{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T21:36:38Z","timestamp":1782855398781,"version":"3.54.5"},"reference-count":39,"publisher":"Royal Society of Chemistry (RSC)","issue":"5","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"am","delay-in-days":377,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Anal. Methods"],"abstract":"<jats:p>\n                    In this study, a new RP-HPLC method using two detectors was developed for the analysis of degradation and process impurities of ivabradine with the capability to separate diastereomeric\n                    <jats:italic>N<\/jats:italic>\n                    -oxides in pharmaceutical preparations.\n                  <\/jats:p>","DOI":"10.1039\/d4ay01986e","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T11:27:31Z","timestamp":1736767651000},"page":"1111-1124","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A new stability indicating HPLC method with QDa and PDA detectors for the determination of process and degradation impurities of ivabradine including separation of diastereomeric\n                    <i>N<\/i>\n                    -oxides"],"prefix":"10.1039","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7029-8004","authenticated-orcid":false,"given":"B\u00fc\u015fra","family":"G\u00fcl\u015fen","sequence":"first","affiliation":[{"name":"Istanbul University, Graduate School of Health Sciences, Istanbul, Turkey"},{"name":"Ali Raif \u0130la\u00e7 Sanayi, \u0130kitelli Organize Sanayi B\u00f6lgesi 10. Cadde No:3\/1A, Ba\u015fak\u015fehir, 34306, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6827-8362","authenticated-orcid":false,"given":"S\u0131d\u0131ka","family":"Ert\u00fcrk Toker","sequence":"additional","affiliation":[{"name":"Istanbul University, Faculty of Pharmacy, Department of Analytical Chemistry, 34116, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D4AY01986E\/cit1\/1","unstructured":"Drugbank Online ,  https:\/\/go.drugbank.com\/drugs\/DB09083 , (accessed May 2024)"},{"key":"D4AY01986E\/cit2\/1","first-page":"e449","volume":"171","author":"Gammone","year":"2020","journal-title":"Clin. Ter."},{"key":"D4AY01986E\/cit3\/1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1159\/000380812","volume":"131","author":"Bocchi","year":"2015","journal-title":"Cardiology"},{"key":"D4AY01986E\/cit4\/1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s12325-015-0185-5","volume":"32","author":"Bagriy","year":"2015","journal-title":"Adv. Ther."},{"key":"D4AY01986E\/cit5\/1","doi-asserted-by":"crossref","first-page":"105715","DOI":"10.1016\/j.yrtph.2024.105715","volume":"153","author":"Liu","year":"2024","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"D4AY01986E\/cit6\/1","volume-title":"Identification and Determination of Impurities in Drugs","author":"G\u00f6r\u00f6g","year":"2000","unstructured":"S.G\u00f6r\u00f6g ,  Identification and Determination of Impurities in Drugs ,  Elsevier ,  Amsterdam ,  2000"},{"key":"D4AY01986E\/cit7\/1","volume-title":"Impurities Evaluation of Pharmaceuticals","author":"Ahuja","year":"1998","unstructured":"S.Ahuja ,  Impurities Evaluation of Pharmaceuticals ,  Marcel Dekker ,  New York ,  1998"},{"key":"D4AY01986E\/cit8\/1","first-page":"1032","volume":"3","author":"Rezowanur Rahman","year":"2012","journal-title":"Res. J. Pharm., Biol. Chem. Sci."},{"key":"D4AY01986E\/cit9\/1","doi-asserted-by":"crossref","first-page":"228","DOI":"10.25004\/IJPSDR.2017.090505","volume":"9","author":"Rehman","year":"2017","journal-title":"Int. J. Pharm. Sci. Drug Res."},{"key":"D4AY01986E\/cit10\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/jrptps.JRPTPS_110_19","volume":"9","author":"Polker","year":"2020","journal-title":"J. Rep. Pharm. Sci."},{"key":"D4AY01986E\/cit11\/1","doi-asserted-by":"crossref","first-page":"446","DOI":"10.2174\/1573412913666161213105900","volume":"13","author":"Ranjha","year":"2017","journal-title":"Curr. Pharm. Anal."},{"key":"D4AY01986E\/cit12\/1","first-page":"358","volume":"8","author":"Gandhimathi","year":"2016","journal-title":"Pharm. Lett."},{"key":"D4AY01986E\/cit13\/1","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.52711\/0974-360X.2023.00535","volume":"16","author":"Reddy","year":"2023","journal-title":"Res. J. Pharm. Technol."},{"key":"D4AY01986E\/cit14\/1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1556\/1326.2019.00659","volume":"32","author":"Tomi\u0107","year":"2020","journal-title":"Acta Chromatogr."},{"key":"D4AY01986E\/cit15\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1556\/1326.2021.00885","volume":"34","author":"Tomi\u0107","year":"2022","journal-title":"Acta Chromatogr."