{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T20:07:37Z","timestamp":1783454857739,"version":"3.55.0"},"reference-count":61,"publisher":"Royal Society of Chemistry (RSC)","issue":"16","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"am","delay-in-days":546,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"publisher","award":["21ZR1423200"],"award-info":[{"award-number":["21ZR1423200"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020732","name":"Innovative Research Team of High-level Local University in Shanghai","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Biomater. Sci."],"abstract":"<jats:p>A low-dose X-ray-triggered X-PDT system was prepared, which involves GSH consumption, self-supplied NO, mitochondrial damage alleviation, and hypoxia relief to generate ROS and RNS with synergistically enhanced anti-tumor effects.<\/jats:p>","DOI":"10.1039\/d4bm00593g","type":"journal-article","created":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T22:21:05Z","timestamp":1719699665000},"page":"4211-4225","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Low-dose X-ray stimulated NO-releasing nanocomposites for closed-loop dual-mode cancer therapy"],"prefix":"10.1039","volume":"12","author":[{"given":"Xiaoli","family":"Tang","sequence":"first","affiliation":[{"name":"School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[{"name":"School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longhao","family":"Lv","sequence":"additional","affiliation":[{"name":"School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1688-5969","authenticated-orcid":false,"given":"Jinliang","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2024]]},"reference":[{"key":"D4BM00593G\/cit1\/1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/nrclinonc.2015.120","volume":"12","author":"Schaue","year":"2015","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"D4BM00593G\/cit2\/1","doi-asserted-by":"crossref","first-page":"5233","DOI":"10.1021\/acsnano.7b03675","volume":"11","author":"Goel","year":"2017","journal-title":"ACS Nano"},{"key":"D4BM00593G\/cit3\/1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.tips.2017.11.003","volume":"39","author":"Wang","year":"2018","journal-title":"Trends Pharmacol. Sci."},{"key":"D4BM00593G\/cit4\/1","doi-asserted-by":"crossref","first-page":"15654","DOI":"10.1021\/acsnano.0c06541","volume":"14","author":"Xia","year":"2020","journal-title":"ACS Nano"},{"key":"D4BM00593G\/cit5\/1","doi-asserted-by":"crossref","first-page":"1909285","DOI":"10.1002\/adfm.201909285","volume":"30","author":"Fan","year":"2020","journal-title":"Adv. Funct. Mater."},{"key":"D4BM00593G\/cit6\/1","first-page":"2305744","volume":"62","author":"Ge","year":"2023","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4BM00593G\/cit7\/1","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.canlet.2012.09.012","volume":"334","author":"Lim","year":"2013","journal-title":"Cancer Lett."},{"key":"D4BM00593G\/cit8\/1","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.biopha.2018.07.049","volume":"106","author":"Kwiatkowski","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"D4BM00593G\/cit9\/1","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.3390\/pharmaceutics13091332","volume":"13","author":"Correia","year":"2021","journal-title":"Pharmaceutics"},{"key":"D4BM00593G\/cit10\/1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.canlet.2012.07.026","volume":"326","author":"Anand","year":"2012","journal-title":"Cancer Lett."},{"key":"D4BM00593G\/cit11\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jphotobiol.2009.04.001","volume":"96","author":"Robertson","year":"2009","journal-title":"J. Photochem. Photobiol., B"},{"key":"D4BM00593G\/cit12\/1","doi-asserted-by":"crossref","first-page":"3626","DOI":"10.3390\/app11083626","volume":"11","author":"Niculescu","year":"2021","journal-title":"Appl. Sci."},{"key":"D4BM00593G\/cit13\/1","doi-asserted-by":"crossref","first-page":"5007","DOI":"10.1088\/0031-9155\/58\/14\/5007","volume":"58","author":"Jacques","year":"2013","journal-title":"Phys. Med. Biol."},{"key":"D4BM00593G\/cit14\/1","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3389\/fbioe.2019.00487","volume":"7","author":"Cao","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"D4BM00593G\/cit15\/1","doi-asserted-by":"crossref","first-page":"20200122","DOI":"10.1002\/VIW.20200122","volume":"2","author":"Jiang","year":"2021","journal-title":"VIEW"},{"key":"D4BM00593G\/cit16\/1","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1021\/nl504044p","volume":"15","author":"Chen","year":"2015","journal-title":"Nano Lett."