{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:40:02Z","timestamp":1790278802390,"version":"4.1.0"},"reference-count":42,"publisher":"Royal Society of Chemistry (RSC)","issue":"21","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"am","delay-in-days":618,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22174031"],"award-info":[{"award-number":["22174031"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22374033"],"award-info":[{"award-number":["22374033"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["ZD2022B001"],"award-info":[{"award-number":["ZD2022B001"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Biomater. Sci."],"abstract":"<jats:p>Compared to PEG-iLNPs, PS80-iLNPs showed a 1.14-fold increase in stealthiness, 1.12 times higher cell viability and superior protein adsorption resistance.<\/jats:p>","DOI":"10.1039\/d4bm00523f","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T02:20:57Z","timestamp":1725934857000},"page":"5573-5581","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Polysorbate 80-containing ionizable lipid nanoparticles for mRNA delivery"],"prefix":"10.1039","volume":"12","author":[{"given":"Xuefeng","family":"Tang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Urban Water Resource and Environment, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shixiao","family":"Ding","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Urban Water Resource and Environment, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4350-5870","authenticated-orcid":false,"given":"Shilin","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Urban Water Resource and Environment, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqiao","family":"Cheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Urban Water Resource and Environment, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanyu","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Urban Water Resource and Environment, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Urban Water Resource and Environment, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8571-6187","authenticated-orcid":false,"given":"Xiaojun","family":"Han","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Urban Water Resource and Environment, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2024]]},"reference":[{"key":"D4BM00523F\/cit1\/1","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1056\/NEJMoa2034577","volume":"383","author":"Polack","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"D4BM00523F\/cit2\/1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1056\/NEJMoa2035389","volume":"384","author":"Baden","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"D4BM00523F\/cit3\/1","doi-asserted-by":"crossref","first-page":"3090","DOI":"10.1038\/s41467-021-23318-2","volume":"12","author":"Cao","year":"2021","journal-title":"Nat. Commun."},{"key":"D4BM00523F\/cit4\/1","doi-asserted-by":"crossref","first-page":"5339","DOI":"10.1038\/s41467-020-19156-3","volume":"11","author":"Jiang","year":"2020","journal-title":"Nat. Commun."},{"key":"D4BM00523F\/cit5\/1","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1056\/NEJMoa2107454","volume":"385","author":"Gillmore","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"D4BM00523F\/cit6\/1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/s41586-021-03534-y","volume":"593","author":"Musunuru","year":"2021","journal-title":"Nature"},{"key":"D4BM00523F\/cit7\/1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nature03121","volume":"432","author":"Soutschek","year":"2004","journal-title":"Nature"},{"key":"D4BM00523F\/cit8\/1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.it.2015.02.001","volume":"36","author":"Rigby","year":"2015","journal-title":"Trends Immunol."},{"key":"D4BM00523F\/cit9\/1","doi-asserted-by":"crossref","first-page":"10384","DOI":"10.1039\/D0TB01821J","volume":"8","author":"Li","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"D4BM00523F\/cit10\/1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3109\/02652048.2016.1156176","volume":"33","author":"Zong","year":"2016","journal-title":"J. Microencapsulation"},{"key":"D4BM00523F\/cit11\/1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41392-021-00799-7","volume":"3","author":"Zhong","year":"2021","journal-title":"Signal Transduction Targeted Ther."},{"key":"D4BM00523F\/cit12\/1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s13534-021-00199-4","volume":"11","author":"Sioson","year":"2021","journal-title":"Biomed. Eng. Lett."},{"key":"D4BM00523F\/cit13\/1","doi-asserted-by":"crossref","first-page":"8078","DOI":"10.1039\/C8TB01891J","volume":"6","author":"Cui","year":"2018","journal-title":"J. Mater. Chem. B"},{"key":"D4BM00523F\/cit14\/1","doi-asserted-by":"crossref","first-page":"123961","DOI":"10.1016\/j.cej.2019.123961","volume":"386","author":"Yang","year":"2020","journal-title":"Chem. Eng. J."},{"key":"D4BM00523F\/cit15\/1","doi-asserted-by":"crossref","first-page":"4283","DOI":"10.1021\/acs.accounts.1c00550","volume":"54","author":"Wang","year":"2021","journal-title":"Acc. Chem. Res."},{"key":"D4BM00523F\/cit16\/1","doi-asserted-by":"crossref","first-page":"135116","DOI":"10.1016\/j.cej.2022.135116","volume":"435","author":"Tang","year":"2022","journal-title":"Chem. Eng. J."},{"key":"D4BM00523F\/cit17\/1","doi-asserted-by":"crossref","first-page":"7233","DOI":"10.1038\/s41467-021-27493-0","volume":"12","author":"Han","year":"2021","journal-title":"Nat. Commun."