{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T11:53:43Z","timestamp":1792929223315,"version":"4.5.0"},"reference-count":53,"publisher":"Royal Society of Chemistry (RSC)","issue":"5","license":[{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"vor","delay-in-days":71,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100007898","name":"Frances and Augustus Newman Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007898","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["337969"],"award-info":[{"award-number":["337969"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004222","name":"Pembroke College, University of Cambridge","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004222","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003343","name":"Cambridge Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003343","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/L015978\/1"],"award-info":[{"award-number":["EP\/L015978\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Chem. Biol."],"abstract":"<jats:p>The aggregation of amyloid-\u03b2 (A\u03b2) into fibrils\/plaques is associated with Alzheimer's Disease. Lipids play a crucial role in this process. We show that ganglioside lipids inhibit A\u03b240\/A\u03b242 aggregation. This could be used to prevent fibril formation.<\/jats:p>","DOI":"10.1039\/d4cb00189c","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T13:01:00Z","timestamp":1741870860000},"page":"809-822","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Ganglioside lipids inhibit the aggregation of the Alzheimer's amyloid-\u03b2 peptide"],"prefix":"10.1039","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1964-8432","authenticated-orcid":false,"given":"Zenon","family":"Toprakcioglu","sequence":"first","affiliation":[{"name":"Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhila K.","family":"Jayaram","sequence":"additional","affiliation":[{"name":"Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK"},{"name":"Cavendish Laboratory, Department of Physics, University of Cambridge, J J Thomson Avenue, Cambridge CB3 0HE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0016-3008","authenticated-orcid":false,"given":"Tuomas P. J.","family":"Knowles","sequence":"additional","affiliation":[{"name":"Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2025]]},"reference":[{"key":"D4CB00189C\/cit1\/1","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.1038\/s41380-021-01249-0","volume":"26","author":"Hampel","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"D4CB00189C\/cit2\/1","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/aps.2017.28","volume":"38","author":"Chen","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"key":"D4CB00189C\/cit3\/1","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nrm3810","volume":"15","author":"Knowles","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"D4CB00189C\/cit4\/1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1146\/annurev-biochem-061516-045115","volume":"20","author":"Chiti","year":"2017","journal-title":"Annu. Rev. Biochem."},{"key":"D4CB00189C\/cit5\/1","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1038\/nature02261","volume":"426","author":"Dobson","year":"2003","journal-title":"Nature"},{"key":"D4CB00189C\/cit6\/1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1146\/annurev.biochem.75.101304.123901","volume":"75","author":"Chiti","year":"2006","journal-title":"Annu. Rev. Biochem."},{"key":"D4CB00189C\/cit7\/1","doi-asserted-by":"crossref","first-page":"7606","DOI":"10.1039\/C4CP05563B","volume":"17","author":"Arosio","year":"2015","journal-title":"Phys. Chem. Chem. Phys."},{"key":"D4CB00189C\/cit8\/1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1021\/ja408765u","volume":"136","author":"Arosio","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"D4CB00189C\/cit9\/1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jmb.2012.02.031","volume":"421","author":"Cohen","year":"2012","journal-title":"J. Mol. Biol."},{"key":"D4CB00189C\/cit10\/1","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/78682","volume":"6","author":"Bard","year":"2000","journal-title":"Nat. Med."},{"key":"D4CB00189C\/cit11\/1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/1750-1326-6-45","volume":"6","author":"Pan","year":"2011","journal-title":"Mol. Neurodegener."