{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T09:13:10Z","timestamp":1783588390827,"version":"3.55.0"},"reference-count":70,"publisher":"Royal Society of Chemistry (RSC)","issue":"13","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"am","delay-in-days":503,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Biomater. Sci."],"abstract":"<jats:p>KAPs-depleted residual hair biomaterial incites a thin fibrous capsule with minimal immune cells in subcutaneous implantation and promotes faster wound-healing with increased vascularization in a full-thickness skin excision.<\/jats:p>","DOI":"10.1039\/d4bm00777h","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T09:19:37Z","timestamp":1747646377000},"page":"3633-3649","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Biocompatibility and wound-healing prospect of KAPs-depleted residual hair biomaterial"],"prefix":"10.1039","volume":"13","author":[{"given":"Allison","family":"Meer","sequence":"first","affiliation":[{"name":"Bioengineering Program, Department of Engineering, Hofstra University, Hempstead, NY 11549, USA."},{"name":"Department of Biology, Hofstra University, Hempstead, NY 11549, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aidan","family":"Mathews","sequence":"additional","affiliation":[{"name":"Bioengineering Program, Department of Engineering, Hofstra University, Hempstead, NY 11549, USA."},{"name":"Department of Biology, Hofstra University, Hempstead, NY 11549, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6596-4410","authenticated-orcid":false,"given":"Mariana","family":"Cabral","sequence":"additional","affiliation":[{"name":"Bioengineering Program, Department of Engineering, Hofstra University, Hempstead, NY 11549, USA."},{"name":"Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Tarabokija","sequence":"additional","affiliation":[{"name":"Bioengineering Program, Department of Engineering, Hofstra University, Hempstead, NY 11549, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6069-039X","authenticated-orcid":false,"given":"Evan","family":"Carroll","sequence":"additional","affiliation":[{"name":"Bioengineering Program, Department of Engineering, Hofstra University, Hempstead, NY 11549, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henna","family":"Chaudhry","sequence":"additional","affiliation":[{"name":"Bioengineering Program, Department of Engineering, Hofstra University, Hempstead, NY 11549, USA."},{"name":"Department of Chemistry, Hofstra University, Hempstead, NY 11549, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Paszek","sequence":"additional","affiliation":[{"name":"Bioengineering Program, Department of Engineering, Hofstra University, Hempstead, NY 11549, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Radecker","sequence":"additional","affiliation":[{"name":"Department of Biology, Hofstra University, Hempstead, NY 11549, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Palaia","sequence":"additional","affiliation":[{"name":"Department of Foundations of Medicine, New York University School of Medicine, Mineola, NY 11501, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hazel Consunji","family":"de Guzman","sequence":"additional","affiliation":[{"name":"Department of Foundations of Medicine, New York University School of Medicine, Mineola, NY 11501, USA"},{"name":"Hair Life Regeneration LLC, Copiague, NY 11726, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6051-4765","authenticated-orcid":false,"given":"Roche C.","family":"de Guzman","sequence":"additional","affiliation":[{"name":"Bioengineering Program, Department of Engineering, Hofstra University, Hempstead, NY 11549, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D4BM00777H\/cit1\/1","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-25611-0","volume-title":"Chemical and physical behavior of human hair","author":"Robbins","year":"2012","unstructured":"C. R.Robbins ,  Chemical and physical behavior of human hair ,  Springer ,  Heidelberg , 5th edn,  2012"},{"key":"D4BM00777H\/cit2\/1","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.ijbiomac.2017.03.052","volume":"101","author":"Cruz","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"D4BM00777H\/cit3\/1","doi-asserted-by":"crossref","DOI":"10.1007\/978-981-10-8195-8","volume-title":"The hair fibre : proteins, structure and development","author":"Plowman","year":"2018","unstructured":"J.Plowman ,  The hair fibre : proteins, structure and development ,  Springer Berlin Heidelberg ,  New York, NY ,  2018"},{"key":"D4BM00777H\/cit4\/1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.jsb.2014.01.010","volume":"185","author":"Harland","year":"2014","journal-title":"J. Struct. Biol."