ebiom.2022.104340","volume":"86","author":"Fan","year":"2022","journal-title":"EBioMedicine"},{"key":"D4AN00312H\/cit16\/1","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ebiom.2018.03.009","volume":"30","author":"Zhang","year":"2018","journal-title":"EBioMedicine"},{"key":"D4AN00312H\/cit17\/1","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1007\/s11427-021-2070-y","volume":"65","author":"Liu","year":"2022","journal-title":"Sci. China: Life Sci."},{"key":"D4AN00312H\/cit18\/1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1186\/s12916-023-03137-6","volume":"21","author":"Wang","year":"2023","journal-title":"BMC Med."},{"key":"D4AN00312H\/cit19\/1","doi-asserted-by":"crossref","first-page":"6244","DOI":"10.1021\/acsomega.2c05487","volume":"8","author":"Prestagiacomo","year":"2023","journal-title":"ACS Omega"},{"key":"D4AN00312H\/cit20\/1","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1002\/pmic.200401143","volume":"5","author":"Tantipaiboonwong","year":"2005","journal-title":"Proteomics"},{"key":"D4AN00312H\/cit21\/1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ab.2013.07.027","volume":"442","author":"Sampson","year":"2013","journal-title":"Anal. Biochem."},{"key":"D4AN00312H\/cit22\/1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3390\/mps2020046","volume":"2","author":"Saito","year":"2019","journal-title":"Methods Protoc."},{"key":"D4AN00312H\/cit23\/1","first-page":"e1800152","volume":"13","author":"Zhao","year":"2019","journal-title":"Proteomics: Clin. Appl."},{"key":"D4AN00312H\/cit24\/1","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.21037\/tp-21-193","volume":"10","author":"Meng","year":"2021","journal-title":"Transl. Pediatr."},{"key":"D4AN00312H\/cit25\/1","doi-asserted-by":"crossref","first-page":"5859","DOI":"10.1038\/s41467-020-19706-9","volume":"11","author":"Tian","year":"2020","journal-title":"Nat. Commun."},{"key":"D4AN00312H\/cit26\/1","doi-asserted-by":"crossref","first-page":"110271","DOI":"10.1016\/j.celrep.2021.110271","volume":"38","author":"Bi","year":"2022","journal-title":"Cell Rep."},{"key":"D4AN00312H\/cit27\/1","doi-asserted-by":"crossref","first-page":"4074","DOI":"10.1021\/pr400618v","volume":"12","author":"Rainczuk","year":"2013","journal-title":"J. Proteome Res."},{"key":"D4AN00312H\/cit28\/1","doi-asserted-by":"crossref","first-page":"946791","DOI":"10.3389\/fimmu.2022.946791","volume":"13","author":"Pan","year":"2022","journal-title":"Front. Immunol."},{"key":"D4AN00312H\/cit29\/1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/978-3-030-12298-0_5","volume":"1073","author":"S\u00e1nchez-Juanes","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"D4AN00312H\/cit30\/1","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1021\/acs.jproteome.7b00913","volume":"17","author":"Moggridge","year":"2018","journal-title":"J. Proteome Res."},{"key":"D4AN00312H\/cit31\/1","doi-asserted-by":"crossref","first-page":"757","DOI":"10.15252\/msb.20145625","volume":"10","author":"Hughes","year":"2014","journal-title":"Mol. Syst. Biol."},{"key":"D4AN00312H\/cit32\/1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/s41596-018-0082-x","volume":"14","author":"Hughes","year":"2019","journal-title":"Nat. Protoc."},{"key":"D4AN00312H\/cit33\/1","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1111\/j.1523-1755.2002.kid565.x","volume":"62","author":"Thongboonkerd","year":"2002","journal-title":"Kidney Int."},{"key":"D4AN00312H\/cit34\/1","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1021\/pr060305y","volume":"5","author":"Khan","year":"2006","journal-title":"J. Proteome Res."},{"key":"D4AN00312H\/cit35\/1","doi-asserted-by":"crossref","first-page":"4060","DOI":"10.1021\/acs.jproteome.7b00433","volume":"16","author":"Sielaff","year":"2017","journal-title":"J. Proteome Res."},{"key":"D4AN00312H\/cit36\/1","doi-asserted-by":"crossref","first-page":"635550","DOI":"10.3389\/fpls.2021.635550","volume":"12","author":"Mikul\u00e1\u0161ek","year":"2021","journal-title":"Front. Plant Sci."},{"key":"D4AN00312H\/cit37\/1","doi-asserted-by":"crossref","first-page":"10320","DOI":"10.1021\/acs.analchem.1c04200","volume":"94","author":"Johnston","year":"2022","journal-title":"Anal. Chem."},{"key":"D4AN00312H\/cit38\/1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3322\/caac.21763","volume":"73","author":"Siegel","year":"2023","journal-title":"CA-Cancer J. Clin."},{"key":"D4AN00312H\/cit39\/1","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1056\/NEJMoa031918","volume":"350","author":"Thompson","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"D4AN00312H\/cit40\/1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3892\/ol.2023.13759","volume":"25","author":"De Souza Dutra","year":"2023","journal-title":"Oncol. Lett."