{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T19:57:12Z","timestamp":1783454232121,"version":"3.55.0"},"reference-count":27,"publisher":"Royal Society of Chemistry (RSC)","issue":"19","license":[{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"vor","delay-in-days":204,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/100014132","name":"European Metrology Programme for Innovation and Research","doi-asserted-by":"publisher","award":["15HLT09-NeuroMET"],"award-info":[{"award-number":["15HLT09-NeuroMET"]}],"id":[{"id":"10.13039\/100014132","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014132","name":"European Metrology Programme for Innovation and Research","doi-asserted-by":"publisher","award":["18HLT09-NeuroMET2"],"award-info":[{"award-number":["18HLT09-NeuroMET2"]}],"id":[{"id":"10.13039\/100014132","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Analyst"],"abstract":"<jats:p>An SI traceable primary calibrator was used for the development of a reference measurement procedure for \u03b1-synuclein. A targeted proteomics workflow allowed for the SI traceable quantification of \u03b1-synuclein in cerebrospinal fluid.<\/jats:p>","DOI":"10.1039\/d4an00634h","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T11:06:42Z","timestamp":1721732802000},"page":"4842-4850","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A candidate reference measurement procedure for the quantification of \u03b1-synuclein in cerebrospinal fluid using an SI traceable primary calibrator and multiple reaction monitoring"],"prefix":"10.1039","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1051-8132","authenticated-orcid":false,"given":"Leran","family":"Zhang","sequence":"first","affiliation":[{"name":"LGC Group, Queens Road, TW11 0LY Teddington, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5232-8196","authenticated-orcid":false,"given":"Eva","family":"Illes-Toth","sequence":"additional","affiliation":[{"name":"LGC Group, Queens Road, TW11 0LY Teddington, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Cryar","sequence":"additional","affiliation":[{"name":"LGC Group, Queens Road, TW11 0LY Teddington, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giles","family":"Drinkwater","sequence":"additional","affiliation":[{"name":"LGC Group, Queens Road, TW11 0LY Teddington, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4394-3730","authenticated-orcid":false,"given":"Lucia","family":"Di Vagno","sequence":"additional","affiliation":[{"name":"LGC Group, Queens Road, TW11 0LY Teddington, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7776-1444","authenticated-orcid":false,"given":"Marie-Laure","family":"Pons","sequence":"additional","affiliation":[{"name":"LBPC-PPC, Univ Montpellier, IRMB CHU Montpellier, INM INSERM, 34295 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Mateyka","sequence":"additional","affiliation":[{"name":"LGC Group, Queens Road, TW11 0LY Teddington, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"McCullough","sequence":"additional","affiliation":[{"name":"LGC Group, Queens Road, TW11 0LY Teddington, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli","family":"Achtar","sequence":"additional","affiliation":[{"name":"LGC Group, Queens Road, TW11 0LY Teddington, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cailean","family":"Clarkson","sequence":"additional","affiliation":[{"name":"LGC Group, Queens Road, TW11 0LY Teddington, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6592-2493","authenticated-orcid":false,"given":"Laura","family":"G\u00f6schel","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Department of Neurology, 10117 Berlin, Germany"},{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Neuroscience Clinical Research Center, 10117 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1262-6169","authenticated-orcid":false,"given":"Peter","family":"K\u00f6rtv\u00e9lyessy","sequence":"additional","affiliation":[{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Department of Neurology, 10117 Berlin, Germany"},{"name":"Labor Berlin, Innovations, Sylter Strasse 2, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Mussell","sequence":"additional","affiliation":[{"name":"LGC Group, Queens Road, TW11 0LY Teddington, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Hopley","sequence":"additional","affiliation":[{"name":"LGC Group, Queens Road, TW11 0LY Teddington, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1475-5872","authenticated-orcid":false,"given":"Agnes","family":"Fl\u00f6el","sequence":"additional","affiliation":[{"name":"Department of Neurology, Universit\u00e4tsmedizin Greifswald, 17475 Greifswald, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7313-0629","authenticated-orcid":false,"given":"Christophe","family":"Hirtz","sequence":"additional","affiliation":[{"name":"LBPC-PPC, Univ Montpellier, IRMB CHU Montpellier, INM INSERM, 34295 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6117-562X","authenticated-orcid":false,"given":"Sylvain","family":"Lehmann","sequence":"additional","affiliation":[{"name":"LBPC-PPC, Univ Montpellier, IRMB CHU Montpellier, INM INSERM, 34295 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0771-5555","authenticated-orcid":false,"given":"Milena","family":"Quaglia","sequence":"additional","affiliation":[{"name":"LGC Group, Queens Road, TW11 0LY Teddington, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2024]]},"reference":[{"key":"D4AN00634H\/cit1\/1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0014-5793(94)00395-5","volume":"345","author":"Jakes","year":"1994","journal-title":"FEBS Lett."