},{"key":"D4BM00777H\/cit5\/1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.matt.2019.09.019","volume":"2","author":"Yang","year":"2020","journal-title":"Matter"},{"key":"D4BM00777H\/cit6\/1","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s11837-012-0302-8","volume":"64","author":"McKittrick","year":"2012","journal-title":"JOM"},{"key":"D4BM00777H\/cit7\/1","doi-asserted-by":"crossref","first-page":"8205","DOI":"10.1016\/j.biomaterials.2011.07.054","volume":"32","author":"de Guzman","year":"2011","journal-title":"Biomaterials"},{"key":"D4BM00777H\/cit8\/1","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/j.biomaterials.2012.11.002","volume":"34","author":"de Guzman","year":"2013","journal-title":"Biomaterials"},{"key":"D4BM00777H\/cit9\/1","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1039\/C7BM00411G","volume":"5","author":"Shavandi","year":"2017","journal-title":"Biomater. Sci."},{"key":"D4BM00777H\/cit10\/1","first-page":"496","volume":"5","author":"Feroz","year":"2020","journal-title":"Bioact. Mater."},{"key":"D4BM00777H\/cit11\/1","doi-asserted-by":"crossref","first-page":"612","DOI":"10.2174\/1389450111314050010","volume":"14","author":"Vasconcelos","year":"2013","journal-title":"Curr. Drug Targets"},{"key":"D4BM00777H\/cit12\/1","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1089\/ten.tec.2021.022333","volume":"28","author":"Vitus","year":"2022","journal-title":"Tissue Eng., Part C"},{"key":"D4BM00777H\/cit13\/1","doi-asserted-by":"crossref","first-page":"e020319","DOI":"10.1136\/bmjopen-2017-020319","volume":"8","author":"Jull","year":"2018","journal-title":"BMJ Open"},{"key":"D4BM00777H\/cit14\/1","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/ans.12520","volume":"85","author":"Jina","year":"2015","journal-title":"ANZ J. Surg."},{"key":"D4BM00777H\/cit15\/1","unstructured":"Evaluating The Efficacy Of A Keratin Graft In Treating Non-Healing Diabetic Foot Ulcers ClinicalTrials.gov: ID NCT05797285 Sponsor: ProgenaCare Global, LLC Information provided by: ProgenaCare Global, LLC (Responsible Party) Last Update Posted: 2024-02-23,  https:\/\/clinicaltrials.gov\/study\/NCT05797285"},{"key":"D4BM00777H\/cit16\/1","doi-asserted-by":"publisher","DOI":"10.1177\/15330338231222137","volume":"23","author":"Winkfield","year":"2024","journal-title":"Technol. Cancer Res. Treat."},{"key":"D4BM00777H\/cit17\/1","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.3390\/pharmaceutics13122029","volume":"13","author":"Konop","year":"2021","journal-title":"Pharmaceutics"},{"key":"D4BM00777H\/cit18\/1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/wrr.13137","volume":"32","author":"Ramey-Ward","year":"2024","journal-title":"Wound Repair Regen."},{"key":"D4BM00777H\/cit19\/1","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1038\/s41598-018-20041-9","volume":"8","author":"Adav","year":"2018","journal-title":"Sci. Rep."},{"key":"D4BM00777H\/cit20\/1","doi-asserted-by":"crossref","first-page":"rbae123","DOI":"10.1093\/rb\/rbae123","volume":"11","author":"Philips","year":"2024","journal-title":"Regener. Biomater."},{"key":"D4BM00777H\/cit21\/1","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1016\/j.dental.2022.11.018","volume":"38","author":"Nedeljkovic","year":"2022","journal-title":"Dent. Mater."},{"key":"D4BM00777H\/cit22\/1","doi-asserted-by":"crossref","first-page":"4916464","DOI":"10.1155\/2022\/4916464","volume":"2022","author":"Bajantri","year":"2022","journal-title":"Int. J. Dent."},{"key":"D4BM00777H\/cit23\/1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jim.2007.11.012","volume":"332","author":"Harrell","year":"2008","journal-title":"J. Immunol. Methods"},{"key":"D4BM00777H\/cit24\/1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/exd.13549","volume":"27","author":"Nicu","year":"2018","journal-title":"Exp. Dermatol."},{"key":"D4BM00777H\/cit25\/1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/exd.12450","volume":"23","author":"Driskell","year":"2014","journal-title":"Exp. Dermatol."},{"key":"D4BM00777H\/cit26\/1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/joa.12840","volume":"233","author":"Naldaiz-Gastesi","year":"2018","journal-title":"J. Anat."