},{"key":"D4CB00189C\/cit12\/1","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/s41557-018-0031-x","volume":"10","author":"Habchi","year":"2018","journal-title":"Nat. Chem."},{"key":"D4CB00189C\/cit13\/1","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1021\/acschemneuro.0c00101","volume":"11","author":"Sanguanini","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"D4CB00189C\/cit14\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/biomedicines10020363","volume":"10","author":"Fazzari","year":"2022","journal-title":"Biomedicines"},{"key":"D4CB00189C\/cit15\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms21030868","volume":"21","author":"Chiricozzi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"D4CB00189C\/cit16\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-021-02374-x","volume":"19","author":"Galleguillos","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"D4CB00189C\/cit17\/1","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1194\/jlr.R800007-JLR200","volume":"49","author":"Ariga","year":"2008","journal-title":"J. Lipid Res."},{"key":"D4CB00189C\/cit18\/1","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1007\/s00018-005-5188-y","volume":"62","author":"Mocchetti","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"key":"D4CB00189C\/cit19\/1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s10719-015-9579-5","volume":"32","author":"Yanagisawa","year":"2015","journal-title":"Glycoconjugate J."},{"key":"D4CB00189C\/cit20\/1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0166-4328(94)00129-4","volume":"66","author":"Wiegandt","year":"1995","journal-title":"Behav. Brain Res."},{"key":"D4CB00189C\/cit21\/1","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1046\/j.1471-4159.1994.63051802.x","volume":"63","author":"Svennerholm","year":"1994","journal-title":"J. Neurochem."},{"key":"D4CB00189C\/cit22\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnins.2020.572965","volume":"14","author":"Sipione","year":"2020","journal-title":"Front. Neurosci."},{"key":"D4CB00189C\/cit23\/1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/978-1-4939-8552-4_2","volume":"1804","author":"Ledeen","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"D4CB00189C\/cit24\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13024-019-0339-z","volume":"14","author":"Huebecker","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"D4CB00189C\/cit25\/1","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jns.2012.10.024","volume":"324","author":"Schneider","year":"2013","journal-title":"J. Neurol. Sci."},{"key":"D4CB00189C\/cit26\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnins.2018.00045","volume":"12","author":"Forsayeth","year":"2018","journal-title":"Front. Neurosci."},{"key":"D4CB00189C\/cit27\/1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/bs.pmbts.2017.12.009","volume":"156","author":"Ledeen","year":"2018","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"D4CB00189C\/cit28\/1","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.bbalip.2010.01.008","volume":"1801","author":"Matsuzaki","year":"2010","journal-title":"Biochim. Biophys. Acta, Mol. Cell Biol. Lipids"},{"key":"D4CB00189C\/cit29\/1","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1021\/ar500127z","volume":"47","author":"Matsuzaki","year":"2014","journal-title":"Acc. Chem. Res."},{"key":"D4CB00189C\/cit30\/1","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1021\/acschemneuro.2c00221","volume":"13","author":"Zhang","year":"2022","journal-title":"ACS Chem. Neurosci."},{"key":"D4CB00189C\/cit31\/1","doi-asserted-by":"crossref","first-page":"9411","DOI":"10.1002\/anie.201603178","volume":"55","author":"Amaro","year":"2016","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4CB00189C\/cit32\/1","doi-asserted-by":"crossref","first-page":"9303","DOI":"10.1021\/acs.jpclett.2c02362","volume":"13","author":"Chakravorty","year":"2022","journal-title":"J. Phys. Chem. Lett."},{"key":"D4CB00189C\/cit33\/1","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.bpj.2017.03.009","volume":"113","author":"Cebecauer","year":"2017","journal-title":"Biophys. J."