{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T01:16:42Z","timestamp":1783127802838,"version":"3.54.6"},"reference-count":20,"publisher":"Royal Society of Chemistry (RSC)","issue":"13","license":[{"start":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:00:00Z","timestamp":1741305600000},"content-version":"am","delay-in-days":431,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012478","name":"Secretaria de Ciencia y Tecnolog\u00eda - Universidad Nacional de C\u00f3rdoba","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006668","name":"Fondo para la Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006668","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Anal. Methods"],"abstract":"<jats:p>The intracellular concentration of rifampicin (RIF) loaded into chitosan (CS)\/Tween 80 (T80)-coated alginate nanoparticles determined by a validated RP-HPLC method and fluorescence microscopy studies demonstrated that the nanoparticles promote the cellular internalization of RIF.<\/jats:p>","DOI":"10.1039\/d4ay00234b","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T06:00:47Z","timestamp":1709791247000},"page":"1908-1915","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Quantification of rifampicin loaded into inhaled polymeric nanoparticles by reversed phase high-performance liquid chromatography in pulmonary nonphagocytic cellular uptake"],"prefix":"10.1039","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0570-7053","authenticated-orcid":false,"given":"Ivana Romina","family":"Scolari","sequence":"first","affiliation":[{"name":"Unidad de Investigaci\u00f3n Y Desarrollo en Tecnolog\u00eda Farmac\u00e9utica (UNITEFA \u2013 CONICET), Departamento de Ciencias Farmac\u00e9uticas, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba, X5000HUA, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6800-6634","authenticated-orcid":false,"given":"Benjam\u00edn","family":"De La Cruz-Thea","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n M\u00e9dica Mercedes y Mart\u00edn Ferreyra, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Universidad Nacional de C\u00f3rdoba (INIMEC-CONICET-UNC), C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9159-5497","authenticated-orcid":false,"given":"Melina Mara","family":"Musri","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n M\u00e9dica Mercedes y Mart\u00edn Ferreyra, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas, Universidad Nacional de C\u00f3rdoba (INIMEC-CONICET-UNC), C\u00f3rdoba, Argentina"},{"name":"Facultad de Ciencias Exactas F\u00edsicas y Naturales, Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2142-1675","authenticated-orcid":false,"given":"Gladys Ester","family":"Granero","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Y Desarrollo en Tecnolog\u00eda Farmac\u00e9utica (UNITEFA \u2013 CONICET), Departamento de Ciencias Farmac\u00e9uticas, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba, X5000HUA, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2024]]},"reference":[{"key":"D4AY00234B\/cit1\/1","doi-asserted-by":"publisher","first-page":"1858","DOI":"10.1021\/acsinfecdis.3c00186","volume":"9","author":"Shi","year":"2023","journal-title":"ACS Infect. Dis."},{"key":"D4AY00234B\/cit2\/1","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.meegid.2019.103937","volume":"548","author":"Khadka","year":"2018","journal-title":"Int. J. Pharm."},{"issue":"1","key":"D4AY00234B\/cit3\/1","doi-asserted-by":"publisher","first-page":"e01948","DOI":"10.1128\/aac.01948-20","volume":"65","author":"Rifat","year":"2020","journal-title":"Antimicrob. Agents Chemother."},{"key":"D4AY00234B\/cit4\/1","doi-asserted-by":"publisher","first-page":"S7","DOI":"10.1016\/j.ijid.2021.02.107","volume":"113","author":"Chakaya","year":"2021","journal-title":"Int. J. Infect. Dis."},{"key":"D4AY00234B\/cit5\/1","volume-title":"Global Tuberculosis report 2022","year":"2022","unstructured":"Global Tuberculosis report 2022 ,  2022 ,  https:\/\/iris.who.int\/bitstream\/handle\/10665\/363752\/9789240061729-eng.pdf?sequence=1"},{"key":"D4AY00234B\/cit6\/1","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1038\/icb.2015.43","volume":"93","author":"Randall","year":"2015","journal-title":"Immunol. Cell Biol."