},{"key":"D4AY01986E\/cit16\/1","doi-asserted-by":"crossref","first-page":"112851","DOI":"10.1016\/j.jpba.2019.112851","volume":"177","author":"Ferencz","year":"2020","journal-title":"J. Pharm. Biomed. Anal."},{"key":"D4AY01986E\/cit17\/1","doi-asserted-by":"crossref","first-page":"460407","DOI":"10.1016\/j.chroma.2019.460407","volume":"1608","author":"Casado","year":"2019","journal-title":"J. Chromatogr. A"},{"key":"D4AY01986E\/cit18\/1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3389\/fphar.2016.00117","volume":"7","author":"Pikul","year":"2016","journal-title":"Front. Pharmacol"},{"key":"D4AY01986E\/cit19\/1","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/jms.3533","volume":"50","author":"Patel","year":"2015","journal-title":"J. Mass Spectrom."},{"key":"D4AY01986E\/cit20\/1","first-page":"1992","volume":"39","author":"Jia","year":"2022","journal-title":"Chin. J. Mod. Appl. Pharm."},{"key":"D4AY01986E\/cit21\/1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1080\/22297928.2017.11952555","volume":"7","author":"Mostafa","year":"2017","journal-title":"Anal. Chem. Lett."},{"key":"D4AY01986E\/cit22\/1","first-page":"53","volume":"5","author":"Maheshwari","year":"2010","journal-title":"Eurasian J. Anal. Chem."},{"key":"D4AY01986E\/cit23\/1","first-page":"141","volume":"6","author":"Damle","year":"2015","journal-title":"Pharma Sci. Monit."},{"key":"D4AY01986E\/cit24\/1","first-page":"378","volume":"6","author":"Kumar","year":"2014","journal-title":"Int. J. Pharmacol. Pharm. Sci."},{"key":"D4AY01986E\/cit25\/1","first-page":"706","volume":"8","author":"Gangrade","year":"2017","journal-title":"Int. J. Pharma Sci. Res."},{"key":"D4AY01986E\/cit26\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/2069571","volume":"2017","author":"Nowakowska","year":"2017","journal-title":"J. Chem."},{"key":"D4AY01986E\/cit27\/1","doi-asserted-by":"crossref","first-page":"105730","DOI":"10.1016\/j.yrtph.2024.105730","volume":"154","author":"Li","year":"2024","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"D4AY01986E\/cit28\/1","doi-asserted-by":"crossref","first-page":"4303","DOI":"10.1021\/acs.oprd.4c00328","volume":"28","author":"Reddy","year":"2024","journal-title":"Org. Process Res. Dev."},{"key":"D4AY01986E\/cit29\/1","unstructured":"International Council For Harmonisation ,  https:\/\/database.ich.org\/sites\/default\/files\/ICH_Q2%28R2%29_Guideline_2023_1130.pdf , (accessed December 2023)"},{"key":"D4AY01986E\/cit30\/1","unstructured":"Food and Drug Administration ,  https:\/\/www.fda.gov\/media\/152208\/download , (accessed December 2023)"},{"key":"D4AY01986E\/cit31\/1","unstructured":"International Council For Harmonisation ,  https:\/\/database.ich.org\/sites\/default\/files\/Q3B%28R2%29Guideline.pdf , (accessed December 2023)"},{"key":"D4AY01986E\/cit32\/1","unstructured":"National Library of Medicine ,  https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Ivabradine#section=Computed-Properties , (accessed September 2024)"},{"key":"D4AY01986E\/cit33\/1","doi-asserted-by":"crossref","first-page":"132033","DOI":"10.1016\/j.molstruc.2021.132033","volume":"1251","author":"Brandes","year":"2022","journal-title":"J. Mol. Struct."},{"key":"D4AY01986E\/cit34\/1","first-page":"162","volume":"4","author":"Patel","year":"2017","journal-title":"Pharm. Biol. Eval."},{"key":"D4AY01986E\/cit35\/1","doi-asserted-by":"crossref","first-page":"192","DOI":"10.22159\/ijap.2021v13i4.41931","volume":"13","author":"Mohanty","year":"2021","journal-title":"Int. J. Appl. Pharm."},{"key":"D4AY01986E\/cit36\/1","first-page":"457","volume":"1","author":"Swapna","year":"2015","journal-title":"Int. J. Trends Pharm. Life Sci."},{"key":"D4AY01986E\/cit37\/1","first-page":"3072","volume":"8","author":"Sunitha","year":"2019","journal-title":"Int. J. Res."},{"key":"D4AY01986E\/cit38\/1","doi-asserted-by":"crossref","first-page":"216","DOI":"10.22159\/ijap.2019v11i3.31953","volume":"11","author":"Kumar","year":"2019","journal-title":"Int. J. Appl. Pharm."},{"key":"D4AY01986E\/cit39\/1","doi-asserted-by":"crossref","first-page":"e02420","DOI":"10.1016\/j.heliyon.2019.e02420","volume":"5","author":"Kumar","year":"2019","journal-title":"Heliyon"}],"container-title":["Analytical Methods"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/AY\/D4AY01986E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:32:04Z","timestamp":1782851524000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/ay\/article\/17\/5\/1111-1124\/837509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,1,30]]}},"URL":"https:\/\/doi.org\/10.1039\/d4ay01986e","relation":{},"ISSN":["1759-9660","1759-9679"],"issn-type":[{"value":"1759-9660","type":"print"},{"value":"1759-9679","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}