},{"key":"D4CB00189C\/cit34\/1","doi-asserted-by":"crossref","first-page":"9758","DOI":"10.1073\/pnas.1218402110","volume":"110","author":"Cohen","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D4CB00189C\/cit35\/1","doi-asserted-by":"crossref","first-page":"9384","DOI":"10.1073\/pnas.1401564111","volume":"111","author":"Meisl","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D4CB00189C\/cit36\/1","doi-asserted-by":"crossref","first-page":"e2109718119","DOI":"10.1073\/pnas.2109718119","volume":"119","author":"Toprakcioglu","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D4CB00189C\/cit37\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.celrep.2020.108132","volume":"32","author":"Fitzner","year":"2020","journal-title":"Cell Rep."},{"key":"D4CB00189C\/cit38\/1","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1007\/s11064-007-9304-2","volume":"32","author":"Sokolova","year":"2007","journal-title":"Neurochem. Res."},{"key":"D4CB00189C\/cit39\/1","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1159\/000063604","volume":"14","author":"Svennerholm","year":"2002","journal-title":"Dementia Geriatr. Cognit. Disord."},{"key":"D4CB00189C\/cit40\/1","doi-asserted-by":"crossref","first-page":"8362","DOI":"10.1038\/s41598-019-42847-x","volume":"9","author":"Schneider","year":"2019","journal-title":"Sci. Rep."},{"key":"D4CB00189C\/cit41\/1","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1007\/s10072-012-1263-y","volume":"34","author":"Yang","year":"2013","journal-title":"Neurol. Sci."},{"key":"D4CB00189C\/cit42\/1","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1021\/bi061749a","volume":"46","author":"Martinez","year":"2007","journal-title":"Biochemistry"},{"key":"D4CB00189C\/cit43\/1","doi-asserted-by":"crossref","first-page":"e103727","DOI":"10.1371\/journal.pone.0103727","volume":"9","author":"Bartels","year":"2014","journal-title":"PLoS One"},{"key":"D4CB00189C\/cit44\/1","doi-asserted-by":"crossref","first-page":"14146","DOI":"10.1074\/jbc.RA118.002787","volume":"293","author":"Matsubara","year":"2018","journal-title":"J. Biol. Chem."},{"key":"D4CB00189C\/cit45\/1","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/nprot.2016.010","volume":"11","author":"Meisl","year":"2016","journal-title":"Nat. Protoc."},{"key":"D4CB00189C\/cit46\/1","first-page":"1","volume":"10","author":"Abelein","year":"2020","journal-title":"Anal. Chem."},{"key":"D4CB00189C\/cit47\/1","doi-asserted-by":"crossref","first-page":"3849","DOI":"10.1021\/acs.analchem.7b04523","volume":"90","author":"Challa","year":"2018","journal-title":"Anal. Chem."},{"key":"D4CB00189C\/cit48\/1","doi-asserted-by":"crossref","first-page":"153702","DOI":"10.1063\/1.5145109","volume":"116","author":"Kartanas","year":"2020","journal-title":"Appl. Phys. Lett."},{"key":"D4CB00189C\/cit49\/1","doi-asserted-by":"crossref","first-page":"2848","DOI":"10.1021\/acs.analchem.0c04149","volume":"93","author":"Kartanas","year":"2021","journal-title":"Anal. Chem."},{"key":"D4CB00189C\/cit50\/1","doi-asserted-by":"crossref","first-page":"3082","DOI":"10.1039\/C9SM02274K","volume":"16","author":"Toprakcioglu","year":"2020","journal-title":"Soft Matter"},{"key":"D4CB00189C\/cit51\/1","doi-asserted-by":"crossref","first-page":"6739","DOI":"10.1021\/acsami.0c16019","volume":"13","author":"Czekalska","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D4CB00189C\/cit52\/1","doi-asserted-by":"crossref","first-page":"16401","DOI":"10.1021\/jacs.1c03681","volume":"143","author":"Hakala","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"D4CB00189C\/cit53\/1","doi-asserted-by":"crossref","first-page":"2007188","DOI":"10.1002\/smll.202007188","volume":"17","author":"Shimanovich","year":"2021","journal-title":"Small"}],"container-title":["RSC Chemical Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2025\/CB\/D4CB00189C","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:39:13Z","timestamp":1782851953000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.rsc.org\/cb\/article\/6\/5\/809-822\/838355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":53,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5,8]]}},"URL":"https:\/\/doi.org\/10.1039\/d4cb00189c","relation":{},"ISSN":["2633-0679"],"issn-type":[{"value":"2633-0679","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}