},{"key":"D4AY00234B\/cit7\/1","doi-asserted-by":"publisher","first-page":"2671","DOI":"10.3390\/molecules26092671","volume":"26","author":"Terreni","year":"2021","journal-title":"Molecules"},{"key":"D4AY00234B\/cit8\/1","doi-asserted-by":"publisher","first-page":"8030","DOI":"10.1007\/s13346-022-01287-3","volume":"12","author":"Maghrebi","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D4AY00234B\/cit9\/1","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1208\/s12249-018-1278-7","volume":"20","author":"Scolari","year":"2019","journal-title":"AAPS PharmSciTech"},{"key":"D4AY00234B\/cit10\/1","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/s0882-4010(03)00089-5","volume":"35","author":"Garc\u00eda-P\u00e9rez","year":"2003","journal-title":"Microb. Pathog."},{"key":"D4AY00234B\/cit11\/1","doi-asserted-by":"publisher","first-page":"195","DOI":"10.3390\/pharmaceutics12020195","volume":"12","author":"Santove\u00f1a-Est\u00e9vez","year":"2020","journal-title":"Pharmaceutics"},{"key":"D4AY00234B\/cit12\/1","volume-title":"Validation Of Analytical Procedures Q2(R2)","author":"International Council For Harmonisation Of Technical Requirements For Pharmaceuticals For Human Use","year":"2022","unstructured":"International Council For Harmonisation Of Technical Requirements For Pharmaceuticals For Human Use ,  Validation Of Analytical Procedures Q2(R2) ,  2022 ,  https:\/\/database.ich.org\/sites\/default\/files\/ICH_Q2-R2_Document_Step2_Guideline_2022_0324.pdf"},{"key":"D4AY00234B\/cit13\/1","volume-title":"M10 Bioanalytical Method Validation And Study Sample Analysis Guidance for Industry","author":"Food and Drug Administration (FDA)","year":"2022","unstructured":"Food and Drug Administration (FDA) ,  M10 Bioanalytical Method Validation And Study Sample Analysis Guidance for Industry ,  2022 ,  https:\/\/www.fda.gov\/media\/162903\/download"},{"key":"D4AY00234B\/cit14\/1","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.trac.2015.12.006","volume":"77","author":"Raposo","year":"2016","journal-title":"TrAC, Trends Anal. Chem."},{"key":"D4AY00234B\/cit15\/1","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.talanta.2017.05.049","volume":"172","author":"Jurado","year":"2017","journal-title":"Talanta"},{"key":"D4AY00234B\/cit16\/1","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1007\/s13346-019-00705-3","volume":"10","author":"Scolari","year":"2020","journal-title":"Drug Delivery Transl. Res."},{"key":"D4AY00234B\/cit17\/1","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.jpba.2016.02.013","volume":"123","author":"Goutal","year":"2016","journal-title":"J. Pharm. Biomed. Anal."},{"key":"D4AY00234B\/cit18\/1","doi-asserted-by":"publisher","first-page":"2067","DOI":"10.3390\/molecules26072067","volume":"26","author":"Motiei","year":"2021","journal-title":"Molecules"},{"key":"D4AY00234B\/cit19\/1","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1007\/s10337-022-04160-0","volume":"85","author":"Kahsay","year":"2022","journal-title":"Chromatographia"},{"issue":"28","key":"D4AY00234B\/cit20\/1","doi-asserted-by":"publisher","first-page":"25101","DOI":"10.1021\/acsomega.3c01791","volume":"8","author":"Sharma","year":"2023","journal-title":"ACS Omega"}],"container-title":["Analytical Methods"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/AY\/D4AY00234B","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:25:13Z","timestamp":1782926713000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ay\/article\/16\/13\/1908-1915\/836852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":20,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2024,3,28]]}},"URL":"https:\/\/doi.org\/10.1039\/d4ay00234b","relation":{},"ISSN":["1759-9660","1759-9679"],"issn-type":[{"value":"1759-9660","type":"print"},{"value":"1759-9679","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}