},{"key":"D4BM00593G\/cit17\/1","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/j.drudis.2018.05.029","volume":"23","author":"Ren","year":"2018","journal-title":"Drug Discovery Today"},{"key":"D4BM00593G\/cit18\/1","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.1021\/acsnano.6b01401","volume":"10","author":"Kamkaew","year":"2016","journal-title":"ACS Nano"},{"key":"D4BM00593G\/cit19\/1","doi-asserted-by":"crossref","first-page":"14851","DOI":"10.1021\/jacs.8b08658","volume":"140","author":"Li","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"D4BM00593G\/cit20\/1","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.7150\/thno.52997","volume":"11","author":"Xiang","year":"2021","journal-title":"Theranostics"},{"key":"D4BM00593G\/cit21\/1","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/j.apsb.2020.01.004","volume":"10","author":"Sun","year":"2020","journal-title":"Acta Pharm. Sin. B"},{"key":"D4BM00593G\/cit22\/1","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.3390\/ijms20051148","volume":"20","author":"Yang","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"D4BM00593G\/cit23\/1","doi-asserted-by":"crossref","first-page":"3644","DOI":"10.1021\/acsbiomaterials.2c00287","volume":"8","author":"Viswanath","year":"2022","journal-title":"ACS Biomater. Sci. Eng."},{"key":"D4BM00593G\/cit24\/1","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.7150\/thno.41578","volume":"10","author":"Sun","year":"2020","journal-title":"Theranostics"},{"key":"D4BM00593G\/cit25\/1","first-page":"55","volume":"4","author":"Cai","year":"2023","journal-title":"Eng. Regener."},{"key":"D4BM00593G\/cit26\/1","doi-asserted-by":"crossref","first-page":"6488","DOI":"10.1039\/C6CS00616G","volume":"45","author":"Fan","year":"2016","journal-title":"Chem. Soc. Rev."},{"key":"D4BM00593G\/cit27\/1","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.actbio.2020.06.044","volume":"113","author":"Liu","year":"2020","journal-title":"Acta Biomater."},{"key":"D4BM00593G\/cit28\/1","doi-asserted-by":"crossref","first-page":"105437","DOI":"10.1016\/j.nanoen.2020.105437","volume":"79","author":"Lu","year":"2021","journal-title":"Nano Energy"},{"key":"D4BM00593G\/cit29\/1","doi-asserted-by":"crossref","first-page":"119862","DOI":"10.1016\/j.jlumin.2023.119862","volume":"261","author":"Zhang","year":"2023","journal-title":"J. Lumin."},{"key":"D4BM00593G\/cit30\/1","doi-asserted-by":"crossref","first-page":"1901812","DOI":"10.1002\/adhm.201901812","volume":"9","author":"Park","year":"2020","journal-title":"Adv. Healthcare Mater."},{"key":"D4BM00593G\/cit31\/1","doi-asserted-by":"crossref","first-page":"110875","DOI":"10.1016\/j.apradiso.2023.110875","volume":"198","author":"Bradley","year":"2023","journal-title":"Appl. Radiat. Isot."},{"key":"D4BM00593G\/cit32\/1","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/s41586-021-03251-6","volume":"590","author":"Ou","year":"2021","journal-title":"Nature"},{"key":"D4BM00593G\/cit33\/1","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1021\/acs.bioconjchem.9b00429","volume":"30","author":"Zhang","year":"2019","journal-title":"Bioconjugate Chem."},{"key":"D4BM00593G\/cit34\/1","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1021\/cr000040l","volume":"102","author":"Peng George Wang","year":"2002","journal-title":"Chem. Rev."},{"key":"D4BM00593G\/cit35\/1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.biomaterials.2018.03.023","volume":"167","author":"Vong","year":"2018","journal-title":"Biomaterials"},{"key":"D4BM00593G\/cit36\/1","doi-asserted-by":"crossref","first-page":"2103003","DOI":"10.1002\/smll.202103003","volume":"17","author":"Zhao","year":"2021","journal-title":"Small"},{"key":"D4BM00593G\/cit37\/1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.ccell.2016.09.009","volume":"30","author":"Marigo","year":"2016","journal-title":"Cancer Cell"},{"key":"D4BM00593G\/cit38\/1","doi-asserted-by":"crossref","first-page":"215052","DOI":"10.1016\/j.ccr.2023.215052","volume":"481","author":"Navale","year":"2023","journal-title":"Coord. Chem. Rev."},{"key":"D4BM00593G\/cit39\/1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1177\/1099800402004001002","volume":"4","author":"David","year":"2002","journal-title":"Biol. Res. Nurs."