},{"key":"D4BM00777H\/cit28\/1","doi-asserted-by":"crossref","first-page":"3772","DOI":"10.2174\/138161211798357854","volume":"17","author":"Kennelly","year":"2011","journal-title":"Curr. Pharm. Des."},{"key":"D4BM00777H\/cit29\/1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/rb\/rbw041","volume":"4","author":"Selders","year":"2017","journal-title":"Regener. Biomater."},{"key":"D4BM00777H\/cit30\/1","doi-asserted-by":"crossref","first-page":"eadd0014","DOI":"10.1126\/sciadv.add0014","volume":"8","author":"Parlani","year":"2022","journal-title":"Sci. Adv."},{"key":"D4BM00777H\/cit31\/1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0738-081X(84)90032-4","volume":"2","author":"Eaglstein","year":"1984","journal-title":"Clin. Dermatol."},{"key":"D4BM00777H\/cit32\/1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/PSN.0b013e318256d638","volume":"32","author":"Spear","year":"2012","journal-title":"Plast. Surg. Nurs."},{"key":"D4BM00777H\/cit33\/1","first-page":"289","volume":"34","author":"de Guzman","year":"2023","journal-title":"Biomed. Mater. Eng."},{"key":"D4BM00777H\/cit34\/1","doi-asserted-by":"crossref","first-page":"781","DOI":"10.3390\/ph14080781","volume":"14","author":"Mohamed","year":"2021","journal-title":"Pharmaceuticals"},{"key":"D4BM00777H\/cit35\/1","doi-asserted-by":"crossref","first-page":"5505","DOI":"10.3390\/polym14245505","volume":"14","author":"Hao","year":"2022","journal-title":"Polymers"},{"key":"D4BM00777H\/cit36\/1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s13770-017-0083-9","volume":"15","author":"Fan","year":"2018","journal-title":"Tissue Eng. Regener. Med."},{"key":"D4BM00777H\/cit37\/1","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1046\/j.1087-0024.2003.00805.x","volume":"8","author":"Tobin","year":"2003","journal-title":"J. Invest. Dermatol. Symp. Proc."},{"key":"D4BM00777H\/cit38\/1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/978-981-10-8195-8_4","volume":"1054","author":"Eckhart","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"D4BM00777H\/cit39\/1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-981-10-8195-8_5","volume":"1054","author":"Wu","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"D4BM00777H\/cit40\/1","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0968-4328(97)00039-5","volume":"28","author":"Jones","year":"1997","journal-title":"Micron"},{"key":"D4BM00777H\/cit41\/1","doi-asserted-by":"crossref","first-page":"e506","DOI":"10.7717\/peerj.506","volume":"2","author":"Laatsch","year":"2014","journal-title":"PeerJ"},{"key":"D4BM00777H\/cit42\/1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jsb.2006.03.018","volume":"155","author":"Parry","year":"2006","journal-title":"J. Struct. Biol."},{"key":"D4BM00777H\/cit43\/1","doi-asserted-by":"crossref","first-page":"608","DOI":"10.3390\/polym15030608","volume":"15","author":"Fernandes","year":"2023","journal-title":"Polymers"},{"key":"D4BM00777H\/cit44\/1","doi-asserted-by":"crossref","first-page":"e619","DOI":"10.7717\/peerj.619","volume":"2","author":"Yang","year":"2014","journal-title":"PeerJ"},{"key":"D4BM00777H\/cit45\/1","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1016\/j.bbamcr.2013.06.010","volume":"1833","author":"Eckhart","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"D4BM00777H\/cit46\/1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12862-015-0360-y","volume":"15","author":"Strasser","year":"2015","journal-title":"BMC Evol. Biol."},{"key":"D4BM00777H\/cit47\/1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-981-10-8195-8_3","volume":"1054","author":"Plowman","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"D4BM00777H\/cit48\/1","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1098\/rsta.2004.1395","volume":"362","author":"Akkermans","year":"2004","journal-title":"Philos. Trans. R. Soc., A"},{"key":"D4BM00777H\/cit49\/1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/978-981-10-8195-8_7","volume":"1054","author":"Fraser","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"D4BM00777H\/cit50\/1","doi-asserted-by":"crossref","first-page":"D523","DOI":"10.1093\/nar\/gkac1052","volume":"51","author":"UniProt","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"D4BM00777H\/cit51\/1","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/j.1469-7580.2009.01066.x","volume":"214","author":"Bragulla","year":"2009","journal-title":"J. Anat."