},{"key":"D4BM00523F\/cit18\/1","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/s41467-020-14527-2","volume":"11","author":"Patel","year":"2020","journal-title":"Nat. Commun."},{"key":"D4BM00523F\/cit19\/1","doi-asserted-by":"crossref","first-page":"4289","DOI":"10.1039\/D0BM01947J","volume":"9","author":"Herrera","year":"2021","journal-title":"Biomater. Sci."},{"key":"D4BM00523F\/cit20\/1","doi-asserted-by":"crossref","first-page":"e2020401118","DOI":"10.1073\/pnas.2020401118","volume":"118","author":"Qiu","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D4BM00523F\/cit21\/1","doi-asserted-by":"crossref","first-page":"589959","DOI":"10.3389\/fchem.2020.589959","volume":"8","author":"Guevara","year":"2020","journal-title":"Front. Chem."},{"key":"D4BM00523F\/cit22\/1","doi-asserted-by":"crossref","first-page":"E3351","DOI":"10.1073\/pnas.1720542115","volume":"115","author":"Yanez Arteta","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D4BM00523F\/cit23\/1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jconrel.2018.10.015","volume":"291","author":"Parhiz","year":"2018","journal-title":"J. Controlled Release"},{"key":"D4BM00523F\/cit24\/1","doi-asserted-by":"crossref","first-page":"e202300515","DOI":"10.1002\/asia.202300515","volume":"18","author":"Salehirozveh","year":"2023","journal-title":"Chem. \u2013 Asian J."},{"key":"D4BM00523F\/cit25\/1","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1001\/jama.2021.1967","volume":"325","author":"Shimabukuro","year":"2021","journal-title":"J. Am. Med. Assoc."},{"key":"D4BM00523F\/cit26\/1","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1007\/s40264-021-01104-9","volume":"44","author":"Iguchi","year":"2021","journal-title":"Drug Saf."},{"key":"D4BM00523F\/cit27\/1","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1056\/NEJMra2035343","volume":"384","author":"Castells","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"D4BM00523F\/cit28\/1","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.alit.2022.05.007","volume":"71","author":"Mouri","year":"2022","journal-title":"Allergol. Int."},{"key":"D4BM00523F\/cit29\/1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.addr.2020.07.024","volume":"154\u2013155","author":"Kozma","year":"2020","journal-title":"Adv. Drug Delivery Rev."},{"key":"D4BM00523F\/cit30\/1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jconrel.2018.08.022","volume":"287","author":"Grenier","year":"2018","journal-title":"J. Controlled Release"},{"key":"D4BM00523F\/cit31\/1","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1080\/14686996.2019.1627174","volume":"20","author":"Mohamed","year":"2019","journal-title":"Sci. Technol. Adv. Mater."},{"key":"D4BM00523F\/cit32\/1","doi-asserted-by":"crossref","first-page":"115175","DOI":"10.1016\/j.addr.2023.115175","volume":"205","author":"Sharma","year":"2024","journal-title":"Adv. Drug Delivery Rev."},{"key":"D4BM00523F\/cit33\/1","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1517\/17425247.2012.720969","volume":"9","author":"Garay","year":"2012","journal-title":"Expert Opin. Drug Delivery"},{"key":"D4BM00523F\/cit34\/1","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.3390\/nano11061484","volume":"11","author":"Korolev","year":"2021","journal-title":"Nanomaterials"},{"key":"D4BM00523F\/cit35\/1","doi-asserted-by":"crossref","first-page":"121496","DOI":"10.1016\/j.ijpharm.2022.121496","volume":"615","author":"Bensaid","year":"2022","journal-title":"Int. J. Pharm."},{"key":"D4BM00523F\/cit36\/1","doi-asserted-by":"crossref","first-page":"119285","DOI":"10.1016\/j.ijpharm.2020.119285","volume":"581","author":"Brovc","year":"2020","journal-title":"Int. J. Pharm."},{"key":"D4BM00523F\/cit37\/1","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1002\/jps.21190","volume":"97","author":"Kerwin","year":"2008","journal-title":"J. Pharm. Sci."},{"key":"D4BM00523F\/cit38\/1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/cea.14064","volume":"52","author":"Sellaturay","year":"2022","journal-title":"Clin. Exp. Allergy"},{"key":"D4BM00523F\/cit39\/1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3390\/vaccines9010065","volume":"9","author":"Buschmann","year":"2021","journal-title":"Vaccines"},{"key":"D4BM00523F\/cit40\/1","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.1073\/pnas.1418494112","volume":"112","author":"Wei","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D4BM00523F\/cit41\/1","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41563-020-00886-0","volume":"20","author":"Liu","year":"2021","journal-title":"Nat. Mater."},{"key":"D4BM00523F\/cit42\/1","doi-asserted-by":"crossref","first-page":"e1805308","DOI":"10.1002\/adma.201805308","volume":"30","author":"Cheng","year":"2018","journal-title":"Adv. Mater."}],"container-title":["Biomaterials Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/BM\/D4BM00523F","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:12:40Z","timestamp":1782929560000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/bm\/article\/12\/21\/5573-5581\/837908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":42,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2024,10,22]]}},"URL":"https:\/\/doi.org\/10.1039\/d4bm00523f","relation":{},"ISSN":["2047-4830","2047-4849"],"issn-type":[{"value":"2047-4830","type":"print"},{"value":"2047-4849","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}