},{"key":"D4AN00312H\/cit41\/1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s13402-016-0268-6","volume":"39","author":"Saini","year":"2016","journal-title":"Cell. Oncol."},{"key":"D4AN00312H\/cit42\/1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrurol.2009.261","volume":"7","author":"Ploussard","year":"2010","journal-title":"Nat. Rev. Urol."},{"key":"D4AN00312H\/cit43\/1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s12911-023-02312-2","volume":"23","author":"Talens","year":"2023","journal-title":"BMC Med. Inf. Decis. Making"},{"key":"D4AN00312H\/cit44\/1","doi-asserted-by":"crossref","first-page":"831","DOI":"10.2217\/bmm.13.112","volume":"7","author":"Prager","year":"2013","journal-title":"Biomarkers Med."},{"key":"D4AN00312H\/cit45\/1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/path.2205","volume":"213","author":"Sahadevan","year":"2007","journal-title":"J. Pathol."},{"key":"D4AN00312H\/cit46\/1","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1007\/s00432-022-04380-9","volume":"149","author":"Ge","year":"2023","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"D4AN00312H\/cit47\/1","doi-asserted-by":"crossref","first-page":"1181370","DOI":"10.3389\/fimmu.2023.1181370","volume":"14","author":"Yao","year":"2023","journal-title":"Front. Immunol."},{"key":"D4AN00312H\/cit48\/1","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1593\/neo.08922","volume":"10","author":"Varambally","year":"2008","journal-title":"Neoplasia"},{"key":"D4AN00312H\/cit49\/1","first-page":"e15147","volume":"29","author":"Prager","year":"2011","journal-title":"Biomarkers Med."},{"key":"D4AN00312H\/cit50\/1","doi-asserted-by":"crossref","first-page":"15330338231153618","DOI":"10.1177\/15330338231153618","volume":"22","author":"Qin","year":"2023","journal-title":"Technol. Cancer Res. Treat."},{"key":"D4AN00312H\/cit51\/1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1593\/neo.05679","volume":"8","author":"Loberg","year":"2006","journal-title":"Neoplasia"},{"key":"D4AN00312H\/cit52\/1","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.4161\/epi.22333","volume":"7","author":"Shinojima","year":"2012","journal-title":"Epigenetics"},{"key":"D4AN00312H\/cit53\/1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1365-2559.2008.03058.x","volume":"53","author":"Richardsen","year":"2008","journal-title":"Histopathology"},{"key":"D4AN00312H\/cit54\/1","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jsbmb.2009.02.002","volume":"114","author":"L\u00e9veill\u00e9","year":"2009","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"D4AN00312H\/cit55\/1","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/sj.pcan.4500663","volume":"6","author":"Tohtong","year":"2003","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"D4AN00312H\/cit56\/1","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.ejca.2005.12.017","volume":"42","author":"Gu","year":"2006","journal-title":"Eur. J. Cancer"},{"key":"D4AN00312H\/cit57\/1","doi-asserted-by":"crossref","first-page":"382","DOI":"10.4161\/cam.5.5.18162","volume":"5","author":"McAuley","year":"2011","journal-title":"Cell Adhes. Migr."},{"key":"D4AN00312H\/cit58\/1","doi-asserted-by":"crossref","first-page":"538019","DOI":"10.1155\/2015\/538019","volume":"2015","author":"Brahmkhatri","year":"2015","journal-title":"BioMed Res. Int."},{"key":"D4AN00312H\/cit59\/1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/ije\/dyac124","volume":"52","author":"Watts","year":"2023","journal-title":"Int. J. Epidemiol."},{"key":"D4AN00312H\/cit60\/1","doi-asserted-by":"crossref","first-page":"101245","DOI":"10.1016\/j.molmet.2021.101245","volume":"52","author":"LeRoith","year":"2021","journal-title":"Mol. Metab."},{"key":"D4AN00312H\/cit61\/1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.12688\/wellcomeopenres.16417.1","volume":"6","author":"Stankovic","year":"2021","journal-title":"Wellcome Open Res."},{"key":"D4AN00312H\/cit62\/1","doi-asserted-by":"crossref","first-page":"4014","DOI":"10.1158\/0008-5472.CAN-20-1281","volume":"80","author":"Knuppel","year":"2020","journal-title":"Cancer Res."},{"key":"D4AN00312H\/cit63\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cells10092426","volume":"10","author":"Netti","year":"2021","journal-title":"Cells"}],"container-title":["The Analyst"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/AN\/D4AN00312H","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:39:28Z","timestamp":1783532368000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/an\/article\/149\/13\/3625-3635\/836318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":63,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2024,6,24]]}},"URL":"https:\/\/doi.org\/10.1039\/d4an00312h","relation":{},"ISSN":["0003-2654","1364-5528"],"issn-type":[{"value":"0003-2654","type":"print"},{"value":"1364-5528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}