},{"key":"D4BM00777H\/cit52\/1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/onc.2016.234","volume":"36","author":"Berens","year":"2017","journal-title":"Oncogene"},{"key":"D4BM00777H\/cit53\/1","doi-asserted-by":"crossref","first-page":"8746","DOI":"10.3390\/ijms21228746","volume":"21","author":"Briot","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"D4BM00777H\/cit54\/1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1021\/acsbiomaterials.0c01507","volume":"7","author":"Lai","year":"2021","journal-title":"ACS Biomater. Sci. Eng."},{"key":"D4BM00777H\/cit55\/1","doi-asserted-by":"crossref","first-page":"18681","DOI":"10.1021\/acsami.9b01725","volume":"11","author":"Gao","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D4BM00777H\/cit56\/1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/jmicro\/dfv372","volume":"65","author":"Imai","year":"2016","journal-title":"Microscopy"},{"key":"D4BM00777H\/cit57\/1","doi-asserted-by":"crossref","first-page":"4360","DOI":"10.3390\/ijms24054360","volume":"24","author":"Guo","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"D4BM00777H\/cit58\/1","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nri3073","volume":"11","author":"Murray","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"D4BM00777H\/cit59\/1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/jbm.a.36798","volume":"108","author":"Chu","year":"2020","journal-title":"J. Biomed. Mater. Res., Part A"},{"key":"D4BM00777H\/cit60\/1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s00238-017-1308-9","volume":"40","author":"Ibrahim","year":"2017","journal-title":"Eur. J. Plast. Surg."},{"key":"D4BM00777H\/cit61\/1","doi-asserted-by":"crossref","first-page":"5671","DOI":"10.3390\/ma8095269","volume":"8","author":"Sheikh","year":"2015","journal-title":"Materials"},{"key":"D4BM00777H\/cit62\/1","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1056\/NEJM199909023411006","volume":"341","author":"Singer","year":"1999","journal-title":"N. Engl. J. Med."},{"issue":"Suppl 1","key":"D4BM00777H\/cit63\/1","first-page":"S1","volume":"11","author":"Schultz","year":"2003","journal-title":"Wound Repair Regen."},{"key":"D4BM00777H\/cit64\/1","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/sj.jid.5700701","volume":"127","author":"Eming","year":"2007","journal-title":"J. Invest. Dermatol."},{"key":"D4BM00777H\/cit65\/1","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/jid.2011.450","volume":"132","author":"Coulombe","year":"2012","journal-title":"J. Invest. Dermatol."},{"key":"D4BM00777H\/cit66\/1","first-page":"173","volume":"31","author":"McGowan","year":"1998","journal-title":"Subcell. Biochem."},{"key":"D4BM00777H\/cit67\/1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1046\/j.1087-0024.2000.00014.x","volume":"5","author":"Tonnesen","year":"2000","journal-title":"J. Invest. Dermatol. Symp. Proc."},{"key":"D4BM00777H\/cit68\/1","author":"International Organization for Standardization","year":"2019","unstructured":"International Organization for Standardization ,  ISO 10993-5:2009 Part 5: Tests for in vitro cytotoxicity , 3rd edn,  2019"},{"key":"D4BM00777H\/cit69\/1","author":"International Organization for Standardization","year":"2021","unstructured":"International Organization for Standardization ,  ISO 10993-12:2021 Part 12: Sample preparation and reference materials , 5th edn,  2021"},{"key":"D4BM00777H\/cit70\/1","author":"International Organization for Standardization","year":"2006","unstructured":"International Organization for Standardization ,  ISO 10993-2:2006 Part 2: Animal welfare requirements , 2nd edn,  2006"},{"key":"D4BM00777H\/cit71\/1","author":"International Organization for Standardization","year":"2016","unstructured":"International Organization for Standardization ,  ISO 10993-6:2016 Part 6: Tests for local effects after implantation , 3rd edn,  2016"}],"container-title":["Biomaterials Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/BM\/D4BM00777H","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:55:05Z","timestamp":1782885305000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/bm\/article\/13\/13\/3633-3649\/837964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":70,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2025,6,25]]}},"URL":"https:\/\/doi.org\/10.1039\/d4bm00777h","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.04.29.591537","asserted-by":"object"}]},"ISSN":["2047-4830","2047-4849"],"issn-type":[{"value":"2047-4830","type":"print"},{"value":"2047-4849","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}