},{"key":"D4BM00593G\/cit40\/1","doi-asserted-by":"crossref","first-page":"109741","DOI":"10.1016\/j.msec.2019.109741","volume":"103","author":"Hasan","year":"2019","journal-title":"Mater. Sci. Eng., C"},{"key":"D4BM00593G\/cit41\/1","doi-asserted-by":"crossref","first-page":"8587","DOI":"10.7150\/thno.62572","volume":"11","author":"Ji","year":"2021","journal-title":"Theranostics"},{"key":"D4BM00593G\/cit42\/1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1039\/C9NH00564A","volume":"5","author":"Jiang","year":"2020","journal-title":"Nanoscale Horiz."},{"key":"D4BM00593G\/cit43\/1","doi-asserted-by":"crossref","first-page":"2206554","DOI":"10.1002\/adfm.202206554","volume":"32","author":"Wang","year":"2022","journal-title":"Adv. Funct. Mater."},{"key":"D4BM00593G\/cit44\/1","doi-asserted-by":"crossref","first-page":"3637","DOI":"10.1039\/C7NR00231A","volume":"9","author":"Jin","year":"2017","journal-title":"Nanoscale"},{"key":"D4BM00593G\/cit45\/1","doi-asserted-by":"crossref","first-page":"2206423","DOI":"10.1002\/smll.202206423","volume":"19","author":"Chang","year":"2022","journal-title":"Small"},{"key":"D4BM00593G\/cit46\/1","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.freeradbiomed.2014.11.012","volume":"79","author":"Chang","year":"2015","journal-title":"Free Radicals Biol. Med."},{"key":"D4BM00593G\/cit47\/1","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1021\/acs.nanolett.9b01093","volume":"19","author":"Hu","year":"2019","journal-title":"Nano Lett."},{"key":"D4BM00593G\/cit48\/1","doi-asserted-by":"crossref","first-page":"128049","DOI":"10.1016\/j.cej.2020.128049","volume":"417","author":"Sun","year":"2021","journal-title":"Chem. Eng. J."},{"key":"D4BM00593G\/cit49\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/SMMD.20230035","volume":"3","author":"Rajora","year":"2024","journal-title":"Smart Med."},{"key":"D4BM00593G\/cit50\/1","doi-asserted-by":"crossref","first-page":"27551","DOI":"10.1021\/acsami.2c02949","volume":"14","author":"Zhang","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D4BM00593G\/cit51\/1","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1007\/s11426-021-1045-9","volume":"64","author":"Wu","year":"2021","journal-title":"Sci. China: Chem."},{"key":"D4BM00593G\/cit52\/1","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1021\/acs.bioconjchem.3c00250","volume":"34","author":"Zhang","year":"2023","journal-title":"Bioconjugate Chem."},{"key":"D4BM00593G\/cit53\/1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.biomaterials.2018.03.046","volume":"168","author":"Hu","year":"2018","journal-title":"Biomaterials"},{"key":"D4BM00593G\/cit54\/1","doi-asserted-by":"crossref","first-page":"13094","DOI":"10.1021\/acsami.2c01138","volume":"14","author":"Wu","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D4BM00593G\/cit55\/1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.bmt.2022.11.012","volume":"2","author":"Yang","year":"2023","journal-title":"Biomed. Technol."},{"key":"D4BM00593G\/cit56\/1","first-page":"1","volume":"2","author":"Huang","year":"2023","journal-title":"Smart Med."},{"key":"D4BM00593G\/cit57\/1","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/s41565-019-0395-0","volume":"14","author":"Prigozhin","year":"2019","journal-title":"Nat. Nanotechnol."},{"key":"D4BM00593G\/cit58\/1","doi-asserted-by":"crossref","first-page":"2302395","DOI":"10.1002\/advs.202302395","volume":"10","author":"Yu","year":"2023","journal-title":"Adv. Sci."},{"key":"D4BM00593G\/cit59\/1","doi-asserted-by":"crossref","first-page":"4228","DOI":"10.1021\/acsnano.1c10231","volume":"16","author":"Huang","year":"2022","journal-title":"ACS Nano"},{"key":"D4BM00593G\/cit60\/1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.bmt.2023.09.003","volume":"6","author":"Li","year":"2024","journal-title":"Biomed. Technol."},{"key":"D4BM00593G\/cit61\/1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s12195-018-00557-w","volume":"12","author":"Wang","year":"2019","journal-title":"Cell. Mol. Bioeng."}],"container-title":["Biomaterials Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/BM\/D4BM00593G","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:50:06Z","timestamp":1783450206000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/bm\/article\/12\/16\/4211-4225\/837924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":61,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2024,8,6]]}},"URL":"https:\/\/doi.org\/10.1039\/d4bm00593g","relation":{},"ISSN":["2047-4830","2047-4849"],"issn-type":[{"value":"2047-4830","type":"print"},{"value":"2047-4849","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}