},{"key":"D4AN00634H\/cit2\/1","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1111\/jnc.14809","volume":"150","author":"Fayyad","year":"2019","journal-title":"J. Neurochem."},{"key":"D4AN00634H\/cit3\/1","doi-asserted-by":"crossref","first-page":"a009399","DOI":"10.1101\/cshperspect.a009399","volume":"2","author":"Stefanis","year":"2012","journal-title":"Cold Spring Harbor Perspect. Med."},{"key":"D4AN00634H\/cit4\/1","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/nrn3549","volume":"14","author":"Irwin","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"D4AN00634H\/cit5\/1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13024-019-0320-x","volume":"14","author":"Twohig","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"D4AN00634H\/cit6\/1","doi-asserted-by":"crossref","first-page":"6469","DOI":"10.1073\/pnas.95.11.6469","volume":"95","author":"Spillantini","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D4AN00634H\/cit7\/1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S1474-4422(11)70014-X","volume":"10","author":"Mollenhauer","year":"2011","journal-title":"Lancet Neurol."},{"key":"D4AN00634H\/cit8\/1","doi-asserted-by":"crossref","first-page":"683","DOI":"10.2217\/bmm.10.90","volume":"4","author":"Mollenhauer","year":"2010","journal-title":"Biomarkers Med."},{"key":"D4AN00634H\/cit9\/1","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1002\/mds.26036","volume":"29","author":"Sako","year":"2014","journal-title":"Mov. Disord."},{"key":"D4AN00634H\/cit10\/1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.bbrc.2006.08.024","volume":"349","author":"Tokuda","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"D4AN00634H\/cit11\/1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s40478-021-01175-w","volume":"9","author":"Bargar","year":"2021","journal-title":"Acta Neuropathol. Commun."},{"key":"D4AN00634H\/cit12\/1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S1474-4422(20)30449-X","volume":"20","author":"Iranzo","year":"2021","journal-title":"Lancet Neurol."},{"key":"D4AN00634H\/cit13\/1","first-page":"1700045","volume":"11","author":"Yang","year":"2017","journal-title":"Proteomics: Clin. Appl."},{"key":"D4AN00634H\/cit14\/1","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1074\/mcp.M116.059915","volume":"15","author":"Oeckl","year":"2016","journal-title":"Mol. Cell. Proteomics"},{"key":"D4AN00634H\/cit15\/1","doi-asserted-by":"crossref","first-page":"818606","DOI":"10.3389\/fnagi.2022.818606","volume":"14","author":"Pons","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"D4AN00634H\/cit16\/1","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1038\/s41596-022-00787-3","volume":"18","author":"Concha-Marambio","year":"2023","journal-title":"Nat. Protoc."},{"key":"D4AN00634H\/cit17\/1","doi-asserted-by":"crossref","first-page":"7579","DOI":"10.1007\/s00216-015-8961-2","volume":"407","author":"Liu","year":"2015","journal-title":"Anal. Bioanal. Chem."},{"key":"D4AN00634H\/cit18\/1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1515\/CCLM.2002.016","volume":"40","author":"Jeppsson","year":"2002","journal-title":"Clin. Chem. Lab. Med."},{"key":"D4AN00634H\/cit19\/1","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1515\/cclm-2016-1054","volume":"55","author":"Torma","year":"2017","journal-title":"Clin. Chem. Lab. Med."},{"key":"D4AN00634H\/cit20\/1","doi-asserted-by":"crossref","first-page":"044006","DOI":"10.1088\/1681-7575\/ab27e5","volume":"56","author":"Josephs","year":"2019","journal-title":"Metrologia"},{"key":"D4AN00634H\/cit21\/1","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1373\/clinchem.2009.124354","volume":"55","author":"Pritchard","year":"2009","journal-title":"Clin. Chem."},{"key":"D4AN00634H\/cit22\/1","volume-title":"Quantifying uncertainty in analytical measurement","author":"Ellison","year":"2012","unstructured":"S.Ellison  and  A.Williams ,  Quantifying uncertainty in analytical measurement ,  Eurachem ,  London , 3rd edn,  2012"},{"key":"D4AN00634H\/cit23\/1","volume-title":"Guide to the expression of uncertainty in measurement","author":"ISO","year":"1995","unstructured":"ISO ,  Guide to the expression of uncertainty in measurement ,  International Organisation for Standardisation ,  Geneva , 1st edn,  1995"},{"key":"D4AN00634H\/cit24\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.25135\/jcm.1.17.02.030","volume":"11","author":"Josephs","year":"2017","journal-title":"J. Chem. Metrol."},{"key":"D4AN00634H\/cit25\/1","doi-asserted-by":"crossref","first-page":"9686","DOI":"10.1021\/jacs.0c03990","volume":"142","author":"Ahmed","year":"2020","journal-title":"J. Am. Chem. Soc."},{"key":"D4AN00634H\/cit26\/1","doi-asserted-by":"crossref","first-page":"3070","DOI":"10.1039\/C4AN02306D","volume":"140","author":"Phillips","year":"2015","journal-title":"Analyst"},{"key":"D4AN00634H\/cit27\/1","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1093\/bioinformatics\/btq054","volume":"26","author":"MacLean","year":"2010","journal-title":"Bioinformatics"}],"container-title":["The Analyst"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/AN\/D4AN00634H","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:40:51Z","timestamp":1783449651000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/an\/article\/149\/19\/4842-4850\/836408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":27,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2024,9,23]]}},"URL":"https:\/\/doi.org\/10.1039\/d4an00634h","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.03.20.585804","asserted-by":"object"}]},"ISSN":["0003-2654","1364-5528"],"issn-type":[{"value":"0003-2654","type":"print"},{"value":"1364-5528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}